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Protein

Eukaryotic translation initiation factor 1A, X-chromosomal

Gene

EIF1AX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • translation factor activity, RNA binding Source: ProtInc
  • translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1A, X-chromosomal
Short name:
eIF-1A X isoform
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name:
eIF-4C
Gene namesi
Name:EIF1AX
Synonyms:EIF1A, EIF4C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000173674.10
HGNCiHGNC:3250 EIF1AX
MIMi300186 gene
neXtProtiNX_P47813

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1964
MalaCardsiEIF1AX
OpenTargetsiENSG00000173674
PharmGKBiPA27684

Polymorphism and mutation databases

BioMutaiEIF1AX
DMDMi1352425

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001451011 – 144Eukaryotic translation initiation factor 1A, X-chromosomalAdd BLAST144

Proteomic databases

EPDiP47813
MaxQBiP47813
PaxDbiP47813
PeptideAtlasiP47813
PRIDEiP47813
ProteomicsDBi55799
TopDownProteomicsiP47813

PTM databases

iPTMnetiP47813
PhosphoSitePlusiP47813

Expressioni

Gene expression databases

BgeeiENSG00000173674
CleanExiHS_EIF1AX
ExpressionAtlasiP47813 baseline and differential
GenevisibleiP47813 HS

Organism-specific databases

HPAiHPA002561

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108284, 41 interactors
CORUMiP47813
DIPiDIP-40995N
IntActiP47813, 18 interactors
MINTiP47813
STRINGi9606.ENSP00000368927

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 12Combined sources6
Beta strandi33 – 41Combined sources9
Beta strandi43 – 51Combined sources9
Turni52 – 54Combined sources3
Beta strandi55 – 60Combined sources6
Helixi64 – 67Combined sources4
Beta strandi76 – 80Combined sources5
Beta strandi82 – 87Combined sources6
Beta strandi90 – 95Combined sources6
Turni97 – 99Combined sources3
Helixi100 – 106Combined sources7
Beta strandi120 – 122Combined sources3

3D structure databases

DisProtiDP00903
ProteinModelPortaliP47813
SMRiP47813
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47813

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 96S1-likeAdd BLAST75

Sequence similaritiesi

Belongs to the eIF-1A family.Curated

Phylogenomic databases

eggNOGiKOG3403 Eukaryota
COG0361 LUCA
GeneTreeiENSGT00390000008256
HOGENOMiHOG000223675
HOVERGENiHBG001131
InParanoidiP47813
KOiK03236
OMAiLGGNHVR
OrthoDBiEOG091G195V
PhylomeDBiP47813
TreeFamiTF350394

Family and domain databases

CDDicd05793 S1_IF1A, 1 hit
HAMAPiMF_00216 aIF_1A, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR001253 TIF_eIF-1A
IPR018104 TIF_eIF-1A_CS
PANTHERiPTHR21668 PTHR21668, 1 hit
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005579 TIF_eIF-1A, 1 hit
SMARTiView protein in SMART
SM00652 eIF1a, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00523 eIF-1A, 1 hit
PROSITEiView protein in PROSITE
PS01262 IF1A, 1 hit
PS50832 S1_IF1_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

P47813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM
60 70 80 90 100
CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA
110 120 130 140
RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI
Length:144
Mass (Da):16,460
Last modified:January 23, 2007 - v2
Checksum:i1C4209855B21BFD4
GO

Sequence cautioni

The sequence CAI40551 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18960 mRNA Translation: AAA19812.1
AK312320 mRNA Translation: BAG35242.1
BT007064 mRNA Translation: AAP35727.1
AL732366 Genomic DNA Translation: CAI40550.1
AL732366 Genomic DNA Translation: CAI40551.1 Sequence problems.
BC000793 mRNA Translation: AAH00793.1
BC067851 mRNA Translation: AAH67851.1
CCDSiCCDS14196.1
PIRiC53045
RefSeqiNP_001403.1, NM_001412.3
XP_016855198.1, XM_016999709.1
UniGeneiHs.522590

Genome annotation databases

EnsembliENST00000379607; ENSP00000368927; ENSG00000173674
GeneIDi1964
KEGGihsa:107984923
hsa:1964
UCSCiuc004czt.4 human

Entry informationi

Entry nameiIF1AX_HUMAN
AccessioniPrimary (citable) accession number: P47813
Secondary accession number(s): B2R5U5
, Q0VGC2, Q5JPS5, Q5JPS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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