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Protein

P2X purinoceptor 1

Gene

P2rx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processApoptosis, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-418346 Platelet homeostasis
R-RNO-6798695 Neutrophil degranulation

Protein family/group databases

TCDBi1.A.7.1.1 the atp-gated p2x receptor cation channel (p2x receptor) family

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 1
Short name:
P2X1
Alternative name(s):
ATP receptor
Purinergic receptor
RP-2 protein
Gene namesi
Name:P2rx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3240 P2rx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 50Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini51 – 338ExtracellularSequence analysisAdd BLAST288
Transmembranei339 – 358Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini359 – 399CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2530
GuidetoPHARMACOLOGYi478

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615471 – 399P2X purinoceptor 1Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi117 ↔ 165By similarity
Disulfide bondi126 ↔ 149By similarity
Disulfide bondi132 ↔ 159By similarity
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 227By similarity
Disulfide bondi261 ↔ 270By similarity
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei387PhosphoserineBy similarity1
Modified residuei388PhosphoserineBy similarity1
Modified residuei389PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP47824
PRIDEiP47824

PTM databases

iPTMnetiP47824
PhosphoSitePlusiP47824

Expressioni

Tissue specificityi

High levels in vas deferens and urinary bladder. Lower extent in spinal cord, coeliac ganglion, lung and spleen (probably in the smooth muscle part of both organs).

Developmental stagei

Expressed during apoptosis in thymocytes.

Inductioni

By irradiation and dexamethasone (in thymocytes).

Gene expression databases

BgeeiENSRNOG00000017606 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasiP47824 baseline and differential
GenevisibleiP47824 RN

Interactioni

Subunit structurei

Homo- or heteropolymers.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024068

Chemistry databases

BindingDBiP47824

Structurei

3D structure databases

SMRiP47824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni331 – 338Pore-forming motifSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi351 – 354Poly-Leu4

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiP47824
KOiK05215
OMAiFKYAEDM
OrthoDBiEOG091G0A2U
PhylomeDBiP47824

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003044 P2X1_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF9 PTHR10125:SF9, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01308 P2X1RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P47824-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRLQDELS AFFFEYDTPR MVLVRNKKVG VIFRLIQLVV LVYVIGWVFV
60 70 80 90 100
YEKGYQTSSD LISSVSVKLK GLAVTQLQGL GPQVWDVADY VFPAHGDSSF
110 120 130 140 150
VVMTNFIVTP QQTQGHCAEN PEGGICQDDS GCTPGKAERK AQGIRTGNCV
160 170 180 190 200
PFNGTVKTCE IFGWCPVEVD DKIPSPALLR EAENFTLFIK NSISFPRFKV
210 220 230 240 250
NRRNLVEEVN GTYMKKCLYH KIQHPLCPVF NLGYVVRESG QDFRSLAEKG
260 270 280 290 300
GVVGITIDWK CDLDWHVRHC KPIYQFHGLY GEKNLSPGFN FRFARHFVQN
310 320 330 340 350
GTNRRHLFKV FGIHFDILVD GKAGKFDIIP TMTTIGSGIG IFGVATVLCD
360 370 380 390
LLLLHILPKR HYYKQKKFKY AEDMGPGEGE HDPVATSSTL GLQENMRTS
Length:399
Mass (Da):44,957
Last modified:February 1, 1996 - v1
Checksum:i04B79E171D78AEC2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9JIF8Q9JIF8_RAT
P2X purinoceptor
P2rx1 rCG_33902
372Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189 – 201IKNSI…RFKVN → PQLAHGCYPCPPH (PubMed:2072913).CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80477 mRNA Translation: CAA56647.1
BC061742 mRNA Translation: AAH61742.1
M80602 mRNA Translation: AAA42065.1
PIRiS50860
RefSeqiNP_001135839.1, NM_001142367.2
NP_001272344.1, NM_001285415.1
NP_037129.1, NM_012997.3
UniGeneiRn.91176

Genome annotation databases

EnsembliENSRNOT00000024068; ENSRNOP00000024068; ENSRNOG00000017606
GeneIDi25505
KEGGirno:25505

Similar proteinsi

Entry informationi

Entry nameiP2RX1_RAT
AccessioniPrimary (citable) accession number: P47824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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