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Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-331-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Ordered Locus Names:MG273
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622231 – 326Pyruvate dehydrogenase E1 component subunit betaAdd BLAST326

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

GO - Molecular functioni

  • glycosylation-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

STRINGi243273.MgenG_010200002649

Structurei

3D structure databases

ProteinModelPortaliP47515
SMRiP47515
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CPP Bacteria
COG0022 LUCA
KOiK00162
OMAiVQERCFH
OrthoDBiPOG091H04FE

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit

Sequencei

Sequence statusi: Complete.

P47515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIQVNNIE ALNNAMDLAL ERDQNVVLYG QDAGFEGGVF RATKGLQQKY
60 70 80 90 100
GSERVWDCPI AENSMAGIGV GAAIGGLKPI VEIQFSGFSF PAMFQIFVHA
110 120 130 140 150
ARIRNRSRGV YTAPLVVRMP MGGGIKALEH HSETLEAIYA QIAGLKTVMP
160 170 180 190 200
SNPYDTKGLF LAAIESPDPV IFFEPKKLYR AFRQEIPSDY YTVPIGEANL
210 220 230 240 250
ISEGSELTIV SYGPTMFDLI NLVYSGELKD KGIELIDLRT ISPWDKQTVF
260 270 280 290 300
NSVKKTGRLL VVTEAVKSFT TSAEIITSVT EELFTYLKKA PQRVTGFDIV
310 320
VPLARGEKYQ FEINARVIDA VNQLLK
Length:326
Mass (Da):36,026
Last modified:February 1, 1996 - v1
Checksum:i7C5A0ECCD8A17DD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71495.1
PIRiB64230
RefSeqiWP_009885905.1, NZ_AAGX01000009.1

Genome annotation databases

EnsemblBacteriaiAAC71495; AAC71495; MG_273
KEGGimge:MG_273

Similar proteinsi

Entry informationi

Entry nameiODPB_MYCGE
AccessioniPrimary (citable) accession number: P47515
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names

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