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Protein

Cytosolic phospholipase A2

Gene

PLA2G4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=2.7 µmol/min/mg enzyme for the phospholipase A2 reaction1 Publication
    2. Vmax=4.6 µmol/min/mg enzyme for the lysophosphatase reaction1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi40Calcium 11
    Metal bindingi40Calcium 21
    Metal bindingi41Calcium 1; via carbonyl oxygen1
    Metal bindingi43Calcium 11
    Metal bindingi43Calcium 21
    Metal bindingi65Calcium 11
    Metal bindingi93Calcium 21
    Metal bindingi94Calcium 2; via carbonyl oxygen1
    Metal bindingi95Calcium 21
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei228Nucleophile4 Publications1
    Active sitei549Proton acceptor2 Publications1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processLipid degradation, Lipid metabolism
    LigandCalcium, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS04039-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.1.1.4 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-111995 phospho-PLA2 pathway
    R-HSA-1482788 Acyl chain remodelling of PC
    R-HSA-1482798 Acyl chain remodeling of CL
    R-HSA-1482801 Acyl chain remodelling of PS
    R-HSA-1482839 Acyl chain remodelling of PE
    R-HSA-1482922 Acyl chain remodelling of PI
    R-HSA-1482925 Acyl chain remodelling of PG
    R-HSA-1483115 Hydrolysis of LPC
    R-HSA-1483166 Synthesis of PA
    R-HSA-2142753 Arachidonic acid metabolism
    R-HSA-418592 ADP signalling through P2Y purinoceptor 1
    R-HSA-432142 Platelet sensitization by LDL
    R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P47712

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000565

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytosolic phospholipase A2
    Short name:
    cPLA2
    Alternative name(s):
    Phospholipase A2 group IVA
    Including the following 2 domains:
    Phospholipase A2 (EC:3.1.1.4)
    Alternative name(s):
    Phosphatidylcholine 2-acylhydrolase
    Lysophospholipase (EC:3.1.1.5)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PLA2G4A
    Synonyms:CPLA2, PLA2G4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000116711.9

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:9035 PLA2G4A

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    600522 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P47712

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993).1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi139C → A: No effect on phospholipase activity; when associated with A-141 and A-151. 1 Publication1
    Mutagenesisi141C → A: No effect on phospholipase activity; when associated with A-139 and A-151. 1 Publication1
    Mutagenesisi151C → A: No effect on phospholipase activity; when associated with A-139 and A-141. 1 Publication1
    Mutagenesisi195S → A: 5-fold reduced phospholipase and lysophosphatase activities. 100-fold reduced phospholipase and lysophosphatase activities; when associated with A-577. 1 Publication1
    Mutagenesisi200R → A or H: Abolishes phospholipase activity. 1 Publication1
    Mutagenesisi200R → K: Reduces phospholipase activity 200-fold. 1 Publication1
    Mutagenesisi215S → A: No effect on phospholipase or lysophosphatase activity. 1 Publication1
    Mutagenesisi220C → A: No effect on phospholipase activity. 1 Publication1
    Mutagenesisi228S → A, C or T: Abolishes both phospholipase and lysophosphatase activities. 3 Publications1
    Mutagenesisi324C → A: No effect on phospholipase activity; when associated with A-331. 1 Publication1
    Mutagenesisi331C → A: No effect on phospholipase activity; when associated with A-324. 1 Publication1
    Mutagenesisi505S → A: Decreases agonist-stimulated release of arachidonic acid. 1 Publication1
    Mutagenesisi549D → A: Abolishes phospholipiase activity. 1 Publication1
    Mutagenesisi549D → E: Reduces phospholipiase activity 2000-fold. 1 Publication1
    Mutagenesisi549D → N: Reduces phospholipiase activity 300-fold. 1 Publication1
    Mutagenesisi577S → A: 7-fold reduced phospholipase and lysophosphatase activities. 100-fold reduced phospholipase and lysophosphatase activities; when associated with A-195. 1 Publication1
    Mutagenesisi620C → A: No effect on phospholipase activity; when associated with A-634. 1 Publication1
    Mutagenesisi634C → A: No effect on phospholipase activity; when associated with A-620. 1 Publication1
    Mutagenesisi726C → A: No effect on phospholipase activity. 1 Publication1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    5321

    MalaCards human disease database

    More...
    MalaCardsi
    PLA2G4A

    Open Targets

    More...
    OpenTargetsi
    ENSG00000116711

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    468635 Cryptogenic multifocal ulcerous stenosing enteritis
    477787 Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA271

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3816

    Drug and drug target database

    More...
    DrugBanki
    DB00041 Aldesleukin
    DB00411 Carbachol
    DB00578 Carbenicillin
    DB05029 Duramycin
    DB00445 Epirubicin
    DB04827 Ethyl carbamate
    DB00591 Fluocinolone Acetonide
    DB00588 Fluticasone Propionate
    DB04552 Niflumic Acid
    DB01083 Orlistat
    DB01103 Quinacrine
    DB00086 Streptokinase
    DB04786 Suramin

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    1424

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PLA2G4A

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    317373312

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001872621 – 749Cytosolic phospholipase A2Add BLAST749

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineCombined sources1
    Modified residuei268PhosphothreonineCombined sources1
    Modified residuei434PhosphoserineBy similarity1
    Modified residuei435PhosphoserineCombined sources1
    Modified residuei437PhosphoserineCombined sources1
    Modified residuei505Phosphoserine; by MAPK2 Publications1
    Modified residuei515PhosphoserineBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki541Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Cross-linki606Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
    Modified residuei727PhosphoserineCombined sources1 Publication1
    Modified residuei729PhosphoserineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Activated by phosphorylation at both Ser-505 and Ser-727.2 Publications

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P47712

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P47712

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P47712

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P47712

    PeptideAtlas

    More...
    PeptideAtlasi
    P47712

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P47712

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    55788

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P47712

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P47712

    Miscellaneous databases

    CutDB - Proteolytic event database

    More...
    PMAP-CutDBi
    P47712

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000116711 Expressed in 190 organ(s), highest expression level in seminal vesicle

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_PLA2G4A

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P47712 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB010050
    HPA050062
    HPA054206

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with KAT5.4 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    111338, 34 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-40991N

    Protein interaction database and analysis system

    More...
    IntActi
    P47712, 9 interactors

    Molecular INTeraction database

    More...
    MINTi
    P47712

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000356436

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P47712

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1749
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1BCINMR-A1-138[»]
    1CJYX-ray2.50A/B1-749[»]
    1RLWX-ray2.40A17-141[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P47712

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P47712

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P47712

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 106C2PROSITE-ProRule annotationAdd BLAST102
    Domaini140 – 740PLA2cPROSITE-ProRule annotationAdd BLAST601

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 178Phospholipid bindingCuratedAdd BLAST178

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+.2 Publications

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1012 Eukaryota
    KOG1325 Eukaryota
    ENOG410XR72 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153184

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000115420

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG053479

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P47712

    KEGG Orthology (KO)

    More...
    KOi
    K16342

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WVQRMLM

    Database of Orthologous Groups

    More...
    OrthoDBi
    302848at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P47712

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF325228

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.150, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016035 Acyl_Trfase/lysoPLipase
    IPR000008 C2_dom
    IPR035892 C2_domain_sf
    IPR002642 LysoPLipase_cat_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00168 C2, 1 hit
    PF01735 PLA2_B, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00239 C2, 1 hit
    SM00022 PLAc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52151 SSF52151, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50004 C2, 1 hit
    PS51210 PLA2C, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P47712-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSFIDPYQHI IVEHQYSHKF TVVVLRATKV TKGAFGDMLD TPDPYVELFI
    60 70 80 90 100
    STTPDSRKRT RHFNNDINPV WNETFEFILD PNQENVLEIT LMDANYVMDE
    110 120 130 140 150
    TLGTATFTVS SMKVGEKKEV PFIFNQVTEM VLEMSLEVCS CPDLRFSMAL
    160 170 180 190 200
    CDQEKTFRQQ RKEHIRESMK KLLGPKNSEG LHSARDVPVV AILGSGGGFR
    210 220 230 240 250
    AMVGFSGVMK ALYESGILDC ATYVAGLSGS TWYMSTLYSH PDFPEKGPEE
    260 270 280 290 300
    INEELMKNVS HNPLLLLTPQ KVKRYVESLW KKKSSGQPVT FTDIFGMLIG
    310 320 330 340 350
    ETLIHNRMNT TLSSLKEKVN TAQCPLPLFT CLHVKPDVSE LMFADWVEFS
    360 370 380 390 400
    PYEIGMAKYG TFMAPDLFGS KFFMGTVVKK YEENPLHFLM GVWGSAFSIL
    410 420 430 440 450
    FNRVLGVSGS QSRGSTMEEE LENITTKHIV SNDSSDSDDE SHEPKGTENE
    460 470 480 490 500
    DAGSDYQSDN QASWIHRMIM ALVSDSALFN TREGRAGKVH NFMLGLNLNT
    510 520 530 540 550
    SYPLSPLSDF ATQDSFDDDE LDAAVADPDE FERIYEPLDV KSKKIHVVDS
    560 570 580 590 600
    GLTFNLPYPL ILRPQRGVDL IISFDFSARP SDSSPPFKEL LLAEKWAKMN
    610 620 630 640 650
    KLPFPKIDPY VFDREGLKEC YVFKPKNPDM EKDCPTIIHF VLANINFRKY
    660 670 680 690 700
    RAPGVPRETE EEKEIADFDI FDDPESPFST FNFQYPNQAF KRLHDLMHFN
    710 720 730 740
    TLNNIDVIKE AMVESIEYRR QNPSRCSVSL SNVEARRFFN KEFLSKPKA
    Length:749
    Mass (Da):85,239
    Last modified:January 11, 2011 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE71CA0EBE617856
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029276103G → R. Corresponds to variant dbSNP:rs28395828Ensembl.1
    Natural variantiVAR_070778111S → P Probable disease-associated mutation found in a compound heterozygote affected by phospholipase A2 deficiency also carrying H-485. 1 PublicationCorresponds to variant dbSNP:rs121434634EnsemblClinVar.1
    Natural variantiVAR_018760224V → I1 PublicationCorresponds to variant dbSNP:rs12720588Ensembl.1
    Natural variantiVAR_035826442H → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs370896190Ensembl.1
    Natural variantiVAR_070779485R → H Probable disease-associated mutation found in a compound heterozygote affected by phospholipase A2 deficiency also carrying P-111. 1 PublicationCorresponds to variant dbSNP:rs121434635EnsemblClinVar.1
    Natural variantiVAR_062128637I → V. Corresponds to variant dbSNP:rs28395831Ensembl.1
    Natural variantiVAR_018424651R → K5 PublicationsCorresponds to variant dbSNP:rs2307198Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M72393 mRNA Translation: AAB00789.1
    M68874 mRNA Translation: AAA60105.1
    AY552098 Genomic DNA Translation: AAS45712.1
    AL022147 Genomic DNA No translation available.
    AL049797 Genomic DNA No translation available.
    BC114340 mRNA Translation: AAI14341.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS1372.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A39329

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001298122.1, NM_001311193.1
    NP_077734.1, NM_024420.2
    XP_011507944.1, XM_011509642.2

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.497200

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000367466; ENSP00000356436; ENSG00000116711

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5321

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:5321

    UCSC genome browser

    More...
    UCSCi
    uc001gsc.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M72393 mRNA Translation: AAB00789.1
    M68874 mRNA Translation: AAA60105.1
    AY552098 Genomic DNA Translation: AAS45712.1
    AL022147 Genomic DNA No translation available.
    AL049797 Genomic DNA No translation available.
    BC114340 mRNA Translation: AAI14341.1
    CCDSiCCDS1372.1
    PIRiA39329
    RefSeqiNP_001298122.1, NM_001311193.1
    NP_077734.1, NM_024420.2
    XP_011507944.1, XM_011509642.2
    UniGeneiHs.497200

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1BCINMR-A1-138[»]
    1CJYX-ray2.50A/B1-749[»]
    1RLWX-ray2.40A17-141[»]
    ProteinModelPortaliP47712
    SMRiP47712
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111338, 34 interactors
    DIPiDIP-40991N
    IntActiP47712, 9 interactors
    MINTiP47712
    STRINGi9606.ENSP00000356436

    Chemistry databases

    BindingDBiP47712
    ChEMBLiCHEMBL3816
    DrugBankiDB00041 Aldesleukin
    DB00411 Carbachol
    DB00578 Carbenicillin
    DB05029 Duramycin
    DB00445 Epirubicin
    DB04827 Ethyl carbamate
    DB00591 Fluocinolone Acetonide
    DB00588 Fluticasone Propionate
    DB04552 Niflumic Acid
    DB01083 Orlistat
    DB01103 Quinacrine
    DB00086 Streptokinase
    DB04786 Suramin
    GuidetoPHARMACOLOGYi1424
    SwissLipidsiSLP:000000565

    PTM databases

    iPTMnetiP47712
    PhosphoSitePlusiP47712

    Polymorphism and mutation databases

    BioMutaiPLA2G4A
    DMDMi317373312

    Proteomic databases

    EPDiP47712
    jPOSTiP47712
    MaxQBiP47712
    PaxDbiP47712
    PeptideAtlasiP47712
    PRIDEiP47712
    ProteomicsDBi55788

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000367466; ENSP00000356436; ENSG00000116711
    GeneIDi5321
    KEGGihsa:5321
    UCSCiuc001gsc.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5321
    DisGeNETi5321
    EuPathDBiHostDB:ENSG00000116711.9

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PLA2G4A
    HGNCiHGNC:9035 PLA2G4A
    HPAiCAB010050
    HPA050062
    HPA054206
    MalaCardsiPLA2G4A
    MIMi600522 gene
    neXtProtiNX_P47712
    OpenTargetsiENSG00000116711
    Orphaneti468635 Cryptogenic multifocal ulcerous stenosing enteritis
    477787 Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder
    PharmGKBiPA271

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1012 Eukaryota
    KOG1325 Eukaryota
    ENOG410XR72 LUCA
    GeneTreeiENSGT00940000153184
    HOGENOMiHOG000115420
    HOVERGENiHBG053479
    InParanoidiP47712
    KOiK16342
    OMAiWVQRMLM
    OrthoDBi302848at2759
    PhylomeDBiP47712
    TreeFamiTF325228

    Enzyme and pathway databases

    BioCyciMetaCyc:HS04039-MONOMER
    BRENDAi3.1.1.4 2681
    ReactomeiR-HSA-111995 phospho-PLA2 pathway
    R-HSA-1482788 Acyl chain remodelling of PC
    R-HSA-1482798 Acyl chain remodeling of CL
    R-HSA-1482801 Acyl chain remodelling of PS
    R-HSA-1482839 Acyl chain remodelling of PE
    R-HSA-1482922 Acyl chain remodelling of PI
    R-HSA-1482925 Acyl chain remodelling of PG
    R-HSA-1483115 Hydrolysis of LPC
    R-HSA-1483166 Synthesis of PA
    R-HSA-2142753 Arachidonic acid metabolism
    R-HSA-418592 ADP signalling through P2Y purinoceptor 1
    R-HSA-432142 Platelet sensitization by LDL
    R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
    SIGNORiP47712

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PLA2G4A human
    EvolutionaryTraceiP47712

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PLA2G4A

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    5321
    PMAP-CutDBiP47712

    Protein Ontology

    More...
    PROi
    PR:P47712

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000116711 Expressed in 190 organ(s), highest expression level in seminal vesicle
    CleanExiHS_PLA2G4A
    GenevisibleiP47712 HS

    Family and domain databases

    Gene3Di2.60.40.150, 1 hit
    InterProiView protein in InterPro
    IPR016035 Acyl_Trfase/lysoPLipase
    IPR000008 C2_dom
    IPR035892 C2_domain_sf
    IPR002642 LysoPLipase_cat_dom
    PfamiView protein in Pfam
    PF00168 C2, 1 hit
    PF01735 PLA2_B, 1 hit
    SMARTiView protein in SMART
    SM00239 C2, 1 hit
    SM00022 PLAc, 1 hit
    SUPFAMiSSF52151 SSF52151, 1 hit
    PROSITEiView protein in PROSITE
    PS50004 C2, 1 hit
    PS51210 PLA2C, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24A_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47712
    Secondary accession number(s): B1AKG4, Q29R80
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 11, 2011
    Last modified: January 16, 2019
    This is version 196 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
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