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Entry version 90 (11 Dec 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Uncharacterized ATP-dependent helicase MG140

Gene

MG140

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi313 – 320ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MGEN243273:G1GJ2-162-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized ATP-dependent helicase MG140 (EC:3.6.4.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:MG140
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243273 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000807 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000807281 – 1113Uncharacterized ATP-dependent helicase MG140Add BLAST1113

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P47386

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243273.MG_140

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA2/NAM7 helicase family.Curated

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRERNND

Database of Orthologous Groups

More...
OrthoDBi
616258at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR025103 DUF4011
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit
PF13195 DUF4011, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47386-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDWQWLKNR LVNSKTKSVS FWLPQTSSNI IDIAELIKCC SELKNTSING
60 70 80 90 100
LIDFLNQQDK LEFNLTRLKE IDVEDGKQLF GIETSVYKHF QNEIARFYKQ
110 120 130 140 150
VNKHFRETGS ESLFLALPVI EGINEFNDIF RAPLLYVGVK LKVSPRFERF
160 170 180 190 200
WLEINKEEIF LNPTIIGVET NKRNSLFKNN YDTTKIDVND ALKVFSELEY
210 220 230 240 250
EFRMPLTSEL KSFSKKAKSD FNTEKRTNYL INNVLLGIFD VKGDQLFQNF
260 270 280 290 300
NEILNTDPDV LDELLKDRRD LLLENREFRE QFDLKDTYLF SHLDIYQQYA
310 320 330 340 350
VKQALLGDLI IEGPPGTGKS ETIVNILVNL VLNNKKVLFV SEKVTALDVV
360 370 380 390 400
YNRLGSFKHI ALFNASVAAE KKRFYNQFAE FETYFTTYFS KKDLDATLPT
410 420 430 440 450
FEGKWVDDIL GAFQALQALY DTKINSGENL FSFKEIVSSF QMLDASYIKI
460 470 480 490 500
KEYERFDEWV RVFSNPLWLE KHLSYQELKK ELSQRWNGID NFYQLQSLLN
510 520 530 540 550
QTKKRKVLNY VLEHFEQFNT VISPKHVLFY KPSNKSQLLL KQLKQDVEQY
560 570 580 590 600
TSLQRFQSPT KFETIKLNFI NQVNENPTPW FFSWFIQFHA KPLLEKLVSF
610 620 630 640 650
ESNIIKTKQA YLNGIESYVA SCKKLLKTTI LNNFFQLYQT NKDELLEICR
660 670 680 690 700
QAKNPVLKEI TWWFKKHFEL LKKLFPVHIM TLESAATLTP NQRGLYDYVV
710 720 730 740 750
IDEASQVFLE RAIPILFRAD KYIIAGDTKQ LKPANFFQSR AEYDVDEEFE
760 770 780 790 800
DGNIEAAVHS SSLLHFLKNR SRILTLLKFH YRSDSADLIA FTNNRIYDNE
810 820 830 840 850
LIFMNKANAD QRVFIVHDVI DGIWKNNRNL QEARDVVQRL EQLTTTNDYK
860 870 880 890 900
KSLGVICFNK NQADLIEYLI DKQNNPLLNE WRERQNDVGE YEGLFVKNIE
910 920 930 940 950
NVQGDERDII IFSLGYDRSV NSYGPISKQG GENRLNVAIT RAKQRIELFK
960 970 980 990 1000
TNRGEDYNGL SSSSLGSKLL VEYLLYCEAM AKNQGEKITF QAVKRKETKA
1010 1020 1030 1040 1050
KYELAVENDF FNQLQAIFGG EFEIKRNVNE GAYFFSFVFY FNNIPYLAID
1060 1070 1080 1090 1100
FNIPIPTSRK QVMEGILYRE QFLKKRQWNL INIWIDEWKL NPIGVISKIR
1110
SSLAVHQNQH EEI
Length:1,113
Mass (Da):130,580
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF0C51F926725D3F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti267D → R (PubMed:1945886).Curated1
Sequence conflicti267D → R (PubMed:8253680).Curated1
Sequence conflicti394L → W (PubMed:8253680).Curated1
Sequence conflicti1092 – 1100PIGVISKIR → QLGWFLKSD (PubMed:8253680).Curated9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71358.1
X61512 Genomic DNA Translation: CAA43726.1
U01729 Unassigned DNA Translation: AAC43207.1
U01742 Genomic DNA Translation: AAD10552.1
U02156 Genomic DNA Translation: AAD12438.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E64215

NCBI Reference Sequences

More...
RefSeqi
WP_010869351.1, NC_000908.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC71358; AAC71358; MG_140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mge:MG_140

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71358.1
X61512 Genomic DNA Translation: CAA43726.1
U01729 Unassigned DNA Translation: AAC43207.1
U01742 Genomic DNA Translation: AAD10552.1
U02156 Genomic DNA Translation: AAD12438.1
PIRiE64215
RefSeqiWP_010869351.1, NC_000908.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi243273.MG_140

Proteomic databases

PRIDEiP47386

Genome annotation databases

EnsemblBacteriaiAAC71358; AAC71358; MG_140
KEGGimge:MG_140

Phylogenomic databases

OMAiWRERNND
OrthoDBi616258at2

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-162-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR025103 DUF4011
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13086 AAA_11, 1 hit
PF13087 AAA_12, 1 hit
PF13195 DUF4011, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiY140_MYCGE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47386
Secondary accession number(s): Q49203
, Q49283, Q49445, Q49472
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 11, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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