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Protein

Aquaporin-1

Gene

AQP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Miscellaneous

Pharmacologically inhibited by submillimolar concentrations of mercury.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei58Substrate discrimination1
Sitei182Substrate discrimination1
Sitei191Hg(2+)-sensitive residue1
Sitei197Substrate discrimination1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-BTA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-BTA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-432047 Passive transport by Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-1
Short name:
AQP-1
Alternative name(s):
Aquaporin-CHIP
Water channel protein CHIP29
Water channel protein for red blood cells and kidney proximal tubule
Gene namesi
Name:AQP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9Cytoplasmic9
Transmembranei10 – 34Helical; Name=Helix 1Add BLAST25
Topological domaini35 – 50ExtracellularAdd BLAST16
Transmembranei51 – 68Helical; Name=Helix 2Add BLAST18
Topological domaini69 – 73Cytoplasmic5
Intramembranei74 – 785
Intramembranei79 – 88Helical; Name=Helix B10
Topological domaini89 – 92Cytoplasmic4
Transmembranei93 – 117Helical; Name=Helix 3Add BLAST25
Topological domaini118 – 142ExtracellularAdd BLAST25
Transmembranei143 – 158Helical; Name=Helix 4Add BLAST16
Topological domaini159 – 169CytoplasmicAdd BLAST11
Transmembranei170 – 187Helical; Name=Helix 5Add BLAST18
Topological domaini188 – 189Extracellular2
Intramembranei190 – 1934
Intramembranei194 – 204Helical; Name=Helix EAdd BLAST11
Topological domaini205 – 215ExtracellularAdd BLAST11
Transmembranei216 – 230Helical; Name=Helix 6Add BLAST15
Topological domaini231 – 271CytoplasmicAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639181 – 271Aquaporin-1Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei249PhosphoserineBy similarity1
Modified residuei255PhosphotyrosineBy similarity1
Modified residuei264PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP47865
PRIDEiP47865

Expressioni

Gene expression databases

BgeeiENSBTAG00000000745 Expressed in 10 organ(s), highest expression level in adult mammalian kidney

Interactioni

Subunit structurei

Homotetramer. Interacts with EPHB2; involved in endolymph production in the inner ear. Identified in a complex with STOM (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000993

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP47865
SMRiP47865
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47865

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi78 – 80NPA 13
Motifi194 – 196NPA 23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi161 – 164Poly-Arg4

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG000312
InParanoidiP47865
KOiK09864
OMAiELFGTFW
OrthoDBiEOG091G166T
TreeFamiTF312940

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023274 Aquaporin_1
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02013 AQUAPORIN1
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

P47865-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASEFKKKLF WRAVVAEFLA MILFIFISIG SALGFHYPIK SNQTTGAVQD
60 70 80 90 100
NVKVSLAFGL SIATLAQSVG HISGAHLNPA VTLGLLLSCQ ISVLRAIMYI
110 120 130 140 150
IAQCVGAIVA TAILSGITSS LPDNSLGLNA LAPGVNSGQG LGIEIIGTLQ
160 170 180 190 200
LVLCVLATTD RRRRDLGGSG PLAIGFSVAL GHLLAIDYTG CGINPARSFG
210 220 230 240 250
SSVITHNFQD HWIFWVGPFI GAALAVLIYD FILAPRSSDL TDRVKVWTSG
260 270
QVEEYDLDAD DINSRVEMKP K
Length:271
Mass (Da):28,800
Last modified:January 23, 2007 - v3
Checksum:i3A1C9A2071CDA5E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74759 mRNA Translation: AAB32365.1
AF028005 mRNA Translation: AAB84190.1
BT025412 mRNA Translation: ABF57368.1
BC105525 mRNA Translation: AAI05526.1
PIRiJC2348
RefSeqiNP_777127.1, NM_174702.3
UniGeneiBt.1525

Genome annotation databases

EnsembliENSBTAT00000000993; ENSBTAP00000000993; ENSBTAG00000000745
GeneIDi282653
KEGGibta:282653

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74759 mRNA Translation: AAB32365.1
AF028005 mRNA Translation: AAB84190.1
BT025412 mRNA Translation: ABF57368.1
BC105525 mRNA Translation: AAI05526.1
PIRiJC2348
RefSeqiNP_777127.1, NM_174702.3
UniGeneiBt.1525

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J4NX-ray2.20A1-271[»]
ProteinModelPortaliP47865
SMRiP47865
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000993

Proteomic databases

PaxDbiP47865
PRIDEiP47865

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000993; ENSBTAP00000000993; ENSBTAG00000000745
GeneIDi282653
KEGGibta:282653

Organism-specific databases

CTDi358

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG000312
InParanoidiP47865
KOiK09864
OMAiELFGTFW
OrthoDBiEOG091G166T
TreeFamiTF312940

Enzyme and pathway databases

ReactomeiR-BTA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-BTA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-432047 Passive transport by Aquaporins

Miscellaneous databases

EvolutionaryTraceiP47865

Gene expression databases

BgeeiENSBTAG00000000745 Expressed in 10 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023274 Aquaporin_1
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02013 AQUAPORIN1
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAQP1_BOVIN
AccessioniPrimary (citable) accession number: P47865
Secondary accession number(s): Q2HJE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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