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Protein

Probable cation-transporting P-type ATPase

Gene

pacL

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could mediate calcium influx.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3314-aspartylphosphate intermediateBy similarity1
Metal bindingi589MagnesiumBy similarity1
Metal bindingi593MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-83-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting P-type ATPase (EC:3.6.3.-)
Gene namesi
Name:pacL
Ordered Locus Names:MG071
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 79ExtracellularSequence analysisAdd BLAST17
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 237CytoplasmicSequence analysisAdd BLAST137
Transmembranei238 – 257HelicalSequence analysisAdd BLAST20
Topological domaini258 – 275ExtracellularSequence analysisAdd BLAST18
Transmembranei276 – 293HelicalSequence analysisAdd BLAST18
Topological domaini294 – 644CytoplasmicSequence analysisAdd BLAST351
Transmembranei645 – 664HelicalSequence analysisAdd BLAST20
Topological domaini665 – 687ExtracellularSequence analysisAdd BLAST23
Transmembranei688 – 708HelicalSequence analysisAdd BLAST21
Topological domaini709 – 726CytoplasmicSequence analysisAdd BLAST18
Transmembranei727 – 749HelicalSequence analysisAdd BLAST23
Topological domaini750 – 770ExtracellularSequence analysisAdd BLAST21
Transmembranei771 – 790HelicalSequence analysisAdd BLAST20
Topological domaini791 – 803CytoplasmicSequence analysisAdd BLAST13
Transmembranei804 – 826HelicalSequence analysisAdd BLAST23
Topological domaini827 – 844ExtracellularSequence analysisAdd BLAST18
Transmembranei845 – 865HelicalSequence analysisAdd BLAST21
Topological domaini866 – 874CytoplasmicSequence analysis9

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461621 – 874Probable cation-transporting P-type ATPaseAdd BLAST874

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi243273.MgenG_010200002846

Structurei

3D structure databases

ProteinModelPortaliP47317
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C52 Bacteria
COG0474 LUCA
KOiK01537
OMAiCRSESKS
OrthoDBiPOG091H02HV

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01494 ATPase_P-type, 4 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

P47317-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSWTGLSEQ AAIKSRQEHG ANFLPEKKAT PFWLLFLQQF KSLVVILLLL
60 70 80 90 100
ASLLSFVVAI VSGLRSNWNF NHDLIIEWVQ PFIILLTVFA NSLIGSIQEF
110 120 130 140 150
KAQKSASALK SLTKSFTRVF RNGELISINV SEVVVGDIIF VDAGDIIPAD
160 170 180 190 200
GKLLQVNNLR CLESFLTGES TPVDKTIDSN EKATILEQTN LVFSGAQVVY
210 220 230 240 250
GSGVFQVEAV GIKTQVGKIA KTVDDSVTKL SPLQQKLEKI GKWFSWFGLG
260 270 280 290 300
LFAVVFLVQT ALLGFDNFTN NWSIALIGAI ALVVAIIPEG LVTFINVIFA
310 320 330 340 350
LSVQKLTKQK AIIKYLSVIE TLGSVQIICT DKTGTLTQNQ MKVVDHFCFN
360 370 380 390 400
STTQTDLARA LCLCNNASIS KDANKTGDPT EIALLEWKDR SQLDLKTYYR
410 420 430 440 450
VYEKAFDSIR KLMTVVVQKD NRFIVIVKGA PDVLLPLCNN VQNEVKNIEN
460 470 480 490 500
LLDQSAGQGL RTLAVALKVL YKFDQNDQKQ IDELENNLEF LGFVSLQDPP
510 520 530 540 550
RKESKEAILA CKKANITPIM ITGDHLKTAT VIAKELGILT LDNQAVLGSE
560 570 580 590 600
LDEKKILDYR VFARVTPQQK LAIVSAWKEA GFTVSVTGDG VNDAPALIKS
610 620 630 640 650
DVGCCMGITG VDIAKDASDL IISDDNFATI VNGIEEGRKT FLTCKRVLLN
660 670 680 690 700
LFLTSIAGTV VVLLGLFILG QVFKTNLLQQ GHDFQVFSPT QLLIINLFVH
710 720 730 740 750
GFPAVALAVQ PVKEKLMVGS FSTKNLFYNR QGFDLIWQSL FLSFLTLLFY
760 770 780 790 800
SLGIIYAINN RDLQTSGDLI NRAGSTCGFF ILGASAALNS LNLMVDKPLL
810 820 830 840 850
MTNPWFFKLV WIGSLASILV FLLIIFINPL GLVFNVLQDL TNHPVLISYS
860 870
FGGVILYMGM NEVVKLIRLG YGNI
Length:874
Mass (Da):96,318
Last modified:February 1, 1996 - v1
Checksum:iEEFAADA0BD4DBF7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71289.1
X61532 Genomic DNA Translation: CAA43744.1
PIRiH64207
RefSeqiWP_009885927.1, NZ_AAGX01000011.1

Genome annotation databases

EnsemblBacteriaiAAC71289; AAC71289; MG_071
KEGGimge:MG_071

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71289.1
X61532 Genomic DNA Translation: CAA43744.1
PIRiH64207
RefSeqiWP_009885927.1, NZ_AAGX01000011.1

3D structure databases

ProteinModelPortaliP47317
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MgenG_010200002846

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71289; AAC71289; MG_071
KEGGimge:MG_071

Phylogenomic databases

eggNOGiENOG4105C52 Bacteria
COG0474 LUCA
KOiK01537
OMAiCRSESKS
OrthoDBiPOG091H02HV

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-83-MONOMER

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01494 ATPase_P-type, 4 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATCL_MYCGE
AccessioniPrimary (citable) accession number: P47317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
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Main funding by: National Institutes of Health

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