pacL

Functionⁱ

Could mediate calcium influx.

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	331	4-aspartylphosphate intermediateBy similarity	1
Metal bindingⁱ	589	MagnesiumBy similarity	1
Metal bindingⁱ	593	MagnesiumBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
hydrolase activity Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MGEN243273:G1GJ2-83-MONOMER

BioCycⁱ

MGEN243273:G1GJ2-83-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable cation-transporting P-type ATPase (EC:3.6.3.-)
Gene namesⁱ	Name:pacL Ordered Locus Names:MG071
Organismⁱ	Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifierⁱ	243273 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium
Proteomesⁱ	UP000000807 Componentⁱ: Chromosome

Subcellular locationⁱ

Cell membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 41	CytoplasmicSequence analysisAdd BLAST	41
Transmembraneⁱ	42 – 62	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	63 – 79	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	80 – 100	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	101 – 237	CytoplasmicSequence analysisAdd BLAST	137
Transmembraneⁱ	238 – 257	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	258 – 275	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	276 – 293	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	294 – 644	CytoplasmicSequence analysisAdd BLAST	351
Transmembraneⁱ	645 – 664	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	665 – 687	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	688 – 708	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	709 – 726	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	727 – 749	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	750 – 770	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	771 – 790	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	791 – 803	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	804 – 826	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	827 – 844	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	845 – 865	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	866 – 874	CytoplasmicSequence analysis	9

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046162	1 – 874	Probable cation-transporting P-type ATPaseAdd BLAST		874

Keywords - PTMⁱ

Phosphoprotein

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	243273.MgenG_010200002846

STRINGⁱ

243273.MgenG_010200002846

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47317
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type II subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105C52 Bacteria COG0474 LUCA
KEGG Orthology (KO) More...KOⁱ	K01537
OMAⁱ	CRSESKS
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02HV

Family and domain databases

Gene3Dⁱ	3.40.1110.10, 2 hits 3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR006068 ATPase_P-typ_cation-transptr_C IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR001757 P_typ_ATPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00689 Cation_ATPase_C, 1 hit PF00690 Cation_ATPase_N, 1 hit
PRINTSⁱ	PR00120 HATPASE
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 2 hits SSF81653 SSF81653, 1 hit SSF81665 SSF81665, 3 hits
TIGRFAMsⁱ	TIGR01494 ATPase_P-type, 4 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P47317-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNSWTGLSEQ AAIKSRQEHG ANFLPEKKAT PFWLLFLQQF KSLVVILLLL 
        60         70         80         90        100
ASLLSFVVAI VSGLRSNWNF NHDLIIEWVQ PFIILLTVFA NSLIGSIQEF 
       110        120        130        140        150
KAQKSASALK SLTKSFTRVF RNGELISINV SEVVVGDIIF VDAGDIIPAD 
       160        170        180        190        200
GKLLQVNNLR CLESFLTGES TPVDKTIDSN EKATILEQTN LVFSGAQVVY 
       210        220        230        240        250
GSGVFQVEAV GIKTQVGKIA KTVDDSVTKL SPLQQKLEKI GKWFSWFGLG 
       260        270        280        290        300
LFAVVFLVQT ALLGFDNFTN NWSIALIGAI ALVVAIIPEG LVTFINVIFA 
       310        320        330        340        350
LSVQKLTKQK AIIKYLSVIE TLGSVQIICT DKTGTLTQNQ MKVVDHFCFN 
       360        370        380        390        400
STTQTDLARA LCLCNNASIS KDANKTGDPT EIALLEWKDR SQLDLKTYYR 
       410        420        430        440        450
VYEKAFDSIR KLMTVVVQKD NRFIVIVKGA PDVLLPLCNN VQNEVKNIEN 
       460        470        480        490        500
LLDQSAGQGL RTLAVALKVL YKFDQNDQKQ IDELENNLEF LGFVSLQDPP 
       510        520        530        540        550
RKESKEAILA CKKANITPIM ITGDHLKTAT VIAKELGILT LDNQAVLGSE 
       560        570        580        590        600
LDEKKILDYR VFARVTPQQK LAIVSAWKEA GFTVSVTGDG VNDAPALIKS 
       610        620        630        640        650
DVGCCMGITG VDIAKDASDL IISDDNFATI VNGIEEGRKT FLTCKRVLLN 
       660        670        680        690        700
LFLTSIAGTV VVLLGLFILG QVFKTNLLQQ GHDFQVFSPT QLLIINLFVH 
       710        720        730        740        750
GFPAVALAVQ PVKEKLMVGS FSTKNLFYNR QGFDLIWQSL FLSFLTLLFY 
       760        770        780        790        800
SLGIIYAINN RDLQTSGDLI NRAGSTCGFF ILGASAALNS LNLMVDKPLL 
       810        820        830        840        850
MTNPWFFKLV WIGSLASILV FLLIIFINPL GLVFNVLQDL TNHPVLISYS 
       860        870 
FGGVILYMGM NEVVKLIRLG YGNI

Length:874

Mass (Da):96,318

Last modified:February 1, 1996 - v1

Checksum:ⁱEEFAADA0BD4DBF7D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L43967 Genomic DNA Translation: AAC71289.1 X61532 Genomic DNA Translation: CAA43744.1
PIRⁱ	H64207
NCBI Reference Sequences More...RefSeqⁱ	WP_009885927.1, NZ_AAGX01000011.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC71289; AAC71289; MG_071
KEGGⁱ	mge:MG_071

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47317	Probable cation-transporting P-type ATPase		MYCPN		872	UniRef50_P47317
E1-E2 ATPase		MYCPB		872
UPI00027B397B		MYCGT		874
UPI00080432D9		MYCPM		872
UPI00027B33FD		MYCGT		874
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L43967 Genomic DNA Translation: AAC71289.1 X61532 Genomic DNA Translation: CAA43744.1
PIRⁱ	H64207
RefSeqⁱ	WP_009885927.1, NZ_AAGX01000011.1

3D structure databases

ProteinModelPortalⁱ	P47317
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	243273.MgenG_010200002846

STRINGⁱ

243273.MgenG_010200002846

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC71289; AAC71289; MG_071
KEGGⁱ	mge:MG_071

Phylogenomic databases

eggNOGⁱ	ENOG4105C52 Bacteria COG0474 LUCA
KOⁱ	K01537
OMAⁱ	CRSESKS
OrthoDBⁱ	POG091H02HV

Enzyme and pathway databases

BioCycⁱ	MGEN243273:G1GJ2-83-MONOMER

BioCycⁱ

MGEN243273:G1GJ2-83-MONOMER

Family and domain databases

Gene3Dⁱ	3.40.1110.10, 2 hits 3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR006068 ATPase_P-typ_cation-transptr_C IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR001757 P_typ_ATPase
Pfamⁱ	View protein in Pfam PF00689 Cation_ATPase_C, 1 hit PF00690 Cation_ATPase_N, 1 hit
PRINTSⁱ	PR00120 HATPASE
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 2 hits SSF81653 SSF81653, 1 hit SSF81665 SSF81665, 3 hits
TIGRFAMsⁱ	TIGR01494 ATPase_P-type, 4 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATCL_MYCGE
Accessionⁱ	P47317Primary (citable) accession number: P47317
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	February 28, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Mycoplasma genitalium
Mycoplasma genitalium (strain G-37): entries and gene names

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P47317 (ATCL_MYCGE)

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Probable cation-transporting P-type ATPase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ