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Protein

Aquaporin-5

Gene

Aqp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells.By similarity

GO - Molecular functioni

  • identical protein binding Source: Ensembl
  • water channel activity Source: RGD

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-432047 Passive transport by Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-5
Short name:
AQP-5
Gene namesi
Name:Aqp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2144 Aqp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 36ExtracellularSequence analysis3
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 87CytoplasmicSequence analysisAdd BLAST30
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 126ExtracellularSequence analysisAdd BLAST18
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 161CytoplasmicSequence analysisAdd BLAST14
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 205ExtracellularSequence analysisAdd BLAST23
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 265CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639531 – 265Aquaporin-5Add BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP47864
PRIDEiP47864

PTM databases

iPTMnetiP47864
PhosphoSitePlusiP47864

Expressioni

Tissue specificityi

Salivary glands, lacrimal glands, corneal epithelium in eye, trachea and lung.

Gene expression databases

BgeeiENSRNOG00000051970 Expressed in 5 organ(s), highest expression level in lung
GenevisibleiP47864 RN

Interactioni

Subunit structurei

Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024102

Structurei

3D structure databases

ProteinModelPortaliP47864
SMRiP47864
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 71NPA 13
Motifi185 – 187NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOVERGENiHBG000312
InParanoidiP47864
KOiK09867
OMAiWEDHREE
OrthoDBiEOG091G166T
TreeFamiTF312940

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023276 Aquaporin_5
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PTHR19139:SF38 PTHR19139:SF38, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02017 AQUAPORIN5
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

P47864-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKEVCSLAF FKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQISIAFG
60 70 80 90 100
LAIGTLAQAL GPVSGGHINP AITLALLIGN QISLLRAVFY VAAQLVGAIA
110 120 130 140 150
GAGILYWLAP LNARGNLAVN ALNNNTTPGK AMVVELILTF QLALCIFSST
160 170 180 190 200
DSRRTSPVGS PALSIGLSVT LGHLVGIYFT GCSMNPARSF GPAVVMNRFS
210 220 230 240 250
PSHWVFWVGP IVGAMLAAIL YFYLLFPSSL SLHDRVAVVK GTYEPEEDWE
260
DHREERKKTI ELTAH
Length:265
Mass (Da):28,421
Last modified:February 1, 1996 - v1
Checksum:iDE0F1BED9D2C0600
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16245 mRNA Translation: AAA66221.1
BC092572 mRNA Translation: AAH92572.2
BC110045 mRNA Translation: AAI10046.1
PIRiA55630
RefSeqiNP_036911.1, NM_012779.1
UniGeneiRn.10066

Genome annotation databases

EnsembliENSRNOT00000084911; ENSRNOP00000073596; ENSRNOG00000051970
GeneIDi25241
KEGGirno:25241
UCSCiRGD:2144 rat

Similar proteinsi

Entry informationi

Entry nameiAQP5_RAT
AccessioniPrimary (citable) accession number: P47864
Secondary accession number(s): Q2YDV0, Q569C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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