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Protein

Glucagon receptor

Gene

GCGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glucagon receptor activity Source: UniProtKB
  • G protein-coupled peptide receptor activity Source: GO_Central
  • guanyl-nucleotide exchange factor activity Source: Reactome
  • peptide hormone binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P47871

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucagon receptor
Short name:
GL-R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCGR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000215644.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4192 GCGR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
138033 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P47871

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 136Extracellular3 PublicationsAdd BLAST111
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei137 – 161Helical; Name=13 PublicationsAdd BLAST25
Topological domaini162 – 173Cytoplasmic3 PublicationsAdd BLAST12
Transmembranei174 – 198Helical; Name=23 PublicationsAdd BLAST25
Topological domaini199 – 225Extracellular3 PublicationsAdd BLAST27
Transmembranei226 – 249Helical; Name=33 PublicationsAdd BLAST24
Topological domaini250 – 263Cytoplasmic3 PublicationsAdd BLAST14
Transmembranei264 – 285Helical; Name=43 PublicationsAdd BLAST22
Topological domaini286 – 303Extracellular3 PublicationsAdd BLAST18
Transmembranei304 – 326Helical; Name=53 PublicationsAdd BLAST23
Topological domaini327 – 350Cytoplasmic3 PublicationsAdd BLAST24
Transmembranei351 – 369Helical; Name=63 PublicationsAdd BLAST19
Topological domaini370 – 381Extracellular3 PublicationsAdd BLAST12
Transmembranei382 – 402Helical; Name=73 PublicationsAdd BLAST21
Topological domaini403 – 477Cytoplasmic3 PublicationsAdd BLAST75

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi36W → A: Abolishes glucagon binding. 1 Publication1
Mutagenesisi63D → A: Abolishes glucagon binding. 1 Publication1
Mutagenesisi65Y → A: Strongly reduced affinity for glucagon. Increased constitutive signaling via G-proteins. 1 Publication1
Mutagenesisi113Q → A or N: No effect on affinity for glucagon. 1 Publication1
Mutagenesisi113Q → C: Causes the formation of an artifactual disulfide bond that abolishes glucagon binding; when associated with C-209. 1 Publication1
Mutagenesisi113Q → E: Strongly reduced affinity for glucagon. 1 Publication1
Mutagenesisi130V → C: Causes the formation of an artifactual disulfide bond that interferes with glucagon binding; when associated with C-210. 1 Publication1
Mutagenesisi135A → P: Abolishes glucagon binding. 1 Publication1
Mutagenesisi145Y → A: Abolishes glucagon binding. 1 Publication1
Mutagenesisi149Y → A: Abolishes expression at cell surface and glucagon binding. 1 Publication1
Mutagenesisi198L → A: Abolishes glucagon binding. 1 Publication1
Mutagenesisi201R → D: Abolishes glucagon binding. 1 Publication1
Mutagenesisi202Y → A: Abolishes glucagon binding. 1 Publication1
Mutagenesisi208D → Q: Abolishes glucagon binding. 1 Publication1
Mutagenesisi209D → C: Causes the formation of an artifactual disulfide bond that abolishes glucagon binding; when associated with C-113. 1 Publication1
Mutagenesisi210L → C: Causes the formation of an artifactual disulfide bond that interferes with glucagon binding; when associated with C-130. 1 Publication1
Mutagenesisi215W → L: Abolishes glucagon binding. 1 Publication1
Mutagenesisi232Q → L: Abolishes expression at cell surface and glucagon binding. 1 Publication1
Mutagenesisi233Y → A: Abolishes glucagon binding. Strongly reduces expression at the cell surface. 1 Publication1
Mutagenesisi286K → L: Abolishes glucagon binding. 1 Publication1
Mutagenesisi290E → A: Abolishes glucagon binding. 1 Publication1
Mutagenesisi294C → A or S: Abolishes glucagon binding. 1 Publication1
Mutagenesisi295W → A or H: Abolishes glucagon binding. 1 Publication1
Mutagenesisi304W → Q: Abolishes glucagon binding. 1 Publication1
Mutagenesisi350S → A: Strongly decreases affinity for synthetic antagonist. 1 Publication1
Mutagenesisi353T → A: Loss of synthetic antagonist binding. 1 Publication1
Mutagenesisi382L → A: Abolishes glucagon binding. 1 Publication1
Mutagenesisi386L → F: Abolishes glucagon binding. 1 Publication1

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNET

More...
DisGeNETi
2642

MalaCards human disease database

More...
MalaCardsi
GCGR

Open Targets

More...
OpenTargetsi
ENSG00000215644

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
438274 GCGR-related hyperglucagonemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28607

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1985

Drug and drug target database

More...
DrugBanki
DB00040 Glucagon recombinant

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
251

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GCGR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1346144

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001283226 – 477Glucagon receptorAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi43 ↔ 67Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi58 ↔ 100Combined sources2 Publications
Glycosylationi59N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi74N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi78N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Disulfide bondi81 ↔ 121Combined sources2 Publications
Disulfide bondi224 ↔ 294Combined sources3 Publications
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei456PhosphoserineCombined sources1
Modified residuei459PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P47871

PeptideAtlas

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PeptideAtlasi
P47871

PRoteomics IDEntifications database

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PRIDEi
P47871

ProteomicsDB human proteome resource

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ProteomicsDBi
55805

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P47871

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P47871

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000215644 Expressed in 69 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_GCGR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P47871 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P47871 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA071228

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108912, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P47871, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000383558

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P47871

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1477
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P47871

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P47871

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P47871

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni350 – 353Allosteric inhibitor binding2 Publications4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4564 Eukaryota
ENOG410XRS2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157969

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008250

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG008318

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P47871

KEGG Orthology (KO)

More...
KOi
K04583

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P47871

TreeFam database of animal gene trees

More...
TreeFami
TF315710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003290 GPCR_2_GLP1/glucagon_rcpt
IPR003291 GPCR_2_glucagon_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01353 GLUCAGNFAMLY
PR01354 GLUCAGONR
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00008 HormR, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF111418 SSF111418, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P47871-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPCQPQRPL LLLLLLLACQ PQVPSAQVMD FLFEKWKLYG DQCHHNLSLL
60 70 80 90 100
PPPTELVCNR TFDKYSCWPD TPANTTANIS CPWYLPWHHK VQHRFVFKRC
110 120 130 140 150
GPDGQWVRGP RGQPWRDASQ CQMDGEEIEV QKEVAKMYSS FQVMYTVGYS
160 170 180 190 200
LSLGALLLAL AILGGLSKLH CTRNAIHANL FASFVLKASS VLVIDGLLRT
210 220 230 240 250
RYSQKIGDDL SVSTWLSDGA VAGCRVAAVF MQYGIVANYC WLLVEGLYLH
260 270 280 290 300
NLLGLATLPE RSFFSLYLGI GWGAPMLFVV PWAVVKCLFE NVQCWTSNDN
310 320 330 340 350
MGFWWILRFP VFLAILINFF IFVRIVQLLV AKLRARQMHH TDYKFRLAKS
360 370 380 390 400
TLTLIPLLGV HEVVFAFVTD EHAQGTLRSA KLFFDLFLSS FQGLLVAVLY
410 420 430 440 450
CFLNKEVQSE LRRRWHRWRL GKVLWEERNT SNHRASSSPG HGPPSKELQF
460 470
GRGGGSQDSS AETPLAGGLP RLAESPF
Length:477
Mass (Da):54,009
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADBB477C6267AE6E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L454I3L454_HUMAN
Glucagon receptor
GCGR
523Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1L8I3L1L8_HUMAN
Glucagon receptor
GCGR
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00358140G → S1 PublicationCorresponds to variant dbSNP:rs1801483EnsemblClinVar.1
Natural variantiVAR_06981586P → S Abolishes glucagon binding. 2 Publications1
Natural variantiVAR_014837114P → A. Corresponds to variant dbSNP:rs5385Ensembl.1
Natural variantiVAR_033966303F → C. Corresponds to variant dbSNP:rs5387Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U03469 mRNA Translation: AAC52063.1
L20316 mRNA Translation: AAA53628.1
BC104854 mRNA Translation: AAI04855.1
BC112041 mRNA Translation: AAI12042.1
L24751 Genomic DNA Translation: AAA35897.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS54177.1

Protein sequence database of the Protein Information Resource

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PIRi
JC2041

NCBI Reference Sequences

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RefSeqi
NP_000151.1, NM_000160.4
XP_006722340.1, XM_006722277.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.208

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000400723; ENSP00000383558; ENSG00000215644

Database of genes from NCBI RefSeq genomes

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GeneIDi
2642

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2642

UCSC genome browser

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UCSCi
uc010wuw.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03469 mRNA Translation: AAC52063.1
L20316 mRNA Translation: AAA53628.1
BC104854 mRNA Translation: AAI04855.1
BC112041 mRNA Translation: AAI12042.1
L24751 Genomic DNA Translation: AAA35897.1
CCDSiCCDS54177.1
PIRiJC2041
RefSeqiNP_000151.1, NM_000160.4
XP_006722340.1, XM_006722277.1
UniGeneiHs.208

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A83X-ray1.40C412-420[»]
3CZFX-ray1.20C412-420[»]
4ERSX-ray2.64A28-123[»]
4L6RX-ray3.30A123-432[»]
4LF3X-ray2.74C/F29-123[»]
5EE7X-ray2.50A136-254[»]
A259-417[»]
5XEZX-ray3.00A/B27-432[»]
ProteinModelPortaliP47871
SMRiP47871
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108912, 3 interactors
IntActiP47871, 4 interactors
STRINGi9606.ENSP00000383558

Chemistry databases

BindingDBiP47871
ChEMBLiCHEMBL1985
DrugBankiDB00040 Glucagon recombinant
GuidetoPHARMACOLOGYi251

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiP47871
PhosphoSitePlusiP47871

Polymorphism and mutation databases

BioMutaiGCGR
DMDMi1346144

Proteomic databases

PaxDbiP47871
PeptideAtlasiP47871
PRIDEiP47871
ProteomicsDBi55805

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400723; ENSP00000383558; ENSG00000215644
GeneIDi2642
KEGGihsa:2642
UCSCiuc010wuw.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2642
DisGeNETi2642
EuPathDBiHostDB:ENSG00000215644.9

GeneCards: human genes, protein and diseases

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GeneCardsi
GCGR
HGNCiHGNC:4192 GCGR
HPAiHPA071228
MalaCardsiGCGR
MIMi138033 gene
neXtProtiNX_P47871
OpenTargetsiENSG00000215644
Orphaneti438274 GCGR-related hyperglucagonemia
PharmGKBiPA28607

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00940000157969
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiP47871
KOiK04583
PhylomeDBiP47871
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-416476 G alpha (q) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors
SIGNORiP47871

Miscellaneous databases

EvolutionaryTraceiP47871

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Glucagon_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2642

Protein Ontology

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PROi
PR:P47871

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000215644 Expressed in 69 organ(s), highest expression level in right lobe of liver
CleanExiHS_GCGR
ExpressionAtlasiP47871 baseline and differential
GenevisibleiP47871 HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003290 GPCR_2_GLP1/glucagon_rcpt
IPR003291 GPCR_2_glucagon_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01353 GLUCAGNFAMLY
PR01354 GLUCAGONR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47871
Secondary accession number(s): Q2M3M5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 5, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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