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Protein

Aldehyde dehydrogenase, mitochondrial

Gene

Aldh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Is capable of converting retinaldehyde to retinoic acid.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, mitochondrial (Aldh2), Aldehyde dehydrogenase family 3 member B2 (Aldh3b2), Aldehyde dehydrogenase X, mitochondrial (Aldh1b1), Aldehyde dehydrogenase family 3 member B1 (Aldh3b1), Aldehyde dehydrogenase, cytosolic 1 (Aldh1a7)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei188Transition state stabilizerBy similarity1
Active sitei287Proton acceptorPROSITE-ProRule annotation1
Active sitei321NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi264 – 269NADBy similarity6

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: MGI
  • identical protein binding Source: MGI
  • NAD binding Source: CAFA
  • NADH binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDAi1.2.1.3 3474
ReactomeiR-MMU-380612 Metabolism of serotonin
R-MMU-71384 Ethanol oxidation
UniPathwayiUPA00780; UER00768

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
Alternative name(s):
AHD-M1
ALDH class 2
ALDH-E2
ALDHI
Gene namesi
Name:Aldh2
Synonyms:Ahd-1, Ahd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:99600 Aldh2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionBy similarityAdd BLAST19
ChainiPRO_000000716920 – 519Aldehyde dehydrogenase, mitochondrialAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54N6-acetyllysineCombined sources1
Modified residuei75N6-acetyllysineCombined sources1
Modified residuei80N6-acetyllysineCombined sources1
Modified residuei161N6-acetyllysineCombined sources1
Modified residuei370N6-acetyllysineCombined sources1
Modified residuei377N6-acetyllysineCombined sources1
Modified residuei385N6-acetyllysineCombined sources1
Modified residuei409N6-acetyllysineCombined sources1
Modified residuei428N6-acetyllysineCombined sources1
Modified residuei430N6-acetyllysineCombined sources1
Modified residuei443N6-acetyllysineCombined sources1
Modified residuei453N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP47738
PaxDbiP47738
PeptideAtlasiP47738
PRIDEiP47738

2D gel databases

REPRODUCTION-2DPAGEiP47738
SWISS-2DPAGEiP47738
UCD-2DPAGEiP47738

PTM databases

iPTMnetiP47738
PhosphoSitePlusiP47738
SwissPalmiP47738

Expressioni

Inductioni

By retinoic acid; 3-5 fold increase.

Gene expression databases

BgeeiENSMUSG00000029455
CleanExiMM_ALDH2
ExpressionAtlasiP47738 baseline and differential
GenevisibleiP47738 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Sirt3Q8R1042EBI-2308120,EBI-6999888

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198064, 1 interactor
IntActiP47738, 12 interactors
MINTiP47738
STRINGi10090.ENSMUSP00000031411

Structurei

3D structure databases

ProteinModelPortaliP47738
SMRiP47738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00760000118999
HOGENOMiHOG000271505
HOVERGENiHBG000097
InParanoidiP47738
KOiK00128
OMAiTFVQEDV
OrthoDBiEOG091G05E8
PhylomeDBiP47738
TreeFamiTF300455

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRAALTTVR RGPRLSRLLS AAATSAVPAP NHQPEVFCNQ IFINNEWHDA
60 70 80 90 100
VSRKTFPTVN PSTGEVICQV AEGNKEDVDK AVKAARAAFQ LGSPWRRMDA
110 120 130 140 150
SDRGRLLYRL ADLIERDRTY LAALETLDNG KPYVISYLVD LDMVLKCLRY
160 170 180 190 200
YAGWADKYHG KTIPIDGDFF SYTRHEPVGV CGQIIPWNFP LLMQAWKLGP
210 220 230 240 250
ALATGNVVVM KVAEQTPLTA LYVANLIKEA GFPPGVVNIV PGFGPTAGAA
260 270 280 290 300
IASHEGVDKV AFTGSTEVGH LIQVAAGSSN LKRVTLELGG KSPNIIMSDA
310 320 330 340 350
DMDWAVEQAH FALFFNQGQC CCAGSRTFVQ ENVYDEFVER SVARAKSRVV
360 370 380 390 400
GNPFDSRTEQ GPQVDETQFK KILGYIKSGQ QEGAKLLCGG GAAADRGYFI
410 420 430 440 450
QPTVFGDVKD GMTIAKEEIF GPVMQILKFK TIEEVVGRAN DSKYGLAAAV
460 470 480 490 500
FTKDLDKANY LSQALQAGTV WINCYDVFGA QSPFGGYKMS GSGRELGEYG
510
LQAYTEVKTV TVKVPQKNS
Length:519
Mass (Da):56,538
Last modified:February 1, 1996 - v1
Checksum:i200806F63D48F4DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88 – 89AF → C in AAC60691 (PubMed:8058062).Curated2
Sequence conflicti181Missing in AAC60691 (PubMed:8058062).Curated1
Sequence conflicti227I → S in AAC60691 (PubMed:8058062).Curated1
Sequence conflicti344R → G in AAC60691 (PubMed:8058062).Curated1
Sequence conflicti370K → N in AAC60691 (PubMed:8058062).Curated1
Sequence conflicti378S → M in AAC60691 (PubMed:8058062).Curated1
Sequence conflicti476D → V in AAC60691 (PubMed:8058062).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07235 mRNA Translation: AAA64636.1
S71509 mRNA Translation: AAC60691.1
BC005476 mRNA Translation: AAH05476.1
Z32545 Genomic DNA No translation available.
CCDSiCCDS19638.1
PIRiI48966
RefSeqiNP_033786.1, NM_009656.4
UniGeneiMm.284446

Genome annotation databases

EnsembliENSMUST00000031411; ENSMUSP00000031411; ENSMUSG00000029455
GeneIDi11669
KEGGimmu:11669
UCSCiuc008zjt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiALDH2_MOUSE
AccessioniPrimary (citable) accession number: P47738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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