UniProtKB - P47708 (RP3A_MOUSE)
Rabphilin-3A
Rph3a
Functioni
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 409 | Calcium 1; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 410 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 410 | Calcium 2Combined sources1 Publication | 1 | |
Metal bindingi | 416 | Calcium 2Combined sources1 Publication | 1 | |
Metal bindingi | 471 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 471 | Calcium 2Combined sources1 Publication | 1 | |
Metal bindingi | 472 | Calcium 2; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 473 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 473 | Calcium 2Combined sources1 Publication | 1 | |
Metal bindingi | 479 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 526 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 568 | Calcium 3By similarity | 1 | |
Metal bindingi | 568 | Calcium 4By similarity | 1 | |
Metal bindingi | 574 | Calcium 3By similarity | 1 | |
Metal bindingi | 628 | Calcium 3By similarity | 1 | |
Metal bindingi | 628 | Calcium 4By similarity | 1 | |
Metal bindingi | 629 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 630 | Calcium 3By similarity | 1 | |
Metal bindingi | 630 | Calcium 4By similarity | 1 | |
Metal bindingi | 636 | Calcium 4By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 88 – 145 | FYVE-typePROSITE-ProRule annotationAdd BLAST | 58 |
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: UniProtKB
- calcium ion binding Source: UniProtKB
- inositol 1,4,5 trisphosphate binding Source: ParkinsonsUK-UCL
- phosphate ion binding Source: ParkinsonsUK-UCL
- phosphatidylinositol-4,5-bisphosphate binding Source: ParkinsonsUK-UCL
- protein-containing complex binding Source: ParkinsonsUK-UCL
- Rab GTPase binding Source: InterPro
- selenium binding Source: ParkinsonsUK-UCL
- zinc ion binding Source: ParkinsonsUK-UCL
GO - Biological processi
- dendritic spine organization Source: MGI
- intracellular protein transport Source: InterPro
- regulation of NMDA receptor activity Source: MGI
- spontaneous neurotransmitter secretion Source: MGI
Keywordsi
Biological process | Protein transport, Transport |
Ligand | Calcium, Lipid-binding, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Rabphilin-3AAlternative name(s): Exophilin-1 |
Gene namesi | Name:Rph3a |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102788, Rph3a |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane By similarity
Other locations
- synaptic vesicle membrane By similarity
- dendritic spine By similarity
- Membrane By similarity; Peripheral membrane protein By similarity
Cytosol
- cytosol Source: ParkinsonsUK-UCL
Plasma Membrane
- postsynaptic membrane Source: MGI
Other locations
- dendritic spine Source: MGI
- extrinsic component of membrane Source: ParkinsonsUK-UCL
- neuron projection Source: ParkinsonsUK-UCL
- protein-containing complex Source: ParkinsonsUK-UCL
- secretory granule Source: ParkinsonsUK-UCL
- synapse Source: ParkinsonsUK-UCL
- synaptic vesicle Source: MGI
- synaptic vesicle membrane Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190228 | 1 – 681 | Rabphilin-3AAdd BLAST | 681 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 223 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 271 | PhosphoserineCombined sources | 1 | |
Modified residuei | 679 | PhosphoserineBy similarity | 1 | |
Modified residuei | 680 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P47708 |
PaxDbi | P47708 |
PeptideAtlasi | P47708 |
PRIDEi | P47708 |
PTM databases
iPTMneti | P47708 |
PhosphoSitePlusi | P47708 |
SwissPalmi | P47708 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000029608, Expressed in primary visual cortex and 122 other tissues |
Genevisiblei | P47708, MM |
Interactioni
Subunit structurei
Interacts with RAB3B, RAB3C, RAB3D, RAB8A, RAB27A and RAB27B (PubMed:12578829).
Interacts with RAB3A; this interaction recruits RPH3A to synaptic vesicules (By similarity).
Interacts (via C2B domain) with SNAP25 (By similarity).
Interacts with deubiquitinating enzyme CAND1; this interaction results in the deubiquitination of RPH3A (By similarity).
Interacts with GRIN2A and DLG4; this ternary complex regulates NMDA receptor composition at postsynaptic membranes (By similarity).
Interacts with SNCA (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsP47708
With | #Exp. | IntAct |
---|---|---|
Rab27a [Q9ERI2] | 2 | EBI-398376,EBI-398172 |
Rab3a [P63011] | 2 | EBI-398376,EBI-398393 |
Rab8a [P55258] | 2 | EBI-398376,EBI-398411 |
GO - Molecular functioni
- Rab GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 202964, 15 interactors |
IntActi | P47708, 8 interactors |
MINTi | P47708 |
STRINGi | 10090.ENSMUSP00000078198 |
Miscellaneous databases
RNActi | P47708, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P47708 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P47708 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 157 | RabBDPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 379 – 501 | C2 1PROSITE-ProRule annotationAdd BLAST | 123 | |
Domaini | 537 – 670 | C2 2PROSITE-ProRule annotationAdd BLAST | 134 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 277 – 361 | Pro-richAdd BLAST | 85 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 88 – 145 | FYVE-typePROSITE-ProRule annotationAdd BLAST | 58 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1013, Eukaryota |
GeneTreei | ENSGT00940000157468 |
HOGENOMi | CLU_011461_2_0_1 |
InParanoidi | P47708 |
OMAi | IICEDCR |
OrthoDBi | 374694at2759 |
PhylomeDBi | P47708 |
TreeFami | TF351844 |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR041282, FYVE_2 IPR010911, Rab_BD IPR043566, Rabphilin/DOC2/Noc2 IPR028698, RPH3A IPR001565, Synaptotagmin IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45729, PTHR45729, 1 hit PTHR45729:SF3, PTHR45729:SF3, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits PF02318, FYVE_2, 1 hit |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits PS50916, RABBD, 1 hit PS50178, ZF_FYVE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MTDTVVNRWM YPGDGPLQSN DKEQLQAGWS VHPGAQTDRQ RKQEELTDEE
60 70 80 90 100
KEIINRVIAR AEKMEAMEQE RIGRLVDRLE TMRKNVAGDG VNRCILCGEQ
110 120 130 140 150
LGMLGSACVV CEDCKKNVCT KCGVETSNNR PHPVWLCKIC LEQREVWKRS
160 170 180 190 200
GAWFFKGFPK QVLPQPMPIK KTKPQQPAGE PATQEQPTPE SRHPARAPAR
210 220 230 240 250
GDMEDRRPPG QKPGPDLTSA PGRGSHGPPT RRASEARMST AARDSEGWDH
260 270 280 290 300
AHGGGTGDTS RSPAGLRRAN SVQAARPAPA PVPSPAPPQP VQPGPPGGSR
310 320 330 340 350
ATPGPGRFPE QSTEAPPSDP GYPGAVAPAR EERTGPAGGF QAAPHTAAPY
360 370 380 390 400
SQAAPARQPP PAEEEEEEAN SYDSDEATTL GALEFSLLYD QDNSNLQCTI
410 420 430 440 450
IRAKGLKPMD SNGLADPYVK LHLLPGASKS NKLRTKTLRN TRNPVWNETL
460 470 480 490 500
QYHGITEEDM QRKTLRISVC DEDKFGHNEF IGETRFSLKK LKANQRKNFN
510 520 530 540 550
ICLERVIPMK RAGTTGSARG MALYEEEQVE RIGDIEERGK ILVSLMYSTQ
560 570 580 590 600
QGGLIVGIIR CVHLAAMDAN GYSDPFVKLW LKPDMGKKAK HKTQIKKKTL
610 620 630 640 650
NPEFNEEFFY DIKHSDLAKK SLDISVWDYD IGKSNDYIGG CQLGISAKGE
660 670 680
RLKHWYECLK NKDKKIERWH QLQNENHVSS D
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YV12 | A0A0J9YV12_MOUSE | Rabphilin-3A | Rph3a | 49 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC042585 mRNA Translation: AAH42585.1 BC050883 mRNA Translation: AAH50883.1 D29965 mRNA Translation: BAA06231.2 |
CCDSi | CCDS39246.1 |
PIRi | JX0338 |
RefSeqi | NP_001289273.1, NM_001302344.1 NP_001289274.1, NM_001302345.1 NP_035416.1, NM_011286.3 |
Genome annotation databases
Ensembli | ENSMUST00000079204; ENSMUSP00000078198; ENSMUSG00000029608 ENSMUST00000202326; ENSMUSP00000144291; ENSMUSG00000029608 ENSMUST00000202406; ENSMUSP00000143917; ENSMUSG00000029608 |
GeneIDi | 19894 |
KEGGi | mmu:19894 |
UCSCi | uc008zil.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC042585 mRNA Translation: AAH42585.1 BC050883 mRNA Translation: AAH50883.1 D29965 mRNA Translation: BAA06231.2 |
CCDSi | CCDS39246.1 |
PIRi | JX0338 |
RefSeqi | NP_001289273.1, NM_001302344.1 NP_001289274.1, NM_001302345.1 NP_035416.1, NM_011286.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K3H | NMR | - | A | 368-507 | [»] | |
SMRi | P47708 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 202964, 15 interactors |
IntActi | P47708, 8 interactors |
MINTi | P47708 |
STRINGi | 10090.ENSMUSP00000078198 |
PTM databases
iPTMneti | P47708 |
PhosphoSitePlusi | P47708 |
SwissPalmi | P47708 |
Proteomic databases
MaxQBi | P47708 |
PaxDbi | P47708 |
PeptideAtlasi | P47708 |
PRIDEi | P47708 |
Protocols and materials databases
Antibodypediai | 996, 263 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000079204; ENSMUSP00000078198; ENSMUSG00000029608 ENSMUST00000202326; ENSMUSP00000144291; ENSMUSG00000029608 ENSMUST00000202406; ENSMUSP00000143917; ENSMUSG00000029608 |
GeneIDi | 19894 |
KEGGi | mmu:19894 |
UCSCi | uc008zil.2, mouse |
Organism-specific databases
CTDi | 22895 |
MGIi | MGI:102788, Rph3a |
Phylogenomic databases
eggNOGi | KOG1013, Eukaryota |
GeneTreei | ENSGT00940000157468 |
HOGENOMi | CLU_011461_2_0_1 |
InParanoidi | P47708 |
OMAi | IICEDCR |
OrthoDBi | 374694at2759 |
PhylomeDBi | P47708 |
TreeFami | TF351844 |
Miscellaneous databases
BioGRID-ORCSi | 19894, 1 hit in 17 CRISPR screens |
ChiTaRSi | Rph3a, mouse |
EvolutionaryTracei | P47708 |
PROi | PR:P47708 |
RNActi | P47708, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029608, Expressed in primary visual cortex and 122 other tissues |
Genevisiblei | P47708, MM |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR041282, FYVE_2 IPR010911, Rab_BD IPR043566, Rabphilin/DOC2/Noc2 IPR028698, RPH3A IPR001565, Synaptotagmin IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR45729, PTHR45729, 1 hit PTHR45729:SF3, PTHR45729:SF3, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits PF02318, FYVE_2, 1 hit |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits PS50916, RABBD, 1 hit PS50178, ZF_FYVE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RP3A_MOUSE | |
Accessioni | P47708Primary (citable) accession number: P47708 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | June 6, 2002 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references