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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-332-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:MG274
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622001 – 358Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST358

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

GO - Molecular functioni

  • glycosylation-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

STRINGi243273.MgenG_010200002654

Structurei

3D structure databases

ProteinModelPortaliP47516
SMRiP47516
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4107RUY Bacteria
COG1071 LUCA
KOiK00161
OMAiNTMDKIL
OrthoDBiPOG091H04RI

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017596 PdhA/BkdA
IPR029061 THDP-binding
PANTHERiPTHR11516:SF41 PTHR11516:SF41, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03181 PDH_E1_alph_x, 1 hit

Sequencei

Sequence statusi: Complete.

P47516-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILIKNKVP TTLYQVYDNE GKLIDPNHKI TLTDEQLKHA YYLMNLSRMM
60 70 80 90 100
DKKMLVWQRA GKMLNFAPNL GEEALQVGMG LGLNENDWVC PTFRSGALML
110 120 130 140 150
YRGVKPEQLL LYWNGNEKGS QIDAKYKTLP INITIGAQYS HAAGLGYMLH
160 170 180 190 200
YKKQPNVAVT MIGDGGTAEG EFYEAMNIAS IHKWNTVFCI NNNQFAISTR
210 220 230 240 250
TKLESAVSDL SVKAIACGIP RVRVDGNDLI ASYEAMQDAA NYARGGNGPV
260 270 280 290 300
LIEFFSYRQG PHTTSDDPSI YRTKQEEEEG MKSDPVKRLR NFLFDRSILN
310 320 330 340 350
QAQEEEMFSK IEQEIQAAYE KMVLDTPVSV DEVFDYNYQE LTPELVEQKQ

IAKKYFKD
Length:358
Mass (Da):40,651
Last modified:February 1, 1996 - v1
Checksum:i9C85D2335F80842E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71496.1
PIRiC64230
RefSeqiWP_009885906.1, NZ_AAGX01000009.1

Genome annotation databases

EnsemblBacteriaiAAC71496; AAC71496; MG_274
KEGGimge:MG_274

Similar proteinsi

Entry informationi

Entry nameiODPA_MYCGE
AccessioniPrimary (citable) accession number: P47516
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names

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