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Entry version 130 (29 Sep 2021)
Sequence version 2 (20 Jun 2001)
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Protein

DNA polymerase III PolC-type

Gene

polC

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MPUL272635:G1GT6-689-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase III PolC-typeUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
PolIIIUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:MYPU_6750
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycoplasma pulmonis (strain UAB CTIP)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri272635 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasmopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000528 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002045841 – 1435DNA polymerase III PolC-typeAdd BLAST1435

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
272635.MYPU_6750

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P47729

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini404 – 562ExonucleaseAdd BLAST159

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-C family. PolC subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2176, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003297_2_0_14

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYAAYFT

Database of Orthologous Groups

More...
OrthoDBi
561611at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.700, 2 hits
3.30.420.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00356, DNApol_PolC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR029460, DNAPol_HHH
IPR006054, DnaQ
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR006308, PolC_gram_pos
IPR044923, PolC_middle_finger_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07733, DNA_pol3_alpha, 2 hits
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
PF00929, RNase_T, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00479, EXOIII, 1 hit
SM00481, POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098, SSF53098, 1 hit
SSF89550, SSF89550, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00573, dnaq, 1 hit
TIGR01405, polC_Gram_pos, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47729-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQESFLNFCQ EINFDIPEYL KNTKIANPYH DEEKSFFSCE IDFLETPKFE
60 70 80 90 100
DFKSFYLKTK NFLNQLVKEQ KLLFKIENIF YEKSEIKKYL DWIAEHFFKN
110 120 130 140 150
FDFKNTFRID DLKVNLDGKI FLTAHSKHSF DLYKDFVEFA NKKMQSFGFE
160 170 180 190 200
NFLLKLELNQ IEITNNQPLV SSINSQVKTQ ASSENQSFKK SNFYNKKRHI
210 220 230 240 250
QLSLKELIKT QEMFVSVVGM VFKKEIITTN SKTKIFKISI TDFQEATRAQ
260 270 280 290 300
KFSYLEKDQE IFDSIQINDW VNVCGEIQLE KMSLKQFIKI EKIEKIRSPI
310 320 330 340 350
KDRQDNEKEK RIELSFRSKM STMDGILSPL DIVKQAKKFN HSSIAILDHN
360 370 380 390 400
SVQAFPDFHN LTYKDKDFKV IYGMTLSVIS KRNKIFVEPL KDKFFDYKIL
410 420 430 440 450
DQEYVVYDIE TTGLSPMLNE LIQFGASVIK NGRIIETHHF FIKPKSKLDS
460 470 480 490 500
FTTKLTGITQ EHLEKGYELQ EALEKISSIF KARIMVAHNA AFDHNFLKQK
510 520 530 540 550
FIDNNIEFEE MISIDTLNLA KVLNPIYRSY RLGEVASKLS VVYDPSIAHR
560 570 580 590 600
ADYDSSVLTN IFILQMSHLK EKGINLFKEL NSLSSEKFYS KMFAKDISII
610 620 630 640 650
AKNQAGLKEL FKINSDVLTK YYFANPKMFW EDIKRSKNLL IGSGGLNSPL
660 670 680 690 700
IDKLLFSTQE DVLNEIDKYD YIEIPSPNNF SHFWTTKFSD QQIKIQLQKL
710 720 730 740 750
IKWAKEKNKI IVAIGEPRYN EKWQKIIHEI YINSTGIENS LHPLFIIKKD
760 770 780 790 800
MDTFYPEQIY KTTNEMKQEF SFLYDPELIE EIVVKNPNLI SSQIEKIQVI
810 820 830 840 850
KDKLYTPKFD DSHIKLKKLV YENAWKKYGK NLPEIIEQRI EKELTPILNY
860 870 880 890 900
GFDVIYWISS ILVQKSLSDG YLVGSRGSIG SSLVATLSGI TEVNPLAPHY
910 920 930 940 950
ICSKCQYFEL VKDPMTNSGF DLDDKKCPKC NSFLDKDGQT IPFETFLGFK
960 970 980 990 1000
ADKVPDIDLN FSGEYQGKIH DEVKRLFGSK HTFRAGTIST VAEKTAYGYI
1010 1020 1030 1040 1050
KKYLETASLD YSDNFVDFLT EKSTGVKRTT GQHPGGIIII PKEFDVEDFT
1060 1070 1080 1090 1100
PVNFPANDTE SSWKTTHFDF HAIHDNVLKL DILGHDDPTA LKMLEKLTGV
1110 1120 1130 1140 1150
NVKDIPKKDE KIISIFTSPK ALGISSEEIL GEKTGALGIP EFGTNFVRQM
1160 1170 1180 1190 1200
LSEAKPKTFA DLVSISGLSH GTDVWINNAH YIIQSLGKTL DQVISCRDDI
1210 1220 1230 1240 1250
MVDLIKKGVP IDLSFTIMEQ VRKGKGLSLE QKRKLIEHGI ENWYIESMEK
1260 1270 1280 1290 1300
IKYMFPKAHA TAYVLMAWRV AFYKVYYPLE YYATYFSTRT EFFDIEIMSK
1310 1320 1330 1340 1350
DKLTLESKIK ELAYRENLRN DNQLTTKEKN TLPTLYIANE MKARGFNIQN
1360 1370 1380 1390 1400
INLKISLAND WIIDKNSKSL IPPFNVIDGL GETLAQKIVD SRNEKEFLSV
1410 1420 1430
EDFINRTGIN STLVEKFKSM GIFEQIPETN QIFLI
Length:1,435
Mass (Da):166,375
Last modified:June 20, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E6527A88725503F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti786 – 787NP → S in AAA18178 (PubMed:7815943).Curated2
Sequence conflicti1233R → KE in AAA18178 (PubMed:7815943).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U06833 Genomic DNA Translation: AAA18178.1
AL445565 Genomic DNA Translation: CAC13848.1
L25415 Genomic DNA Translation: AAA65635.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C90596
S54697

NCBI Reference Sequences

More...
RefSeqi
WP_010925476.1, NC_002771.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAC13848; CAC13848; CAC13848

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mpu:MYPU_6750

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06833 Genomic DNA Translation: AAA18178.1
AL445565 Genomic DNA Translation: CAC13848.1
L25415 Genomic DNA Translation: AAA65635.1
PIRiC90596
S54697
RefSeqiWP_010925476.1, NC_002771.1

3D structure databases

SMRiP47729
ModBaseiSearch...

Protein-protein interaction databases

STRINGi272635.MYPU_6750

Genome annotation databases

EnsemblBacteriaiCAC13848; CAC13848; CAC13848
KEGGimpu:MYPU_6750

Phylogenomic databases

eggNOGiCOG2176, Bacteria
HOGENOMiCLU_003297_2_0_14
OMAiYYAAYFT
OrthoDBi561611at2

Enzyme and pathway databases

BioCyciMPUL272635:G1GT6-689-MONOMER

Family and domain databases

Gene3Di1.10.150.700, 2 hits
3.30.420.10, 1 hit
HAMAPiMF_00356, DNApol_PolC, 1 hit
InterProiView protein in InterPro
IPR011708, DNA_pol3_alpha_NTPase_dom
IPR040982, DNA_pol3_finger
IPR029460, DNAPol_HHH
IPR006054, DnaQ
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR004013, PHP_dom
IPR003141, Pol/His_phosphatase_N
IPR016195, Pol/histidinol_Pase-like
IPR006308, PolC_gram_pos
IPR044923, PolC_middle_finger_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PfamiView protein in Pfam
PF07733, DNA_pol3_alpha, 2 hits
PF17657, DNA_pol3_finger, 1 hit
PF14579, HHH_6, 1 hit
PF02811, PHP, 1 hit
PF00929, RNase_T, 1 hit
SMARTiView protein in SMART
SM00479, EXOIII, 1 hit
SM00481, POLIIIAc, 1 hit
SUPFAMiSSF53098, SSF53098, 1 hit
SSF89550, SSF89550, 1 hit
TIGRFAMsiTIGR00573, dnaq, 1 hit
TIGR01405, polC_Gram_pos, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPO3_MYCPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47729
Secondary accession number(s): Q79E72
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 20, 2001
Last modified: September 29, 2021
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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