Emp1

Functionⁱ

GO - Biological processⁱ

bleb assembly Source: MGI
cell death Source: MGI

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Epithelial membrane protein 1 Short name: EMP-1 Alternative name(s): Tumor-associated membrane protein
Gene namesⁱ	Name:Emp1 Synonyms:Tmp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:107941 Emp1

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	1 – 21	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	67 – 87	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	95 – 115	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	137 – 157	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000164654	1 – 160	Epithelial membrane protein 1Add BLAST		160

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	35	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	43	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	128	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	P47801
PeptideAtlas More...PeptideAtlasⁱ	P47801
PRIDEⁱ	P47801

PTM databases

iPTMnetⁱ	P47801

iPTMnetⁱ

P47801

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030208 Expressed in 242 organ(s), highest expression level in conjunctival fornix
CleanExⁱ	MM_EMP1
ExpressionAtlasⁱ	P47801 baseline and differential
Genevisibleⁱ	P47801 MM

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	P47801, 1 interactor
STRINGⁱ	10090.ENSMUSP00000032330

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47801
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IW7W Eukaryota ENOG410Z5WT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046328
HOGENOMⁱ	HOG000059542
HOVERGENⁱ	HBG001690
InParanoidⁱ	P47801
OMAⁱ	WICFCFS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RF4
PhylomeDBⁱ	P47801
TreeFamⁱ	TF330414

Family and domain databases

InterProⁱ	View protein in InterPro IPR003932 EMP_1 IPR004031 PMP22/EMP/MP20/Claudin IPR004032 PMP22_EMP_MP20
PANTHERⁱ	PTHR10671:SF6 PTHR10671:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01453 EPMEMFAMILY PR01454 EPMEMPROT1
PROSITEⁱ	View protein in PROSITE PS01221 PMP22_1, 1 hit PS01222 PMP22_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P47801-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLVLLAGLFV VHIATAIMLF VSTIANVWMV ADYANASVGL WKNCTGGNCD 
        60         70         80         90        100
GSLSYGNEDA IKAVQAFMIL SIIFSIISLV VFVFQLFTME KGNRFFLSGS 
       110        120        130        140        150
TMLVCWLCIL VGVSIYTHHY AHSEGNFNSS SHQGYCFILT WICFCFSFII 
       160
GILYMVLRKK

Length:160

Mass (Da):17,813

Last modified:November 1, 1997 - v2

Checksum:ⁱ1B91687E547A2905

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	S4R2U4	S4R2U4_MOUSE		Epithelial membrane protein 1 Epithelial membrane protein 1	Emp1	41	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25633 mRNA Translation: AAC52968.1 X98403 mRNA Translation: CAA67053.1 X98471 Genomic DNA Translation: CAA67106.1 BC046299 mRNA Translation: AAH46299.1 BC050899 mRNA Translation: AAH50899.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20647.1
PIRⁱ	JC5730
NCBI Reference Sequences More...RefSeqⁱ	NP_001275556.1, NM_001288627.1 NP_001275557.1, NM_001288628.1 NP_034258.1, NM_010128.4 XP_006505565.1, XM_006505502.1
UniGeneⁱ	Mm.182785

Genome annotation databases

Ensemblⁱ	ENSMUST00000032330; ENSMUSP00000032330; ENSMUSG00000030208 ENSMUST00000111907; ENSMUSP00000107538; ENSMUSG00000030208 ENSMUST00000205156; ENSMUSP00000145069; ENSMUSG00000030208
GeneIDⁱ	13730
KEGGⁱ	mmu:13730
UCSC genome browser More...UCSCⁱ	uc009elo.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47801	Epithelial membrane protein 1		MOUSE		160	UniRef100_P47801
Epithelial membrane protein 1 (Fragment)		MOUSE		133
Epithelial membrane protein 1		MOUSE		132

Protein	Similar proteins		Species	Score	Length	Source
P47801	Epithelial membrane protein 1		RAT		160	UniRef90_P47801
Epithelial membrane protein 1		MOUSE		160
UPI000A3043C1		MUSPA		160
UPI000A319309		MUSCR		160
UPI000B4FCA56		MERUN		160
+3

Protein	Similar proteins		Species	Score	Length	Source
P47801	Epithelial membrane protein 1		HUMAN		157	UniRef50_P54849
Epithelial membrane protein 1		PONAB		157
Epithelial membrane protein 1		RAT		160
Epithelial membrane protein 1		RABIT		160
Epithelial membrane protein 1		PANTR		157
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U25633 mRNA Translation: AAC52968.1 X98403 mRNA Translation: CAA67053.1 X98471 Genomic DNA Translation: CAA67106.1 BC046299 mRNA Translation: AAH46299.1 BC050899 mRNA Translation: AAH50899.1
CCDSⁱ	CCDS20647.1
PIRⁱ	JC5730
RefSeqⁱ	NP_001275556.1, NM_001288627.1 NP_001275557.1, NM_001288628.1 NP_034258.1, NM_010128.4 XP_006505565.1, XM_006505502.1
UniGeneⁱ	Mm.182785

3D structure databases

ProteinModelPortalⁱ	P47801
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P47801, 1 interactor
STRINGⁱ	10090.ENSMUSP00000032330

PTM databases

iPTMnetⁱ	P47801

iPTMnetⁱ

P47801

Proteomic databases

PaxDbⁱ	P47801
PeptideAtlasⁱ	P47801
PRIDEⁱ	P47801

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032330; ENSMUSP00000032330; ENSMUSG00000030208 ENSMUST00000111907; ENSMUSP00000107538; ENSMUSG00000030208 ENSMUST00000205156; ENSMUSP00000145069; ENSMUSG00000030208
GeneIDⁱ	13730
KEGGⁱ	mmu:13730
UCSCⁱ	uc009elo.1 mouse

Organism-specific databases

CTDⁱ	2012
MGIⁱ	MGI:107941 Emp1

Phylogenomic databases

eggNOGⁱ	ENOG410IW7W Eukaryota ENOG410Z5WT LUCA
GeneTreeⁱ	ENSGT00510000046328
HOGENOMⁱ	HOG000059542
HOVERGENⁱ	HBG001690
InParanoidⁱ	P47801
OMAⁱ	WICFCFS
OrthoDBⁱ	EOG091G0RF4
PhylomeDBⁱ	P47801
TreeFamⁱ	TF330414

Miscellaneous databases

ChiTaRSⁱ	Emp1 mouse
Protein Ontology More...PROⁱ	PR:P47801
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030208 Expressed in 242 organ(s), highest expression level in conjunctival fornix
CleanExⁱ	MM_EMP1
ExpressionAtlasⁱ	P47801 baseline and differential
Genevisibleⁱ	P47801 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR003932 EMP_1 IPR004031 PMP22/EMP/MP20/Claudin IPR004032 PMP22_EMP_MP20
PANTHERⁱ	PTHR10671:SF6 PTHR10671:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01453 EPMEMFAMILY PR01454 EPMEMPROT1
PROSITEⁱ	View protein in PROSITE PS01221 PMP22_1, 1 hit PS01222 PMP22_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EMP1_MOUSE
Accessionⁱ	P47801Primary (citable) accession number: P47801
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	November 1, 1997
	Last modified:	September 12, 2018
	This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P47801 (EMP1_MOUSE)

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Epithelial membrane protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ