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Protein

Secretin receptor

Gene

SCTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • peptide hormone binding Source: GO_Central
  • secretin receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors
SignaLinkiP47872

Protein family/group databases

TCDBi9.A.14.4.10 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin receptor
Short name:
SCT-R
Gene namesi
Name:SCTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000080293.9
HGNCiHGNC:10608 SCTR
MIMi182098 gene
neXtProtiNX_P47872

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 143ExtracellularSequence analysisAdd BLAST121
Transmembranei144 – 167Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini168 – 174CytoplasmicSequence analysis7
Transmembranei175 – 194Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini195 – 216ExtracellularSequence analysisAdd BLAST22
Transmembranei217 – 240Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini241 – 254CytoplasmicSequence analysisAdd BLAST14
Transmembranei255 – 276Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini277 – 294ExtracellularSequence analysisAdd BLAST18
Transmembranei295 – 317Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini318 – 343CytoplasmicSequence analysisAdd BLAST26
Transmembranei344 – 362Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini363 – 369ExtracellularSequence analysis7
Transmembranei370 – 392Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini393 – 440CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6344
OpenTargetsiENSG00000080293
PharmGKBiPA35018

Chemistry databases

ChEMBLiCHEMBL1925
DrugBankiDB00021 Secretin
GuidetoPHARMACOLOGYi252

Polymorphism and mutation databases

BioMutaiSCTR
DMDMi2506489

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001285223 – 440Secretin receptorAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP47872
PeptideAtlasiP47872
PRIDEiP47872
ProteomicsDBi55806

PTM databases

iPTMnetiP47872
PhosphoSitePlusiP47872

Expressioni

Gene expression databases

BgeeiENSG00000080293
CleanExiHS_SCTR
ExpressionAtlasiP47872 baseline and differential
GenevisibleiP47872 HS

Organism-specific databases

HPAiHPA007269

Interactioni

Protein-protein interaction databases

BioGridi112248, 6 interactors
IntActiP47872, 3 interactors
MINTiP47872
STRINGi9606.ENSP00000019103

Chemistry databases

BindingDBiP47872

Structurei

3D structure databases

ProteinModelPortaliP47872
SMRiP47872
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008249
HOVERGENiHBG008318
InParanoidiP47872
KOiK04588
OMAiQEEQDQC
OrthoDBiEOG091G0NF8
PhylomeDBiP47872
TreeFamiTF315710

Family and domain databases

CDDicd15275 7tmB1_secretin, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR002144 GPCR_2_secretin_rcpt
PANTHERiPTHR12011:SF29 PTHR12011:SF29, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00490 SECRETINR
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS
60 70 80 90 100
REQTGDLGTE QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN
110 120 130 140 150
GSLFRNCTQD GWSETFPRPN LACGVNVNDS SNEKRHSYLL KLKVMYTVGY
160 170 180 190 200
SSSLVMLLVA LGILCAFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF
210 220 230 240 250
SSDDVTYCDA HRAGCKLVMV LFQYCIMANY SWLLVEGLYL HTLLAISFFS
260 270 280 290 300
ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG
310 320 330 340 350
PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL
360 370 380 390 400
FGIHYIVFAF SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ
410 420 430 440
KKWQQWHLRE FPLHPVASFS NSTKASHLEQ SQGTCRTSII
Length:440
Mass (Da):50,207
Last modified:November 1, 1997 - v2
Checksum:iE22CDD0EE7C0ACC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124G → A in AAC50106 (PubMed:7864894).Curated1
Sequence conflicti210A → P in AAA87556 (PubMed:7612008).Curated1
Sequence conflicti308I → F in AAA64949 (PubMed:7700244).Curated1
Sequence conflicti333E → Q in AAA64949 (PubMed:7700244).Curated1
Sequence conflicti377G → A in AAC50106 (PubMed:7864894).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049456110D → N. Corresponds to variant dbSNP:rs6726491Ensembl.1
Natural variantiVAR_033970122A → P. Corresponds to variant dbSNP:rs3731600Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20178 mRNA Translation: AAC50106.1
U28281 mRNA Translation: AAA87556.1
U13989 mRNA Translation: AAA64949.1
AB065660 Genomic DNA Translation: BAC05886.1
AY462218 mRNA Translation: AAR25625.1
AC013275 Genomic DNA Translation: AAY14741.1
CH471103 Genomic DNA Translation: EAW95219.1
CCDSiCCDS2127.1
PIRiJC2532
RefSeqiNP_002971.2, NM_002980.2
UniGeneiHs.42091

Genome annotation databases

EnsembliENST00000019103; ENSP00000019103; ENSG00000080293
GeneIDi6344
KEGGihsa:6344
UCSCiuc002tma.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSCTR_HUMAN
AccessioniPrimary (citable) accession number: P47872
Secondary accession number(s): Q12961, Q13213, Q53T00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: July 18, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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