UniProtKB - P47866 (CRFR2_RAT)
Corticotropin-releasing factor receptor 2
Crhr2
Functioni
GO - Molecular functioni
- corticotrophin-releasing factor receptor activity Source: GO_Central
- corticotropin-releasing hormone receptor activity Source: RGD
- G protein-coupled receptor activity Source: RGD
- peptide hormone binding Source: RGD
GO - Biological processi
- actin filament organization Source: RGD
- catecholamine biosynthetic process Source: RGD
- cell surface receptor signaling pathway Source: InterPro
- cellular response to glucocorticoid stimulus Source: RGD
- cerebellum development Source: RGD
- epithelial cell differentiation Source: RGD
- feeding behavior Source: RGD
- gastric motility Source: RGD
- hypothalamus development Source: RGD
- long-term synaptic potentiation Source: RGD
- negative regulation of calcium ion import Source: RGD
- negative regulation of defecation Source: RGD
- negative regulation of epinephrine secretion Source: RGD
- negative regulation of feeding behavior Source: RGD
- negative regulation of follicle-stimulating hormone secretion Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
- negative regulation of luteinizing hormone secretion Source: RGD
- negative regulation of norepinephrine secretion Source: RGD
- positive regulation of blood pressure Source: RGD
- positive regulation of cAMP-mediated signaling Source: RGD
- positive regulation of DNA biosynthetic process Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of heart rate Source: RGD
- positive regulation of interleukin-6 production Source: RGD
- positive regulation of NF-kappaB transcription factor activity Source: RGD
- positive regulation of serotonin secretion Source: RGD
- positive regulation of stress-activated MAPK cascade Source: RGD
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: RGD
- regulation of ERK1 and ERK2 cascade Source: RGD
- sensory perception of pain Source: RGD
- skeletal muscle tissue growth Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-373080 Class B/2 (Secretin family receptors) R-RNO-418555 G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Corticotropin-releasing factor receptor 2Short name: CRF-R-2 Short name: CRF-R2 Short name: CRFR-2 Alternative name(s): Corticotropin-releasing hormone receptor 2 Short name: CRH-R-2 Short name: CRH-R2 |
Gene namesi | Name:Crhr2 Synonyms:Crf2r |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70547 Crhr2 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Endoplasmic reticulum
- rough endoplasmic reticulum Source: RGD
Golgi apparatus
- Golgi apparatus Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- axon Source: RGD
- axon terminus Source: RGD
- cell body fiber Source: RGD
- dendrite Source: RGD
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: RGD
- perikaryon Source: RGD
- varicosity Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 108 | ExtracellularBy similarityAdd BLAST | 108 | |
Transmembranei | 109 – 139 | Helical; Name=1By similarityAdd BLAST | 31 | |
Topological domaini | 140 – 146 | CytoplasmicBy similarity | 7 | |
Transmembranei | 147 – 171 | Helical; Name=2By similarityAdd BLAST | 25 | |
Topological domaini | 172 – 185 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 186 – 214 | Helical; Name=3By similarityAdd BLAST | 29 | |
Topological domaini | 215 – 221 | CytoplasmicBy similarity | 7 | |
Transmembranei | 222 – 249 | Helical; Name=4By similarityAdd BLAST | 28 | |
Topological domaini | 250 – 265 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 266 – 291 | Helical; Name=5By similarityAdd BLAST | 26 | |
Topological domaini | 292 – 302 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 303 – 327 | Helical; Name=6By similarityAdd BLAST | 25 | |
Topological domaini | 328 – 334 | ExtracellularBy similarity | 7 | |
Transmembranei | 335 – 364 | Helical; Name=7By similarityAdd BLAST | 30 | |
Topological domaini | 365 – 411 | CytoplasmicBy similarityAdd BLAST | 47 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 13 | N → A, F or I: Allows cleavage of signal peptide. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3581 |
DrugCentrali | P47866 |
GuidetoPHARMACOLOGYi | 213 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000012822 | 1 – 411 | Corticotropin-releasing factor receptor 2Add BLAST | 411 | |
Signal peptidei | 1 – 19 | Not cleavedAdd BLAST | 19 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 13 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 14 ↔ 50 | By similarity | ||
Disulfide bondi | 40 ↔ 83 | By similarity | ||
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 64 ↔ 98 | By similarity | ||
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 184 ↔ 254 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P47866 |
PRIDEi | P47866 |
PTM databases
iPTMneti | P47866 |
PhosphoSitePlusi | P47866 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000011145 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue |
ExpressionAtlasi | P47866 baseline and differential |
Genevisiblei | P47866 RN |
Interactioni
Subunit structurei
Monomer.
Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3 (By similarity).
By similarityProtein-protein interaction databases
BioGridi | 249194, 7 interactors |
STRINGi | 10116.ENSRNOP00000014925 |
Chemistry databases
BindingDBi | P47866 |
Family & Domainsi
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000156795 |
HOGENOMi | HOG000230719 |
InParanoidi | P47866 |
KOi | K04579 |
OrthoDBi | 1163977at2759 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR003053 GPCR_2_CRF2_rcpt IPR003051 GPCR_2_CRF_rcpt IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR01279 CRFRECEPTOR PR01281 CRFRECEPTOR2 PR00249 GPCRSECRETIN |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDAALLLSLL EANCSLALAE ELLLDGWGEP PDPEGPYSYC NTTLDQIGTC
60 70 80 90 100
WPQSAPGALV ERPCPEYFNG IKYNTTRNAY RECLENGTWA SRVNYSHCEP
110 120 130 140 150
ILDDKQRKYD LHYRIALIIN YLGHCVSVVA LVAAFLLFLV LRSIRCLRNV
160 170 180 190 200
IHWNLITTFI LRNITWFLLQ LIDHEVHEGN EVWCRCVTTI FNYFVVTNFF
210 220 230 240 250
WMFVEGCYLH TAIVMTYSTE HLRKWLFLFI GWCIPCPIIV AWAVGKLYYE
260 270 280 290 300
NEQCWFGKEP GDLVDYIYQG PIILVLLINF VFLFNIVRIL MTKLRASTTS
310 320 330 340 350
ETIQYRKAVK ATLVLLPLLG ITYMLFFVNP GEDDLSQIVF IYFNSFLQSF
360 370 380 390 400
QGFFVSVFYC FFNGEVRSAL RKRWHRWQDH HALRVPVARA MSIPTSPTRI
410
SFHSIKQTAA V
The sequence of this isoform differs from the canonical sequence as follows:
1-34: MDAALLLSLLEANCSLALAEELLLDGWGEPPDPE → MGHPGSLPSA...CHRTTTRNFS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD4A5C4 | D4A5C4_RAT | Corticotropin releasing hormone rec... | Crhr2 rCG_52335 | 431 | Annotation score: | ||
A0A0G2K9U2 | A0A0G2K9U2_RAT | Corticotropin-releasing factor rece... | Crhr2 | 140 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 | V → I in AAC52159 (PubMed:7846062).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002001 | 1 – 34 | MDAAL…PPDPE → MGHPGSLPSAQLLLCLYSLL PLLQVAQPGRPLQDQPLWTL LEQYCHRTTTRNFS in isoform CRF2-beta. CuratedAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U16253 mRNA Translation: AAC52159.1 AABR06031050 Genomic DNA No translation available. CH474011 Genomic DNA Translation: EDL88099.1 |
PIRi | A55610 |
RefSeqi | NP_073205.1, NM_022714.1 |
Genome annotation databases
Ensembli | ENSRNOT00000033672; ENSRNOP00000035712; ENSRNOG00000011145 [P47866-1] |
GeneIDi | 64680 |
KEGGi | rno:64680 |
UCSCi | RGD:70547 rat [P47866-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U16253 mRNA Translation: AAC52159.1 AABR06031050 Genomic DNA No translation available. CH474011 Genomic DNA Translation: EDL88099.1 |
PIRi | A55610 |
RefSeqi | NP_073205.1, NM_022714.1 |
3D structure databases
SMRi | P47866 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 249194, 7 interactors |
STRINGi | 10116.ENSRNOP00000014925 |
Chemistry databases
BindingDBi | P47866 |
ChEMBLi | CHEMBL3581 |
DrugCentrali | P47866 |
GuidetoPHARMACOLOGYi | 213 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | P47866 |
PhosphoSitePlusi | P47866 |
Proteomic databases
PaxDbi | P47866 |
PRIDEi | P47866 |
Genome annotation databases
Ensembli | ENSRNOT00000033672; ENSRNOP00000035712; ENSRNOG00000011145 [P47866-1] |
GeneIDi | 64680 |
KEGGi | rno:64680 |
UCSCi | RGD:70547 rat [P47866-1] |
Organism-specific databases
CTDi | 1395 |
RGDi | 70547 Crhr2 |
Phylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000156795 |
HOGENOMi | HOG000230719 |
InParanoidi | P47866 |
KOi | K04579 |
OrthoDBi | 1163977at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-373080 Class B/2 (Secretin family receptors) R-RNO-418555 G alpha (s) signalling events |
Miscellaneous databases
PROi | PR:P47866 |
Gene expression databases
Bgeei | ENSRNOG00000011145 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue |
ExpressionAtlasi | P47866 baseline and differential |
Genevisiblei | P47866 RN |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR003053 GPCR_2_CRF2_rcpt IPR003051 GPCR_2_CRF_rcpt IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR01279 CRFRECEPTOR PR01281 CRFRECEPTOR2 PR00249 GPCRSECRETIN |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRFR2_RAT | |
Accessioni | P47866Primary (citable) accession number: P47866 Secondary accession number(s): G3V948 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | January 22, 2014 | |
Last modified: | September 18, 2019 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families