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Protein

Signal recognition particle receptor subunit beta

Gene

Srprb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118GTP; via amide nitrogen1 Publication1
Binding sitei246GTP; via amide nitrogen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 77GTP1 Publication9
Nucleotide bindingi90 – 93GTP1 Publication4
Nucleotide bindingi178 – 181GTP1 Publication4

GO - Molecular functioni

Keywordsi

Molecular functionReceptor
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit beta
Short name:
SR-beta
Gene namesi
Name:Srprb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:102964 Srprb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012281 – 269Signal recognition particle receptor subunit betaAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineBy similarity1
Modified residuei212PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP47758
MaxQBiP47758
PaxDbiP47758
PeptideAtlasiP47758
PRIDEiP47758
TopDownProteomicsiP47758

PTM databases

iPTMnetiP47758
PhosphoSitePlusiP47758
SwissPalmiP47758

Expressioni

Gene expression databases

BgeeiENSMUSG00000032553 Expressed in 258 organ(s), highest expression level in fibroblast
CleanExiMM_SRPRB
ExpressionAtlasiP47758 baseline and differential
GenevisibleiP47758 MM

Interactioni

Subunit structurei

Heterodimer with SRPRA.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203504, 1 interactor
IntActiP47758, 1 interactor
MINTiP47758
STRINGi10090.ENSMUSP00000035157

Structurei

Secondary structure

1269
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP47758
SMRiP47758
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47758

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP receptor beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0090 Eukaryota
COG2229 LUCA
GeneTreeiENSGT00510000048347
HOGENOMiHOG000241847
HOVERGENiHBG054206
InParanoidiP47758
KOiK12272
OrthoDBiEOG091G0242
PhylomeDBiP47758
TreeFamiTF106190

Family and domain databases

CDDicd04105 SR_beta, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR019009 SRP_receptor_beta_su
PANTHERiPTHR11485:SF34 PTHR11485:SF34, 1 hit
PfamiView protein in Pfam
PF09439 SRPRB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P47758-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASANTRRVG DGAGGAFQPY LDSLRQELQQ RDPTLLSVAV ALLAVLLTLV
60 70 80 90 100
FWKFIWSRKS SQRAVLFVGL CDSGKTLLFV RLLTGQYRDT QTSITDSSAI
110 120 130 140 150
YKVNNNRGNS LTLIDLPGHE SLRFQLLDRF KSSARAVVFV VDSAAFQREV
160 170 180 190 200
KDVAEFLYQV LIDSMALKNS PSLLIACNKQ DIAMAKSAKL IQQQLEKELN
210 220 230 240 250
TLRVTRSAAP STLDSSSTAP AQLGKKGKEF EFSQLPLKVE FLECSAKGGR
260
GDTGSADIQD LEKWLAKIA
Length:269
Mass (Da):29,579
Last modified:February 1, 1996 - v1
Checksum:i041175FA6891DA37
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P830A0A1W2P830_MOUSE
Signal recognition particle recepto...
Srprb
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16A → P in BAB25638 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17343 mRNA Translation: AAA69976.1
AK004854 mRNA Translation: BAB23618.1
AK007859 mRNA Translation: BAB25311.1
AK008383 mRNA Translation: BAB25638.1
AK015469 mRNA Translation: BAB29860.1
AK030437 mRNA Translation: BAC26963.1
AK167039 mRNA Translation: BAE39207.1
BC003798 mRNA Translation: AAH03798.1
CCDSiCCDS23450.1
PIRiA56487
RefSeqiNP_033301.1, NM_009275.4
UniGeneiMm.273053

Genome annotation databases

EnsembliENSMUST00000035157; ENSMUSP00000035157; ENSMUSG00000032553
GeneIDi20818
KEGGimmu:20818
UCSCiuc009rgg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17343 mRNA Translation: AAA69976.1
AK004854 mRNA Translation: BAB23618.1
AK007859 mRNA Translation: BAB25311.1
AK008383 mRNA Translation: BAB25638.1
AK015469 mRNA Translation: BAB29860.1
AK030437 mRNA Translation: BAC26963.1
AK167039 mRNA Translation: BAE39207.1
BC003798 mRNA Translation: AAH03798.1
CCDSiCCDS23450.1
PIRiA56487
RefSeqiNP_033301.1, NM_009275.4
UniGeneiMm.273053

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FH5X-ray2.45B58-269[»]
2GO5electron microscopy7.40258-269[»]
ProteinModelPortaliP47758
SMRiP47758
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203504, 1 interactor
IntActiP47758, 1 interactor
MINTiP47758
STRINGi10090.ENSMUSP00000035157

PTM databases

iPTMnetiP47758
PhosphoSitePlusiP47758
SwissPalmiP47758

Proteomic databases

EPDiP47758
MaxQBiP47758
PaxDbiP47758
PeptideAtlasiP47758
PRIDEiP47758
TopDownProteomicsiP47758

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035157; ENSMUSP00000035157; ENSMUSG00000032553
GeneIDi20818
KEGGimmu:20818
UCSCiuc009rgg.1 mouse

Organism-specific databases

CTDi58477
MGIiMGI:102964 Srprb

Phylogenomic databases

eggNOGiKOG0090 Eukaryota
COG2229 LUCA
GeneTreeiENSGT00510000048347
HOGENOMiHOG000241847
HOVERGENiHBG054206
InParanoidiP47758
KOiK12272
OrthoDBiEOG091G0242
PhylomeDBiP47758
TreeFamiTF106190

Miscellaneous databases

ChiTaRSiSrprb mouse
EvolutionaryTraceiP47758
PROiPR:P47758
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032553 Expressed in 258 organ(s), highest expression level in fibroblast
CleanExiMM_SRPRB
ExpressionAtlasiP47758 baseline and differential
GenevisibleiP47758 MM

Family and domain databases

CDDicd04105 SR_beta, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR019009 SRP_receptor_beta_su
PANTHERiPTHR11485:SF34 PTHR11485:SF34, 1 hit
PfamiView protein in Pfam
PF09439 SRPRB, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRPRB_MOUSE
AccessioniPrimary (citable) accession number: P47758
Secondary accession number(s): Q544X9, Q9D872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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