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UniProtKB - P47710 (CASA1_HUMAN)

Entry version 166 (02 Jun 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Alpha-S1-casein

Gene

CSN1S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important role in the capacity of milk to transport calcium phosphate.

Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.

Miscellaneous

In milk, the alpha s1- and beta-caseins precipitate in presence of calcium (so-called calcium-sensitive caseins). Kappa-casein prevents the precipitation of the other caseins by calcium through the formation of large stable colloidal particles termed micelles.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMilk protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P47710

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5223345, Miscellaneous transport and binding events

SIGNOR Signaling Network Open Resource

More...SIGNORi		P47710

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-S1-casein
Cleaved into the following chain:
Casoxin-D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSN1S1
Synonyms:CASA, CSN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2445, CSN1S1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		115450, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P47710

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000126545.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1446

Open Targets

More...OpenTargetsi		ENSG00000126545

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26948

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P47710, Tbio

Protein family/group databases

Allergome; a platform for allergen knowledge

More...Allergomei		1064, Hom s 8

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CSN1S1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 152 PublicationsAdd BLAST15
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000445016 – 185Alpha-S1-caseinAdd BLAST170
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_0000004451158 – 164Casoxin-D7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31Phosphoserine1 Publication1
Modified residuei33Phosphoserine3 Publications1
Modified residuei41PhosphoserineCombined sources3 Publications1
Modified residuei71PhosphoserineBy similarity1
Modified residuei85PhosphoserineBy similarity1
Modified residuei86Phosphoserine1 Publication1
Modified residuei88Phosphoserine2 Publications1
Modified residuei89Phosphoserine1 Publication1
Modified residuei90Phosphoserine2 Publications1
Modified residuei91Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Not glycosylated.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P47710

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P47710

PeptideAtlas

More...PeptideAtlasi		P47710

PRoteomics IDEntifications database

More...PRIDEi		P47710

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19152
55785 [P47710-1]
55786 [P47710-2]
55787 [P47710-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2932, 81 N-Linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P47710

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P47710

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P47710

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126545, Expressed in layer of synovial tissue and 92 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P47710, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P47710, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000126545, Tissue enriched (breast)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heteromultimers of alpha-s1 casein and kappa-casein; disulfide-linked.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107833, 26 interactors

Protein interaction database and analysis system

More...IntActi		P47710, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000246891

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P47710, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P47710

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502TEWT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017378

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P47710

Identification of Orthologs from Complete Genome Data

More...OMAi		SKCAEQF

Database of Orthologous Groups

More...OrthoDBi		1478191at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P47710

TreeFam database of animal gene trees

More...TreeFami		TF340763

Family and domain databases

Database of protein disorder

More...DisProti		DP02005

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026999, Alpha-s1_casein
IPR031305, Casein_CS

The PANTHER Classification System

More...PANTHERi		PTHR10240, PTHR10240, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00306, CASEIN_ALPHA_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P47710-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN 
        60         70         80         90        100
RQRNILREKQ TDEIKDTRNE STQNCVVAEP EKMESSISSS SEEMSLSKCA 
       110        120        130        140        150
EQFCRLNEYN QLQLQAAHAQ EQIRRMNENS HVQVPFQQLN QLAAYPYAVW 
       160        170        180 
YYPQIMQYVP FPPFSDISNP TAHENYEKNN VMLQW
Length:185
Mass (Da):21,671
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7717899CDC7D563
GO
Isoform 2 (identifier: P47710-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Missing.

Show »
Length:184
Mass (Da):21,543
Checksum:i9427BB3C275D7B86
GO
Isoform 3 (identifier: P47710-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-73: Missing.

Show »
Length:177
Mass (Da):20,740
Checksum:iCF67025C444CC8CF
GO
Isoform 4 (identifier: P47710-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Missing.
     93-100: Missing.

Show »
Length:176
Mass (Da):20,693
Checksum:i1E03F910FA37C369
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDQ1E9PDQ1_HUMAN
Alpha-S1-casein
CSN1S1
177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF34D6RF34_HUMAN
Alpha-S1-casein
CSN1S1
169Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8K1H0Y8K1_HUMAN
Alpha-S1-casein
CSN1S1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVR3A0A0J9YVR3_HUMAN
Alpha-S1-casein
CSN1S1
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80P → S in AAY68392 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048614117A → V1 PublicationCorresponds to variant dbSNP:rs10030475Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00079552Missing in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_00079666 – 73Missing in isoform 3. 2 Publications8
Alternative sequenceiVSP_04613093 – 100Missing in isoform 4. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X78416 mRNA Translation: CAA55185.1
U23157 mRNA Translation: AAA69477.1
DQ064604 mRNA Translation: AAY68392.1
AC108941 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05599.1
BC128227 mRNA Translation: AAI28228.1
BC128228 mRNA Translation: AAI28229.1
X98084 mRNA Translation: CAA66708.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47067.1 [P47710-1]
CCDS54769.1 [P47710-4]

Protein sequence database of the Protein Information Resource

More...PIRi		S56013

NCBI Reference Sequences

More...RefSeqi		NP_001020275.1, NM_001025104.1 [P47710-4]
NP_001881.1, NM_001890.1 [P47710-1]
XP_006714152.1, XM_006714089.2 [P47710-2]
XP_006714153.1, XM_006714090.2 [P47710-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000246891; ENSP00000246891; ENSG00000126545 [P47710-1]
ENST00000507763; ENSP00000422611; ENSG00000126545 [P47710-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1446

UCSC genome browser

More...UCSCi		uc003hep.2, human [P47710-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78416 mRNA Translation: CAA55185.1
U23157 mRNA Translation: AAA69477.1
DQ064604 mRNA Translation: AAY68392.1
AC108941 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05599.1
BC128227 mRNA Translation: AAI28228.1
BC128228 mRNA Translation: AAI28229.1
X98084 mRNA Translation: CAA66708.1
CCDSiCCDS47067.1 [P47710-1]
CCDS54769.1 [P47710-4]
PIRiS56013
RefSeqiNP_001020275.1, NM_001025104.1 [P47710-4]
NP_001881.1, NM_001890.1 [P47710-1]
XP_006714152.1, XM_006714089.2 [P47710-2]
XP_006714153.1, XM_006714090.2 [P47710-3]

3D structure databases

SMRiP47710
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107833, 26 interactors
IntActiP47710, 15 interactors
STRINGi9606.ENSP00000246891

Protein family/group databases

Allergomei1064, Hom s 8

PTM databases

GlyConnecti2932, 81 N-Linked glycans (1 site)
iPTMnetiP47710
PhosphoSitePlusiP47710
SwissPalmiP47710

Genetic variation databases

BioMutaiCSN1S1

Proteomic databases

MassIVEiP47710
PaxDbiP47710
PeptideAtlasiP47710
PRIDEiP47710
ProteomicsDBi19152
55785 [P47710-1]
55786 [P47710-2]
55787 [P47710-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24253, 171 antibodies

The DNASU plasmid repository

More...DNASUi		1446

Genome annotation databases

EnsembliENST00000246891; ENSP00000246891; ENSG00000126545 [P47710-1]
ENST00000507763; ENSP00000422611; ENSG00000126545 [P47710-4]
GeneIDi1446
KEGGihsa:1446
UCSCiuc003hep.2, human [P47710-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1446
DisGeNETi1446

GeneCards: human genes, protein and diseases

More...GeneCardsi		CSN1S1
HGNCiHGNC:2445, CSN1S1
HPAiENSG00000126545, Tissue enriched (breast)
MIMi115450, gene
neXtProtiNX_P47710
OpenTargetsiENSG00000126545
PharmGKBiPA26948
VEuPathDBiHostDB:ENSG00000126545.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502TEWT, Eukaryota
GeneTreeiENSGT00390000017378
InParanoidiP47710
OMAiSKCAEQF
OrthoDBi1478191at2759
PhylomeDBiP47710
TreeFamiTF340763

Enzyme and pathway databases

PathwayCommonsiP47710
ReactomeiR-HSA-5223345, Miscellaneous transport and binding events
SIGNORiP47710

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1446, 9 hits in 977 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CSN1S1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1446
PharosiP47710, Tbio

Protein Ontology

More...PROi		PR:P47710
RNActiP47710, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126545, Expressed in layer of synovial tissue and 92 other tissues
ExpressionAtlasiP47710, baseline and differential
GenevisibleiP47710, HS

Family and domain databases

DisProtiDP02005
InterProiView protein in InterPro
IPR026999, Alpha-s1_casein
IPR031305, Casein_CS
PANTHERiPTHR10240, PTHR10240, 1 hit
PROSITEiView protein in PROSITE
PS00306, CASEIN_ALPHA_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47710
Secondary accession number(s): A1A510
, A1A511, E9PB60, Q4PNR5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 2, 2021
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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