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Protein

Zinc finger protein GLI1

Gene

Gli1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri238 – 263C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri271 – 298C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri304 – 328C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri334 – 359C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri365 – 390C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610787 Hedgehog 'off' state
R-MMU-5632684 Hedgehog 'on' state

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein GLI1
Alternative name(s):
Glioma-associated oncogene homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gli1
Synonyms:Gli
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95727 Gli1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5007

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000471981 – 1111Zinc finger protein GLI1Add BLAST1111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei520N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1008Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in vitro by ULK3.By similarity
Acetylation at Lys-520 down-regulates transcriptional activity. Deacetylated by HDAC1.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P47806

PRoteomics IDEntifications database

More...
PRIDEi
P47806

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P47806

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P47806

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Is detected on days 10 through 18 of embryonic development. During gestation it is detected in meckels precartilage mesenchyme, the basis occipitus, rib mesenchymal condensations, primordial vertebral bodies, digital mesenchymal condensations in forefoot and hindfoot plates, the ependymal layer of the spinal cord, and the mesoderm of the gastrointestinal tract. Expression persists throughout gestation in developing bone and cartilage of the extremities, the ribs, and the vertebral bodies as well as the gastrointestinal tract mesoderm.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025407 Expressed in 312 organ(s), highest expression level in spermatogonium

CleanEx database of gene expression profiles

More...
CleanExi
MM_GLI1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P47806 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P47806 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KIF7 (PubMed:19592253). Interacts with STK36. Interacts with ZIC1; the interaction enhances transcription activation. Interacts with SUFU; this inhibits transcriptional activation by GLI1 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
199942, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-147 GLI1-SUFU complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P47806

Protein interaction database and analysis system

More...
IntActi
P47806, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000026474

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P47806

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P47806

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni123 – 127Interaction with SUFUBy similarity5
Regioni286 – 294Interaction with DNABy similarity9
Regioni348 – 353Interaction with DNABy similarity6
Regioni378 – 384Interaction with DNABy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1042 – 1059Asp/Glu-rich (acidic)Add BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri238 – 263C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri271 – 298C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri304 – 328C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri334 – 359C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri365 – 390C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160235

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290688

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080668

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P47806

KEGG Orthology (KO)

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KOi
K16797

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCHQANL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01XS

TreeFam database of animal gene trees

More...
TreeFami
TF350216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032850 GLI1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

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PANTHERi
PTHR19818:SF2 PTHR19818:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P47806-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNPMTPPQV NSYSEPCCLR PLHSQGVPSM GTEGLSGLPF CHQANFMSGS
60 70 80 90 100
QGYGAARETS SCTEGSLFPP PPPPRSSVKL TKKRALSISP LSDASLDLQT
110 120 130 140 150
VIRTSPSSLV AFINSRCTSP GGSYGHLSIG TMSPSLGFPP QMSHQKGTSP
160 170 180 190 200
PYGVQPCVPH DSTRGSMMLH PQSRGPRATC QLKSELDMMV GKCPEDPLEG
210 220 230 240 250
DMSSPNSTGT QDHLLGMLDG REDLEREEKP EPESVYETDC RWDGCSQEFD
260 270 280 290 300
SQEQLVHHIN SEHIHGERKE FVCHWGGCSR ELRPFKAQYM LVVHMRRHTG
310 320 330 340 350
EKPHKCTFEG CRKSYSRLEN LKTHLRSHTG EKPYMCEQEG CSKAFSNASD
360 370 380 390 400
RAKHQNRTHS NEKPYVCKLP GCTKRYTDPS SLRKHVKTVH GPDAHVTKRH
410 420 430 440 450
RGDGPLPRAQ PLSTVEPKRE REGGSGREES RLTVPESAMP QQSPGAQSSC
460 470 480 490 500
SSDHSPAGSA ANTDSGVEMA GNAGGSTEDL SSLDEGPCVS ATGLSTLRRL
510 520 530 540 550
ENLRLDQLHQ LRPIGSRGLK LPSLTHAGAP VSRRLGPPVS LDRRSSSSSS
560 570 580 590 600
MSSAYTVSRR SSLASPFPPG TPPENGASSL PGLTPAQHYM LRARYASARG
610 620 630 640 650
SGTPPTAAHS LDRMGGLSVP PWRSRTEYPG YNPNAGVTRR ASDPARAADH
660 670 680 690 700
PAPARVQRFK SLGCVHTPPS VATGRNFDPH HPTSVYSPQP PSITENVAMD
710 720 730 740 750
TRGLQEEPEV GTSVMGNGLN PYMDFSSTDT LGYGGPEGTA AEPYEARGPG
760 770 780 790 800
SLPLGPGPPT NYGPGHCAQQ VSYPDPTPEN WGEFPSHAGV YPSNKAPGAA
810 820 830 840 850
YSQCPRLEHY GQVQVKPEQG CPVGSDSTGL APCLNAHPSE GSPGPQPLFS
860 870 880 890 900
HHPQLPQPQY PQSGPYPQPP HGYLSTEPRL GLNFNPSSSH STGQLKAQLV
910 920 930 940 950
CNYVQSQQEL LWEGRNRGGL PNQELPYQSP KFLGGSQVSQ SPAKTPAAAA
960 970 980 990 1000
AAYGSGFAPA SANHKSGSYP APSPCHETFT VGVNRPSHRP AAPPRLLPPL
1010 1020 1030 1040 1050
SPCYGPLKVG DTNPSCGHPE VGRLGAGPAL YPPPEGQVCN ALDSLDLDNT
1060 1070 1080 1090 1100
QLDFVAILDE AQGLSPPLSH EQGDSSKNTP SPSGPPNMAV GNMSVLLGSL
1110
PGETQFLNSS A
Length:1,111
Mass (Da):118,560
Last modified:October 3, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A83B254DCBB9BDC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4Q8I4D4Q8I4_MOUSE
GLI-Kruppel family member GLI1 spli...
Gli1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154V → L in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti170H → Y in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti173S → A in BAA85004 (PubMed:10433919).Curated1
Sequence conflicti179T → I in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti194P → R in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti210T → I in BAA85004 (PubMed:10433919).Curated1
Sequence conflicti271F → S in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti474Missing in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti567 – 569FPP → LPT in AAC09169 (PubMed:9524201).Curated3
Sequence conflicti707E → D in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti777Missing in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti864G → V in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti919 – 920GL → RA in AAC09169 (PubMed:9524201).Curated2
Sequence conflicti936S → Y in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti947Missing in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti951 – 952AA → RR in AAC09169 (PubMed:9524201).Curated2
Sequence conflicti967G → R in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti990P → A in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti1029A → P in AAC09169 (PubMed:9524201).Curated1
Sequence conflicti1062 – 1063QG → R in AAC09169 (PubMed:9524201).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF026305 mRNA Translation: AAC09169.1
AB025922 mRNA Translation: BAA85004.1
AC114678 Genomic DNA No translation available.
CH466578 Genomic DNA Translation: EDL24501.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS24238.1

NCBI Reference Sequences

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RefSeqi
NP_034426.2, NM_010296.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.391450

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000026474; ENSMUSP00000026474; ENSMUSG00000025407

Database of genes from NCBI RefSeq genomes

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GeneIDi
14632

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:14632

UCSC genome browser

More...
UCSCi
uc007hjf.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026305 mRNA Translation: AAC09169.1
AB025922 mRNA Translation: BAA85004.1
AC114678 Genomic DNA No translation available.
CH466578 Genomic DNA Translation: EDL24501.1
CCDSiCCDS24238.1
RefSeqiNP_034426.2, NM_010296.2
UniGeneiMm.391450

3D structure databases

ProteinModelPortaliP47806
SMRiP47806
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199942, 4 interactors
ComplexPortaliCPX-147 GLI1-SUFU complex
CORUMiP47806
IntActiP47806, 1 interactor
STRINGi10090.ENSMUSP00000026474

Chemistry databases

ChEMBLiCHEMBL5007

PTM databases

iPTMnetiP47806
PhosphoSitePlusiP47806

Proteomic databases

PaxDbiP47806
PRIDEiP47806

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026474; ENSMUSP00000026474; ENSMUSG00000025407
GeneIDi14632
KEGGimmu:14632
UCSCiuc007hjf.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2735
MGIiMGI:95727 Gli1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000160235
HOGENOMiHOG000290688
HOVERGENiHBG080668
InParanoidiP47806
KOiK16797
OMAiFCHQANL
OrthoDBiEOG091G01XS
TreeFamiTF350216

Enzyme and pathway databases

ReactomeiR-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610787 Hedgehog 'off' state
R-MMU-5632684 Hedgehog 'on' state

Miscellaneous databases

Protein Ontology

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PROi
PR:P47806

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000025407 Expressed in 312 organ(s), highest expression level in spermatogonium
CleanExiMM_GLI1
ExpressionAtlasiP47806 baseline and differential
GenevisibleiP47806 MM

Family and domain databases

InterProiView protein in InterPro
IPR032850 GLI1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR19818:SF2 PTHR19818:SF2, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLI1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47806
Secondary accession number(s): G5E857, Q9QYK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: December 5, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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