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Protein

Epithelial membrane protein 1

Gene

Emp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 1
Short name:
EMP-1
Alternative name(s):
Tumor-associated membrane protein
Gene namesi
Name:Emp1
Synonyms:Tmp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107941 Emp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646541 – 160Epithelial membrane protein 1Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP47801
PeptideAtlasiP47801
PRIDEiP47801

PTM databases

iPTMnetiP47801

Expressioni

Gene expression databases

BgeeiENSMUSG00000030208 Expressed in 242 organ(s), highest expression level in conjunctival fornix
CleanExiMM_EMP1
ExpressionAtlasiP47801 baseline and differential
GenevisibleiP47801 MM

Interactioni

Protein-protein interaction databases

IntActiP47801, 1 interactor
STRINGi10090.ENSMUSP00000032330

Structurei

3D structure databases

ProteinModelPortaliP47801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW7W Eukaryota
ENOG410Z5WT LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiP47801
OMAiWICFCFS
OrthoDBiEOG091G0RF4
PhylomeDBiP47801
TreeFamiTF330414

Family and domain databases

InterProiView protein in InterPro
IPR003932 EMP_1
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF6 PTHR10671:SF6, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01454 EPMEMPROT1
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P47801-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVLLAGLFV VHIATAIMLF VSTIANVWMV ADYANASVGL WKNCTGGNCD
60 70 80 90 100
GSLSYGNEDA IKAVQAFMIL SIIFSIISLV VFVFQLFTME KGNRFFLSGS
110 120 130 140 150
TMLVCWLCIL VGVSIYTHHY AHSEGNFNSS SHQGYCFILT WICFCFSFII
160
GILYMVLRKK
Length:160
Mass (Da):17,813
Last modified:November 1, 1997 - v2
Checksum:i1B91687E547A2905
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2U4S4R2U4_MOUSE
Epithelial membrane protein 1
Emp1
41Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25633 mRNA Translation: AAC52968.1
X98403 mRNA Translation: CAA67053.1
X98471 Genomic DNA Translation: CAA67106.1
BC046299 mRNA Translation: AAH46299.1
BC050899 mRNA Translation: AAH50899.1
CCDSiCCDS20647.1
PIRiJC5730
RefSeqiNP_001275556.1, NM_001288627.1
NP_001275557.1, NM_001288628.1
NP_034258.1, NM_010128.4
XP_006505565.1, XM_006505502.1
UniGeneiMm.182785

Genome annotation databases

EnsembliENSMUST00000032330; ENSMUSP00000032330; ENSMUSG00000030208
ENSMUST00000111907; ENSMUSP00000107538; ENSMUSG00000030208
ENSMUST00000205156; ENSMUSP00000145069; ENSMUSG00000030208
GeneIDi13730
KEGGimmu:13730
UCSCiuc009elo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25633 mRNA Translation: AAC52968.1
X98403 mRNA Translation: CAA67053.1
X98471 Genomic DNA Translation: CAA67106.1
BC046299 mRNA Translation: AAH46299.1
BC050899 mRNA Translation: AAH50899.1
CCDSiCCDS20647.1
PIRiJC5730
RefSeqiNP_001275556.1, NM_001288627.1
NP_001275557.1, NM_001288628.1
NP_034258.1, NM_010128.4
XP_006505565.1, XM_006505502.1
UniGeneiMm.182785

3D structure databases

ProteinModelPortaliP47801
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47801, 1 interactor
STRINGi10090.ENSMUSP00000032330

PTM databases

iPTMnetiP47801

Proteomic databases

PaxDbiP47801
PeptideAtlasiP47801
PRIDEiP47801

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032330; ENSMUSP00000032330; ENSMUSG00000030208
ENSMUST00000111907; ENSMUSP00000107538; ENSMUSG00000030208
ENSMUST00000205156; ENSMUSP00000145069; ENSMUSG00000030208
GeneIDi13730
KEGGimmu:13730
UCSCiuc009elo.1 mouse

Organism-specific databases

CTDi2012
MGIiMGI:107941 Emp1

Phylogenomic databases

eggNOGiENOG410IW7W Eukaryota
ENOG410Z5WT LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiP47801
OMAiWICFCFS
OrthoDBiEOG091G0RF4
PhylomeDBiP47801
TreeFamiTF330414

Miscellaneous databases

ChiTaRSiEmp1 mouse
PROiPR:P47801
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030208 Expressed in 242 organ(s), highest expression level in conjunctival fornix
CleanExiMM_EMP1
ExpressionAtlasiP47801 baseline and differential
GenevisibleiP47801 MM

Family and domain databases

InterProiView protein in InterPro
IPR003932 EMP_1
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF6 PTHR10671:SF6, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01454 EPMEMPROT1
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEMP1_MOUSE
AccessioniPrimary (citable) accession number: P47801
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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