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Protein

Gamma-aminobutyric acid receptor subunit beta-2

Gene

GABRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei224AgonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-977441 GABA A receptor activation

Protein family/group databases

TCDBi1.A.9.5.2 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit beta-2
Alternative name(s):
GABA(A) receptor subunit beta-2
Gene namesi
Name:GABRB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145864.12
HGNCiHGNC:4082 GABRB2
MIMi600232 gene
neXtProtiNX_P47870

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 244ExtracellularCuratedAdd BLAST219
Transmembranei245 – 266HelicalCuratedAdd BLAST22
Transmembranei270 – 292HelicalCuratedAdd BLAST23
Transmembranei304 – 326HelicalCuratedAdd BLAST23
Topological domaini327 – 489CytoplasmicCuratedAdd BLAST163
Transmembranei490 – 511HelicalCuratedAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Epileptic encephalopathy, infantile or early childhood, 2 (IECEE2)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. IECEE2 is an autosomal dominant condition with variable age at seizure onset, ranging from early infancy to 6 years.
See also OMIM:617829
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08071279M → T in IECEE2; unknown pathological significance. 2 Publications1
Natural variantiVAR_080713244Y → H in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080714277L → S in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080715284T → K in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080716287T → P in IECEE2; loss of localization to the cell membrane; retained intracellularly it affects the cell surface expression of the GABA receptor; decreased GABA receptor activity. 1 Publication1
Natural variantiVAR_080717293R → P in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080718303K → R in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080719304A → V in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080720316V → I in IECEE2; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi389T → A: Displays reduced current rundown following repeated receptor activation. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNETi2561
MalaCardsiGABRB2
MIMi617829 phenotype
OpenTargetsiENSG00000145864
Orphaneti442835 Undetermined early-onset epileptic encephalopathy
PharmGKBiPA28496

Chemistry databases

ChEMBLiCHEMBL1920
DrugBankiDB00659 Acamprosate
DB00546 Adinazolam
DB00404 Alprazolam
DB00543 Amoxapine
DB01558 Bromazepam
DB00237 Butabarbital
DB00241 Butalbital
DB00475 Chlordiazepoxide
DB01594 Cinolazepam
DB00349 Clobazam
DB01068 Clonazepam
DB00628 Clorazepate
DB01559 Clotiazepam
DB01189 Desflurane
DB00829 Diazepam
DB00228 Enflurane
DB01049 Ergoloid mesylate
DB01215 Estazolam
DB00402 Eszopiclone
DB00898 Ethanol
DB00189 Ethchlorvynol
DB00292 Etomidate
DB01567 Fludiazepam
DB01205 Flumazenil
DB00690 Flurazepam
DB06716 Fospropofol
DB01381 Ginkgo biloba
DB01437 Glutethimide
DB00801 Halazepam
DB01159 Halothane
DB00753 Isoflurane
DB00186 Lorazepam
DB00371 Meprobamate
DB00463 Metharbital
DB01028 Methoxyflurane
DB01107 Methyprylon
DB00683 Midazolam
DB01595 Nitrazepam
DB00334 Olanzapine
DB00842 Oxazepam
DB00312 Pentobarbital
DB01708 Prasterone
DB01588 Prazepam
DB00794 Primidone
DB00818 Propofol
DB01589 Quazepam
DB01236 Sevoflurane
DB00306 Talbutal
DB00231 Temazepam
DB11582 Thiocolchicoside
DB00273 Topiramate
DB00897 Triazolam

Polymorphism and mutation databases

BioMutaiGABRB2
DMDMi292495010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000000045926 – 512Gamma-aminobutyric acid receptor subunit beta-2Add BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 174By similarity
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei441PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP47870
PaxDbiP47870
PeptideAtlasiP47870
PRIDEiP47870
ProteomicsDBi55801
55802 [P47870-1]
55803 [P47870-3]
55804 [P47870-4]

PTM databases

iPTMnetiP47870
PhosphoSitePlusiP47870

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.2 Publications

Gene expression databases

BgeeiENSG00000145864 Expressed in 133 organ(s), highest expression level in primary visual cortex
CleanExiHS_GABRB2
ExpressionAtlasiP47870 baseline and differential
GenevisibleiP47870 HS

Organism-specific databases

HPAiCAB001964
HPA067632

Interactioni

Subunit structurei

Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed:8264558). Interacts with UBQLN1 (By similarity). Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). May interact with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi108835, 4 interactors
ComplexPortaliCPX-2159 GABA-A receptor, alpha-1/beta-2/gamma-2
CPX-2952 GABA-A receptor, alpha-6/beta-2/delta
CPX-2953 GABA-A receptor, alpha-4/beta-2/delta
CORUMiP47870
IntActiP47870, 1 interactor
MINTiP47870
STRINGi9606.ENSP00000274547

Chemistry databases

BindingDBiP47870

Structurei

3D structure databases

ProteinModelPortaliP47870
SMRiP47870
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 121Agonist bindingBy similarity3
Regioni179 – 181Agonist bindingBy similarity3
Regioni289 – 310Allosteric effector bindingBy similarityAdd BLAST22

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOVERGENiHBG051707
InParanoidiP47870
KOiK05181
OMAiKNKMDPH
OrthoDBiEOG091G0805
PhylomeDBiP47870
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR002289 GABAAb_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01160 GABAARBETA
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P47870-2) [UniParc]FASTAAdd to basket
Also known as: Long, Beta-2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWRVRKRGYF GIWSFPLIIA AVCAQSVNDP SNMSLVKETV DRLLKGYDIR
60 70 80 90 100
LRPDFGGPPV AVGMNIDIAS IDMVSEVNMD YTLTMYFQQA WRDKRLSYNV
110 120 130 140 150
IPLNLTLDNR VADQLWVPDT YFLNDKKSFV HGVTVKNRMI RLHPDGTVLY
160 170 180 190 200
GLRITTTAAC MMDLRRYPLD EQNCTLEIES YGYTTDDIEF YWRGDDNAVT
210 220 230 240 250
GVTKIELPQF SIVDYKLITK KVVFSTGSYP RLSLSFKLKR NIGYFILQTY
260 270 280 290 300
MPSILITILS WVSFWINYDA SAARVALGIT TVLTMTTINT HLRETLPKIP
310 320 330 340 350
YVKAIDMYLM GCFVFVFMAL LEYALVNYIF FGRGPQRQKK AAEKAASANN
360 370 380 390 400
EKMRLDVNKI FYKDIKQNGT QYRSLWDPTG NLSPTRRTTN YDFSLYTMDP
410 420 430 440 450
HENILLSTLE IKNEMATSEA VMGLGDPRST MLAYDASSIQ YRKAGLPRHS
460 470 480 490 500
FGRNALERHV AQKKSRLRRR ASQLKITIPD LTDVNAIDRW SRIFFPVVFS
510
FFNIVYWLYY VN
Length:512
Mass (Da):59,150
Last modified:March 23, 2010 - v2
Checksum:iC390A0C92815DD89
GO
Isoform 2 (identifier: P47870-1) [UniParc]FASTAAdd to basket
Also known as: Short, Beta-2S

The sequence of this isoform differs from the canonical sequence as follows:
     360-397: Missing.

Show »
Length:474
Mass (Da):54,606
Checksum:i1390A982EB616332
GO
Isoform 3 (identifier: P47870-3) [UniParc]FASTAAdd to basket
Also known as: Beta-2S1

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     360-376: IFYKDIKQNGTQYRSLW → VNSEGKPSLLLKLMEEC
     377-512: Missing.

Show »
Length:313
Mass (Da):36,086
Checksum:i5914B38B94A611B2
GO
Isoform 4 (identifier: P47870-4) [UniParc]FASTAAdd to basket
Also known as: Beta-2S2

The sequence of this isoform differs from the canonical sequence as follows:
     360-397: Missing.
     410-410: E → D
     411-512: Missing.

Show »
Length:372
Mass (Da):42,741
Checksum:i0550692E2DD2662C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z279B7Z279_HUMAN
Gamma-aminobutyric acid receptor su...
GABRB2
314Annotation score:
E7EV50E7EV50_HUMAN
Gamma-aminobutyric acid receptor su...
GABRB2
411Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti336Q → L in BAF82419 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08071279M → T in IECEE2; unknown pathological significance. 2 Publications1
Natural variantiVAR_080713244Y → H in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080714277L → S in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080715284T → K in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080716287T → P in IECEE2; loss of localization to the cell membrane; retained intracellularly it affects the cell surface expression of the GABA receptor; decreased GABA receptor activity. 1 Publication1
Natural variantiVAR_080717293R → P in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080718303K → R in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080719304A → V in IECEE2; unknown pathological significance. 1 Publication1
Natural variantiVAR_080720316V → I in IECEE2; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0388231 – 63Missing in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_038825360 – 397Missing in isoform 2 and isoform 4. 5 PublicationsAdd BLAST38
Alternative sequenceiVSP_038824360 – 376IFYKD…YRSLW → VNSEGKPSLLLKLMEEC in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_038828377 – 512Missing in isoform 3. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_038826410E → D in isoform 4. 1 Publication1
Alternative sequenceiVSP_038827411 – 512Missing in isoform 4. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67368 mRNA Translation: AAB29370.1
S77554 mRNA Translation: AAB33983.1
S77553 mRNA Translation: AAB33982.1
GU086163 mRNA Translation: ACY69094.1
GU086164 mRNA Translation: ACY69095.1
AK289730 mRNA Translation: BAF82419.1
AK289815 mRNA Translation: BAF82504.1
CH471062 Genomic DNA Translation: EAW61543.1
BC099705 mRNA Translation: AAH99705.1
BC099719 mRNA Translation: AAH99719.1
BC105639 mRNA Translation: AAI05640.1
CCDSiCCDS4354.1 [P47870-1]
CCDS4355.1 [P47870-2]
PIRiI52656
RefSeqiNP_000804.1, NM_000813.2 [P47870-1]
NP_068711.1, NM_021911.2 [P47870-2]
UniGeneiHs.303527

Genome annotation databases

EnsembliENST00000274547; ENSP00000274547; ENSG00000145864 [P47870-2]
ENST00000353437; ENSP00000274546; ENSG00000145864 [P47870-1]
ENST00000393959; ENSP00000377531; ENSG00000145864 [P47870-2]
ENST00000520240; ENSP00000429320; ENSG00000145864 [P47870-1]
ENST00000612710; ENSP00000480066; ENSG00000145864 [P47870-3]
GeneIDi2561
KEGGihsa:2561
UCSCiuc003lyr.2 human [P47870-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Forbidden fruit - Issue 56 of March 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67368 mRNA Translation: AAB29370.1
S77554 mRNA Translation: AAB33983.1
S77553 mRNA Translation: AAB33982.1
GU086163 mRNA Translation: ACY69094.1
GU086164 mRNA Translation: ACY69095.1
AK289730 mRNA Translation: BAF82419.1
AK289815 mRNA Translation: BAF82504.1
CH471062 Genomic DNA Translation: EAW61543.1
BC099705 mRNA Translation: AAH99705.1
BC099719 mRNA Translation: AAH99719.1
BC105639 mRNA Translation: AAI05640.1
CCDSiCCDS4354.1 [P47870-1]
CCDS4355.1 [P47870-2]
PIRiI52656
RefSeqiNP_000804.1, NM_000813.2 [P47870-1]
NP_068711.1, NM_021911.2 [P47870-2]
UniGeneiHs.303527

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6D6Telectron microscopy3.80A/C25-331[»]
6D6Uelectron microscopy3.80A/C25-331[»]
ProteinModelPortaliP47870
SMRiP47870
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108835, 4 interactors
ComplexPortaliCPX-2159 GABA-A receptor, alpha-1/beta-2/gamma-2
CPX-2952 GABA-A receptor, alpha-6/beta-2/delta
CPX-2953 GABA-A receptor, alpha-4/beta-2/delta
CORUMiP47870
IntActiP47870, 1 interactor
MINTiP47870
STRINGi9606.ENSP00000274547

Chemistry databases

BindingDBiP47870
ChEMBLiCHEMBL1920
DrugBankiDB00659 Acamprosate
DB00546 Adinazolam
DB00404 Alprazolam
DB00543 Amoxapine
DB01558 Bromazepam
DB00237 Butabarbital
DB00241 Butalbital
DB00475 Chlordiazepoxide
DB01594 Cinolazepam
DB00349 Clobazam
DB01068 Clonazepam
DB00628 Clorazepate
DB01559 Clotiazepam
DB01189 Desflurane
DB00829 Diazepam
DB00228 Enflurane
DB01049 Ergoloid mesylate
DB01215 Estazolam
DB00402 Eszopiclone
DB00898 Ethanol
DB00189 Ethchlorvynol
DB00292 Etomidate
DB01567 Fludiazepam
DB01205 Flumazenil
DB00690 Flurazepam
DB06716 Fospropofol
DB01381 Ginkgo biloba
DB01437 Glutethimide
DB00801 Halazepam
DB01159 Halothane
DB00753 Isoflurane
DB00186 Lorazepam
DB00371 Meprobamate
DB00463 Metharbital
DB01028 Methoxyflurane
DB01107 Methyprylon
DB00683 Midazolam
DB01595 Nitrazepam
DB00334 Olanzapine
DB00842 Oxazepam
DB00312 Pentobarbital
DB01708 Prasterone
DB01588 Prazepam
DB00794 Primidone
DB00818 Propofol
DB01589 Quazepam
DB01236 Sevoflurane
DB00306 Talbutal
DB00231 Temazepam
DB11582 Thiocolchicoside
DB00273 Topiramate
DB00897 Triazolam

Protein family/group databases

TCDBi1.A.9.5.2 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

PTM databases

iPTMnetiP47870
PhosphoSitePlusiP47870

Polymorphism and mutation databases

BioMutaiGABRB2
DMDMi292495010

Proteomic databases

EPDiP47870
PaxDbiP47870
PeptideAtlasiP47870
PRIDEiP47870
ProteomicsDBi55801
55802 [P47870-1]
55803 [P47870-3]
55804 [P47870-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274547; ENSP00000274547; ENSG00000145864 [P47870-2]
ENST00000353437; ENSP00000274546; ENSG00000145864 [P47870-1]
ENST00000393959; ENSP00000377531; ENSG00000145864 [P47870-2]
ENST00000520240; ENSP00000429320; ENSG00000145864 [P47870-1]
ENST00000612710; ENSP00000480066; ENSG00000145864 [P47870-3]
GeneIDi2561
KEGGihsa:2561
UCSCiuc003lyr.2 human [P47870-2]

Organism-specific databases

CTDi2561
DisGeNETi2561
EuPathDBiHostDB:ENSG00000145864.12
GeneCardsiGABRB2
HGNCiHGNC:4082 GABRB2
HPAiCAB001964
HPA067632
MalaCardsiGABRB2
MIMi600232 gene
617829 phenotype
neXtProtiNX_P47870
OpenTargetsiENSG00000145864
Orphaneti442835 Undetermined early-onset epileptic encephalopathy
PharmGKBiPA28496
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOVERGENiHBG051707
InParanoidiP47870
KOiK05181
OMAiKNKMDPH
OrthoDBiEOG091G0805
PhylomeDBiP47870
TreeFamiTF315453

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-977441 GABA A receptor activation

Miscellaneous databases

ChiTaRSiGABRB2 human
GeneWikiiGABRB2
GenomeRNAii2561
PROiPR:P47870
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145864 Expressed in 133 organ(s), highest expression level in primary visual cortex
CleanExiHS_GABRB2
ExpressionAtlasiP47870 baseline and differential
GenevisibleiP47870 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR002289 GABAAb_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01160 GABAARBETA
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBRB2_HUMAN
AccessioniPrimary (citable) accession number: P47870
Secondary accession number(s): A8K115
, A8K1A0, D1LYT0, D1LYT1, Q16323, Q4FZB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 23, 2010
Last modified: November 7, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
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