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Protein

Tumor necrosis factor receptor superfamily member 4

Gene

Tnfrsf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).By similarity

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 4
Alternative name(s):
OX40 antigen
OX40L receptor
CD_antigen: CD134
Gene namesi
Name:Tnfrsf4
Synonyms:Ox40, Txgp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104512 Tnfrsf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 211ExtracellularSequence analysisAdd BLAST192
Transmembranei212 – 236HelicalSequence analysisAdd BLAST25
Topological domaini237 – 272CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003455520 – 272Tumor necrosis factor receptor superfamily member 4Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 38PROSITE-ProRule annotation
Disulfide bondi39 ↔ 52PROSITE-ProRule annotation
Disulfide bondi42 ↔ 60PROSITE-ProRule annotation
Disulfide bondi63 ↔ 77PROSITE-ProRule annotation
Disulfide bondi80 ↔ 95PROSITE-ProRule annotation
Disulfide bondi83 ↔ 103PROSITE-ProRule annotation
Disulfide bondi105 ↔ 123PROSITE-ProRule annotation
Disulfide bondi126 ↔ 139PROSITE-ProRule annotation
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 164PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP47741
PaxDbiP47741
PRIDEiP47741

Interactioni

Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5.By similarity

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-6239N
IntActiP47741, 13 interactors
STRINGi10090.ENSMUSP00000030952

Structurei

3D structure databases

ProteinModelPortaliP47741
SMRiP47741
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 61TNFR-Cys 1Add BLAST36
Repeati62 – 103TNFR-Cys 2Add BLAST42
Repeati104 – 124TNFR-Cys 3; truncatedAdd BLAST21
Repeati125 – 165TNFR-Cys 4Add BLAST41

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0US Eukaryota
ENOG4111DUJ LUCA
HOGENOMiHOG000049154
HOVERGENiHBG005031
InParanoidiP47741
KOiK05142
PhylomeDBiP47741

Family and domain databases

CDDicd13406 TNFRSF4, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020445 TNFR_4
IPR034022 TNFRSF4_N
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01921 TNFACTORR4
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P47741-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYVWVQQPTA LLLLALTLGV TARRLNCVKH TYPSGHKCCR ECQPGHGMVS
60 70 80 90 100
RCDHTRDTLC HPCETGFYNE AVNYDTCKQC TQCNHRSGSE LKQNCTPTQD
110 120 130 140 150
TVCRCRPGTQ PRQDSGYKLG VDCVPCPPGH FSPGNNQACK PWTNCTLSGK
160 170 180 190 200
QTRHPASDSL DAVCEDRSLL ATLLWETQRP TFRPTTVQST TVWPRTSELP
210 220 230 240 250
SPPTLVTPEG PAFAVLLGLG LGLLAPLTVL LALYLLRKAW RLPNTPKPCW
260 270
GNSFRTPIQE EHTDAHFTLA KI
Length:272
Mass (Da):30,154
Last modified:February 1, 1996 - v1
Checksum:i06E7BB4156F0D08E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ASL3B1ASL3_MOUSE
Tumor necrosis factor receptor supe...
Tnfrsf4 mCG_23346
272Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15A → G in CAA59476 (PubMed:7737295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21674 mRNA Translation: CAA79772.1
X85214 Genomic DNA Translation: CAA59476.1
CCDSiCCDS19055.1
PIRiI48700
RefSeqiNP_035789.1, NM_011659.2
UniGeneiMm.13885

Genome annotation databases

GeneIDi22163
KEGGimmu:22163

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21674 mRNA Translation: CAA79772.1
X85214 Genomic DNA Translation: CAA59476.1
CCDSiCCDS19055.1
PIRiI48700
RefSeqiNP_035789.1, NM_011659.2
UniGeneiMm.13885

3D structure databases

ProteinModelPortaliP47741
SMRiP47741
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6239N
IntActiP47741, 13 interactors
STRINGi10090.ENSMUSP00000030952

Proteomic databases

EPDiP47741
PaxDbiP47741
PRIDEiP47741

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22163
KEGGimmu:22163

Organism-specific databases

CTDi7293
MGIiMGI:104512 Tnfrsf4

Phylogenomic databases

eggNOGiENOG410J0US Eukaryota
ENOG4111DUJ LUCA
HOGENOMiHOG000049154
HOVERGENiHBG005031
InParanoidiP47741
KOiK05142
PhylomeDBiP47741

Miscellaneous databases

PROiPR:P47741
SOURCEiSearch...

Family and domain databases

CDDicd13406 TNFRSF4, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020445 TNFR_4
IPR034022 TNFRSF4_N
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01921 TNFACTORR4
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNR4_MOUSE
AccessioniPrimary (citable) accession number: P47741
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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