Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rabphilin-3A

Gene

Rph3a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi412Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi413Calcium 1Combined sources1
Metal bindingi413Calcium 2By similarity1
Metal bindingi419Calcium 2By similarity1
Metal bindingi474Calcium 1By similarity1
Metal bindingi474Calcium 2By similarity1
Metal bindingi475Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi476Calcium 1Combined sources1
Metal bindingi476Calcium 2By similarity1
Metal bindingi482Calcium 1By similarity1
Metal bindingi529Calcium 3; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi571Calcium 3Combined sources1 Publication1
Metal bindingi571Calcium 4Combined sources1 Publication1
Metal bindingi577Calcium 3Combined sources1 Publication1
Metal bindingi631Calcium 3Combined sources1 Publication1
Metal bindingi631Calcium 4Combined sources1 Publication1
Metal bindingi632Calcium 3; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi633Calcium 3Combined sources1 Publication1
Metal bindingi633Calcium 4Combined sources1 Publication1
Metal bindingi639Calcium 4Combined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 145FYVE-typePROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rabphilin-3A
Alternative name(s):
Exophilin-1
Gene namesi
Name:Rph3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620073 Rph3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902291 – 684Rabphilin-3AAdd BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223Omega-N-methylarginineBy similarity1
Modified residuei274PhosphoserineBy similarity1
Modified residuei682PhosphoserineCombined sources1
Modified residuei683PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiP47709
PRIDEiP47709

PTM databases

iPTMnetiP47709
PhosphoSitePlusiP47709

Miscellaneous databases

PMAP-CutDBiP47709

Expressioni

Tissue specificityi

Specifically expressed in brain.

Interactioni

Subunit structurei

Interacts with RAB3B, RAB3C, RAB3D, RAB8A, RAB27A and RAB27B (By similarity). Interacts with RAB3A. Monomer.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251056, 1 interactor
IntActiP47709, 3 interactors
MINTiP47709
STRINGi10116.ENSRNOP00000001844

Structurei

Secondary structure

1684
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP47709
SMRiP47709
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47709

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 157RabBDPROSITE-ProRule annotationAdd BLAST118
Domaini384 – 488C2 1PROSITE-ProRule annotationAdd BLAST105
Domaini542 – 645C2 2PROSITE-ProRule annotationAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 364Pro-richAdd BLAST85

Domaini

Binds calcium via the C2 domains. The calcium-bound C2 domains mediate interactions with phospholipid bilayers.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 145FYVE-typePROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1013 Eukaryota
ENOG410XQXA LUCA
HOGENOMiHOG000294226
HOVERGENiHBG017739
InParanoidiP47709
KOiK19938
PhylomeDBiP47709

Family and domain databases

Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010911 Rab_BD
IPR028698 RPH3A
IPR001565 Synaptotagmin
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF118 PTHR10024:SF118, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P47709-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDTVVNRWM YPGDGPLQSN DKEQLQAGWS VHPGAQTDRQ RKQEELTDEE
60 70 80 90 100
KEIINRVIAR AEKMETMEQE RIGRLVDRLE TMRKNVAGDG VNRCILCGEQ
110 120 130 140 150
LGMLGSACVV CEDCKKNVCT KCGVETSNNR PHPVWLCKIC LEQREVWKRS
160 170 180 190 200
GAWFFKGFPK QVLPQPMPIK KTKPQQPAGE PATQEQPTPE SRHPARAPAR
210 220 230 240 250
GDMEDRRAPG QKPGPDLTSA PGRGSHGPPT RRASEARMST TTRDSEGWDH
260 270 280 290 300
GHGGGAGDTS RSPGGEQGLR RANSVQASRP APASMPSPAP PQPVQPGPPG
310 320 330 340 350
GSRAAPGPGR FPEQSTEAPP SDPGYPGAVA PAREERTGPT GGFQAAPHTA
360 370 380 390 400
GPYSQAAPAR QPPPAEEEEE EANSYDSDQA TTLGALEFSL LYDQDNSNLQ
410 420 430 440 450
CTIIRAKGLK PMDSNGLADP YVKLHLLPGA SKSNKLRTKT LRNTRNPVWN
460 470 480 490 500
ETLQYHGITE EDMQRKTLRI SVCDEDKFGH NEFIGETRFS LKKLKANQRK
510 520 530 540 550
NFNICLERVI PMKRAGTTGS ARGMALYEEE QVERIGDIEE RGKILVSLMY
560 570 580 590 600
STQQGGLIVG IIRCVHLAAM DANGYSDPFV KLWLKPDMGK KAKHKTQIKK
610 620 630 640 650
KTLNPEFNEE FFYDIKHSDL AKKSLDISVW DYDIGKSNDY IGGCQLGISA
660 670 680
KGERLKHWYE CLKNKDKKIE RWHQLQNENH VSSD
Length:684
Mass (Da):75,832
Last modified:February 1, 1996 - v1
Checksum:i05838BC3C7A86444
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LPB9F1LPB9_RAT
Rabphilin-3A
Rph3a
684Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12571 mRNA Translation: AAA62662.1
PIRiI58166
RefSeqiNP_598202.1, NM_133518.1
UniGeneiRn.10976

Genome annotation databases

GeneIDi171039
KEGGirno:171039
UCSCiRGD:620073 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12571 mRNA Translation: AAA62662.1
PIRiI58166
RefSeqiNP_598202.1, NM_133518.1
UniGeneiRn.10976

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZBDX-ray2.60B41-170[»]
2CHDX-ray1.92A371-510[»]
2CM5X-ray1.28A519-684[»]
2CM6X-ray1.85A/B519-684[»]
3RPBNMR-A541-680[»]
4LT7X-ray2.50A378-510[»]
4NP9X-ray1.92A378-510[»]
4NS0X-ray1.80A378-510[»]
5LO8X-ray2.50A/B536-680[»]
5LOBX-ray3.30A/B/C536-680[»]
5LOWX-ray2.80A/B/C/H/I/J536-680[»]
ProteinModelPortaliP47709
SMRiP47709
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251056, 1 interactor
IntActiP47709, 3 interactors
MINTiP47709
STRINGi10116.ENSRNOP00000001844

PTM databases

iPTMnetiP47709
PhosphoSitePlusiP47709

Proteomic databases

PaxDbiP47709
PRIDEiP47709

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171039
KEGGirno:171039
UCSCiRGD:620073 rat

Organism-specific databases

CTDi22895
RGDi620073 Rph3a

Phylogenomic databases

eggNOGiKOG1013 Eukaryota
ENOG410XQXA LUCA
HOGENOMiHOG000294226
HOVERGENiHBG017739
InParanoidiP47709
KOiK19938
PhylomeDBiP47709

Miscellaneous databases

EvolutionaryTraceiP47709
PMAP-CutDBiP47709
PROiPR:P47709

Family and domain databases

Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010911 Rab_BD
IPR028698 RPH3A
IPR001565 Synaptotagmin
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF118 PTHR10024:SF118, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRP3A_RAT
AccessioniPrimary (citable) accession number: P47709
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again