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Protein

Protein Wnt-4a

Gene

wnt4a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Inhibits cell movements.

GO - Molecular functioni

GO - Biological processi

  • cell fate commitment Source: GO_Central
  • cell migration involved in gastrulation Source: ZFIN
  • embryonic viscerocranium morphogenesis Source: ZFIN
  • habenula development Source: ZFIN
  • heart development Source: ZFIN
  • multicellular organism development Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: ZFIN
  • regulation of axon extension involved in axon guidance Source: ZFIN
  • sensory epithelium regeneration Source: ZFIN
  • Wnt signaling pathway Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-4a
Gene namesi
Name:wnt4a
Synonyms:wnt-4, wnt4
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 11

Organism-specific databases

ZFINiZDB-GENE-980526-352 wnt4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004142423 – 352Protein Wnt-4aAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 89By similarity
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 136By similarity
Disulfide bondi138 ↔ 155By similarity
Disulfide bondi206 ↔ 220By similarity
Disulfide bondi208 ↔ 215By similarity
Lipidationi212O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi297 ↔ 312By similarity
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi327 ↔ 342By similarity
Disulfide bondi329 ↔ 339By similarity
Disulfide bondi334 ↔ 335By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiP47793

Expressioni

Tissue specificityi

Caudal forebrain and neural keel, the floor plate, the gill slit and the developing pronephros.

Developmental stagei

First detected at the end of gastrulation in the anterior neuroectoderm. Expression increases in the developing brain during somitogenesis but has gone by 36 hours. Expression in the floor plate begins at the 10 somite stage and persists at 72 hours.1 Publication

Gene expression databases

BgeeiENSDARG00000071208
ExpressionAtlasiP47793 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095904

Structurei

3D structure databases

ProteinModelPortaliP47793
SMRiP47793
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039528
HOVERGENiHBG001595
InParanoidiP47793
KOiK00408
OMAiNSQFKPH
OrthoDBiEOG091G0OFF
PhylomeDBiP47793
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009142 Wnt4
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01844 WNT4PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEYLIRSL LMLFLALFSA NASNWLYLAK LSSVGSISDE ETCEKLRGLI
60 70 80 90 100
QRQVQICKRN VEVMDAVRRG AQLAIDECQY QFRNRRWNCS TLESVPVFGK
110 120 130 140 150
VVTQGTREAA FVYAISAASV AFAVTRACSS GELDKCGCDR NVHGVSPEGF
160 170 180 190 200
QWSGCSDNIA YGVAFSQSFV DIRERSKGQS SNRALMNLHN NEAGRKAILN
210 220 230 240 250
HMRVECKCHG VSGSCEVKTC WKAMPPFRKV GNVIKEKFDG ATEVELRKVG
260 270 280 290 300
TTKVLVPRNS QFKPHTDEDL VYLDPSPDFC EHDPRTPGIM GTAGRFCNKT
310 320 330 340 350
SKAIDGCELM CCGRGFHTEE VEVVDRCSCK FHWCCYVKCK QCRKMVEMHT

CR
Length:352
Mass (Da):39,431
Last modified:February 1, 1996 - v1
Checksum:iD63CBF9F00886633
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti245 – 246EL → DV in AAA96518 (Ref. 2) Curated2
Sequence conflicti335C → S in AAA96518 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25141 mRNA Translation: AAA96004.1
U51267 mRNA Translation: AAA96518.1
RefSeqiNP_001035477.1, NM_001040387.1
UniGeneiDr.385

Genome annotation databases

EnsembliENSDART00000105133; ENSDARP00000095904; ENSDARG00000071208
GeneIDi30123
KEGGidre:30123

Similar proteinsi

Entry informationi

Entry nameiWNT4A_DANRE
AccessioniPrimary (citable) accession number: P47793
Secondary accession number(s): Q92049
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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