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Protein

Secretogranin-3

Gene

Scg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-3
Alternative name(s):
Secretogranin III
Short name:
SgIII
Gene namesi
Name:Scg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:103032 Scg3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000546223 – 471Secretogranin-3Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP47867
PeptideAtlasiP47867
PRIDEiP47867

PTM databases

iPTMnetiP47867
PhosphoSitePlusiP47867

Expressioni

Tissue specificityi

Expressed in various brain areas, with highest levels in the arcuate nucleus and the lateral hypothalamic area, as well as the paraventricular nucleus and the ventromedial hypothalamus (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000032181 Expressed in 230 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SCG3
ExpressionAtlasiP47867 baseline and differential
GenevisibleiP47867 MM

Interactioni

Subunit structurei

Interacts with CHGA; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034699

Structurei

3D structure databases

ProteinModelPortaliP47867
SMRiP47867
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUH Eukaryota
ENOG4110KQ3 LUCA
GeneTreeiENSGT00390000005488
HOGENOMiHOG000247064
HOVERGENiHBG057085
InParanoidiP47867
OMAiENKPGQS
OrthoDBiEOG091G06X3
PhylomeDBiP47867
TreeFamiTF331266

Family and domain databases

InterProiView protein in InterPro
IPR026197 SCG3
PANTHERiPTHR17388 PTHR17388, 1 hit
PfamiView protein in Pfam
PF15467 SGIII, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P47867-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFLWTGSWI LVLVLNSGPI QAFPKPEGSQ DKSLHNRELS AERPLNEQIA
60 70 80 90 100
EAEADKIKKA FPSESKPSES NYSSVDNLNL LRAITEKETV EKERQSIRSP
110 120 130 140 150
PFDNQLNVED ADSTKNRKLI DEYDSTKSGL DHKFQDDPDG LHQLDGTPLT
160 170 180 190 200
AEDIVHKIAT RIYEENDRGV FDKIVSKLLN LGLITESQAH TLEDEVAEAL
210 220 230 240 250
QKLISKEANN YEETLDKPTS RTENQDGKIP EKVTPVAAVQ DGFTNRENDE
260 270 280 290 300
TVSNTLTLSN GLERRTNPHR EDDFEELQYF PNFYALLTSI DSEKEAKEKE
310 320 330 340 350
TLITIMKTLI DFVKMMVKYG TISPEEGVSY LENLDETIAL QTKNKLEKNT
360 370 380 390 400
TDSKSKLFPA PPEKSQEETD STKEEAAKME KEYGSLKDST KDDNSNLGGK
410 420 430 440 450
TDEATGKTEA YLEAIRKNIE WLKKHNKKGN KEDYDLSKMR DFINQQADAY
460 470
VEKGILDKEE ANAIKRIYSS L
Length:471
Mass (Da):53,326
Last modified:February 1, 1996 - v1
Checksum:iFC1E9C381AFCA564
GO
Isoform 2 (identifier: P47867-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-360: SKLFPA → T

Show »
Length:466
Mass (Da):52,784
Checksum:iAB1CB9667276315C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SV66A0A1L1SV66_MOUSE
Secretogranin-3
Scg3
84Annotation score:
A0A1Y7VLI5A0A1Y7VLI5_MOUSE
Secretogranin-3
Scg3
51Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042877355 – 360SKLFPA → T in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02982 mRNA Translation: AAA56636.1
AK133655 mRNA Translation: BAE21767.1
AK139140 mRNA Translation: BAE23899.1
AK158315 mRNA Translation: BAE34456.1
AK164089 mRNA Translation: BAE37620.1
CH466522 Genomic DNA Translation: EDL26334.1
BC024785 mRNA Translation: AAH24785.1
CCDSiCCDS23347.1 [P47867-1]
RefSeqiNP_001158262.1, NM_001164790.1 [P47867-2]
NP_033156.1, NM_009130.3 [P47867-1]
UniGeneiMm.2386

Genome annotation databases

EnsembliENSMUST00000034699; ENSMUSP00000034699; ENSMUSG00000032181 [P47867-1]
ENSMUST00000213324; ENSMUSP00000149561; ENSMUSG00000032181 [P47867-2]
GeneIDi20255
KEGGimmu:20255
UCSCiuc009qss.2 mouse [P47867-1]
uc009qst.2 mouse [P47867-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02982 mRNA Translation: AAA56636.1
AK133655 mRNA Translation: BAE21767.1
AK139140 mRNA Translation: BAE23899.1
AK158315 mRNA Translation: BAE34456.1
AK164089 mRNA Translation: BAE37620.1
CH466522 Genomic DNA Translation: EDL26334.1
BC024785 mRNA Translation: AAH24785.1
CCDSiCCDS23347.1 [P47867-1]
RefSeqiNP_001158262.1, NM_001164790.1 [P47867-2]
NP_033156.1, NM_009130.3 [P47867-1]
UniGeneiMm.2386

3D structure databases

ProteinModelPortaliP47867
SMRiP47867
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034699

PTM databases

iPTMnetiP47867
PhosphoSitePlusiP47867

Proteomic databases

PaxDbiP47867
PeptideAtlasiP47867
PRIDEiP47867

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034699; ENSMUSP00000034699; ENSMUSG00000032181 [P47867-1]
ENSMUST00000213324; ENSMUSP00000149561; ENSMUSG00000032181 [P47867-2]
GeneIDi20255
KEGGimmu:20255
UCSCiuc009qss.2 mouse [P47867-1]
uc009qst.2 mouse [P47867-2]

Organism-specific databases

CTDi29106
MGIiMGI:103032 Scg3

Phylogenomic databases

eggNOGiENOG410IHUH Eukaryota
ENOG4110KQ3 LUCA
GeneTreeiENSGT00390000005488
HOGENOMiHOG000247064
HOVERGENiHBG057085
InParanoidiP47867
OMAiENKPGQS
OrthoDBiEOG091G06X3
PhylomeDBiP47867
TreeFamiTF331266

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:P47867
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032181 Expressed in 230 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SCG3
ExpressionAtlasiP47867 baseline and differential
GenevisibleiP47867 MM

Family and domain databases

InterProiView protein in InterPro
IPR026197 SCG3
PANTHERiPTHR17388 PTHR17388, 1 hit
PfamiView protein in Pfam
PF15467 SGIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCG3_MOUSE
AccessioniPrimary (citable) accession number: P47867
Secondary accession number(s): Q3UTT1, Q3UZT8, Q8R1D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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