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Protein

Secretogranin-3

Gene

Scg3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-3
Alternative name(s):
1B1075
Secretogranin III
Short name:
SgIII
Gene namesi
Name:Scg3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621209 Scg3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000546323 – 471Secretogranin-3Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei365PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP47868
PRIDEiP47868

PTM databases

iPTMnetiP47868
PhosphoSitePlusiP47868

Expressioni

Tissue specificityi

Expression restricted to the brain and pituitary gland. Not detected in the adrenal gland.1 Publication

Interactioni

Subunit structurei

Interacts with CHGA; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2).1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014491

Structurei

3D structure databases

ProteinModelPortaliP47868
SMRiP47868
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUH Eukaryota
ENOG4110KQ3 LUCA
HOGENOMiHOG000247064
HOVERGENiHBG057085
InParanoidiP47868
PhylomeDBiP47868

Family and domain databases

InterProiView protein in InterPro
IPR026197 SCG3
PANTHERiPTHR17388 PTHR17388, 1 hit
PfamiView protein in Pfam
PF15467 SGIII, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P47868-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFLWTGSWI LVLVLNSGPI QAFPKPEGSQ DKSLHNRELS AERPLNEQIA
60 70 80 90 100
EAEADKIKKT YPSESKPSES NFSSVDNLNL LKAITEKETV EKAKQSIRSS
110 120 130 140 150
PFDNRLNVDD ADSTKNRKLT DEYDSTKSGL DRKVQDDPDG LHQLDGTPLT
160 170 180 190 200
AEDIVHKIAT RIYEENDRGV FDKIVSKLLN LGLITESQAH TLEDEVAEAL
210 220 230 240 250
QKLISKEANN YEEAPEKPTS RTENQDGKIP EKVTPVAATQ DGFTNRENDD
260 270 280 290 300
TVSNTLTLSN GLERRTNPHR DDDFEELQYF PNFYALLTSI DSEKEAKEKE
310 320 330 340 350
TLITIMKTLI DFVKMMVKYG TISPEEGVSY LENLDETIAL QTKNKLEKNT
360 370 380 390 400
TDSKSKLFPA PPEKSHEETD STKEEAAKME KEYGSLKDST KDDNSNLGGK
410 420 430 440 450
TDEAKGKTEA YLEAIRKNIE WLKKHNKKGN KEDYDLSKMR DFINQQADAY
460 470
VEKGILDKEE ANAIKRIYSS L
Length:471
Mass (Da):53,183
Last modified:February 1, 1996 - v1
Checksum:i977B3F8885F33223
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M7L6F1M7L6_RAT
Secretogranin III, isoform CRA_a
Scg3 rCG_25411
471Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02983 mRNA Translation: AAA56637.1
RefSeqiNP_446308.1, NM_053856.2
UniGeneiRn.11093

Genome annotation databases

GeneIDi116635
KEGGirno:116635
UCSCiRGD:621209 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02983 mRNA Translation: AAA56637.1
RefSeqiNP_446308.1, NM_053856.2
UniGeneiRn.11093

3D structure databases

ProteinModelPortaliP47868
SMRiP47868
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014491

PTM databases

iPTMnetiP47868
PhosphoSitePlusiP47868

Proteomic databases

PaxDbiP47868
PRIDEiP47868

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116635
KEGGirno:116635
UCSCiRGD:621209 rat

Organism-specific databases

CTDi29106
RGDi621209 Scg3

Phylogenomic databases

eggNOGiENOG410IHUH Eukaryota
ENOG4110KQ3 LUCA
HOGENOMiHOG000247064
HOVERGENiHBG057085
InParanoidiP47868
PhylomeDBiP47868

Miscellaneous databases

PROiPR:P47868

Family and domain databases

InterProiView protein in InterPro
IPR026197 SCG3
PANTHERiPTHR17388 PTHR17388, 1 hit
PfamiView protein in Pfam
PF15467 SGIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCG3_RAT
AccessioniPrimary (citable) accession number: P47868
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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