Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RPE-retinal G protein-coupled receptor

Gene

RGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.

GO - Molecular functioni

  • G-protein coupled photoreceptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
  • phototransduction Source: UniProtKB-KW
  • protein-chromophore linkage Source: UniProtKB-KW
  • visual perception Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
RPE-retinal G protein-coupled receptor
Gene namesi
Name:RGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148604.13
HGNCiHGNC:9990 RGR
MIMi600342 gene
neXtProtiNX_P47804

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15ExtracellularSequence analysisAdd BLAST15
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini37 – 52CytoplasmicSequence analysisAdd BLAST16
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 91ExtracellularSequence analysisAdd BLAST18
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 130CytoplasmicSequence analysisAdd BLAST18
Transmembranei131 – 151Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini152 – 175ExtracellularSequence analysisAdd BLAST24
Transmembranei176 – 196Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini197 – 219CytoplasmicSequence analysisAdd BLAST23
Transmembranei220 – 240Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini241 – 247ExtracellularSequence analysis7
Transmembranei248 – 268Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini269 – 291CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Retinitis pigmentosa 44 (RP44)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
See also OMIM:613769
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01703466S → R in RP44. 1 Publication1

Keywords - Diseasei

Disease mutation, Retinitis pigmentosa

Organism-specific databases

DisGeNETi5995
GeneReviewsiRGR
MalaCardsiRGR
MIMi613769 phenotype
OpenTargetsiENSG00000148604
Orphaneti791 Retinitis pigmentosa
PharmGKBiPA34360

Polymorphism and mutation databases

BioMutaiRGR
DMDMi1350592

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978221 – 291RPE-retinal G protein-coupled receptorAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi88 ↔ 162PROSITE-ProRule annotation
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei255N6-(retinylidene)lysineBy similarity1

Post-translational modificationi

Covalently binds all-trans- and 11-cis-retinal.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47804
PeptideAtlasiP47804
PRIDEiP47804
ProteomicsDBi55796
55797 [P47804-2]
55798 [P47804-3]

PTM databases

iPTMnetiP47804
PhosphoSitePlusiP47804

Expressioni

Tissue specificityi

Preferentially expressed at high levels in the retinal pigment epithelium (RPE) and Mueller cells of the neural retina.

Gene expression databases

BgeeiENSG00000148604
CleanExiHS_RGR
ExpressionAtlasiP47804 baseline and differential
GenevisibleiP47804 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KIF1BPQ96EK52EBI-745818,EBI-744150

Protein-protein interaction databases

BioGridi111927, 1 interactor
IntActiP47804, 1 interactor
STRINGi9606.ENSP00000352427

Structurei

3D structure databases

ProteinModelPortaliP47804
SMRiP47804
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119394
HOGENOMiHOG000293329
HOVERGENiHBG017721
InParanoidiP47804
KOiK04254
OMAiWPYGSEG
OrthoDBiEOG091G0CL2
PhylomeDBiP47804
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027430 Retinal_BS
IPR001793 RPE_GPCR
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00667 RPERETINALR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P47804-1) [UniParc]FASTAAdd to basket
Also known as: Short

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAETSALPTG FGELEVLAVG MVLLVEALSG LSLNTLTIFS FCKTPELRTP
60 70 80 90 100
CHLLVLSLAL ADSGISLNAL VAATSSLLRR WPYGSDGCQA HGFQGFVTAL
110 120 130 140 150
ASICSSAAIA WGRYHHYCTR SQLAWNSAVS LVLFVWLSSA FWAALPLLGW
160 170 180 190 200
GHYDYEPLGT CCTLDYSKGD RNFTSFLFTM SFFNFAMPLF ITITSYSLME
210 220 230 240 250
QKLGKSGHLQ VNTTLPARTL LLGWGPYAIL YLYAVIADVT SISPKLQMVP
260 270 280 290
ALIAKMVPTI NAINYALGNE MVCRGIWQCL SPQKREKDRT K
Length:291
Mass (Da):31,874
Last modified:February 1, 1996 - v1
Checksum:i85AB087E09719E88
GO
Isoform 2 (identifier: P47804-2) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: L → LRVSH

Show »
Length:295
Mass (Da):32,354
Checksum:i4224150E95726B6D
GO
Isoform 3 (identifier: P47804-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-248: Missing.

Show »
Length:253
Mass (Da):27,728
Checksum:i4D610689536B5767
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01703466S → R in RP44. 1 Publication1
Natural variantiVAR_017055132V → L1 Publication1
Natural variantiVAR_017056152H → N1 PublicationCorresponds to variant dbSNP:rs150808273Ensembl.1
Natural variantiVAR_017058234A → T1 Publication1
Natural variantiVAR_017057241S → F1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00377378L → LRVSH in isoform 2. 2 Publications1
Alternative sequenceiVSP_038387211 – 248Missing in isoform 3. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15790
, U14911, U15785, U15786, U15787, U15788, U15789 Genomic DNA Translation: AAB92384.1
U14910 mRNA Translation: AAA56748.1
AC022389 Genomic DNA No translation available.
BG912392 mRNA No translation available.
BC011349 mRNA Translation: AAH11349.1
CCDSiCCDS41543.1 [P47804-3]
CCDS7374.1 [P47804-2]
PIRiA55980
B55980
RefSeqiNP_001012738.1, NM_001012720.1 [P47804-1]
NP_001012740.1, NM_001012722.1 [P47804-3]
NP_002912.2, NM_002921.3 [P47804-2]
UniGeneiHs.1544

Genome annotation databases

EnsembliENST00000358110; ENSP00000350823; ENSG00000148604 [P47804-3]
ENST00000359452; ENSP00000352427; ENSG00000148604 [P47804-2]
GeneIDi5995
KEGGihsa:5995
UCSCiuc001kdd.2 human [P47804-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRGR_HUMAN
AccessioniPrimary (citable) accession number: P47804
Secondary accession number(s): A6NKK7, Q96FC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health