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Protein

Alpha-S1-casein

Gene

CSN1S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.
Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.

Miscellaneous

In milk, the alpha s1- and beta-caseins precipitate in presence of calcium (so-called calcium-sensitive caseins). Kappa-casein prevents the precipitation of the other caseins by calcium through the formation of large stable colloidal particles termed micelles.

GO - Biological processi

Keywordsi

Molecular functionMilk protein

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events
SIGNORiP47710

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S1-casein
Cleaved into the following chain:
Gene namesi
Name:CSN1S1
Synonyms:CASA, CSN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000126545.13
HGNCiHGNC:2445 CSN1S1
MIMi115450 gene
neXtProtiNX_P47710

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1446
OpenTargetsiENSG00000126545
PharmGKBiPA26948

Protein family/group databases

Allergomei1064 Hom s 8

Polymorphism and mutation databases

BioMutaiCSN1S1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 152 PublicationsAdd BLAST15
ChainiPRO_000000445016 – 185Alpha-S1-caseinAdd BLAST170
PeptideiPRO_0000004451158 – 164Casoxin-D7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31Phosphoserine1 Publication1
Modified residuei33Phosphoserine3 Publications1
Modified residuei41PhosphoserineCombined sources3 Publications1
Modified residuei71PhosphoserineBy similarity1
Modified residuei85PhosphoserineBy similarity1
Modified residuei86Phosphoserine1 Publication1
Modified residuei88Phosphoserine2 Publications1
Modified residuei89Phosphoserine1 Publication1
Modified residuei90Phosphoserine2 Publications1
Modified residuei91Phosphoserine1 Publication1

Post-translational modificationi

Not glycosylated.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP47710
PeptideAtlasiP47710
PRIDEiP47710
ProteomicsDBi55785
55786 [P47710-2]
55787 [P47710-3]

PTM databases

iPTMnetiP47710
PhosphoSitePlusiP47710
SwissPalmiP47710

Miscellaneous databases

PMAP-CutDBiP47710

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSG00000126545
CleanExiHS_CSN1S1
ExpressionAtlasiP47710 baseline and differential
GenevisibleiP47710 HS

Organism-specific databases

HPAiHPA035659
HPA057031

Interactioni

Subunit structurei

Heteromultimers of alpha-s1 casein and kappa-casein; disulfide-linked.

Protein-protein interaction databases

BioGridi107833, 22 interactors
IntActiP47710, 3 interactors
STRINGi9606.ENSP00000246891

Structurei

3D structure databases

ProteinModelPortaliP47710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2MD Eukaryota
ENOG41114JX LUCA
GeneTreeiENSGT00390000017378
HOGENOMiHOG000115954
HOVERGENiHBG005242
InParanoidiP47710
KOiK17281
OMAiSKCAEQF
OrthoDBiEOG091G0XI1
PhylomeDBiP47710
TreeFamiTF340763

Family and domain databases

InterProiView protein in InterPro
IPR026999 Alpha-s1_casein
IPR031305 Casein_CS
PANTHERiPTHR10240 PTHR10240, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P47710-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN
60 70 80 90 100
RQRNILREKQ TDEIKDTRNE STQNCVVAEP EKMESSISSS SEEMSLSKCA
110 120 130 140 150
EQFCRLNEYN QLQLQAAHAQ EQIRRMNENS HVQVPFQQLN QLAAYPYAVW
160 170 180
YYPQIMQYVP FPPFSDISNP TAHENYEKNN VMLQW
Length:185
Mass (Da):21,671
Last modified:February 1, 1996 - v1
Checksum:iA7717899CDC7D563
GO
Isoform 2 (identifier: P47710-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Missing.

Show »
Length:184
Mass (Da):21,543
Checksum:i9427BB3C275D7B86
GO
Isoform 3 (identifier: P47710-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-73: Missing.

Show »
Length:177
Mass (Da):20,740
Checksum:iCF67025C444CC8CF
GO
Isoform 4 (identifier: P47710-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Missing.
     93-100: Missing.

Show »
Length:176
Mass (Da):20,693
Checksum:i1E03F910FA37C369
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80P → S in AAY68392 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048614117A → V1 PublicationCorresponds to variant dbSNP:rs10030475Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00079552Missing in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_00079666 – 73Missing in isoform 3. 2 Publications8
Alternative sequenceiVSP_04613093 – 100Missing in isoform 4. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78416 mRNA Translation: CAA55185.1
U23157 mRNA Translation: AAA69477.1
DQ064604 mRNA Translation: AAY68392.1
AC108941 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05599.1
BC128227 mRNA Translation: AAI28228.1
BC128228 mRNA Translation: AAI28229.1
X98084 mRNA Translation: CAA66708.1
CCDSiCCDS47067.1 [P47710-1]
CCDS54769.1 [P47710-4]
PIRiS56013
RefSeqiNP_001020275.1, NM_001025104.1 [P47710-4]
NP_001881.1, NM_001890.1 [P47710-1]
XP_006714152.1, XM_006714089.2 [P47710-2]
XP_006714153.1, XM_006714090.2 [P47710-3]
UniGeneiHs.3155

Genome annotation databases

EnsembliENST00000246891; ENSP00000246891; ENSG00000126545 [P47710-1]
ENST00000507763; ENSP00000422611; ENSG00000126545 [P47710-4]
GeneIDi1446
KEGGihsa:1446
UCSCiuc003hep.2 human [P47710-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCASA1_HUMAN
AccessioniPrimary (citable) accession number: P47710
Secondary accession number(s): A1A510
, A1A511, E9PB60, Q4PNR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

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