C-C chemokine receptor type 7

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• C-C chemokine binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• C-C chemokine receptor activity Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs."
    Forster R., Schubel A., Breitfeld D., Kremmer E., Renner-Muller I., Wolf E., Lipp M.
    Cell 99:23-33(1999) [PubMed] [Europe PMC] [Abstract]
• C-C motif chemokine 19 receptor activity Source: MGI
• C-C motif chemokine 21 receptor activity Source: MGI
• chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
• chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
• chemokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "The multiple personalities of the chemokine receptor CCR7 in dendritic cells."
    Sanchez-Sanchez N., Riol-Blanco L., Rodriguez-Fernandez J.L.
    J Immunol 176:5153-5159(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• actin cytoskeleton organization Source: BHF-UCLTraceable author statementⁱ
  • "The multiple personalities of the chemokine receptor CCR7 in dendritic cells."
    Sanchez-Sanchez N., Riol-Blanco L., Rodriguez-Fernandez J.L.
    J Immunol 176:5153-5159(2006) [PubMed] [Europe PMC] [Abstract]
• activation of JUN kinase activity Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells."
    Iijima N., Yanagawa Y., Clingan J.M., Onoe K.
    Int Immunol 17:1201-1212(2005) [PubMed] [Europe PMC] [Abstract]
• calcium-mediated signaling Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to cytokine stimulus Source: MGI
• chemotaxis Source: MGIInferred from mutant phenotypeⁱ
  • "CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs."
    Forster R., Schubel A., Breitfeld D., Kremmer E., Renner-Muller I., Wolf E., Lipp M.
    Cell 99:23-33(1999) [PubMed] [Europe PMC] [Abstract]
• establishment of T cell polarity Source: BHF-UCLTraceable author statementⁱ
  • "The multiple personalities of the chemokine receptor CCR7 in dendritic cells."
    Sanchez-Sanchez N., Riol-Blanco L., Rodriguez-Fernandez J.L.
    J Immunol 176:5153-5159(2006) [PubMed] [Europe PMC] [Abstract]
• homeostasis of number of cells Source: MGIInferred from mutant phenotypeⁱ
  • "Differential requirement for CCR4 in the maintenance but not establishment of the invariant Vgamma5(+) dendritic epidermal T-cell pool."
    Nakamura K., White A.J., Parnell S.M., Lane P.J., Jenkinson E.J., Jenkinson W.E., Anderson G.
    PLoS One 8:e74019-e74019(2013) [PubMed] [Europe PMC] [Abstract]
• immune response Source: MGIInferred from mutant phenotypeⁱ
  • "CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs."
    Forster R., Schubel A., Breitfeld D., Kremmer E., Renner-Muller I., Wolf E., Lipp M.
    Cell 99:23-33(1999) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: BHF-UCLTraceable author statementⁱ
  • "The multiple personalities of the chemokine receptor CCR7 in dendritic cells."
    Sanchez-Sanchez N., Riol-Blanco L., Rodriguez-Fernandez J.L.
    J Immunol 176:5153-5159(2006) [PubMed] [Europe PMC] [Abstract]
• lymph node development Source: BHF-UCLTraceable author statementⁱ
  • "Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development."
    Luther S.A., Ansel K.M., Cyster J.G.
    J Exp Med 197:1191-1198(2003) [PubMed] [Europe PMC] [Abstract]
• lymphocyte chemotaxis across high endothelial venule Source: BHF-UCLTraceable author statementⁱ
  • "CCR7 is involved in the migration of neutrophils to lymph nodes."
    Beauvillain C., Cunin P., Doni A., Scotet M., Jaillon S., Loiry M.L., Magistrelli G., Masternak K., Chevailler A., Delneste Y., Jeannin P.
    Blood 117:1196-1204(2011) [PubMed] [Europe PMC] [Abstract]
• lymphocyte migration into lymph node Source: BHF-UCLTraceable author statementⁱ
  • "CCR7 and its ligands: balancing immunity and tolerance."
    Forster R., Davalos-Misslitz A.C., Rot A.
    Nat Rev Immunol 8:362-371(2008) [PubMed] [Europe PMC] [Abstract]
• mature conventional dendritic cell differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• myeloid dendritic cell chemotaxis Source: MGI
• negative regulation of interleukin-12 production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection."
    Eppert B.L., Motz G.T., Wortham B.W., Flury J.L., Borchers M.T.
    Infect Immun 78:2099-2107(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of leukocyte apoptotic process Source: BHF-UCLTraceable author statementⁱ
  • "The multiple personalities of the chemokine receptor CCR7 in dendritic cells."
    Sanchez-Sanchez N., Riol-Blanco L., Rodriguez-Fernandez J.L.
    J Immunol 176:5153-5159(2006) [PubMed] [Europe PMC] [Abstract]
• negative thymic T cell selection Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice."
    Davalos-Misslitz A.C., Worbs T., Willenzon S., Bernhardt G., Forster R.
    Blood 110:4351-4359(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell motility Source: BHF-UCLTraceable author statementⁱ
  • "The multiple personalities of the chemokine receptor CCR7 in dendritic cells."
    Sanchez-Sanchez N., Riol-Blanco L., Rodriguez-Fernandez J.L.
    J Immunol 176:5153-5159(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of dendritic cell chemotaxis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs."
    Forster R., Schubel A., Breitfeld D., Kremmer E., Renner-Muller I., Wolf E., Lipp M.
    Cell 99:23-33(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of filopodium assembly Source: BHF-UCLTraceable author statementⁱ
  • "The multiple personalities of the chemokine receptor CCR7 in dendritic cells."
    Sanchez-Sanchez N., Riol-Blanco L., Rodriguez-Fernandez J.L.
    J Immunol 176:5153-5159(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of GTPase activity Source: BHF-UCLInferred by curatorⁱ
  • "CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities."
    Yanagawa Y., Onoe K.
    Blood 101:4923-4929(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of humoral immune response Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs."
    Forster R., Schubel A., Breitfeld D., Kremmer E., Renner-Muller I., Wolf E., Lipp M.
    Cell 99:23-33(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of hypersensitivity Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs."
    Forster R., Schubel A., Breitfeld D., Kremmer E., Renner-Muller I., Wolf E., Lipp M.
    Cell 99:23-33(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of immunological synapse formation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-12 production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-1 beta production Source: BHF-UCLInferred by curatorⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of macrophage chemotaxis Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Myelin ingestion by macrophages promotes their motility and capacity to recruit myeloid cells."
    van Zwam M., Wierenga-Wolf A.F., Melief M.J., Schrijver B., Laman J.D., Boven L.A.
    J Neuroimmunol 225:112-117(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil chemotaxis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCR7 is involved in the migration of neutrophils to lymph nodes."
    Beauvillain C., Cunin P., Doni A., Scotet M., Jaillon S., Loiry M.L., Magistrelli G., Masternak K., Chevailler A., Delneste Y., Jeannin P.
    Blood 117:1196-1204(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phagocytosis Source: BHF-UCLNon-traceable author statementⁱ
  • "CCR7 ligand-enhanced phagocytosis of various antigens in mature dendritic cells-time course and antigen distribution different from phagocytosis in immature dendritic cells."
    Kikuchi K., Yanagawa Y., Onoe K.
    Microbiol Immunol 49:535-544(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of receptor-mediated endocytosis Source: BHF-UCLInferred by curatorⁱ
  • "CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities."
    Yanagawa Y., Onoe K.
    Blood 101:4923-4929(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell chemotaxis Source: BHF-UCLTraceable author statementⁱ
  • "CCR7 is involved in the migration of neutrophils to lymph nodes."
    Beauvillain C., Cunin P., Doni A., Scotet M., Jaillon S., Loiry M.L., Magistrelli G., Masternak K., Chevailler A., Delneste Y., Jeannin P.
    Blood 117:1196-1204(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell costimulation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell proliferation Source: BHF-UCLInferred by curatorⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell receptor signaling pathway Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice."
    Davalos-Misslitz A.C., Worbs T., Willenzon S., Bernhardt G., Forster R.
    Blood 110:4351-4359(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T-helper 1 cell differentiation Source: BHF-UCLInferred by curatorⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of thymocyte migration Source: BHF-UCLTraceable author statementⁱ
  • "Induction of CCR7 expression in thymocytes requires both ERK signal and Ca(2+) signal."
    Adachi S., Kuwata T., Miyaike M., Iwata M.
    Biochem Biophys Res Commun 288:1188-1193(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tumor necrosis factor production Source: BHF-UCLInferred by curatorⁱ
  • "CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells."
    Marsland B.J., Battig P., Bauer M., Ruedl C., Lassing U., Beerli R.R., Dietmeier K., Ivanova L., Pfister T., Vogt L., Nakano H., Nembrini C., Saudan P., Kopf M., Bachmann M.F.
    Immunity 22:493-505(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of dendritic cell dendrite assembly Source: BHF-UCLInferred by curatorⁱ
  • "CCL19 induces rapid dendritic extension of murine dendritic cells."
    Yanagawa Y., Onoe K.
    Blood 100:1948-1956(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of interferon-gamma production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection."
    Eppert B.L., Motz G.T., Wortham B.W., Flury J.L., Borchers M.T.
    Infect Immun 78:2099-2107(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of interleukin-1 beta production Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection."
    Eppert B.L., Motz G.T., Wortham B.W., Flury J.L., Borchers M.T.
    Infect Immun 78:2099-2107(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of tolerance induction to self antigen Source: BHF-UCLTraceable author statementⁱ
  • "Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice."
    Davalos-Misslitz A.C., Worbs T., Willenzon S., Bernhardt G., Forster R.
    Blood 110:4351-4359(2007) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: BHF-UCLInferred from direct assayⁱ
  • "CCR7 is expressed in astrocytes and upregulated after an inflammatory injury."
    Gomez-Nicola D., Pallas-Bazarra N., Valle-Argos B., Nieto-Sampedro M.
    J Neuroimmunol 227:87-92(2010) [PubMed] [Europe PMC] [Abstract]
• response to nitric oxide Source: BHF-UCLTraceable author statementⁱ
  • "The multiple personalities of the chemokine receptor CCR7 in dendritic cells."
    Sanchez-Sanchez N., Riol-Blanco L., Rodriguez-Fernandez J.L.
    J Immunol 176:5153-5159(2006) [PubMed] [Europe PMC] [Abstract]
• response to prostaglandin E Source: BHF-UCLTraceable author statementⁱ
  • "The multiple personalities of the chemokine receptor CCR7 in dendritic cells."
    Sanchez-Sanchez N., Riol-Blanco L., Rodriguez-Fernandez J.L.
    J Immunol 176:5153-5159(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• C-C chemokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
• chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
• chemokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MDPGKPRKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK 
        60         70         80         90        100
KDVRNFKAWF LPLMYSVICF VGLLGNGLVI LTYIYFKRLK TMTDTYLLNL 
       110        120        130        140        150
AVADILFLLI LPFWAYSEAK SWIFGVYLCK GIFGIYKLSF FSGMLLLLCI 
       160        170        180        190        200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWMLALFLS IPELLYSGLQ 
       210        220        230        240        250
KNSGEDTLRC SLVSAQVEAL ITIQVAQMVF GFLVPMLAMS FCYLIIIRTL 
       260        270        280        290        300
LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITNSSCET 
       310        320        330        340        350
SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE 
       360        370 
RLRHWSSCRH VRNASVSMEA ETTTTFSP                         

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families
3. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries