UniProtKB - P47771 (ALDH2_YEAST)
Protein
Aldehyde dehydrogenase [NAD(P)+] 1
Gene
ALD2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Required for pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis.1 Publication
Miscellaneous
Present with 2070 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:1.2.1.3
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 169 | Transition state stabilizerBy similarity | 1 | |
Active sitei | 268 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 302 | NucleophilePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- aldehyde dehydrogenase (NAD+) activity Source: SGD
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Source: UniProtKB-EC
GO - Biological processi
- beta-alanine biosynthetic process Source: SGD
- pantothenate biosynthetic process Source: UniProtKB-KW
- polyamine catabolic process Source: SGD
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Pantothenate biosynthesis |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | MetaCyc:YMR170C-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ALD2 Synonyms:ALD5 Ordered Locus Names:YMR170C ORF Names:YM8520.19C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YMR170C |
SGDi | S000004780, ALD2 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056439 | 1 – 506 | Aldehyde dehydrogenase [NAD(P)+] 1Add BLAST | 506 |
Proteomic databases
MaxQBi | P47771 |
PaxDbi | P47771 |
PRIDEi | P47771 |
Expressioni
Inductioni
Expression is under the control of MSN2 and MSN4, and is induced during diauxic shift and osmotic stress.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 35348, 50 interactors |
IntActi | P47771, 3 interactors |
MINTi | P47771 |
STRINGi | 4932.YMR170C |
Miscellaneous databases
RNActi | P47771, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG2450, Eukaryota |
GeneTreei | ENSGT00940000176434 |
HOGENOMi | CLU_005391_0_1_1 |
InParanoidi | P47771 |
OMAi | APNGKKW |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
i Sequence
Sequence statusi: Complete.
P47771-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT
60 70 80 90 100
SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT
110 120 130 140 150
LAALETLDAG KPYHSNAKGD LAQILQLTRY FAGSADKFDK GATIPLTFNK
160 170 180 190 200
FAYTLKVPFG VVAQIVPWNY PLAMACWKLQ GALAAGNTVI IKPAENTSLS
210 220 230 240 250
LLYFATLIKK AGFPPGVVNI VPGYGSLVGQ ALASHMDIDK ISFTGSTKVG
260 270 280 290 300
GFVLEASGQS NLKDVTLECG GKSPALVFED ADLDKAIDWI AAGIFYNSGQ
310 320 330 340 350
NCTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS
360 370 380 390 400
STQYDRIKSY IERGKREEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPQTS
410 420 430 440 450
KLLQDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA
460 470 480 490 500
RDIKAGTVWI NSSNDEDVTV PFGGFKMSGI GRELGQSGVD TYLQTKAVHI
NLSLDN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | L → C in CAA59975 (PubMed:8801420).Curated | 1 | |
Sequence conflicti | 462 | S → Q in CAA59975 (PubMed:8801420).Curated | 1 | |
Sequence conflicti | 486 – 488 | QSG → DNV in CAA59975 (PubMed:8801420).Curated | 3 | |
Sequence conflicti | 497 | A → S in CAA59975 (PubMed:8801420).Curated | 1 | |
Sequence conflicti | 500 – 501 | IN → MD in CAA59975 (PubMed:8801420).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X85987 Genomic DNA Translation: CAA59975.1 Z49705 Genomic DNA Translation: CAA89806.1 BK006946 Genomic DNA Translation: DAA10066.1 |
PIRi | S70189, S54615 |
RefSeqi | NP_013893.1, NM_001182674.1 |
Genome annotation databases
EnsemblFungii | YMR170C_mRNA; YMR170C; YMR170C |
GeneIDi | 855206 |
KEGGi | sce:YMR170C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X85987 Genomic DNA Translation: CAA59975.1 Z49705 Genomic DNA Translation: CAA89806.1 BK006946 Genomic DNA Translation: DAA10066.1 |
PIRi | S70189, S54615 |
RefSeqi | NP_013893.1, NM_001182674.1 |
3D structure databases
SMRi | P47771 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35348, 50 interactors |
IntActi | P47771, 3 interactors |
MINTi | P47771 |
STRINGi | 4932.YMR170C |
Proteomic databases
MaxQBi | P47771 |
PaxDbi | P47771 |
PRIDEi | P47771 |
Genome annotation databases
EnsemblFungii | YMR170C_mRNA; YMR170C; YMR170C |
GeneIDi | 855206 |
KEGGi | sce:YMR170C |
Organism-specific databases
EuPathDBi | FungiDB:YMR170C |
SGDi | S000004780, ALD2 |
Phylogenomic databases
eggNOGi | KOG2450, Eukaryota |
GeneTreei | ENSGT00940000176434 |
HOGENOMi | CLU_005391_0_1_1 |
InParanoidi | P47771 |
OMAi | APNGKKW |
Enzyme and pathway databases
BioCyci | MetaCyc:YMR170C-MONOMER |
Miscellaneous databases
PROi | PR:P47771 |
RNActi | P47771, protein |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALDH2_YEAST | |
Accessioni | P47771Primary (citable) accession number: P47771 Secondary accession number(s): D6VZZ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD