CSN1S1

Functionⁱ

Important role in the capacity of milk to transport calcium phosphate.

Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.

Miscellaneous

In milk, the alpha s1- and beta-caseins precipitate in presence of calcium (so-called calcium-sensitive caseins). Kappa-casein prevents the precipitation of the other caseins by calcium through the formation of large stable colloidal particles termed micelles.

GO - Biological processⁱ

response to 11-deoxycorticosterone
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to dehydroepiandrosterone
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to estradiol
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to progesterone
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transmembrane transport Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Milk protein

Molecular function

Milk protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5223345 Miscellaneous transport and binding events
SIGNORⁱ	P47710

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-S1-casein Cleaved into the following chain: Casoxin-D
Gene namesⁱ	Name:CSN1S1 Synonyms:CASA, CSN1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126545.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2445 CSN1S1
MIMⁱ	115450 gene
neXtProtⁱ	NX_P47710

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1446
Open Targets More...OpenTargetsⁱ	ENSG00000126545
PharmGKBⁱ	PA26948

Protein family/group databases

Allergomeⁱ	1064 Hom s 8

Allergomeⁱ

1064 Hom s 8

Polymorphism and mutation databases

BioMutaⁱ	CSN1S1

BioMutaⁱ

CSN1S1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 15	2 PublicationsAdd BLAST	15
ChainⁱPRO_0000004450	16 – 185	Alpha-S1-caseinAdd BLAST	170
PeptideⁱPRO_0000004451	158 – 164	Casoxin-D	7

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	31	Phosphoserine1 Publication	1
Modified residueⁱ	33	Phosphoserine3 Publications	1
Modified residueⁱ	41	PhosphoserineCombined sources3 Publications	1
Modified residueⁱ	71	PhosphoserineBy similarity	1
Modified residueⁱ	85	PhosphoserineBy similarity	1
Modified residueⁱ	86	Phosphoserine1 Publication	1
Modified residueⁱ	88	Phosphoserine2 Publications	1
Modified residueⁱ	89	Phosphoserine1 Publication	1
Modified residueⁱ	90	Phosphoserine2 Publications	1
Modified residueⁱ	91	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Not glycosylated.

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbⁱ	P47710
PeptideAtlas More...PeptideAtlasⁱ	P47710
PRIDEⁱ	P47710
ProteomicsDBⁱ	55785 55786 [P47710-2] 55787 [P47710-3]

PTM databases

iPTMnetⁱ	P47710
PhosphoSitePlusⁱ	P47710
SwissPalmⁱ	P47710

Miscellaneous databases

PMAP-CutDBⁱ	P47710

PMAP-CutDBⁱ

P47710

Expressionⁱ

Tissue specificityⁱ

Mammary gland specific. Secreted in milk.

Gene expression databases

Bgeeⁱ	ENSG00000126545 Expressed in 72 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_CSN1S1
ExpressionAtlasⁱ	P47710 baseline and differential
Genevisibleⁱ	P47710 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035659 HPA057031

HPAⁱ

HPA035659
HPA057031

Interactionⁱ

Subunit structureⁱ

Heteromultimers of alpha-s1 casein and kappa-casein; disulfide-linked.

Protein-protein interaction databases

BioGridⁱ	107833, 22 interactors
IntActⁱ	P47710, 3 interactors
STRINGⁱ	9606.ENSP00000246891

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47710
SMRⁱ	P47710
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the alpha-casein family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J2MD Eukaryota ENOG41114JX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017378
HOGENOMⁱ	HOG000115954
HOVERGENⁱ	HBG005242
InParanoidⁱ	P47710
KEGG Orthology (KO) More...KOⁱ	K17281
OMAⁱ	SKCAEQF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XI1
PhylomeDBⁱ	P47710
TreeFamⁱ	TF340763

Family and domain databases

InterProⁱ	View protein in InterPro IPR026999 Alpha-s1_casein IPR031305 Casein_CS
PANTHERⁱ	PTHR10240 PTHR10240, 1 hit
PROSITEⁱ	View protein in PROSITE PS00306 CASEIN_ALPHA_BETA, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P47710-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN 
        60         70         80         90        100
RQRNILREKQ TDEIKDTRNE STQNCVVAEP EKMESSISSS SEEMSLSKCA 
       110        120        130        140        150
EQFCRLNEYN QLQLQAAHAQ EQIRRMNENS HVQVPFQQLN QLAAYPYAVW 
       160        170        180 
YYPQIMQYVP FPPFSDISNP TAHENYEKNN VMLQW

Length:185

Mass (Da):21,671

Last modified:February 1, 1996 - v1

Checksum:ⁱA7717899CDC7D563

GO

Isoform 2 (identifier: P47710-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
52-52: Missing.

« Hide

        10         20         30         40         50
MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN 
        60         70         80         90        100
RRNILREKQT DEIKDTRNES TQNCVVAEPE KMESSISSSS EEMSLSKCAE 
       110        120        130        140        150
QFCRLNEYNQ LQLQAAHAQE QIRRMNENSH VQVPFQQLNQ LAAYPYAVWY 
       160        170        180 
YPQIMQYVPF PPFSDISNPT AHENYEKNNV MLQW

Show »

Length:184

Mass (Da):21,543

Checksum:ⁱ9427BB3C275D7B86

GO

Isoform 3 (identifier: P47710-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
66-73: Missing.

« Hide

        10         20         30         40         50
MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN 
        60         70         80         90        100
RQRNILREKQ TDEIKNCVVA EPEKMESSIS SSSEEMSLSK CAEQFCRLNE 
       110        120        130        140        150
YNQLQLQAAH AQEQIRRMNE NSHVQVPFQQ LNQLAAYPYA VWYYPQIMQY 
       160        170 
VPFPPFSDIS NPTAHENYEK NNVMLQW

Show »

Length:177

Mass (Da):20,740

Checksum:ⁱCF67025C444CC8CF

GO

Isoform 4 (identifier: P47710-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
52-52: Missing.
93-100: Missing.

« Hide

        10         20         30         40         50
MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN 
        60         70         80         90        100
RRNILREKQT DEIKDTRNES TQNCVVAEPE KMESSISSSS EEQFCRLNEY 
       110        120        130        140        150
NQLQLQAAHA QEQIRRMNEN SHVQVPFQQL NQLAAYPYAV WYYPQIMQYV 
       160        170 
PFPPFSDISN PTAHENYEKN NVMLQW

Show »

Length:176

Mass (Da):20,693

Checksum:ⁱ1E03F910FA37C369

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RF34	D6RF34_HUMAN	Alpha-S1-casein Alpha-S1-casein	CSN1S1	169	Annotation score:
E9PDQ1	E9PDQ1_HUMAN	Alpha-S1-casein Alpha-S1-casein	CSN1S1	177	Annotation score:
H0Y8K1	H0Y8K1_HUMAN	Alpha-S1-casein Alpha-S1-casein	CSN1S1	76	Annotation score:
A0A0J9YVR3	A0A0J9YVR3_HUMAN	Alpha-S1-casein Alpha-S1-casein	CSN1S1	55	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	80	P → S in AAY68392 (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048614	117	A → V1 PublicationCorresponds to variant dbSNP:rs10030475Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_000795	52	Missing in isoform 2 and isoform 4. 3 Publications	1
Alternative sequenceⁱVSP_000796	66 – 73	Missing in isoform 3. 2 Publications	8
Alternative sequenceⁱVSP_046130	93 – 100	Missing in isoform 4. 1 Publication	8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X78416 mRNA Translation: CAA55185.1 U23157 mRNA Translation: AAA69477.1 DQ064604 mRNA Translation: AAY68392.1 AC108941 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05599.1 BC128227 mRNA Translation: AAI28228.1 BC128228 mRNA Translation: AAI28229.1 X98084 mRNA Translation: CAA66708.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47067.1 [P47710-1] CCDS54769.1 [P47710-4]
PIRⁱ	S56013
NCBI Reference Sequences More...RefSeqⁱ	NP_001020275.1, NM_001025104.1 [P47710-4] NP_001881.1, NM_001890.1 [P47710-1] XP_006714152.1, XM_006714089.2 [P47710-2] XP_006714153.1, XM_006714090.2 [P47710-3]
UniGeneⁱ	Hs.3155

Genome annotation databases

Ensemblⁱ	ENST00000246891; ENSP00000246891; ENSG00000126545 [P47710-1] ENST00000507763; ENSP00000422611; ENSG00000126545 [P47710-4]
GeneIDⁱ	1446
KEGGⁱ	hsa:1446
UCSC genome browser More...UCSCⁱ	uc003hep.2 human [P47710-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47710	CSN1S1 isoform 1		PANTR		185	UniRef90_P47710
Casein alpha s1		PONAB		185
Casein alpha s1		GORGO		185
Isoform 2 of Alpha-S1-casein		HUMAN		184
Uncharacterized protein		PANPA		176
+16

Protein	Similar proteins		Species	Score	Length	Source
P47710	Casein alpha s1		GORGO		185	UniRef50_P47710
CSN1S1 isoform 1		PANTR		185
CSN1S1 isoform 1		PONAB		185
Isoform 2 of Alpha-S1-casein		HUMAN		184
Uncharacterized protein		PANPA		176
+49

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X78416 mRNA Translation: CAA55185.1 U23157 mRNA Translation: AAA69477.1 DQ064604 mRNA Translation: AAY68392.1 AC108941 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05599.1 BC128227 mRNA Translation: AAI28228.1 BC128228 mRNA Translation: AAI28229.1 X98084 mRNA Translation: CAA66708.1
CCDSⁱ	CCDS47067.1 [P47710-1] CCDS54769.1 [P47710-4]
PIRⁱ	S56013
RefSeqⁱ	NP_001020275.1, NM_001025104.1 [P47710-4] NP_001881.1, NM_001890.1 [P47710-1] XP_006714152.1, XM_006714089.2 [P47710-2] XP_006714153.1, XM_006714090.2 [P47710-3]
UniGeneⁱ	Hs.3155

3D structure databases

ProteinModelPortalⁱ	P47710
SMRⁱ	P47710
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107833, 22 interactors
IntActⁱ	P47710, 3 interactors
STRINGⁱ	9606.ENSP00000246891

Protein family/group databases

Allergomeⁱ	1064 Hom s 8

Allergomeⁱ

1064 Hom s 8

PTM databases

iPTMnetⁱ	P47710
PhosphoSitePlusⁱ	P47710
SwissPalmⁱ	P47710

Polymorphism and mutation databases

BioMutaⁱ	CSN1S1

BioMutaⁱ

CSN1S1

Proteomic databases

PaxDbⁱ	P47710
PeptideAtlasⁱ	P47710
PRIDEⁱ	P47710
ProteomicsDBⁱ	55785 55786 [P47710-2] 55787 [P47710-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000246891; ENSP00000246891; ENSG00000126545 [P47710-1] ENST00000507763; ENSP00000422611; ENSG00000126545 [P47710-4]
GeneIDⁱ	1446
KEGGⁱ	hsa:1446
UCSCⁱ	uc003hep.2 human [P47710-1]

Organism-specific databases

CTDⁱ	1446
DisGeNETⁱ	1446
EuPathDBⁱ	HostDB:ENSG00000126545.13
GeneCardsⁱ	CSN1S1
HGNCⁱ	HGNC:2445 CSN1S1
HPAⁱ	HPA035659 HPA057031
MIMⁱ	115450 gene
neXtProtⁱ	NX_P47710
OpenTargetsⁱ	ENSG00000126545
PharmGKBⁱ	PA26948
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J2MD Eukaryota ENOG41114JX LUCA
GeneTreeⁱ	ENSGT00390000017378
HOGENOMⁱ	HOG000115954
HOVERGENⁱ	HBG005242
InParanoidⁱ	P47710
KOⁱ	K17281
OMAⁱ	SKCAEQF
OrthoDBⁱ	EOG091G0XI1
PhylomeDBⁱ	P47710
TreeFamⁱ	TF340763

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5223345 Miscellaneous transport and binding events
SIGNORⁱ	P47710

Miscellaneous databases

GeneWikiⁱ	CSN1S1
GenomeRNAiⁱ	1446
PMAP-CutDBⁱ	P47710
Protein Ontology More...PROⁱ	PR:P47710
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000126545 Expressed in 72 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_CSN1S1
ExpressionAtlasⁱ	P47710 baseline and differential
Genevisibleⁱ	P47710 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026999 Alpha-s1_casein IPR031305 Casein_CS
PANTHERⁱ	PTHR10240 PTHR10240, 1 hit
PROSITEⁱ	View protein in PROSITE PS00306 CASEIN_ALPHA_BETA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CASA1_HUMAN
Accessionⁱ	P47710Primary (citable) accession number: P47710 Secondary accession number(s): A1A510 , A1A511, E9PB60, Q4PNR5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P47710 (CASA1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Alpha-S1-casein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Protein family/group databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ