Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aldehyde dehydrogenase, dimeric NADP-preferring

Gene

Aldh3a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:25286108). Preferentially oxidizes aromatic aldehyde substrates (PubMed:11784860). Comprises about 50 percent of corneal epithelial soluble proteins (PubMed:11784860). May play a role in preventing corneal damage caused by ultraviolet light (PubMed:10376761).By similarityCurated3 Publications

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210By similarity1
Active sitei244By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193NAD or NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

BRENDAi1.2.1.5 3474
ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Chemistry databases

SwissLipidsiSLP:000001745

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, dimeric NADP-preferring (EC:1.2.1.51 Publication)
Alternative name(s):
Aldehyde dehydrogenase 4
Aldehyde dehydrogenase family 3 member A1
Dioxin-inducible aldehyde dehydrogenase 3
Gene namesi
Name:Aldh3a1
Synonyms:Ahd-4, Ahd4, Aldh3, Aldh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1353451 Aldh3a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000564712 – 453Aldehyde dehydrogenase, dimeric NADP-preferringAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei178N6-acetyllysineBy similarity1
Modified residuei194N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP47739
PaxDbiP47739
PeptideAtlasiP47739
PRIDEiP47739

PTM databases

PhosphoSitePlusiP47739

Expressioni

Tissue specificityi

Constitutively expressed in cornea, stomach, skin, bladder and lungs. Lowest expression levels in lungs and bladder.1 Publication

Gene expression databases

BgeeiENSMUSG00000019102 Expressed in 93 organ(s), highest expression level in substantia propria of cornea
CleanExiMM_ALDH3A1
ExpressionAtlasiP47739 baseline and differential
GenevisibleiP47739 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi198065, 1 interactor
IntActiP47739, 1 interactor
MINTiP47739
STRINGi10090.ENSMUSP00000019246

Structurei

3D structure databases

ProteinModelPortaliP47739
SMRiP47739
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00390000002825
HOVERGENiHBG050483
InParanoidiP47739
KOiK00129
OMAiKPEYMAR
OrthoDBiEOG091G05HC
TreeFamiTF314264

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P47739-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNISSIVNR ARDAFNSGKT RPLQFRVEQL EALQRMINEN LKGISKALAS
60 70 80 90 100
NLRKNEWTSY YEEVAHVLDE IDFTIKGLSD WAEDEPVAKT RQTQEDDLYI
110 120 130 140 150
HSEPLGVVLV IGAWNYPFNL TIQPMVGAIA AGNAVVLKPS EVSDHMADLL
160 170 180 190 200
STLIPQYMDK DLYPVIKGGV PETTELLKEK FDHIMYTGST AVGKIVMAAA
210 220 230 240 250
AKHLTPVTLE LGGKSPCYVD KDCDLDVACR RIAWGKFMNS GQTCVAPDYI
260 270 280 290 300
LCDPSIQNEI VEKLKKSLKD FYGEDAKQSH DYGRIINDRH FQRVINLIDS
310 320 330 340 350
KKVAHGGTWD QPSRYIAPTI LVDVDPQSPV MQEEIFGPVM PIVCVRSLDE
360 370 380 390 400
AIKFINQREK PLALYVFSNN DKVIKKMIAE TSSGGVTAND VIVHITVPTL
410 420 430 440 450
PFGGVGNSGM GAYHGKKSFE TFSHRRSCLV RSLRNEEANK ARYPPSPAKM

PRH
Length:453
Mass (Da):50,481
Last modified:October 3, 2012 - v2
Checksum:i7B4EA1CC56B5FAA1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ATI6B1ATI6_MOUSE
Aldehyde dehydrogenase, dimeric NAD...
Aldh3a1
34Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88A → G in AAA20670 (PubMed:8148869).Curated1
Sequence conflicti88A → R in AAD15964 (PubMed:10376761).Curated1

Polymorphismi

There are two alleles, Ald3a1a and Ald3a1c. Ald3a1c codes for a low activity enzyme and is associated with extensive corneal clouding after exposure to ultraviolet light. Ald3a1a encodes the high activity enzyme.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti154I → N in allele Ald3a1c. 1 Publication1
Natural varianti305H → R in allele Ald3a1c. 1 Publication1
Natural varianti352I → V in allele Ald3a1c. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12785 mRNA Translation: AAA20670.1
AF072815 mRNA Translation: AAD15964.1
AL646093 Genomic DNA No translation available.
CCDSiCCDS24808.1
RefSeqiNP_001106196.1, NM_001112725.1
NP_031462.2, NM_007436.2
XP_006532089.1, XM_006532026.1
XP_006532090.1, XM_006532027.3
UniGeneiMm.4257

Genome annotation databases

EnsembliENSMUST00000019246; ENSMUSP00000019246; ENSMUSG00000019102
ENSMUST00000108716; ENSMUSP00000104356; ENSMUSG00000019102
GeneIDi11670
KEGGimmu:11670
UCSCiuc007jhd.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12785 mRNA Translation: AAA20670.1
AF072815 mRNA Translation: AAD15964.1
AL646093 Genomic DNA No translation available.
CCDSiCCDS24808.1
RefSeqiNP_001106196.1, NM_001112725.1
NP_031462.2, NM_007436.2
XP_006532089.1, XM_006532026.1
XP_006532090.1, XM_006532027.3
UniGeneiMm.4257

3D structure databases

ProteinModelPortaliP47739
SMRiP47739
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198065, 1 interactor
IntActiP47739, 1 interactor
MINTiP47739
STRINGi10090.ENSMUSP00000019246

Chemistry databases

SwissLipidsiSLP:000001745

PTM databases

PhosphoSitePlusiP47739

Proteomic databases

MaxQBiP47739
PaxDbiP47739
PeptideAtlasiP47739
PRIDEiP47739

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019246; ENSMUSP00000019246; ENSMUSG00000019102
ENSMUST00000108716; ENSMUSP00000104356; ENSMUSG00000019102
GeneIDi11670
KEGGimmu:11670
UCSCiuc007jhd.2 mouse

Organism-specific databases

CTDi218
MGIiMGI:1353451 Aldh3a1

Phylogenomic databases

eggNOGiKOG2456 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00390000002825
HOVERGENiHBG050483
InParanoidiP47739
KOiK00129
OMAiKPEYMAR
OrthoDBiEOG091G05HC
TreeFamiTF314264

Enzyme and pathway databases

BRENDAi1.2.1.5 3474
ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Miscellaneous databases

ChiTaRSiAldh3a2 mouse
PROiPR:P47739
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019102 Expressed in 93 organ(s), highest expression level in substantia propria of cornea
CleanExiMM_ALDH3A1
ExpressionAtlasiP47739 baseline and differential
GenevisibleiP47739 MM

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAL3A1_MOUSE
AccessioniPrimary (citable) accession number: P47739
Secondary accession number(s): B1ATI7, Q9R203
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again