GABRA2

Functionⁱ

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functionⁱ

benzodiazepine receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8391122
GABA-A receptor activity Source: InterPro
GABA-gated chloride ion channel activity
Source: GO_Central
Inferred from direct assayⁱ
- 9039914

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chloride transmembrane transport
Source: GO_Central
Inferred from direct assayⁱ
- 9039914
gamma-aminobutyric acid signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8391122
neurotransmitter transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8391122
regulation of neurotransmitter levels
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8391122

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport
Ligand	Chloride

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-977441 GABA A receptor activation

Reactomeⁱ

R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-977441 GABA A receptor activation

Protein family/group databases

TCDBⁱ	1.A.9.5.2 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

TCDBⁱ

1.A.9.5.2 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gamma-aminobutyric acid receptor subunit alpha-2 Alternative name(s): GABA(A) receptor subunit alpha-2
Gene namesⁱ	Name:GABRA2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151834.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4076 GABRA2
MIMⁱ	137140 gene
neXtProtⁱ	NX_P47869

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	29 – 251	ExtracellularCuratedAdd BLAST	223
Transmembraneⁱ	252 – 273	HelicalCuratedAdd BLAST	22
Transmembraneⁱ	279 – 300	HelicalCuratedAdd BLAST	22
Transmembraneⁱ	313 – 334	HelicalCuratedAdd BLAST	22
Topological domainⁱ	335 – 419	CytoplasmicCuratedAdd BLAST	85
Transmembraneⁱ	420 – 441	HelicalCuratedAdd BLAST	22

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2555
MalaCards human disease database More...MalaCardsⁱ	GABRA2
MIMⁱ	103780 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000151834
PharmGKBⁱ	PA28490

Chemistry databases

ChEMBLⁱ	CHEMBL4956
Drug and drug target database More...DrugBankⁱ	DB00659 Acamprosate DB00546 Adinazolam DB06579 Adipiplon DB00404 Alprazolam DB01351 Amobarbital DB00543 Amoxapine DB01352 Aprobarbital DB01483 Barbital DB01496 Barbituric acid derivative DB01558 Bromazepam DB00237 Butabarbital DB00241 Butalbital DB01353 Butethal DB00475 Chlordiazepoxide DB01594 Cinolazepam DB00349 Clobazam DB01068 Clonazepam DB00628 Clorazepate DB01559 Clotiazepam DB01189 Desflurane DB00829 Diazepam DB00228 Enflurane DB01049 Ergoloid mesylate DB01215 Estazolam DB00402 Eszopiclone DB00898 Ethanol DB00189 Ethchlorvynol DB00292 Etomidate DB01567 Fludiazepam DB01205 Flumazenil DB01544 Flunitrazepam DB00690 Flurazepam DB05087 Ganaxolone DB01437 Glutethimide DB00801 Halazepam DB01159 Halothane DB01354 Heptabarbital DB01355 Hexobarbital DB00753 Isoflurane DB00186 Lorazepam DB00371 Meprobamate DB00463 Metharbital DB01028 Methoxyflurane DB00849 Methylphenobarbital DB01107 Methyprylon DB00683 Midazolam DB01595 Nitrazepam DB00334 Olanzapine DB00842 Oxazepam DB04903 Pagoclone DB00312 Pentobarbital DB01708 Prasterone DB01588 Prazepam DB00794 Primidone DB00818 Propofol DB01589 Quazepam DB01346 Quinidine barbiturate DB00418 Secobarbital DB01236 Sevoflurane DB00306 Talbutal DB00231 Temazepam DB11582 Thiocolchicoside DB00599 Thiopental DB00273 Topiramate DB00897 Triazolam DB00425 Zolpidem DB01198 Zopiclone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	405

Polymorphism and mutation databases

BioMutaⁱ	GABRA2
DMDMⁱ	126302547

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_0000000433	29 – 451	Gamma-aminobutyric acid receptor subunit alpha-2Add BLAST		423

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	38	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	138	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	166 ↔ 180	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P47869
PeptideAtlas More...PeptideAtlasⁱ	P47869
PRIDEⁱ	P47869
ProteomicsDBⁱ	55800

PTM databases

iPTMnetⁱ	P47869
PhosphoSitePlusⁱ	P47869

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000151834 Expressed in 133 organ(s), highest expression level in amygdala
CleanExⁱ	HS_GABRA2
ExpressionAtlasⁱ	P47869 baseline and differential
Genevisibleⁱ	P47869 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB079061

HPAⁱ

CAB079061

Interactionⁱ

Subunit structureⁱ

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with UBQLN1. Interacts with KIF21B.By similarity

Protein-protein interaction databases

BioGridⁱ	108829, 1 interactor
ComplexPortalⁱ	CPX-2174 GABA-A receptor, alpha-2/beta-3/gamma-2
IntActⁱ	P47869, 1 interactor
STRINGⁱ	9606.ENSP00000348897

Chemistry databases

BindingDBⁱ

P47869

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47869
SMRⁱ	P47869
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3642 Eukaryota ENOG410XNQG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119010
HOGENOMⁱ	HOG000231337
HOVERGENⁱ	HBG051707
InParanoidⁱ	P47869
KEGG Orthology (KO) More...KOⁱ	K05175
PhylomeDBⁱ	P47869
TreeFamⁱ	TF315453

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006028 GABAA/Glycine_rcpt IPR001390 GABAAa_rcpt IPR005432 GABBAa2_rcpt IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit PTHR18945:SF218 PTHR18945:SF218, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR01079 GABAARALPHA PR01615 GABAARALPHA2 PR00253 GABAARECEPTR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P47869-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTKLNIYNM QFLLFVFLVW DPARLVLANI QEDEAKNNIT IFTRILDRLL 
        60         70         80         90        100
DGYDNRLRPG LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE 
       110        120        130        140        150
RLKFKGPMNI LRLNNLMASK IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD 
       160        170        180        190        200
DGTLLYTMRL TVQAECPMHL EDFPMDAHSC PLKFGSYAYT TSEVTYIWTY 
       210        220        230        240        250
NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM TAHFHLKRKI 
       260        270        280        290        300
GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA 
       310        320        330        340        350
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV 
       360        370        380        390        400
NDKKKEKASV MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP 
       410        420        430        440        450
ENKPAEAKKT FNSVSKIDRM SRIVFPVLFG TFNLVYWATY LNREPVLGVS 

P

Length:451

Mass (Da):51,326

Last modified:February 20, 2007 - v2

Checksum:ⁱ43F9F708B5A00FFD

GO

Isoform 2 (identifier: P47869-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-85: MKTKLNIYNM...SFGPVSDTDM → MRLKITLPSLREFLTDFWMVTIIGLDQDWE
353-353: K → KSPSIKAEGITLTYNSVKAILQGAKLIWSKYIAFSWPSLFQEKTLEYLEKWMDCLTFKQSS

« Hide

        10         20         30         40         50
MRLKITLPSL REFLTDFWMV TIIGLDQDWE EYTIDVFFRQ KWKDERLKFK 
        60         70         80         90        100
GPMNILRLNN LMASKIWTPD TFFHNGKKSV AHNMTMPNKL LRIQDDGTLL 
       110        120        130        140        150
YTMRLTVQAE CPMHLEDFPM DAHSCPLKFG SYAYTTSEVT YIWTYNASDS 
       160        170        180        190        200
VQVAPDGSRL NQYDLLGQSI GKETIKSSTG EYTVMTAHFH LKRKIGYFVI 
       210        220        230        240        250
QTYLPCIMTV ILSQVSFWLN RESVPARTVF GVTTVLTMTT LSISARNSLP 
       260        270        280        290        300
KVAYATAMDW FIAVCYAFVF SALIEFATVN YFTKRGWAWD GKSVVNDKSP 
       310        320        330        340        350
SIKAEGITLT YNSVKAILQG AKLIWSKYIA FSWPSLFQEK TLEYLEKWMD 
       360        370        380        390        400
CLTFKQSSKK EKASVMIQNN AYAVAVANYA PNLSKDPVLS TISKSATTPE 
       410        420        430        440        450
PNKKPENKPA EAKKTFNSVS KIDRMSRIVF PVLFGTFNLV YWATYLNREP 

VLGVSP

Note: No experimental confirmation available.

Show »

Length:456

Mass (Da):52,064

Checksum:ⁱ040306CCB7836206

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
E9PBQ7	E9PBQ7_HUMAN	Gamma-aminobutyric acid receptor su... Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	511	Annotation score:
G5E9Z6	G5E9Z6_HUMAN	Gamma-aminobutyric acid (GABA) A re... Gamma-aminobutyric acid (GABA) A receptor, alpha 2, isoform CRA_b (Gamma-aminobutyric acid A receptor alpha 2 isoform 1) (Gamma-aminobutyric acid receptor subunit alpha-2)	GABRA2 hCG_15318	367	Annotation score:
A0A0A0MTM5	A0A0A0MTM5_HUMAN	Gamma-aminobutyric acid receptor su... Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	427	Annotation score:
D6RBK9	D6RBK9_HUMAN	Gamma-aminobutyric acid receptor su... Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	159	Annotation score:
D6RB77	D6RB77_HUMAN	Gamma-aminobutyric acid receptor su... Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	151	Annotation score:
D6RBL7	D6RBL7_HUMAN	Gamma-aminobutyric acid receptor su... Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	137	Annotation score:
D6RCS5	D6RCS5_HUMAN	Gamma-aminobutyric acid A receptor ... Gamma-aminobutyric acid A receptor alpha 2 isoform 2 (Gamma-aminobutyric acid receptor subunit alpha-2)	GABRA2	66	Annotation score:
D6RAA9	D6RAA9_HUMAN	Gamma-aminobutyric acid receptor su... Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	73	Annotation score:
H0Y9V8	H0Y9V8_HUMAN	Gamma-aminobutyric acid receptor su... Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	56	Annotation score:

Sequence cautionⁱ

The sequence BAD92532 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	10 – 11	MQ → IE in AAB27278 (PubMed:8391122).Curated		2
Sequence conflictⁱ	343	A → T in AAB27278 (PubMed:8391122).Curated		1

Polymorphismⁱ

Genetic variations in GABRA2 determine the genetic susceptibility to alcoholism [MIMⁱ:103780].

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054277	1 – 85	MKTKL…SDTDM → MRLKITLPSLREFLTDFWMV TIIGLDQDWE in isoform 2. 1 PublicationAdd BLAST		85
Alternative sequenceⁱVSP_054278	353	K → KSPSIKAEGITLTYNSVKAI LQGAKLIWSKYIAFSWPSLF QEKTLEYLEKWMDCLTFKQS S in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S62907 mRNA Translation: AAB27278.1 AK125179 mRNA Translation: BAG54159.1 AK289662 mRNA Translation: BAF82351.1 AK293466 mRNA Translation: BAH11514.1 AB209295 mRNA Translation: BAD92532.1 Different initiation. AC084352 Genomic DNA No translation available. AC093745 Genomic DNA No translation available. AC095060 Genomic DNA No translation available. AC104072 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW93022.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3471.1 [P47869-1]
PIRⁱ	I57947
NCBI Reference Sequences More...RefSeqⁱ	NP_000798.2, NM_000807.3 [P47869-1] NP_001107647.1, NM_001114175.2 [P47869-1] NP_001273756.1, NM_001286827.2 [P47869-2] NP_001317619.1, NM_001330690.1 XP_016863471.1, XM_017007982.1 [P47869-1] XP_016863472.1, XM_017007983.1 [P47869-1]
UniGeneⁱ	Hs.116250 Hs.48372

Genome annotation databases

Ensemblⁱ	ENST00000356504; ENSP00000348897; ENSG00000151834 [P47869-1] ENST00000381620; ENSP00000371033; ENSG00000151834 [P47869-1] ENST00000510861; ENSP00000421828; ENSG00000151834 [P47869-1] ENST00000514090; ENSP00000421300; ENSG00000151834 [P47869-1]
GeneIDⁱ	2555
KEGGⁱ	hsa:2555
UCSC genome browser More...UCSCⁱ	uc003gxc.5 human [P47869-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47869	Gamma-aminobutyric acid (GABA) A receptor, alpha 2, isoform CRA_a		HUMAN		451	UniRef100_P47869
GABRA2 isoform 1		PANTR		451
Gamma-aminobutyric acid type A receptor alpha2 subunit		PANPA		451
Gamma-aminobutyric acid type A receptor alpha2 subunit		GORGO		451

Protein	Similar proteins		Species	Score	Length	Source
P47869	Gamma-aminobutyric acid receptor subunit alpha-2		BOVIN		451	UniRef90_P47869
Gamma-aminobutyric acid receptor subunit alpha-2	)	MOUSE		451
Gamma-aminobutyric acid receptor subunit alpha-2		RAT		451
Gamma-aminobutyric acid (GABA) A receptor, alpha 2, isoform CRA_a		HUMAN		451
GABRA2 isoform 1		PANTR		451
+132
P47869-2	Gamma-aminobutyric acid type A receptor alpha2 subunit		PANTR		434	UniRef90_P47869-2
Gamma-aminobutyric acid type A receptor alpha2 subunit		PANPA		434
UPI0001CA57A5		AOTNA		456
UPI00020AAC6E		NOMLE		456
UPI00053329FF		RHIRO		456
+8

Protein	Similar proteins		Species	Score	Length	Source
P47869	Gamma-aminobutyric acid receptor subunit alpha-1	)	HUMAN		456	UniRef50_P14867
Gamma-aminobutyric acid receptor subunit alpha-1		MACFA		456
Gamma-aminobutyric acid receptor subunit alpha-1		PONAB		456
Gamma-aminobutyric acid receptor subunit alpha-1		BOVIN		456
Gamma-aminobutyric acid receptor subunit alpha-1		CHICK		455
+697
P47869-2	Gamma-aminobutyric acid type A receptor alpha2 subunit		PANTR		434	UniRef50_P47869-2
Gamma-aminobutyric acid type A receptor alpha2 subunit		PANPA		434
Gamma-aminobutyric acid (GABA) A receptor, alpha 6a		ORYLA		421
Uncharacterized protein		TAKRU		415
Gamma-aminobutyric acid (GABA) A receptor, alpha 2, isoform CRA_b		HUMAN		367
+210

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

Forbidden fruit - Issue 56 of March 2005

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S62907 mRNA Translation: AAB27278.1 AK125179 mRNA Translation: BAG54159.1 AK289662 mRNA Translation: BAF82351.1 AK293466 mRNA Translation: BAH11514.1 AB209295 mRNA Translation: BAD92532.1 Different initiation. AC084352 Genomic DNA No translation available. AC093745 Genomic DNA No translation available. AC095060 Genomic DNA No translation available. AC104072 Genomic DNA No translation available. CH471069 Genomic DNA Translation: EAW93022.1
CCDSⁱ	CCDS3471.1 [P47869-1]
PIRⁱ	I57947
RefSeqⁱ	NP_000798.2, NM_000807.3 [P47869-1] NP_001107647.1, NM_001114175.2 [P47869-1] NP_001273756.1, NM_001286827.2 [P47869-2] NP_001317619.1, NM_001330690.1 XP_016863471.1, XM_017007982.1 [P47869-1] XP_016863472.1, XM_017007983.1 [P47869-1]
UniGeneⁱ	Hs.116250 Hs.48372

3D structure databases

ProteinModelPortalⁱ	P47869
SMRⁱ	P47869
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108829, 1 interactor
ComplexPortalⁱ	CPX-2174 GABA-A receptor, alpha-2/beta-3/gamma-2
IntActⁱ	P47869, 1 interactor
STRINGⁱ	9606.ENSP00000348897

Chemistry databases

BindingDBⁱ	P47869
ChEMBLⁱ	CHEMBL4956
DrugBankⁱ	DB00659 Acamprosate DB00546 Adinazolam DB06579 Adipiplon DB00404 Alprazolam DB01351 Amobarbital DB00543 Amoxapine DB01352 Aprobarbital DB01483 Barbital DB01496 Barbituric acid derivative DB01558 Bromazepam DB00237 Butabarbital DB00241 Butalbital DB01353 Butethal DB00475 Chlordiazepoxide DB01594 Cinolazepam DB00349 Clobazam DB01068 Clonazepam DB00628 Clorazepate DB01559 Clotiazepam DB01189 Desflurane DB00829 Diazepam DB00228 Enflurane DB01049 Ergoloid mesylate DB01215 Estazolam DB00402 Eszopiclone DB00898 Ethanol DB00189 Ethchlorvynol DB00292 Etomidate DB01567 Fludiazepam DB01205 Flumazenil DB01544 Flunitrazepam DB00690 Flurazepam DB05087 Ganaxolone DB01437 Glutethimide DB00801 Halazepam DB01159 Halothane DB01354 Heptabarbital DB01355 Hexobarbital DB00753 Isoflurane DB00186 Lorazepam DB00371 Meprobamate DB00463 Metharbital DB01028 Methoxyflurane DB00849 Methylphenobarbital DB01107 Methyprylon DB00683 Midazolam DB01595 Nitrazepam DB00334 Olanzapine DB00842 Oxazepam DB04903 Pagoclone DB00312 Pentobarbital DB01708 Prasterone DB01588 Prazepam DB00794 Primidone DB00818 Propofol DB01589 Quazepam DB01346 Quinidine barbiturate DB00418 Secobarbital DB01236 Sevoflurane DB00306 Talbutal DB00231 Temazepam DB11582 Thiocolchicoside DB00599 Thiopental DB00273 Topiramate DB00897 Triazolam DB00425 Zolpidem DB01198 Zopiclone
GuidetoPHARMACOLOGYⁱ	405

Protein family/group databases

TCDBⁱ	1.A.9.5.2 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

TCDBⁱ

1.A.9.5.2 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

PTM databases

iPTMnetⁱ	P47869
PhosphoSitePlusⁱ	P47869

Polymorphism and mutation databases

BioMutaⁱ	GABRA2
DMDMⁱ	126302547

Proteomic databases

PaxDbⁱ	P47869
PeptideAtlasⁱ	P47869
PRIDEⁱ	P47869
ProteomicsDBⁱ	55800

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356504; ENSP00000348897; ENSG00000151834 [P47869-1] ENST00000381620; ENSP00000371033; ENSG00000151834 [P47869-1] ENST00000510861; ENSP00000421828; ENSG00000151834 [P47869-1] ENST00000514090; ENSP00000421300; ENSG00000151834 [P47869-1]
GeneIDⁱ	2555
KEGGⁱ	hsa:2555
UCSCⁱ	uc003gxc.5 human [P47869-1]

Organism-specific databases

CTDⁱ	2555
DisGeNETⁱ	2555
EuPathDBⁱ	HostDB:ENSG00000151834.15
GeneCardsⁱ	GABRA2
HGNCⁱ	HGNC:4076 GABRA2
HPAⁱ	CAB079061
MalaCardsⁱ	GABRA2
MIMⁱ	103780 phenotype 137140 gene
neXtProtⁱ	NX_P47869
OpenTargetsⁱ	ENSG00000151834
PharmGKBⁱ	PA28490
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3642 Eukaryota ENOG410XNQG LUCA
GeneTreeⁱ	ENSGT00760000119010
HOGENOMⁱ	HOG000231337
HOVERGENⁱ	HBG051707
InParanoidⁱ	P47869
KOⁱ	K05175
PhylomeDBⁱ	P47869
TreeFamⁱ	TF315453

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-977441 GABA A receptor activation

Reactomeⁱ

R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-977441 GABA A receptor activation

Miscellaneous databases

ChiTaRSⁱ	GABRA2 human
GeneWikiⁱ	GABRA2
GenomeRNAiⁱ	2555
Protein Ontology More...PROⁱ	PR:P47869
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151834 Expressed in 133 organ(s), highest expression level in amygdala
CleanExⁱ	HS_GABRA2
ExpressionAtlasⁱ	P47869 baseline and differential
Genevisibleⁱ	P47869 HS

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006028 GABAA/Glycine_rcpt IPR001390 GABAAa_rcpt IPR005432 GABBAa2_rcpt IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit PTHR18945:SF218 PTHR18945:SF218, 1 hit
Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR01079 GABAARALPHA PR01615 GABAARALPHA2 PR00253 GABAARECEPTR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GBRA2_HUMAN
Accessionⁱ	P47869Primary (citable) accession number: P47869 Secondary accession number(s): A8K0U7, B7Z1H8, Q59G14
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 20, 2007
	Last modified:	September 12, 2018
	This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P47869 (GBRA2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Gamma-aminobutyric acid receptor subunit alpha-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ