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Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

SLC2A3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315MonosaccharideBy similarity1
Binding sitei378MonosaccharideBy similarity1
Binding sitei386MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
Glucose transporter type 3, brain
Short name:
GLUT-3
Gene namesi
Name:SLC2A3
Synonyms:GLUT3
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicBy similarity10
Transmembranei11 – 32Helical; Name=1Sequence analysisBy similarityAdd BLAST22
Topological domaini33 – 64ExtracellularBy similarityAdd BLAST32
Transmembranei65 – 85Helical; Name=2Sequence analysisBy similarityAdd BLAST21
Topological domaini86 – 90CytoplasmicBy similarity5
Transmembranei91 – 111Helical; Name=3Sequence analysisBy similarityAdd BLAST21
Topological domaini112 – 118ExtracellularBy similarity7
Transmembranei119 – 142Helical; Name=4Sequence analysisBy similarityAdd BLAST24
Topological domaini143 – 153CytoplasmicBy similarityAdd BLAST11
Transmembranei154 – 174Helical; Name=5Sequence analysisBy similarityAdd BLAST21
Topological domaini175 – 183ExtracellularBy similarity9
Transmembranei184 – 204Helical; Name=6Sequence analysisBy similarityAdd BLAST21
Topological domaini205 – 269CytoplasmicBy similarityAdd BLAST65
Transmembranei270 – 290Helical; Name=7Sequence analysisBy similarityAdd BLAST21
Topological domaini291 – 304ExtracellularBy similarityAdd BLAST14
Transmembranei305 – 325Helical; Name=8Sequence analysisBy similarityAdd BLAST21
Topological domaini326 – 331CytoplasmicBy similarity6
Transmembranei332 – 352Helical; Name=9Sequence analysisBy similarityAdd BLAST21
Topological domaini353 – 363ExtracellularBy similarityAdd BLAST11
Transmembranei364 – 389Helical; Name=10Sequence analysisBy similarityAdd BLAST26
Topological domaini390 – 399CytoplasmicBy similarity10
Transmembranei400 – 420Helical; Name=11Sequence analysisBy similarityAdd BLAST21
Topological domaini421 – 429ExtracellularSequence analysis9
Transmembranei430 – 450Helical; Name=12Sequence analysisBy similarityAdd BLAST21
Topological domaini451 – 495CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503521 – 495Solute carrier family 2, facilitated glucose transporter member 3Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei232PhosphothreonineBy similarity1
Modified residuei485PhosphoserineBy similarity1
Modified residuei492PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP47842
PRIDEiP47842

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020500

Structurei

3D structure databases

ProteinModelPortaliP47842
SMRiP47842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 279Important for selectivity against fructoseBy similarity3
Regioni280 – 286Monosaccharide bindingBy similarity7

Domaini

Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP47842
KOiK08142

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002945 Glc_transpt_3
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01192 GLUCTRSPORT3
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47842-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTQKVTVSL IFALSIATIG SFQFGYNTGV INAPETIIKD FLNYTLEEKS
60 70 80 90 100
ENLPTEVLLT SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLMVNLL
110 120 130 140 150
AVAGGCLMGF CKIAQSVEML ILGRLIIGLF CGLCTGFVPM YIGEISPTAL
160 170 180 190 200
RGAFGTLNQL GIVIGILVAQ IFGLKVIMGT EELWPLLLGF TIIPAVLQSA
210 220 230 240 250
ALPFCPESPR FLLINRKEEE NAKEILQRLW GTQDVSQDIQ EMKDESARMA
260 270 280 290 300
QEKQVTVLEL FRSRSYRQPI IISIMLQLSQ QLSGINAVFY YSTGIFKDAG
310 320 330 340 350
VEEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSILMT
360 370 380 390 400
ISLLLKDNYN WMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA
410 420 430 440 450
AMAVAGCSNW TSNFLVGLLF PSAAFYLGAY VFIIFTGFLI VFLVFTFFKV
460 470 480 490
PETRGRTFEE ITRAFEGQGQ DANRAEKGPI VEMNSMQPVK ETATV
Length:495
Mass (Da):54,283
Last modified:February 1, 1996 - v1
Checksum:i09063C013DAE39C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35267 mRNA Translation: AAA51454.1
RefSeqiNP_001003308.1, NM_001003308.1
UniGeneiCfa.29204

Genome annotation databases

GeneIDi403997
KEGGicfa:403997

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35267 mRNA Translation: AAA51454.1
RefSeqiNP_001003308.1, NM_001003308.1
UniGeneiCfa.29204

3D structure databases

ProteinModelPortaliP47842
SMRiP47842
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000020500

Proteomic databases

PaxDbiP47842
PRIDEiP47842

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403997
KEGGicfa:403997

Organism-specific databases

CTDi6515

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP47842
KOiK08142

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002945 Glc_transpt_3
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01192 GLUCTRSPORT3
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTR3_CANLF
AccessioniPrimary (citable) accession number: P47842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 10, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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