Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 100 (12 Aug 2020)
Sequence version 1 (01 Feb 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Cytadherence high molecular weight protein 2

Gene

hmw2

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCytadherence, Virulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MGEN243273:G1GJ2-262-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytadherence high molecular weight protein 2
Alternative name(s):
Cytadherence accessory protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hmw2
Ordered Locus Names:MG218
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243273 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000807 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840131 – 1805Cytadherence high molecular weight protein 2Add BLAST1805

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P47460

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243273.MG_218

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P47460

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili28 – 838Sequence analysisAdd BLAST811
Coiled coili914 – 1591Sequence analysisAdd BLAST678
Coiled coili1632 – 1723Sequence analysisAdd BLAST92
Coiled coili1777 – 1804Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0419, Bacteria
COG1196, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_237675_0_0_14

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKDCVSR

Database of Orthologous Groups

More...
OrthoDBi
1963013at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016430, Cytadherence_Hmw2

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004800, Hmw2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47460-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPFDKKPSL QPIYDIGFDD GYLQSEYEKN RSKTDVDKIE NQLLKEIKSL
60 70 80 90 100
EDELKNLKGL KNQAEDNPEL DKKINHLEVD LNRLVNEYKN FQFQKNHMVD
110 120 130 140 150
KVSELDNLTR FYKNELTRLQ QENADFLNSK YANLANFQAN YHNKLNDFHR
160 170 180 190 200
LIENQNQTIN RLNQKINGNQ NLIDNNVALL QNPNITVEKK NYLLNVIDQL
210 220 230 240 250
YNELDQLENQ KRLLSIEYEN TYRELVSADN ELQNVYENID QNQIQFKHQY
260 270 280 290 300
QTYRDELSQL ERKIQLTKQE LVDKESALRV KIDDADFYIN ARLAELDDVA
310 320 330 340 350
KQLSFQDGIT KQNAQHVEDK LVALNKEKDR LNTQKEAFFN LRQSALIDIN
360 370 380 390 400
KLQQENELFA KHLEHQQNEF EQKQSDSLLK LETEYKALQH KINEFKNESA
410 420 430 440 450
TKSEELLNQE RELFEKRREI DTLLTQASLE YEHQRESSQL LKDKQNEVKQ
460 470 480 490 500
HFQNLEYAKK ELDKERNLLD QQKKVDSEAI FQLKEKVAQE RKELEELYLV
510 520 530 540 550
KKQKQDQKEN ELLFFEKQLK QHQADFENEL EAKQQELFEA KHALERSFIK
560 570 580 590 600
LEDKEKDLNT KAQQIANEFS QLKTDKSKSA DFELMLQNEY ENLQQEKQKL
610 620 630 640 650
FQERTYFERN AAVLSNRLQQ KREELLQQKE TLDQLTKSFE QERLINQREH
660 670 680 690 700
KELVASVEKQ KEILGKKLQD FSQTSLNASK NLAEREMAIK FKEKEIEATE
710 720 730 740 750
KQLLNDVNNA EVIQADLAQL NQSLNQERSE LQNAKQRIAD FHNDSLKKLN
760 770 780 790 800
EYELSLQKRL QELQTLEANQ KQHSYQNQAY FEGELDKLNR EKQAFLNLRK
810 820 830 840 850
KQTMEVDAIK QRLSDKHQAL NMQQAELDRK THELNNAFLN HDADQKSLQD
860 870 880 890 900
QLATVKETQK LIDLERSALL EKQREFAENV AGFKRHWSNK TSQLQKIYEL
910 920 930 940 950
TKKQESEQTQ KETELKIAFS DLQKDYQVFE LQKDQEFRQI EAKQRELDKL
960 970 980 990 1000
AEKNNQVKLE LDNRFQALQN QKQDTVQAQL ELEREQHQLN LEQTAFNQAN
1010 1020 1030 1040 1050
ESLLKQREQL TKKIQAFHYE LKKRNQFLAL KGKRLFAKEQ DQQRKDQEIN
1060 1070 1080 1090 1100
WRFKQFEKEY TDFDEAKKRE LEELEKIRRS LSQSNVELER KREKLATDFT
1110 1120 1130 1140 1150
NLNKVQHNTQ INRDQLNSQI RQFLLERKNF QRFSNEANAK KAFLIKRLRS
1160 1170 1180 1190 1200
FASNLKLQKE ALAIQKLEFD KRDEQQKKEL QQATLQLEQF KFEKQNFDIE
1210 1220 1230 1240 1250
KQRQLVAIKT QCEKLSDEKK ALNQKLVELK NLSQTYLANK NKAEYSQQQL
1260 1270 1280 1290 1300
QQKYTNLLDL KENLERTKDQ LDKKHRSIFA RLTKFANDLR FEKKQLLKAQ
1310 1320 1330 1340 1350
RIVDDKNRLL KENERNLHFL SNETERKRAV LEDQISYFEK QRKQATDAIL
1360 1370 1380 1390 1400
ASHKEVKKKE GELQKLLVEL ETRKTKLNND FAKFSRQREE FENQRLKLLE
1410 1420 1430 1440 1450
LQKTLQTQTN SNNFKTKAIQ EIENSYKRGM EELNFQKKEF DKNKSRLYEY
1460 1470 1480 1490 1500
FRKMRDEIER KESQVKLVLK ETQRKANLLE AQANKLNIEK NTIDFKEKEL
1510 1520 1530 1540 1550
KAFKDKVDQD IDSTNKQRKE LNELLNENKL LQQSLIERER AINSKDSLLN
1560 1570 1580 1590 1600
KKIETIKRQL HDKEMRVLRL VDRMKLAEQK YQTEINRLRT QTFDSEKQDI
1610 1620 1630 1640 1650
KNFFPPLFKI NGNDMAFPYL YPWLYPQQKQ DDNTLQIRQL FEQQLQFMQQ
1660 1670 1680 1690 1700
RYENELNELR RQRNLLEKKL DQIQLESQLN NKQSEFSKVE SMMEKLLEKT
1710 1720 1730 1740 1750
ESRLNDFDQK INYLTKKVNQ HNTYQPSSYQ PTPSYQDSDK QQLLFRIQEL
1760 1770 1780 1790 1800
EKQNLFQQQF QPAPAVVQQP TSFAAPNITK QQQIAQLNAE INNIKRLIAQ

KAASK
Length:1,805
Mass (Da):216,253
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11D093AF173284FD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71437.1
U02165 Genomic DNA Translation: AAD12447.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A64224

NCBI Reference Sequences

More...
RefSeqi
WP_010869377.1, NC_000908.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC71437; AAC71437; MG_218

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mge:MG_218

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71437.1
U02165 Genomic DNA Translation: AAD12447.1
PIRiA64224
RefSeqiWP_010869377.1, NC_000908.2

3D structure databases

SMRiP47460
ModBaseiSearch...

Protein-protein interaction databases

STRINGi243273.MG_218

Proteomic databases

PRIDEiP47460

Genome annotation databases

EnsemblBacteriaiAAC71437; AAC71437; MG_218
KEGGimge:MG_218

Phylogenomic databases

eggNOGiCOG0419, Bacteria
COG1196, Bacteria
HOGENOMiCLU_237675_0_0_14
OMAiYKDCVSR
OrthoDBi1963013at2

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-262-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR016430, Cytadherence_Hmw2
PIRSFiPIRSF004800, Hmw2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMW2_MYCGE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47460
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: August 12, 2020
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again