UniProtKB - P47756 (CAPZB_HUMAN)
F-actin-capping protein subunit beta
CAPZB
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: GO_Central
- cadherin binding Source: BHF-UCL
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- barbed-end actin filament capping Source: GO_Central
- blood coagulation Source: Reactome
- cell morphogenesis Source: GO_Central
- cytoskeleton organization Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- negative regulation of filopodium assembly Source: GO_Central
- regulation of cell morphogenesis Source: UniProtKB
- regulation of lamellipodium assembly Source: GO_Central
Keywordsi
Molecular function | Actin capping, Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | P47756 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: F-actin-capping protein subunit betaAlternative name(s): CapZ beta |
Gene namesi | Name:CAPZB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000077549.17 |
HGNCi | HGNC:1491, CAPZB |
MIMi | 601572, gene |
neXtProti | NX_P47756 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- sarcomere By similarity
Cytoskeleton
- actin cytoskeleton Source: ProtInc
- cytoskeleton Source: UniProtKB
- F-actin capping protein complex Source: GO_Central
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- sarcomere Source: UniProtKB-SubCell
- WASH complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 832 |
OpenTargetsi | ENSG00000077549 |
PharmGKBi | PA26072 |
Miscellaneous databases
Pharosi | P47756, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295764 |
Polymorphism and mutation databases
BioMutai | CAPZB |
DMDMi | 13124696 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000204634 | 2 – 277 | F-actin-capping protein subunit betaAdd BLAST | 276 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 235 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 263 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P47756 |
jPOSTi | P47756 |
MassIVEi | P47756 |
PaxDbi | P47756 |
PeptideAtlasi | P47756 |
PRIDEi | P47756 |
ProteomicsDBi | 55793 [P47756-1] 55794 [P47756-2] |
TopDownProteomicsi | P47756-2 [P47756-2] |
2D gel databases
DOSAC-COBS-2DPAGEi | P47756 |
OGPi | P47756 |
REPRODUCTION-2DPAGEi | IPI00026185 |
SWISS-2DPAGEi | P47756 |
PTM databases
CarbonylDBi | P47756 |
iPTMneti | P47756 |
MetOSitei | P47756 |
PhosphoSitePlusi | P47756 |
SwissPalmi | P47756 |
Expressioni
Gene expression databases
Bgeei | ENSG00000077549, Expressed in smooth muscle tissue and 249 other tissues |
ExpressionAtlasi | P47756, baseline and differential |
Genevisiblei | P47756, HS |
Organism-specific databases
HPAi | ENSG00000077549, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit.
Interacts with ARHGAP17 (PubMed:16678097). Interaction with RCSD1/CAPZIP (PubMed:15850461).
Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5 (PubMed:19922875).
Interacts with ACTG1 (PubMed:28493397). Directly interacts with CRACD; this interaction decreases binding to actin (PubMed:30361697).
5 PublicationsGO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: GO_Central
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107282, 237 interactors |
CORUMi | P47756 |
IntActi | P47756, 100 interactors |
MINTi | P47756 |
STRINGi | 9606.ENSP00000401010 |
Miscellaneous databases
RNActi | P47756, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3174, Eukaryota |
GeneTreei | ENSGT00390000017957 |
HOGENOMi | CLU_045864_2_0_1 |
InParanoidi | P47756 |
OMAi | GRQAHYK |
OrthoDBi | 1076134at2759 |
PhylomeDBi | P47756 |
TreeFami | TF105732 |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 2.40.160.80, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDQQLDCAL DLMRRLPPQQ IEKNLSDLID LVPSLCEDLL SSVDQPLKIA
60 70 80 90 100
RDKVVGKDYL LCDYNRDGDS YRSPWSNKYD PPLEDGAMPS ARLRKLEVEA
110 120 130 140 150
NNAFDQYRDL YFEGGVSSVY LWDLDHGFAG VILIKKAGDG SKKIKGCWDS
160 170 180 190 200
IHVVEVQEKS SGRTAHYKLT STVMLWLQTN KSGSGTMNLG GSLTRQMEKD
210 220 230 240 250
ETVSDCSPHI ANIGRLVEDM ENKIRSTLNE IYFGKTKDIV NGLRSIDAIP
260 270
DNQKFKQLQR ELSQVLTQRQ IYIQPDN
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AK88 | B1AK88_HUMAN | F-actin-capping protein subunit bet... | CAPZB hCG_41078 | 301 | Annotation score: | ||
B1AK87 | B1AK87_HUMAN | F-actin-capping protein subunit bet... | CAPZB | 244 | Annotation score: | ||
B1AK85 | B1AK85_HUMAN | F-actin-capping protein subunit bet... | CAPZB | 260 | Annotation score: | ||
A0A6I8PRV6 | A0A6I8PRV6_HUMAN | F-actin-capping protein subunit bet... | CAPZB | 59 | Annotation score: | ||
A0A6I8PIN8 | A0A6I8PIN8_HUMAN | CapZ beta | CAPZB | 63 | Annotation score: | ||
A0A6I8PIH4 | A0A6I8PIH4_HUMAN | F-actin-capping protein subunit bet... | CAPZB | 47 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000767 | 246 – 277 | IDAIP…IQPDN → VQTFADKSKQEALKNDLVEA LKRKQQC in isoform 2. 3 PublicationsAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03271 mRNA Translation: AAA87395.1 BT019470 mRNA Translation: AAV38277.1 BT019471 mRNA Translation: AAV38278.1 AL035413 Genomic DNA No translation available. AL359199 Genomic DNA No translation available. AL445163 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94890.1 BC024601 mRNA Translation: AAH24601.1 BC107752 mRNA Translation: AAI07753.1 BC109241 mRNA Translation: AAI09242.1 BC109242 mRNA Translation: AAI09243.1 |
CCDSi | CCDS41277.1 [P47756-2] CCDS55579.1 [P47756-1] |
RefSeqi | NP_001193469.1, NM_001206540.2 [P47756-1] NP_001269091.1, NM_001282162.1 NP_004921.1, NM_004930.4 [P47756-2] |
Genome annotation databases
Ensembli | ENST00000264202; ENSP00000264202; ENSG00000077549 [P47756-2] ENST00000375142; ENSP00000364284; ENSG00000077549 [P47756-1] ENST00000674432; ENSP00000501528; ENSG00000077549 [P47756-1] |
GeneIDi | 832 |
KEGGi | hsa:832 |
UCSCi | uc001bce.5, human [P47756-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03271 mRNA Translation: AAA87395.1 BT019470 mRNA Translation: AAV38277.1 BT019471 mRNA Translation: AAV38278.1 AL035413 Genomic DNA No translation available. AL359199 Genomic DNA No translation available. AL445163 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94890.1 BC024601 mRNA Translation: AAH24601.1 BC107752 mRNA Translation: AAI07753.1 BC109241 mRNA Translation: AAI09242.1 BC109242 mRNA Translation: AAI09243.1 |
CCDSi | CCDS41277.1 [P47756-2] CCDS55579.1 [P47756-1] |
RefSeqi | NP_001193469.1, NM_001206540.2 [P47756-1] NP_001269091.1, NM_001282162.1 NP_004921.1, NM_004930.4 [P47756-2] |
3D structure databases
SMRi | P47756 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107282, 237 interactors |
CORUMi | P47756 |
IntActi | P47756, 100 interactors |
MINTi | P47756 |
STRINGi | 9606.ENSP00000401010 |
Chemistry databases
ChEMBLi | CHEMBL4295764 |
PTM databases
CarbonylDBi | P47756 |
iPTMneti | P47756 |
MetOSitei | P47756 |
PhosphoSitePlusi | P47756 |
SwissPalmi | P47756 |
Polymorphism and mutation databases
BioMutai | CAPZB |
DMDMi | 13124696 |
2D gel databases
DOSAC-COBS-2DPAGEi | P47756 |
OGPi | P47756 |
REPRODUCTION-2DPAGEi | IPI00026185 |
SWISS-2DPAGEi | P47756 |
Proteomic databases
EPDi | P47756 |
jPOSTi | P47756 |
MassIVEi | P47756 |
PaxDbi | P47756 |
PeptideAtlasi | P47756 |
PRIDEi | P47756 |
ProteomicsDBi | 55793 [P47756-1] 55794 [P47756-2] |
TopDownProteomicsi | P47756-2 [P47756-2] |
Protocols and materials databases
Antibodypediai | 7956, 280 antibodies |
DNASUi | 832 |
Genome annotation databases
Ensembli | ENST00000264202; ENSP00000264202; ENSG00000077549 [P47756-2] ENST00000375142; ENSP00000364284; ENSG00000077549 [P47756-1] ENST00000674432; ENSP00000501528; ENSG00000077549 [P47756-1] |
GeneIDi | 832 |
KEGGi | hsa:832 |
UCSCi | uc001bce.5, human [P47756-1] |
Organism-specific databases
CTDi | 832 |
DisGeNETi | 832 |
EuPathDBi | HostDB:ENSG00000077549.17 |
GeneCardsi | CAPZB |
HGNCi | HGNC:1491, CAPZB |
HPAi | ENSG00000077549, Low tissue specificity |
MIMi | 601572, gene |
neXtProti | NX_P47756 |
OpenTargetsi | ENSG00000077549 |
PharmGKBi | PA26072 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3174, Eukaryota |
GeneTreei | ENSGT00390000017957 |
HOGENOMi | CLU_045864_2_0_1 |
InParanoidi | P47756 |
OMAi | GRQAHYK |
OrthoDBi | 1076134at2759 |
PhylomeDBi | P47756 |
TreeFami | TF105732 |
Enzyme and pathway databases
PathwayCommonsi | P47756 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
BioGRID-ORCSi | 832, 693 hits in 857 CRISPR screens |
ChiTaRSi | CAPZB, human |
GeneWikii | CAPZB |
GenomeRNAii | 832 |
Pharosi | P47756, Tbio |
PROi | PR:P47756 |
RNActi | P47756, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000077549, Expressed in smooth muscle tissue and 249 other tissues |
ExpressionAtlasi | P47756, baseline and differential |
Genevisiblei | P47756, HS |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 2.40.160.80, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAPZB_HUMAN | |
Accessioni | P47756Primary (citable) accession number: P47756 Secondary accession number(s): Q32Q68 Q9NUC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 203 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM