UniProtKB - P47869 (GBRA2_HUMAN)
Gamma-aminobutyric acid receptor subunit alpha-2
GABRA2
Functioni
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31032849).
Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:29961870, PubMed:31032849).
The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).
The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).
By similarity2 PublicationsActivity regulationi
GO - Molecular functioni
- benzodiazepine receptor activity Source: UniProtKB
- GABA-A receptor activity Source: InterPro
- GABA-gated chloride ion channel activity Source: GO_Central
- inhibitory extracellular ligand-gated ion channel activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- gamma-aminobutyric acid signaling pathway Source: UniProtKB
- inhibitory synapse assembly Source: UniProtKB
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- neurotransmitter transport Source: UniProtKB
- regulation of membrane potential Source: GO_Central
- regulation of neurotransmitter levels Source: UniProtKB
- regulation of postsynaptic membrane potential Source: GO_Central
- signal transduction Source: GO_Central
- synaptic transmission, GABAergic Source: GO_Central
Keywordsi
Molecular function | Chloride channel, Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Enzyme and pathway databases
PathwayCommonsi | P47869 |
Reactomei | R-HSA-977443, GABA receptor activation |
SignaLinki | P47869 |
SIGNORi | P47869 |
Protein family/group databases
TCDBi | 1.A.9.5.2, the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit alpha-2Alternative name(s): GABA(A) receptor subunit alpha-2 |
Gene namesi | Name:GABRA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4076, GABRA2 |
MIMi | 137140, gene |
neXtProti | NX_P47869 |
VEuPathDBi | HostDB:ENSG00000151834 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane By similarity; Multi-pass membrane protein Sequence analysis
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- Cytoplasmic vesicle membrane By similarity
- dendrite By similarity
Plasma Membrane
- dendrite membrane Source: GO_Central
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic specialization membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- axon Source: Ensembl
- chloride channel complex Source: UniProtKB-KW
- GABA-A receptor complex Source: GO_Central
- GABA-ergic synapse Source: Ensembl
- inhibitory synapse Source: Ensembl
- integral component of synaptic vesicle membrane Source: UniProtKB
- neuron projection Source: GO_Central
- neuronal cell body Source: Ensembl
- postsynapse Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 251 | ExtracellularCuratedAdd BLAST | 223 | |
Transmembranei | 252 – 273 | HelicalCuratedAdd BLAST | 22 | |
Transmembranei | 279 – 300 | HelicalCuratedAdd BLAST | 22 | |
Transmembranei | 313 – 334 | HelicalCuratedAdd BLAST | 22 | |
Topological domaini | 335 – 419 | CytoplasmicCuratedAdd BLAST | 85 | |
Transmembranei | 420 – 441 | HelicalCuratedAdd BLAST | 22 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Involvement in diseasei
Developmental and epileptic encephalopathy 78 (DEE78)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083186 | 263 | M → T in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083187 | 284 | V → A in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083188 | 291 | L → V in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083189 | 292 | T → K in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083190 | 325 | F → L in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083191 | 335 | N → H in DEE78; unknown pathological significance. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, EpilepsyOrganism-specific databases
DisGeNETi | 2555 |
MalaCardsi | GABRA2 |
MIMi | 103780, phenotype 618557, phenotype |
OpenTargetsi | ENSG00000151834 |
Orphaneti | 442835, Non-specific early-onset epileptic encephalopathy |
PharmGKBi | PA28490 |
Miscellaneous databases
Pharosi | P47869, Tclin |
Chemistry databases
ChEMBLi | CHEMBL4956 |
DrugBanki | DB00659, Acamprosate DB00546, Adinazolam DB06579, Adipiplon DB00404, Alprazolam DB01351, Amobarbital DB00543, Amoxapine DB11901, Apalutamide DB01352, Aprobarbital DB13994, AZD-7325 DB01483, Barbital DB14719, Bentazepam DB12537, Benzodiazepine DB11859, Brexanolone DB01558, Bromazepam DB09017, Brotizolam DB00237, Butabarbital DB00241, Butalbital DB01353, Butobarbital DB01489, Camazepam DB00475, Chlordiazepoxide DB14715, Cinazepam DB01594, Cinolazepam DB00349, Clobazam DB01068, Clonazepam DB00628, Clorazepic acid DB01559, Clotiazepam DB01553, Cloxazolam DB01511, Delorazepam DB01189, Desflurane DB00829, Diazepam DB01496, Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione DB13837, Doxefazepam DB00228, Enflurane DB01215, Estazolam DB00402, Eszopiclone DB00898, Ethanol DB00189, Ethchlorvynol DB01545, Ethyl loflazepate DB09166, Etizolam DB00292, Etomidate DB01567, Fludiazepam DB01205, Flumazenil DB01544, Flunitrazepam DB00690, Flurazepam DB05087, Ganaxolone DB01437, Glutethimide DB00801, Halazepam DB01159, Halothane DB01354, Heptabarbital DB01355, Hexobarbital DB00753, Isoflurane DB01587, Ketazolam DB00555, Lamotrigine DB13643, Loprazolam DB00186, Lorazepam DB13872, Lormetazepam DB13437, Medazepam DB00603, Medroxyprogesterone acetate DB01043, Memantine DB00371, Meprobamate DB00463, Metharbital DB01028, Methoxyflurane DB00849, Methylphenobarbital DB01107, Methyprylon DB15489, Mexazolam DB00683, Midazolam DB01595, Nitrazepam DB14028, Nordazepam DB00334, Olanzapine DB00842, Oxazepam DB14672, Oxazepam acetate DB04903, Pagoclone DB00312, Pentobarbital DB00252, Phenytoin DB13335, Pinazepam DB01708, Prasterone DB01588, Prazepam DB00794, Primidone DB00818, Propofol DB01589, Quazepam DB01346, Quinidine barbiturate DB12404, Remimazolam DB00418, Secobarbital DB01236, Sevoflurane DB09118, Stiripentol DB00306, Talbutal DB01956, Taurine DB00231, Temazepam DB11582, Thiocolchicoside DB00599, Thiopental DB00897, Triazolam DB00425, Zolpidem DB01198, Zopiclone |
DrugCentrali | P47869 |
GuidetoPHARMACOLOGYi | 405 |
Genetic variation databases
BioMutai | GABRA2 |
DMDMi | 126302547 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000000433 | 29 – 451 | Gamma-aminobutyric acid receptor subunit alpha-2Add BLAST | 423 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 38 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 138 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 166 ↔ 180 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P47869 |
PaxDbi | P47869 |
PeptideAtlasi | P47869 |
PRIDEi | P47869 |
ProteomicsDBi | 55800 [P47869-1] 6330 |
PTM databases
GlyGeni | P47869, 2 sites |
iPTMneti | P47869 |
PhosphoSitePlusi | P47869 |
Expressioni
Gene expression databases
Bgeei | ENSG00000151834, Expressed in amygdala and 154 other tissues |
ExpressionAtlasi | P47869, baseline and differential |
Genevisiblei | P47869, HS |
Organism-specific databases
HPAi | ENSG00000151834, Tissue enhanced (brain, epididymis) |
Interactioni
Subunit structurei
Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.
Interacts with UBQLN1 (By similarity).
Interacts with KIF21B (By similarity).
Interacts with LHFPL4 (By similarity).
Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 108829, 3 interactors |
ComplexPortali | CPX-2174, GABA-A receptor, alpha-2/beta-3/gamma-2 |
IntActi | P47869, 2 interactors |
MINTi | P47869 |
STRINGi | 9606.ENSP00000421828 |
Chemistry databases
BindingDBi | P47869 |
Miscellaneous databases
RNActi | P47869, protein |
Family & Domainsi
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3642, Eukaryota |
GeneTreei | ENSGT00940000157266 |
HOGENOMi | CLU_010920_2_1_1 |
InParanoidi | P47869 |
OMAi | FEGPMNI |
OrthoDBi | 1057372at2759 |
PhylomeDBi | P47869 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR001390, GABAAa_rcpt IPR005432, GABBAa2_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF218, PTHR18945:SF218, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01079, GABAARALPHA PR01615, GABAARALPHA2 PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKTKLNIYNM QFLLFVFLVW DPARLVLANI QEDEAKNNIT IFTRILDRLL
60 70 80 90 100
DGYDNRLRPG LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE
110 120 130 140 150
RLKFKGPMNI LRLNNLMASK IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD
160 170 180 190 200
DGTLLYTMRL TVQAECPMHL EDFPMDAHSC PLKFGSYAYT TSEVTYIWTY
210 220 230 240 250
NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM TAHFHLKRKI
260 270 280 290 300
GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA
310 320 330 340 350
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV
360 370 380 390 400
NDKKKEKASV MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP
410 420 430 440 450
ENKPAEAKKT FNSVSKIDRM SRIVFPVLFG TFNLVYWATY LNREPVLGVS
P
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PBQ7 | E9PBQ7_HUMAN | GABA(A) receptor subunit alpha-2 | GABRA2 | 511 | Annotation score: | ||
G5E9Z6 | G5E9Z6_HUMAN | GABA(A) receptor subunit alpha-2 | GABRA2 hCG_15318 | 367 | Annotation score: | ||
A0A0A0MTM5 | A0A0A0MTM5_HUMAN | GABA(A) receptor subunit alpha-2 | GABRA2 | 427 | Annotation score: | ||
H0Y9V8 | H0Y9V8_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA2 | 56 | Annotation score: | ||
D6RB77 | D6RB77_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA2 | 151 | Annotation score: | ||
D6RBK9 | D6RBK9_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA2 | 159 | Annotation score: | ||
D6RBL7 | D6RBL7_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA2 | 137 | Annotation score: | ||
D6RAA9 | D6RAA9_HUMAN | Gamma-aminobutyric acid receptor su... | GABRA2 | 73 | Annotation score: | ||
D6RCS5 | D6RCS5_HUMAN | Gamma-aminobutyric acid A receptor ... | GABRA2 | 66 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 – 11 | MQ → IE in AAB27278 (PubMed:8391122).Curated | 2 | |
Sequence conflicti | 343 | A → T in AAB27278 (PubMed:8391122).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083186 | 263 | M → T in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083187 | 284 | V → A in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083188 | 291 | L → V in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083189 | 292 | T → K in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083190 | 325 | F → L in DEE78; impaired GABA-gated chloride ion channel activity. 1 Publication | 1 | |
Natural variantiVAR_083191 | 335 | N → H in DEE78; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_083192 | 377 | N → K Found in a patient with epilepsy; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054277 | 1 – 85 | MKTKL…SDTDM → MRLKITLPSLREFLTDFWMV TIIGLDQDWE in isoform 2. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_054278 | 353 | K → KSPSIKAEGITLTYNSVKAI LQGAKLIWSKYIAFSWPSLF QEKTLEYLEKWMDCLTFKQS S in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S62907 mRNA Translation: AAB27278.1 AK125179 mRNA Translation: BAG54159.1 AK289662 mRNA Translation: BAF82351.1 AK293466 mRNA Translation: BAH11514.1 AB209295 mRNA Translation: BAD92532.1 Different initiation. AC084352 Genomic DNA No translation available. AC093745 Genomic DNA No translation available. AC095060 Genomic DNA No translation available. AC104072 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW93022.1 |
CCDSi | CCDS3471.1 [P47869-1] |
PIRi | I57947 |
RefSeqi | NP_000798.2, NM_000807.3 [P47869-1] NP_001107647.1, NM_001114175.2 [P47869-1] NP_001273756.1, NM_001286827.2 [P47869-2] NP_001317619.1, NM_001330690.1 XP_016863471.1, XM_017007982.1 XP_016863472.1, XM_017007983.1 |
Genome annotation databases
Ensembli | ENST00000356504; ENSP00000348897; ENSG00000151834 ENST00000381620; ENSP00000371033; ENSG00000151834 ENST00000510861; ENSP00000421828; ENSG00000151834 ENST00000514090; ENSP00000421300; ENSG00000151834 |
GeneIDi | 2555 |
KEGGi | hsa:2555 |
MANE-Selecti | ENST00000381620.9; ENSP00000371033.4; NM_000807.4; NP_000798.2 |
UCSCi | uc003gxc.5, human [P47869-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Forbidden fruit - Issue 56 of March 2005 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S62907 mRNA Translation: AAB27278.1 AK125179 mRNA Translation: BAG54159.1 AK289662 mRNA Translation: BAF82351.1 AK293466 mRNA Translation: BAH11514.1 AB209295 mRNA Translation: BAD92532.1 Different initiation. AC084352 Genomic DNA No translation available. AC093745 Genomic DNA No translation available. AC095060 Genomic DNA No translation available. AC104072 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW93022.1 |
CCDSi | CCDS3471.1 [P47869-1] |
PIRi | I57947 |
RefSeqi | NP_000798.2, NM_000807.3 [P47869-1] NP_001107647.1, NM_001114175.2 [P47869-1] NP_001273756.1, NM_001286827.2 [P47869-2] NP_001317619.1, NM_001330690.1 XP_016863471.1, XM_017007982.1 XP_016863472.1, XM_017007983.1 |
3D structure databases
SMRi | P47869 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108829, 3 interactors |
ComplexPortali | CPX-2174, GABA-A receptor, alpha-2/beta-3/gamma-2 |
IntActi | P47869, 2 interactors |
MINTi | P47869 |
STRINGi | 9606.ENSP00000421828 |
Chemistry databases
BindingDBi | P47869 |
ChEMBLi | CHEMBL4956 |
DrugBanki | DB00659, Acamprosate DB00546, Adinazolam DB06579, Adipiplon DB00404, Alprazolam DB01351, Amobarbital DB00543, Amoxapine DB11901, Apalutamide DB01352, Aprobarbital DB13994, AZD-7325 DB01483, Barbital DB14719, Bentazepam DB12537, Benzodiazepine DB11859, Brexanolone DB01558, Bromazepam DB09017, Brotizolam DB00237, Butabarbital DB00241, Butalbital DB01353, Butobarbital DB01489, Camazepam DB00475, Chlordiazepoxide DB14715, Cinazepam DB01594, Cinolazepam DB00349, Clobazam DB01068, Clonazepam DB00628, Clorazepic acid DB01559, Clotiazepam DB01553, Cloxazolam DB01511, Delorazepam DB01189, Desflurane DB00829, Diazepam DB01496, Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione DB13837, Doxefazepam DB00228, Enflurane DB01215, Estazolam DB00402, Eszopiclone DB00898, Ethanol DB00189, Ethchlorvynol DB01545, Ethyl loflazepate DB09166, Etizolam DB00292, Etomidate DB01567, Fludiazepam DB01205, Flumazenil DB01544, Flunitrazepam DB00690, Flurazepam DB05087, Ganaxolone DB01437, Glutethimide DB00801, Halazepam DB01159, Halothane DB01354, Heptabarbital DB01355, Hexobarbital DB00753, Isoflurane DB01587, Ketazolam DB00555, Lamotrigine DB13643, Loprazolam DB00186, Lorazepam DB13872, Lormetazepam DB13437, Medazepam DB00603, Medroxyprogesterone acetate DB01043, Memantine DB00371, Meprobamate DB00463, Metharbital DB01028, Methoxyflurane DB00849, Methylphenobarbital DB01107, Methyprylon DB15489, Mexazolam DB00683, Midazolam DB01595, Nitrazepam DB14028, Nordazepam DB00334, Olanzapine DB00842, Oxazepam DB14672, Oxazepam acetate DB04903, Pagoclone DB00312, Pentobarbital DB00252, Phenytoin DB13335, Pinazepam DB01708, Prasterone DB01588, Prazepam DB00794, Primidone DB00818, Propofol DB01589, Quazepam DB01346, Quinidine barbiturate DB12404, Remimazolam DB00418, Secobarbital DB01236, Sevoflurane DB09118, Stiripentol DB00306, Talbutal DB01956, Taurine DB00231, Temazepam DB11582, Thiocolchicoside DB00599, Thiopental DB00897, Triazolam DB00425, Zolpidem DB01198, Zopiclone |
DrugCentrali | P47869 |
GuidetoPHARMACOLOGYi | 405 |
Protein family/group databases
TCDBi | 1.A.9.5.2, the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family |
PTM databases
GlyGeni | P47869, 2 sites |
iPTMneti | P47869 |
PhosphoSitePlusi | P47869 |
Genetic variation databases
BioMutai | GABRA2 |
DMDMi | 126302547 |
Proteomic databases
MassIVEi | P47869 |
PaxDbi | P47869 |
PeptideAtlasi | P47869 |
PRIDEi | P47869 |
ProteomicsDBi | 55800 [P47869-1] 6330 |
Protocols and materials databases
Antibodypediai | 12030, 346 antibodies from 33 providers |
DNASUi | 2555 |
Genome annotation databases
Ensembli | ENST00000356504; ENSP00000348897; ENSG00000151834 ENST00000381620; ENSP00000371033; ENSG00000151834 ENST00000510861; ENSP00000421828; ENSG00000151834 ENST00000514090; ENSP00000421300; ENSG00000151834 |
GeneIDi | 2555 |
KEGGi | hsa:2555 |
MANE-Selecti | ENST00000381620.9; ENSP00000371033.4; NM_000807.4; NP_000798.2 |
UCSCi | uc003gxc.5, human [P47869-1] |
Organism-specific databases
CTDi | 2555 |
DisGeNETi | 2555 |
GeneCardsi | GABRA2 |
HGNCi | HGNC:4076, GABRA2 |
HPAi | ENSG00000151834, Tissue enhanced (brain, epididymis) |
MalaCardsi | GABRA2 |
MIMi | 103780, phenotype 137140, gene 618557, phenotype |
neXtProti | NX_P47869 |
OpenTargetsi | ENSG00000151834 |
Orphaneti | 442835, Non-specific early-onset epileptic encephalopathy |
PharmGKBi | PA28490 |
VEuPathDBi | HostDB:ENSG00000151834 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3642, Eukaryota |
GeneTreei | ENSGT00940000157266 |
HOGENOMi | CLU_010920_2_1_1 |
InParanoidi | P47869 |
OMAi | FEGPMNI |
OrthoDBi | 1057372at2759 |
PhylomeDBi | P47869 |
TreeFami | TF315453 |
Enzyme and pathway databases
PathwayCommonsi | P47869 |
Reactomei | R-HSA-977443, GABA receptor activation |
SignaLinki | P47869 |
SIGNORi | P47869 |
Miscellaneous databases
BioGRID-ORCSi | 2555, 5 hits in 1037 CRISPR screens |
ChiTaRSi | GABRA2, human |
GeneWikii | GABRA2 |
GenomeRNAii | 2555 |
Pharosi | P47869, Tclin |
PROi | PR:P47869 |
RNActi | P47869, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151834, Expressed in amygdala and 154 other tissues |
ExpressionAtlasi | P47869, baseline and differential |
Genevisiblei | P47869, HS |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR001390, GABAAa_rcpt IPR005432, GABBAa2_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF218, PTHR18945:SF218, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01079, GABAARALPHA PR01615, GABAARALPHA2 PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRA2_HUMAN | |
Accessioni | P47869Primary (citable) accession number: P47869 Secondary accession number(s): A8K0U7, B7Z1H8, Q59G14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries