UniProtKB - P47774 (CCR7_MOUSE)
Protein
C-C chemokine receptor type 7
Gene
Ccr7
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for the MIP-3-beta chemokine.By similarity
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- C-C chemokine receptor activity Source: BHF-UCL
- C-C motif chemokine 19 receptor activity Source: MGI
- C-C motif chemokine 21 receptor activity Source: MGI
- chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
- chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
- chemokine binding Source: GO_Central
- G protein-coupled receptor activity Source: BHF-UCL
GO - Biological processi
- actin cytoskeleton organization Source: BHF-UCL
- activation of JUN kinase activity Source: BHF-UCL
- calcium-mediated signaling Source: GO_Central
- cell chemotaxis Source: GO_Central
- cellular response to cytokine stimulus Source: MGI
- chemotaxis Source: MGI
- establishment of T cell polarity Source: BHF-UCL
- homeostasis of number of cells Source: MGI
- immune response Source: MGI
- inflammatory response Source: BHF-UCL
- lymph node development Source: BHF-UCL
- lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
- lymphocyte migration into lymph node Source: BHF-UCL
- mature conventional dendritic cell differentiation Source: BHF-UCL
- myeloid dendritic cell chemotaxis Source: MGI
- negative regulation of interleukin-12 production Source: BHF-UCL
- negative regulation of leukocyte apoptotic process Source: BHF-UCL
- negative thymic T cell selection Source: BHF-UCL
- positive regulation of cell motility Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
- positive regulation of dendritic cell chemotaxis Source: BHF-UCL
- positive regulation of filopodium assembly Source: BHF-UCL
- positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCL
- positive regulation of GTPase activity Source: BHF-UCL
- positive regulation of humoral immune response Source: BHF-UCL
- positive regulation of hypersensitivity Source: BHF-UCL
- positive regulation of immunological synapse formation Source: BHF-UCL
- positive regulation of interleukin-12 production Source: BHF-UCL
- positive regulation of interleukin-1 beta production Source: BHF-UCL
- positive regulation of macrophage chemotaxis Source: BHF-UCL
- positive regulation of neutrophil chemotaxis Source: BHF-UCL
- positive regulation of phagocytosis Source: BHF-UCL
- positive regulation of receptor-mediated endocytosis Source: BHF-UCL
- positive regulation of T cell chemotaxis Source: BHF-UCL
- positive regulation of T cell costimulation Source: BHF-UCL
- positive regulation of T cell proliferation Source: BHF-UCL
- positive regulation of T cell receptor signaling pathway Source: BHF-UCL
- positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
- positive regulation of thymocyte migration Source: BHF-UCL
- positive regulation of tumor necrosis factor production Source: BHF-UCL
- regulation of dendritic cell dendrite assembly Source: BHF-UCL
- regulation of interferon-gamma production Source: BHF-UCL
- regulation of interleukin-1 beta production Source: BHF-UCL
- regulation of tolerance induction to self antigen Source: BHF-UCL
- response to lipopolysaccharide Source: BHF-UCL
- response to nitric oxide Source: BHF-UCL
- response to prostaglandin E Source: BHF-UCL
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-C chemokine receptor type 7Short name: C-C CKR-7 Short name: CC-CKR-7 Short name: CCR-7 Alternative name(s): Epstein-Barr virus-induced G-protein coupled receptor 1 Short name: EBI1 Short name: EBV-induced G-protein coupled receptor 1 MIP-3 beta receptor CD_antigen: CD197 |
Gene namesi | Name:Ccr7 Synonyms:Cmkbr7, Ebi1, Ebi1h |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103011, Ccr7 |
Subcellular locationi
Plasma membrane
Mitochondrion
- mitochondrion Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- plasma membrane Source: BHF-UCL
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 59 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 60 – 86 | Helical; Name=1Sequence analysisAdd BLAST | 27 | |
Topological domaini | 87 – 95 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 96 – 116 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 117 – 130 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 131 – 152 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 153 – 170 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 171 – 191 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 192 – 219 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 220 – 247 | Helical; Name=5Sequence analysisAdd BLAST | 28 | |
Topological domaini | 248 – 263 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 264 – 289 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 290 – 313 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 314 – 331 | Helical; Name=7Sequence analysisAdd BLAST | 18 | |
Topological domaini | 332 – 378 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000012736 | 25 – 378 | C-C chemokine receptor type 7Add BLAST | 354 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 129 ↔ 210 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P47774 |
PaxDbi | P47774 |
PRIDEi | P47774 |
PTM databases
GlyGeni | P47774, 1 site |
PhosphoSitePlusi | P47774 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037944, Expressed in lymph node and 94 other tissues |
Genevisiblei | P47774, MM |
Interactioni
Binary interactionsi
P47774
With | #Exp. | IntAct |
---|---|---|
CD247 [P20963] from Homo sapiens. | 2 | EBI-8038963,EBI-1165705 |
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
- chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
- chemokine binding Source: GO_Central
Protein-protein interaction databases
IntActi | P47774, 1 interactor |
MINTi | P47774 |
STRINGi | 10090.ENSMUSP00000099423 |
Miscellaneous databases
RNActi | P47774, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUZ9, Eukaryota |
GeneTreei | ENSGT00950000182749 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P47774 |
OMAi | TLACFRC |
OrthoDBi | 715251at2759 |
TreeFami | TF330966 |
Family and domain databases
InterProi | View protein in InterPro IPR001718, Chemokine_CCR7 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR00641, CHEMOKINER7 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P47774-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPGKPRKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK
60 70 80 90 100
KDVRNFKAWF LPLMYSVICF VGLLGNGLVI LTYIYFKRLK TMTDTYLLNL
110 120 130 140 150
AVADILFLLI LPFWAYSEAK SWIFGVYLCK GIFGIYKLSF FSGMLLLLCI
160 170 180 190 200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWMLALFLS IPELLYSGLQ
210 220 230 240 250
KNSGEDTLRC SLVSAQVEAL ITIQVAQMVF GFLVPMLAMS FCYLIIIRTL
260 270 280 290 300
LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITNSSCET
310 320 330 340 350
SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE
360 370
RLRHWSSCRH VRNASVSMEA ETTTTFSP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 164 | A → R in AAA74232 (PubMed:7851893).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31580 mRNA Translation: AAA74232.1 AK037965 mRNA Translation: BAC29909.1 AK154349 mRNA Translation: BAE32532.1 AK154849 mRNA Translation: BAE32875.1 AL591366 Genomic DNA No translation available. CH466556 Genomic DNA Translation: EDL16180.1 |
CCDSi | CCDS25373.1 |
PIRi | A55735 |
RefSeqi | NP_001288642.1, NM_001301713.1 NP_031745.2, NM_007719.2 |
Genome annotation databases
Ensembli | ENSMUST00000103134; ENSMUSP00000099423; ENSMUSG00000037944 |
GeneIDi | 12775 |
KEGGi | mmu:12775 |
UCSCi | uc007lih.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31580 mRNA Translation: AAA74232.1 AK037965 mRNA Translation: BAC29909.1 AK154349 mRNA Translation: BAE32532.1 AK154849 mRNA Translation: BAE32875.1 AL591366 Genomic DNA No translation available. CH466556 Genomic DNA Translation: EDL16180.1 |
CCDSi | CCDS25373.1 |
PIRi | A55735 |
RefSeqi | NP_001288642.1, NM_001301713.1 NP_031745.2, NM_007719.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P47774, 1 interactor |
MINTi | P47774 |
STRINGi | 10090.ENSMUSP00000099423 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P47774, 1 site |
PhosphoSitePlusi | P47774 |
Proteomic databases
EPDi | P47774 |
PaxDbi | P47774 |
PRIDEi | P47774 |
Protocols and materials databases
Antibodypediai | 3533, 1041 antibodies |
DNASUi | 12775 |
Genome annotation databases
Ensembli | ENSMUST00000103134; ENSMUSP00000099423; ENSMUSG00000037944 |
GeneIDi | 12775 |
KEGGi | mmu:12775 |
UCSCi | uc007lih.1, mouse |
Organism-specific databases
CTDi | 1236 |
MGIi | MGI:103011, Ccr7 |
Phylogenomic databases
eggNOGi | ENOG502QUZ9, Eukaryota |
GeneTreei | ENSGT00950000182749 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P47774 |
OMAi | TLACFRC |
OrthoDBi | 715251at2759 |
TreeFami | TF330966 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 12775, 1 hit in 17 CRISPR screens |
PROi | PR:P47774 |
RNActi | P47774, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037944, Expressed in lymph node and 94 other tissues |
Genevisiblei | P47774, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001718, Chemokine_CCR7 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR00641, CHEMOKINER7 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCR7_MOUSE | |
Accessioni | P47774Primary (citable) accession number: P47774 Secondary accession number(s): Q8CAS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries