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Protein

Metaxin-1

Gene

Mtx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transport of proteins into the mitochondrion. Essential for embryonic development.1 Publication

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Metaxin-1
Alternative name(s):
Mitochondrial outer membrane import complex protein 1
Gene namesi
Name:Mtx1
Synonyms:Mtx, Mtxn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103025 Mtx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209921 – 317Metaxin-1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki41Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP47802
MaxQBiP47802
PaxDbiP47802
PeptideAtlasiP47802
PRIDEiP47802

PTM databases

iPTMnetiP47802
PhosphoSitePlusiP47802
SwissPalmiP47802

Expressioni

Tissue specificityi

Ubiquitous. Higher levels are seen in the kidney as compared to other tissues.

Gene expression databases

CleanExiMM_MTX1

Interactioni

Subunit structurei

Interacts with MTX2/metaxin-2. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity).By similarity1 Publication

Protein-protein interaction databases

CORUMiP47802
IntActiP47802, 2 interactors
STRINGi10090.ENSMUSP00000073261

Structurei

3D structure databases

ProteinModelPortaliP47802
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metaxin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3028 Eukaryota
ENOG41100SS LUCA
HOGENOMiHOG000237279
HOVERGENiHBG001655
InParanoidiP47802
PhylomeDBiP47802

Family and domain databases

InterProiView protein in InterPro
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR017410 Metaxin
IPR033468 Metaxin_GST
IPR019564 Sam37/metaxin_N
PfamiView protein in Pfam
PF17171 GST_C_6, 1 hit
PF10568 Tom37, 1 hit
PIRSFiPIRSF038150 Metaxin, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P47802-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPMELFCW SGGWGLPSVD LDSLAVLTYT RFTGAPLKIH KTSNPWQSPS
60 70 80 90 100
GTLPALRTSD GKVITVPDKI ITHLRKEKYN ADYDLSARQG ADTLAFMSLL
110 120 130 140 150
EEKLLPVLIH TFWIDAKNYV EVTRKWYAEA MPFPLNFFLP GRMQRQYMER
160 170 180 190 200
LQLLCGEHKS ENEEELEKEL YQEARECLTL LSQRLGSQKF FFGDAPASLD
210 220 230 240 250
AFVFSHLALL LQAKLPSGKL QAHLRGLHNL CAYCTHILNL YFPRDGDEVP
260 270 280 290 300
LPRQTPAAPE TEEEPYRRRT QILSVLAGLA AMVGYALLSG IVSIQRTSPA
310
RAPGTRALGL AEEDEED
Length:317
Mass (Da):35,624
Last modified:February 1, 1996 - v1
Checksum:iF7528371DC986562
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7C846F7C846_MOUSE
Metaxin-1
Mtx1
461Annotation score:
D3YVW0D3YVW0_MOUSE
Metaxin-1
Mtx1
430Annotation score:
G3XA66G3XA66_MOUSE
Metaxin-1
Mtx1
298Annotation score:
D3Z3F4D3Z3F4_MOUSE
Metaxin-1
Mtx1
360Annotation score:
G3UYJ5G3UYJ5_MOUSE
Metaxin-1
Mtx1
162Annotation score:
G3XA75G3XA75_MOUSE
Metaxin-1
Mtx1
172Annotation score:
G3UXX9G3UXX9_MOUSE
Metaxin-1
Mtx1
185Annotation score:
G3UXB5G3UXB5_MOUSE
Metaxin-1
Mtx1
30Annotation score:
G3UXP6G3UXP6_MOUSE
Metaxin-1
Mtx1
68Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36962 mRNA Translation: AAC37672.1
U66257 Genomic DNA Translation: AAC52818.1
AF059277 Genomic DNA Translation: AAC63229.1
PIRiI59379
UniGeneiMm.280943

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36962 mRNA Translation: AAC37672.1
U66257 Genomic DNA Translation: AAC52818.1
AF059277 Genomic DNA Translation: AAC63229.1
PIRiI59379
UniGeneiMm.280943

3D structure databases

ProteinModelPortaliP47802
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP47802
IntActiP47802, 2 interactors
STRINGi10090.ENSMUSP00000073261

PTM databases

iPTMnetiP47802
PhosphoSitePlusiP47802
SwissPalmiP47802

Proteomic databases

EPDiP47802
MaxQBiP47802
PaxDbiP47802
PeptideAtlasiP47802
PRIDEiP47802

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103025 Mtx1

Phylogenomic databases

eggNOGiKOG3028 Eukaryota
ENOG41100SS LUCA
HOGENOMiHOG000237279
HOVERGENiHBG001655
InParanoidiP47802
PhylomeDBiP47802

Miscellaneous databases

PROiPR:P47802
SOURCEiSearch...

Gene expression databases

CleanExiMM_MTX1

Family and domain databases

InterProiView protein in InterPro
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR017410 Metaxin
IPR033468 Metaxin_GST
IPR019564 Sam37/metaxin_N
PfamiView protein in Pfam
PF17171 GST_C_6, 1 hit
PF10568 Tom37, 1 hit
PIRSFiPIRSF038150 Metaxin, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTX1_MOUSE
AccessioniPrimary (citable) accession number: P47802
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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