UniProtKB - P47872 (SCTR_HUMAN)
Secretin receptor
SCTR
Functioni
Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:7612008, PubMed:25332973).
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO3) from the ductal cells of the pancreas (By similarity).
In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).
1 PublicationBy similarity1 PublicationGO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- peptide hormone binding Source: GO_Central
- secretin receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- brain development Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
- cellular water homeostasis Source: UniProtKB
- diet induced thermogenesis Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: GO_Central
- positive regulation of cAMP-mediated signaling Source: UniProtKB
- regulation of appetite Source: UniProtKB
- regulation of synaptic plasticity Source: UniProtKB
- response to nutrient levels Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P47872 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P47872 |
Protein family/group databases
TCDBi | 9.A.14.4.10, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Secretin receptorShort name: SCT-R |
Gene namesi | Name:SCTR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10608, SCTR |
MIMi | 182098, gene |
neXtProti | NX_P47872 |
VEuPathDBi | HostDB:ENSG00000080293 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Cytoskeleton
- cytoplasmic microtubule Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 143 | ExtracellularSequence analysisAdd BLAST | 121 | |
Transmembranei | 144 – 167 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 168 – 174 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 175 – 194 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 195 – 216 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 217 – 240 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 241 – 254 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 255 – 276 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 277 – 294 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 295 – 317 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 318 – 343 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 344 – 362 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 363 – 369 | ExtracellularSequence analysis | 7 | |
Transmembranei | 370 – 392 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 393 – 440 | CytoplasmicSequence analysisAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 6344 |
OpenTargetsi | ENSG00000080293 |
PharmGKBi | PA35018 |
Miscellaneous databases
Pharosi | P47872, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1925 |
DrugBanki | DB09532, Secretin human |
DrugCentrali | P47872 |
GuidetoPHARMACOLOGYi | 252 |
Genetic variation databases
BioMutai | SCTR |
DMDMi | 2506489 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000012852 | 23 – 440 | Secretin receptorAdd BLAST | 418 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 291 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P47872 |
PRIDEi | P47872 |
ProteomicsDBi | 55806 |
PTM databases
GlyGeni | P47872, 5 sites |
iPTMneti | P47872 |
PhosphoSitePlusi | P47872 |
Expressioni
Gene expression databases
Bgeei | ENSG00000080293, Expressed in body of pancreas and 113 other tissues |
ExpressionAtlasi | P47872, baseline and differential |
Genevisiblei | P47872, HS |
Organism-specific databases
HPAi | ENSG00000080293, Group enriched (intestine, pancreas) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112248, 6 interactors |
IntActi | P47872, 2 interactors |
MINTi | P47872 |
STRINGi | 9606.ENSP00000019103 |
Chemistry databases
BindingDBi | P47872 |
Miscellaneous databases
RNActi | P47872, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P47872 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000160618 |
HOGENOMi | CLU_002753_4_4_1 |
InParanoidi | P47872 |
OMAi | NEKRHEY |
OrthoDBi | 651627at2759 |
PhylomeDBi | P47872 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR002144, GPCR_2_secretin_rcpt |
PANTHERi | PTHR45620:SF13, PTHR45620:SF13, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00490, SECRETINR |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS
60 70 80 90 100
REQTGDLGTE QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN
110 120 130 140 150
GSLFRNCTQD GWSETFPRPN LACGVNVNDS SNEKRHSYLL KLKVMYTVGY
160 170 180 190 200
SSSLVMLLVA LGILCAFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF
210 220 230 240 250
SSDDVTYCDA HRAGCKLVMV LFQYCIMANY SWLLVEGLYL HTLLAISFFS
260 270 280 290 300
ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG
310 320 330 340 350
PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL
360 370 380 390 400
FGIHYIVFAF SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ
410 420 430 440
KKWQQWHLRE FPLHPVASFS NSTKASHLEQ SQGTCRTSII
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0D9SFY2 | A0A0D9SFY2_HUMAN | Secretin receptor | SCTR | 243 | Annotation score: | ||
A0A0D9SFV7 | A0A0D9SFV7_HUMAN | Secretin receptor | SCTR | 150 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 124 | G → A in AAC50106 (PubMed:7864894).Curated | 1 | |
Sequence conflicti | 210 | A → P in AAA87556 (PubMed:7612008).Curated | 1 | |
Sequence conflicti | 308 | I → F in AAA64949 (PubMed:7700244).Curated | 1 | |
Sequence conflicti | 333 | E → Q in AAA64949 (PubMed:7700244).Curated | 1 | |
Sequence conflicti | 377 | G → A in AAC50106 (PubMed:7864894).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049456 | 110 | D → N. Corresponds to variant dbSNP:rs6726491EnsemblClinVar. | 1 | |
Natural variantiVAR_033970 | 122 | A → P. Corresponds to variant dbSNP:rs3731600Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20178 mRNA Translation: AAC50106.1 U28281 mRNA Translation: AAA87556.1 U13989 mRNA Translation: AAA64949.1 AB065660 Genomic DNA Translation: BAC05886.1 AY462218 mRNA Translation: AAR25625.1 AC013275 Genomic DNA Translation: AAY14741.1 CH471103 Genomic DNA Translation: EAW95219.1 |
CCDSi | CCDS2127.1 |
PIRi | JC2532 |
RefSeqi | NP_002971.2, NM_002980.2 |
Genome annotation databases
Ensembli | ENST00000019103; ENSP00000019103; ENSG00000080293 |
GeneIDi | 6344 |
KEGGi | hsa:6344 |
MANE-Selecti | ENST00000019103.8; ENSP00000019103.6; NM_002980.3; NP_002971.2 |
UCSCi | uc002tma.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20178 mRNA Translation: AAC50106.1 U28281 mRNA Translation: AAA87556.1 U13989 mRNA Translation: AAA64949.1 AB065660 Genomic DNA Translation: BAC05886.1 AY462218 mRNA Translation: AAR25625.1 AC013275 Genomic DNA Translation: AAY14741.1 CH471103 Genomic DNA Translation: EAW95219.1 |
CCDSi | CCDS2127.1 |
PIRi | JC2532 |
RefSeqi | NP_002971.2, NM_002980.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6WI9 | electron microscopy | 4.30 | R | 22-440 | [»] | |
6WZG | electron microscopy | 2.30 | R | 22-440 | [»] | |
7D3S | electron microscopy | 2.90 | R | 23-440 | [»] | |
SMRi | P47872 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112248, 6 interactors |
IntActi | P47872, 2 interactors |
MINTi | P47872 |
STRINGi | 9606.ENSP00000019103 |
Chemistry databases
BindingDBi | P47872 |
ChEMBLi | CHEMBL1925 |
DrugBanki | DB09532, Secretin human |
DrugCentrali | P47872 |
GuidetoPHARMACOLOGYi | 252 |
Protein family/group databases
TCDBi | 9.A.14.4.10, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P47872, 5 sites |
iPTMneti | P47872 |
PhosphoSitePlusi | P47872 |
Genetic variation databases
BioMutai | SCTR |
DMDMi | 2506489 |
Proteomic databases
PaxDbi | P47872 |
PRIDEi | P47872 |
ProteomicsDBi | 55806 |
Protocols and materials databases
Antibodypediai | 18314, 280 antibodies from 34 providers |
DNASUi | 6344 |
Genome annotation databases
Ensembli | ENST00000019103; ENSP00000019103; ENSG00000080293 |
GeneIDi | 6344 |
KEGGi | hsa:6344 |
MANE-Selecti | ENST00000019103.8; ENSP00000019103.6; NM_002980.3; NP_002971.2 |
UCSCi | uc002tma.4, human |
Organism-specific databases
CTDi | 6344 |
DisGeNETi | 6344 |
GeneCardsi | SCTR |
HGNCi | HGNC:10608, SCTR |
HPAi | ENSG00000080293, Group enriched (intestine, pancreas) |
MIMi | 182098, gene |
neXtProti | NX_P47872 |
OpenTargetsi | ENSG00000080293 |
PharmGKBi | PA35018 |
VEuPathDBi | HostDB:ENSG00000080293 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000160618 |
HOGENOMi | CLU_002753_4_4_1 |
InParanoidi | P47872 |
OMAi | NEKRHEY |
OrthoDBi | 651627at2759 |
PhylomeDBi | P47872 |
TreeFami | TF315710 |
Enzyme and pathway databases
PathwayCommonsi | P47872 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P47872 |
Miscellaneous databases
BioGRID-ORCSi | 6344, 13 hits in 1039 CRISPR screens |
ChiTaRSi | SCTR, human |
GeneWikii | Secretin_receptor |
GenomeRNAii | 6344 |
Pharosi | P47872, Tclin |
PROi | PR:P47872 |
RNActi | P47872, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000080293, Expressed in body of pancreas and 113 other tissues |
ExpressionAtlasi | P47872, baseline and differential |
Genevisiblei | P47872, HS |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR002144, GPCR_2_secretin_rcpt |
PANTHERi | PTHR45620:SF13, PTHR45620:SF13, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00490, SECRETINR |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCTR_HUMAN | |
Accessioni | P47872Primary (citable) accession number: P47872 Secondary accession number(s): Q12961, Q13213, Q53T00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families