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Protein

G-protein coupled receptor 12

Gene

GPR12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.By similarity

Caution

Was originally (PubMed:12220620) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case in human (PubMed:19286662).2 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • phosphatidylcholine binding Source: Ensembl

GO - Biological processi

  • cellular calcium ion homeostasis Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 12
Gene namesi
Name:GPR12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000132975.7
HGNCiHGNC:4466 GPR12
MIMi600752 gene
neXtProtiNX_P47775

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 69Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini70 – 77CytoplasmicSequence analysis8
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 113ExtracellularSequence analysisAdd BLAST15
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 158CytoplasmicSequence analysisAdd BLAST24
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 199ExtracellularSequence analysisAdd BLAST20
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 252CytoplasmicSequence analysisAdd BLAST32
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 282ExtracellularSequence analysis9
Transmembranei283 – 303Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini304 – 334CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2835
OpenTargetsiENSG00000132975
PharmGKBiPA28856

Chemistry databases

ChEMBLiCHEMBL5006
GuidetoPHARMACOLOGYi86

Polymorphism and mutation databases

BioMutaiGPR12
DMDMi1346168

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695271 – 334G-protein coupled receptor 12Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi317S-palmitoyl cysteineBy similarity1
Modified residuei330PhosphoserineSequence analysis1
Modified residuei332PhosphoserineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP47775
PRIDEiP47775
ProteomicsDBi55795

PTM databases

iPTMnetiP47775
PhosphoSitePlusiP47775

Expressioni

Gene expression databases

BgeeiENSG00000132975
CleanExiHS_GPR12
ExpressionAtlasiP47775 baseline and differential
GenevisibleiP47775 HS

Organism-specific databases

HPAiHPA050972

Interactioni

Protein-protein interaction databases

BioGridi109096, 2 interactors
IntActiP47775, 1 interactor
STRINGi9606.ENSP00000370844

Structurei

3D structure databases

ProteinModelPortaliP47775
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000294075
HOVERGENiHBG079561
InParanoidiP47775
KOiK04315
OMAiVTGVNCL
OrthoDBiEOG091G0CNB
PhylomeDBiP47775
TreeFamiTF330052

Family and domain databases

CDDicd15961 7tmA_GPR12, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000599 GPR12
IPR000723 GPR_3/6/12_orphan
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00650 GPR12ORPHANR
PR00644 GPRORPHANR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEDLKVNLS GLPRDYLDAA AAENISAAVS SRVPAVEPEP ELVVNPWDIV
60 70 80 90 100
LCTSGTLISC ENAIVVLIIF HNPSLRAPMF LLIGSLALAD LLAGIGLITN
110 120 130 140 150
FVFAYLLQSE ATKLVTIGLI VASFSASVCS LLAITVDRYL SLYYALTYHS
160 170 180 190 200
ERTVTFTYVM LVMLWGTSIC LGLLPVMGWN CLRDESTCSV VRPLTKNNAA
210 220 230 240 250
ILSVSFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT SHYVTTRKGV
260 270 280 290 300
STLAIILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI
310 320 330
YAFRNQEIQK ALCLICCGCI PSSLAQRARS PSDV
Length:334
Mass (Da):36,730
Last modified:February 1, 1996 - v1
Checksum:i618334A6582D744B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18548 Genomic DNA Translation: AAA91630.1
AL159978 Genomic DNA No translation available.
BC067448 mRNA Translation: AAH67448.1
BC067452 mRNA Translation: AAH67452.1
BC112144 mRNA Translation: AAI12145.1
BC112146 mRNA Translation: AAI12147.1
CCDSiCCDS9319.1
RefSeqiNP_005279.1, NM_005288.3
UniGeneiHs.123034

Genome annotation databases

EnsembliENST00000381436; ENSP00000370844; ENSG00000132975
ENST00000405846; ENSP00000384932; ENSG00000132975
GeneIDi2835
KEGGihsa:2835
UCSCiuc010aal.5 human

Similar proteinsi

Entry informationi

Entry nameiGPR12_HUMAN
AccessioniPrimary (citable) accession number: P47775
Secondary accession number(s): Q5T8P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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