UniProtKB - P47710 (CASA1_HUMAN)
Protein
Alpha-S1-casein
Gene
CSN1S1
Organism
Homo sapiens (Human)
Status
Functioni
Important role in the capacity of milk to transport calcium phosphate.
Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.
Miscellaneous
In milk, the alpha s1- and beta-caseins precipitate in presence of calcium (so-called calcium-sensitive caseins). Kappa-casein prevents the precipitation of the other caseins by calcium through the formation of large stable colloidal particles termed micelles.
GO - Biological processi
- response to 11-deoxycorticosterone Source: GO_Central
- response to dehydroepiandrosterone Source: GO_Central
- response to estradiol Source: GO_Central
- response to progesterone Source: GO_Central
- transmembrane transport Source: Reactome
Keywordsi
Molecular function | Milk protein |
Enzyme and pathway databases
PathwayCommonsi | P47710 |
Reactomei | R-HSA-5223345, Miscellaneous transport and binding events |
SIGNORi | P47710 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CSN1S1 Synonyms:CASA, CSN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000126545.13 |
HGNCi | HGNC:2445, CSN1S1 |
MIMi | 115450, gene |
neXtProti | NX_P47710 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 1446 |
OpenTargetsi | ENSG00000126545 |
PharmGKBi | PA26948 |
Miscellaneous databases
Pharosi | P47710, Tbio |
Protein family/group databases
Allergomei | 1064, Hom s 8 |
Polymorphism and mutation databases
BioMutai | CSN1S1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | 2 PublicationsAdd BLAST | 15 | |
ChainiPRO_0000004450 | 16 – 185 | Alpha-S1-caseinAdd BLAST | 170 | |
PeptideiPRO_0000004451 | 158 – 164 | Casoxin-D | 7 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 31 | Phosphoserine1 Publication | 1 | |
Modified residuei | 33 | Phosphoserine3 Publications | 1 | |
Modified residuei | 41 | PhosphoserineCombined sources3 Publications | 1 | |
Modified residuei | 71 | PhosphoserineBy similarity | 1 | |
Modified residuei | 85 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | Phosphoserine1 Publication | 1 | |
Modified residuei | 88 | Phosphoserine2 Publications | 1 | |
Modified residuei | 89 | Phosphoserine1 Publication | 1 | |
Modified residuei | 90 | Phosphoserine2 Publications | 1 | |
Modified residuei | 91 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Not glycosylated.
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
MassIVEi | P47710 |
PaxDbi | P47710 |
PeptideAtlasi | P47710 |
PRIDEi | P47710 |
ProteomicsDBi | 19152 55785 [P47710-1] 55786 [P47710-2] 55787 [P47710-3] |
PTM databases
iPTMneti | P47710 |
PhosphoSitePlusi | P47710 |
SwissPalmi | P47710 |
Expressioni
Tissue specificityi
Mammary gland specific. Secreted in milk.
Gene expression databases
Bgeei | ENSG00000126545, Expressed in layer of synovial tissue and 92 other tissues |
ExpressionAtlasi | P47710, baseline and differential |
Genevisiblei | P47710, HS |
Organism-specific databases
HPAi | ENSG00000126545, Tissue enriched (breast) |
Interactioni
Subunit structurei
Heteromultimers of alpha-s1 casein and kappa-casein; disulfide-linked.
Binary interactionsi
P47710
With | #Exp. | IntAct |
---|---|---|
UBQLN2 [Q9UHD9] | 3 | EBI-2433045,EBI-947187 |
Protein-protein interaction databases
BioGRIDi | 107833, 26 interactors |
IntActi | P47710, 15 interactors |
STRINGi | 9606.ENSP00000246891 |
Miscellaneous databases
RNActi | P47710, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the alpha-casein family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TEWT, Eukaryota |
GeneTreei | ENSGT00390000017378 |
InParanoidi | P47710 |
OMAi | SKCAEQF |
OrthoDBi | 1478191at2759 |
PhylomeDBi | P47710 |
TreeFami | TF340763 |
Family and domain databases
DisProti | DP02005 |
InterProi | View protein in InterPro IPR026999, Alpha-s1_casein IPR031305, Casein_CS |
PANTHERi | PTHR10240, PTHR10240, 1 hit |
PROSITEi | View protein in PROSITE PS00306, CASEIN_ALPHA_BETA, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P47710-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN
60 70 80 90 100
RQRNILREKQ TDEIKDTRNE STQNCVVAEP EKMESSISSS SEEMSLSKCA
110 120 130 140 150
EQFCRLNEYN QLQLQAAHAQ EQIRRMNENS HVQVPFQQLN QLAAYPYAVW
160 170 180
YYPQIMQYVP FPPFSDISNP TAHENYEKNN VMLQW
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PDQ1 | E9PDQ1_HUMAN | Alpha-S1-casein | CSN1S1 | 177 | Annotation score: | ||
D6RF34 | D6RF34_HUMAN | Alpha-S1-casein | CSN1S1 | 169 | Annotation score: | ||
H0Y8K1 | H0Y8K1_HUMAN | Alpha-S1-casein | CSN1S1 | 76 | Annotation score: | ||
A0A0J9YVR3 | A0A0J9YVR3_HUMAN | Alpha-S1-casein | CSN1S1 | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 | P → S in AAY68392 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048614 | 117 | A → V1 PublicationCorresponds to variant dbSNP:rs10030475Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000795 | 52 | Missing in isoform 2 and isoform 4. 3 Publications | 1 | |
Alternative sequenceiVSP_000796 | 66 – 73 | Missing in isoform 3. 2 Publications | 8 | |
Alternative sequenceiVSP_046130 | 93 – 100 | Missing in isoform 4. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78416 mRNA Translation: CAA55185.1 U23157 mRNA Translation: AAA69477.1 DQ064604 mRNA Translation: AAY68392.1 AC108941 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05599.1 BC128227 mRNA Translation: AAI28228.1 BC128228 mRNA Translation: AAI28229.1 X98084 mRNA Translation: CAA66708.1 |
CCDSi | CCDS47067.1 [P47710-1] CCDS54769.1 [P47710-4] |
PIRi | S56013 |
RefSeqi | NP_001020275.1, NM_001025104.1 [P47710-4] NP_001881.1, NM_001890.1 [P47710-1] XP_006714152.1, XM_006714089.2 [P47710-2] XP_006714153.1, XM_006714090.2 [P47710-3] |
Genome annotation databases
Ensembli | ENST00000246891; ENSP00000246891; ENSG00000126545 [P47710-1] ENST00000507763; ENSP00000422611; ENSG00000126545 [P47710-4] |
GeneIDi | 1446 |
KEGGi | hsa:1446 |
UCSCi | uc003hep.2, human [P47710-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Of buttons, digestion and glue - Issue 16 of November 2001 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78416 mRNA Translation: CAA55185.1 U23157 mRNA Translation: AAA69477.1 DQ064604 mRNA Translation: AAY68392.1 AC108941 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05599.1 BC128227 mRNA Translation: AAI28228.1 BC128228 mRNA Translation: AAI28229.1 X98084 mRNA Translation: CAA66708.1 |
CCDSi | CCDS47067.1 [P47710-1] CCDS54769.1 [P47710-4] |
PIRi | S56013 |
RefSeqi | NP_001020275.1, NM_001025104.1 [P47710-4] NP_001881.1, NM_001890.1 [P47710-1] XP_006714152.1, XM_006714089.2 [P47710-2] XP_006714153.1, XM_006714090.2 [P47710-3] |
3D structure databases
SMRi | P47710 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107833, 26 interactors |
IntActi | P47710, 15 interactors |
STRINGi | 9606.ENSP00000246891 |
Protein family/group databases
Allergomei | 1064, Hom s 8 |
PTM databases
iPTMneti | P47710 |
PhosphoSitePlusi | P47710 |
SwissPalmi | P47710 |
Polymorphism and mutation databases
BioMutai | CSN1S1 |
Proteomic databases
MassIVEi | P47710 |
PaxDbi | P47710 |
PeptideAtlasi | P47710 |
PRIDEi | P47710 |
ProteomicsDBi | 19152 55785 [P47710-1] 55786 [P47710-2] 55787 [P47710-3] |
Protocols and materials databases
Antibodypediai | 24253, 168 antibodies |
Genome annotation databases
Ensembli | ENST00000246891; ENSP00000246891; ENSG00000126545 [P47710-1] ENST00000507763; ENSP00000422611; ENSG00000126545 [P47710-4] |
GeneIDi | 1446 |
KEGGi | hsa:1446 |
UCSCi | uc003hep.2, human [P47710-1] |
Organism-specific databases
CTDi | 1446 |
DisGeNETi | 1446 |
EuPathDBi | HostDB:ENSG00000126545.13 |
GeneCardsi | CSN1S1 |
HGNCi | HGNC:2445, CSN1S1 |
HPAi | ENSG00000126545, Tissue enriched (breast) |
MIMi | 115450, gene |
neXtProti | NX_P47710 |
OpenTargetsi | ENSG00000126545 |
PharmGKBi | PA26948 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TEWT, Eukaryota |
GeneTreei | ENSGT00390000017378 |
InParanoidi | P47710 |
OMAi | SKCAEQF |
OrthoDBi | 1478191at2759 |
PhylomeDBi | P47710 |
TreeFami | TF340763 |
Enzyme and pathway databases
PathwayCommonsi | P47710 |
Reactomei | R-HSA-5223345, Miscellaneous transport and binding events |
SIGNORi | P47710 |
Miscellaneous databases
BioGRID-ORCSi | 1446, 8 hits in 841 CRISPR screens |
GeneWikii | CSN1S1 |
GenomeRNAii | 1446 |
Pharosi | P47710, Tbio |
PROi | PR:P47710 |
RNActi | P47710, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126545, Expressed in layer of synovial tissue and 92 other tissues |
ExpressionAtlasi | P47710, baseline and differential |
Genevisiblei | P47710, HS |
Family and domain databases
DisProti | DP02005 |
InterProi | View protein in InterPro IPR026999, Alpha-s1_casein IPR031305, Casein_CS |
PANTHERi | PTHR10240, PTHR10240, 1 hit |
PROSITEi | View protein in PROSITE PS00306, CASEIN_ALPHA_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CASA1_HUMAN | |
Accessioni | P47710Primary (citable) accession number: P47710 Secondary accession number(s): A1A510 Q4PNR5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations