Corticotropin-releasing factor receptor 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• corticotrophin-releasing factor receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization."
    Bale T.L., Giordano F.J., Hickey R.P., Huang Y., Nath A.K., Peterson K.L., Vale W.W., Lee K.F.
    Proc. Natl. Acad. Sci. U.S.A. 99:7734-7739(2002) [PubMed] [Europe PMC] [Abstract]
  • "Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids."
    Chen A., Perrin M., Brar B., Li C., Jamieson P., DiGruccio M., Lewis K., Vale W.
    Mol. Endocrinol. 19:441-458(2005) [PubMed] [Europe PMC] [Abstract]
• corticotropin-releasing hormone receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin."
    Wigger A., Sanchez M.M., Mathys K.C., Ebner K., Frank E., Liu D., Kresse A., Neumann I.D., Holsboer F., Plotsky P.M., Landgraf R.
    Neuropsychopharmacology 29:1-14(2004) [PubMed] [Europe PMC] [Abstract]
  • "cDNA cloning and analysis of tissue-specific gene expression of rat urocortin II."
    Chae J.I., Ju S.K., Lee M.K., Park J.H., Yoon J.H., Shim J.H., Lee D.S.
    Mol. Biol. (Mosk.) 43:91-96(2009) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled peptide receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I."
    Pedersen W.A., Wan R., Zhang P., Mattson M.P.
    J. Neurosci. 22:404-412(2002) [PubMed] [Europe PMC] [Abstract]
• hormone activity Source: RGDInferred from sequence orthologyⁱ
  • "Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids."
    Chen A., Perrin M., Brar B., Li C., Jamieson P., DiGruccio M., Lewis K., Vale W.
    Mol. Endocrinol. 19:441-458(2005) [PubMed] [Europe PMC] [Abstract]
• peptide hormone binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "cDNA cloning and analysis of tissue-specific gene expression of rat urocortin II."
    Chae J.I., Ju S.K., Lee M.K., Park J.H., Yoon J.H., Shim J.H., Lee D.S.
    Mol. Biol. (Mosk.) 43:91-96(2009) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• actin filament organization Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner."
    Dermitzaki E., Tsatsanis C., Minas V., Chatzaki E., Charalampopoulos I., Venihaki M., Androulidaki A., Lambropoulou M., Spiess J., Michalodimitrakis E., Gravanis A., Margioris A.N.
    Endocrinology 148:1524-1538(2007) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• catecholamine biosynthetic process Source: RGDInferred from mutant phenotypeⁱ
  • "Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner."
    Dermitzaki E., Tsatsanis C., Minas V., Chatzaki E., Charalampopoulos I., Venihaki M., Androulidaki A., Lambropoulou M., Spiess J., Michalodimitrakis E., Gravanis A., Margioris A.N.
    Endocrinology 148:1524-1538(2007) [PubMed] [Europe PMC] [Abstract]
• cell surface receptor signaling pathway Source: InterPro
• cellular response to glucocorticoid stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2alpha in MIN6 insulinoma cells and rodent islets."
    Huising M.O., Pilbrow A.P., Matsumoto M., van der Meulen T., Park H., Vaughan J.M., Lee S., Vale W.W.
    Endocrinology 152:138-150(2011) [PubMed] [Europe PMC] [Abstract]
• cerebellum development Source: RGDInferred from expression patternⁱ
  • "The dynamic developmental localization of the full-length corticotropin-releasing factor receptor type 2 in rat cerebellum."
    Gounko N.V., Kalicharan D., Rybakin V., Gramsbergen A., van der Want J.J.
    Eur. J. Neurosci. 23:3217-3224(2006) [PubMed] [Europe PMC] [Abstract]
• epithelial cell differentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides."
    Estienne M., Claustre J., Clain-Gardechaux G., Paquet A., Tache Y., Fioramonti J., Plaisancie P.
    Gut 59:744-751(2010) [PubMed] [Europe PMC] [Abstract]
• feeding behavior Source: RGD <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake."
    Proulx K., Richard D., Walker C.D.
    Endocrinology 143:4683-4692(2002) [PubMed] [Europe PMC] [Abstract]
• gastric motility Source: RGDInferred from mutant phenotypeⁱ
  • "Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats."
    Chen C.Y., Inui A., Asakawa A., Fujino K., Kato I., Chen C.C., Ueno N., Fujimiya M.
    Gastroenterology 129:8-25(2005) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids."
    Chen A., Perrin M., Brar B., Li C., Jamieson P., DiGruccio M., Lewis K., Vale W.
    Mol. Endocrinol. 19:441-458(2005) [PubMed] [Europe PMC] [Abstract]
• hypothalamus development Source: RGDInferred from expression patternⁱ
  • "Corticotrophin-releasing factor alters the timing of puberty in the female rat."
    Kinsey-Jones J.S., Li X.F., Knox A.M., Lin Y.S., Milligan S.R., Lightman S.L., O'Byrne K.T.
    J. Neuroendocrinol. 22:102-109(2010) [PubMed] [Europe PMC] [Abstract]
• long-term synaptic potentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKA."
    Pollandt S., Liu J., Orozco-Cabal L., Grigoriadis D.E., Vale W.W., Gallagher J.P., Shinnick-Gallagher P.
    Eur. J. Neurosci. 24:1733-1743(2006) [PubMed] [Europe PMC] [Abstract]
  • "Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2."
    Guan X., Zhang R., Xu Y., Li S.
    Neuroscience 161:665-670(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of angiogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization."
    Bale T.L., Giordano F.J., Hickey R.P., Huang Y., Nath A.K., Peterson K.L., Vale W.W., Lee K.F.
    Proc. Natl. Acad. Sci. U.S.A. 99:7734-7739(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of calcium ion import Source: RGDInferred from mutant phenotypeⁱ
  • "Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway."
    Tao J., Zhang Y., Huang H., Jiang X.
    Cell. Signal. 21:1436-1443(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cAMP-mediated signaling Source: RGDInferred from sequence orthologyⁱ
  • "A novel corticotropin-releasing factor receptor splice variant exhibits dominant negative activity: a putative link to stress-induced heart disease."
    Sztainberg Y., Kuperman Y., Issler O., Gil S., Vaughan J., Rivier J., Vale W., Chen A.
    FASEB J. 23:2186-2196(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of defecation Source: RGDInferred from mutant phenotypeⁱ
  • "Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents."
    Gourcerol G., Wu S.V., Yuan P.Q., Pham H., Miampamba M., Larauche M., Sanders P., Amano T., Mulak A., Im E., Pothoulakis C., Rivier J., Tache Y., Million M.
    Gastroenterology 140:1586-96.e6(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epinephrine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner."
    Dermitzaki E., Tsatsanis C., Minas V., Chatzaki E., Charalampopoulos I., Venihaki M., Androulidaki A., Lambropoulou M., Spiess J., Michalodimitrakis E., Gravanis A., Margioris A.N.
    Endocrinology 148:1524-1538(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of feeding behavior Source: RGDInferred from direct assayⁱ
  • "Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat."
    Fedeli A., Policani F., Ubaldi M., Cippitelli A., Massi M., Ciccocioppo R.
    Peptides 27:3284-3291(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of follicle-stimulating hormone secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropins."
    Nemoto T., Yamauchi N., Shibasaki T.
    J. Endocrinol. 201:105-114(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from mutant phenotypeⁱ
  • "Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropins."
    Nemoto T., Yamauchi N., Shibasaki T.
    J. Endocrinol. 201:105-114(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGDInferred from mutant phenotypeⁱ
  • "Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis."
    Li C., Chen P., Vaughan J., Lee K.F., Vale W.
    Proc. Natl. Acad. Sci. U.S.A. 104:4206-4211(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of luteinizing hormone secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropins."
    Nemoto T., Yamauchi N., Shibasaki T.
    J. Endocrinol. 201:105-114(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of norepinephrine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner."
    Dermitzaki E., Tsatsanis C., Minas V., Chatzaki E., Charalampopoulos I., Venihaki M., Androulidaki A., Lambropoulou M., Spiess J., Michalodimitrakis E., Gravanis A., Margioris A.N.
    Endocrinology 148:1524-1538(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • "Excitatory responses of cardiovascular activities to urocortin3 administration into the PVN of the rat."
    Li X., Fan M., Shen L., Cao Y., Zhu D., Hong Z.
    Auton Neurosci 154:108-111(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cAMP-mediated signaling Source: RGDInferred from direct assayⁱ
  • "The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity."
    Schulz K., Rutz C., Westendorf C., Ridelis I., Vogelbein S., Furkert J., Schmidt A., Wiesner B., Schulein R.
    J. Biol. Chem. 285:32878-32887(2010) [PubMed] [Europe PMC] [Abstract]
  • "Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents."
    Gourcerol G., Wu S.V., Yuan P.Q., Pham H., Miampamba M., Larauche M., Sanders P., Amano T., Mulak A., Im E., Pothoulakis C., Rivier J., Tache Y., Million M.
    Gastroenterology 140:1586-96.e6(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA biosynthetic process Source: RGDInferred from mutant phenotypeⁱ
  • "Effects of urocortin II on neonatal rat cardiac myocytes and non-myocytes."
    Ikeda K., Tojo K., Otsubo C., Udagawa T., Hosoya T., Tajima N., Nakao K., Kawamura M.
    Peptides 26:2473-2481(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from mutant phenotypeⁱ
  • "Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropins."
    Nemoto T., Yamauchi N., Shibasaki T.
    J. Endocrinol. 201:105-114(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of heart rate Source: RGDInferred from mutant phenotypeⁱ
  • "Excitatory responses of cardiovascular activities to urocortin3 administration into the PVN of the rat."
    Li X., Fan M., Shen L., Cao Y., Zhu D., Hong Z.
    Auton Neurosci 154:108-111(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-6 production Source: RGDInferred from mutant phenotypeⁱ
  • "Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation."
    Huang M., Kempuraj D., Papadopoulou N., Kourelis T., Donelan J., Manola A., Theoharides T.C.
    J. Mol. Endocrinol. 42:397-405(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NF-kappaB transcription factor activity Source: RGDInferred from mutant phenotypeⁱ
  • "Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation."
    Huang M., Kempuraj D., Papadopoulou N., Kourelis T., Donelan J., Manola A., Theoharides T.C.
    J. Mol. Endocrinol. 42:397-405(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of serotonin secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Chronic amphetamine treatment enhances corticotropin-releasing factor-induced serotonin release in the amygdala."
    Scholl J.L., Vuong S.M., Forster G.L.
    Eur. J. Pharmacol. 644:80-87(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of stress-activated MAPK cascade Source: RGDInferred from mutant phenotypeⁱ
  • "Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation."
    Huang M., Kempuraj D., Papadopoulou N., Kourelis T., Donelan J., Manola A., Theoharides T.C.
    J. Mol. Endocrinol. 42:397-405(2009) [PubMed] [Europe PMC] [Abstract]
• protein kinase C-activating G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway."
    Tao J., Zhang Y., Huang H., Jiang X.
    Cell. Signal. 21:1436-1443(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of ERK1 and ERK2 cascade Source: RGDInferred from mutant phenotypeⁱ
  • "Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents."
    Gourcerol G., Wu S.V., Yuan P.Q., Pham H., Miampamba M., Larauche M., Sanders P., Amano T., Mulak A., Im E., Pothoulakis C., Rivier J., Tache Y., Million M.
    Gastroenterology 140:1586-96.e6(2011) [PubMed] [Europe PMC] [Abstract]
• sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "[Analgesic effect of corticotropin releasing factor (CRF) on somatic pain sensitivity: participation of glucocorticoid and CRF-2 receptors]."
    Iarushkina N.I., Bagaeva T.R., Filaretova L.P.
    Ross Fiziol Zh Im I M Sechenova 94:1118-1125(2008) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle tissue growth Source: RGDInferred from direct assayⁱ
  • "Treatment with a corticotrophin releasing factor 2 receptor agonist modulates skeletal muscle mass and force production in aged and chronically ill animals."
    Hinkle R.T., Lefever F.R., Dolan E.T., Reichart D.L., Zwolshen J.M., Oneill T.P., Maloney K.G., Mattson J.P., Ferreira L.F., Musch T.I., Poole D.C., Isfort R.J.
    BMC Musculoskelet Disord 12:15-15(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• hormone activity Source: RGDInferred from sequence orthologyⁱ
  • "Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids."
    Chen A., Perrin M., Brar B., Li C., Jamieson P., DiGruccio M., Lewis K., Vale W.
    Mol. Endocrinol. 19:441-458(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MDAALLLSLL EANCSLALAE ELLLDGWGEP PDPEGPYSYC NTTLDQIGTC 
        60         70         80         90        100
WPQSAPGALV ERPCPEYFNG IKYNTTRNAY RECLENGTWA SRVNYSHCEP 
       110        120        130        140        150
ILDDKQRKYD LHYRIALIIN YLGHCVSVVA LVAAFLLFLV LRSIRCLRNV 
       160        170        180        190        200
IHWNLITTFI LRNITWFLLQ LIDHEVHEGN EVWCRCVTTI FNYFVVTNFF 
       210        220        230        240        250
WMFVEGCYLH TAIVMTYSTE HLRKWLFLFI GWCIPCPIIV AWAVGKLYYE 
       260        270        280        290        300
NEQCWFGKEP GDLVDYIYQG PIILVLLINF VFLFNIVRIL MTKLRASTTS 
       310        320        330        340        350
ETIQYRKAVK ATLVLLPLLG ITYMLFFVNP GEDDLSQIVF IYFNSFLQSF 
       360        370        380        390        400
QGFFVSVFYC FFNGEVRSAL RKRWHRWQDH HALRVPVARA MSIPTSPTRI 
       410 
SFHSIKQTAA V                                           

        10         20         30         40         50
MGHPGSLPSA QLLLCLYSLL PLLQVAQPGR PLQDQPLWTL LEQYCHRTTT 
        60         70         80         90        100
RNFSGPYSYC NTTLDQIGTC WPQSAPGALV ERPCPEYFNG IKYNTTRNAY 
       110        120        130        140        150
RECLENGTWA SRVNYSHCEP ILDDKQRKYD LHYRIALIIN YLGHCVSVVA 
       160        170        180        190        200
LVAAFLLFLV LRSIRCLRNV IHWNLITTFI LRNITWFLLQ LIDHEVHEGN 
       210        220        230        240        250
EVWCRCVTTI FNYFVVTNFF WMFVEGCYLH TAIVMTYSTE HLRKWLFLFI 
       260        270        280        290        300
GWCIPCPIIV AWAVGKLYYE NEQCWFGKEP GDLVDYIYQG PIILVLLINF 
       310        320        330        340        350
VFLFNIVRIL MTKLRASTTS ETIQYRKAVK ATLVLLPLLG ITYMLFFVNP 
       360        370        380        390        400
GEDDLSQIVF IYFNSFLQSF QGFFVSVFYC FFNGEVRSAL RKRWHRWQDH 
       410        420        430 
HALRVPVARA MSIPTSPTRI SFHSIKQTAA V                     

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries