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Entry version 142 (17 Jun 2020)
Sequence version 1 (01 Feb 1996)
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Protein

PTS system glucose-specific EIICBA component

Gene

ptsG

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei653Phosphocysteine intermediate; for EIIB activityPROSITE-ProRule annotation1
Active sitei815Tele-phosphohistidine intermediate; for EIIA activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MGEN243273:G1GJ2-81-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PTS system glucose-specific EIICBA componentBy similarity (EC:2.7.1.199By similarity)
Alternative name(s):
EII-Glc/EIII-Glc
EIICBA-GlcBy similarity
EIICBA-Glc 1Curated
Including the following 3 domains:
Glucose permease IIC componentBy similarity
Alternative name(s):
PTS system glucose-specific EIIC componentBy similarity
Glucose-specific phosphotransferase enzyme IIB componentBy similarity
Alternative name(s):
PTS system glucose-specific EIIB componentBy similarity
Glucose-specific phosphotransferase enzyme IIA componentBy similarity
Alternative name(s):
PTS system glucose-specific EIIA componentBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ptsG
Ordered Locus Names:MG069
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243273 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000807 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 51HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei71 – 91HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei100 – 120HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei155 – 175HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei189 – 209HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei459 – 479HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei487 – 507HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei509 – 529HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei536 – 556HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei571 – 591HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001865591 – 908PTS system glucose-specific EIICBA componentAdd BLAST908

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P47315

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243273.MG_069

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P47315

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 264PTS EIIC type-1; first partPROSITE-ProRule annotationAdd BLAST264
Domaini451 – 602PTS EIIC type-1; second partPROSITE-ProRule annotationAdd BLAST152
Domaini631 – 713PTS EIIB type-1PROSITE-ProRule annotationAdd BLAST83
Domaini762 – 875PTS EIIA type-1PROSITE-ProRule annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni265 – 450UnknownAdd BLAST186

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation
The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.PROSITE-ProRule annotation
The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CI1 Bacteria
COG1263 LUCA
COG1264 LUCA
COG2190 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012312_1_1_14

KEGG Orthology (KO)

More...
KOi
K20118

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWAFNRF

Database of Orthologous Groups

More...
OrthoDBi
2035550at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00212 PTS_IIB_glc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.70.10, 1 hit
3.30.1360.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011055 Dup_hybrid_motif
IPR036878 Glu_permease_IIB
IPR018113 PTrfase_EIIB_Cys
IPR001127 PTS_EIIA_1_perm
IPR003352 PTS_EIIC
IPR013013 PTS_EIIC_1
IPR001996 PTS_IIB_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00358 PTS_EIIA_1, 1 hit
PF00367 PTS_EIIB, 1 hit
PF02378 PTS_EIIC, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51261 SSF51261, 1 hit
SSF55604 SSF55604, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00826 EIIB_glc, 1 hit
TIGR00830 PTBA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51093 PTS_EIIA_TYPE_1, 1 hit
PS00371 PTS_EIIA_TYPE_1_HIS, 1 hit
PS51098 PTS_EIIB_TYPE_1, 1 hit
PS51103 PTS_EIIC_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQISLVKIRN KFKQRNRGSF RQWVGKLSNG LMIPIAVLPL AGIFLGIGDA
60 70 80 90 100
ISSNSSGIVG VKFFGEFIKQ GGNVVFANLP ILFAVAIAIT FSQDAGVAGF
110 120 130 140 150
SAFVFWATMN AFMSSLIIPV DANNTASGYN ILYWKAVPQS AIASTLGLNS
160 170 180 190 200
LSTSVFGGII VGALTAYLYN KFYAIRLPDV IGFFSGTRFV PIICMTIAIP
210 220 230 240 250
VALLLLMVWP GVSILLNLIG TGLGILGGRG YGANSLIFGY IERALIPFGV
260 270 280 290 300
HHAFYAPLWY TSAGGSLQEI ANQQVWIRAP GSDYVTRVIG WEDFNTPGKW
310 320 330 340 350
VIPAALANGT SGMMNGATTT GQDSTSALSK YMSKESTNFL SWKELVDGLT
360 370 380 390 400
RKGNFDELAK NGLLDGSNKI WIGLNQSGIL GKKVLLSDGK DYTITFKTFA
410 420 430 440 450
NTTPTFWSHG AHALLPISGT PSAITNGVTV NGTANSKTYN VSQFTVAVPS
460 470 480 490 500
LNPAQYSQGK FPFMLIGIPA AGLAMILAAP KGRRKEASSI IGSAAFTSFL
510 520 530 540 550
TGITEPFEFT FLFLAPWLFY GIHAVLAAVS FWLMNLLSAN VGQTFSGSFI
560 570 580 590 600
DFILYGALPD GRGWLANSYL VPIIGIFLAL IYFPTFYFLT IRFNLATPGR
610 620 630 640 650
GGKLITKKEY LAAKAAQKTD QTTNTNFNQT QIEAGMLLRA YGGSENIAEL
660 670 680 690 700
GACITKLRVT VKNPELVNET IIKDLGAAGV MRTTPTFFVA VFGTRAAVYK
710 720 730 740 750
SAMQDIIQGK VNWTELQKVL DKNDSTVEKP EIKPTPVLKV QDEIVILSPV
760 770 780 790 800
NGTLKPLTQV PDDTFKNRLV GDGIAILPSD GHFKAPGDVG VKTELAFPTG
810 820 830 840 850
HAFIFDVDGV KVMLHIGIDT VKINADKKPG EQLEVFDVKT KQGEYTKLKS
860 870 880 890 900
ESVVEVDLKK LKRKYDPITP FIVMQESLDN FKLVPIRQRG EIKVGQPLFK

LIYKDKKS
Length:908
Mass (Da):98,399
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA079970CF625D9E5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71287.1
U02207 Genomic DNA Translation: AAD12499.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F64207

NCBI Reference Sequences

More...
RefSeqi
WP_009885925.1, NZ_AAGX01000011.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC71287; AAC71287; MG_069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mge:MG_069

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71287.1
U02207 Genomic DNA Translation: AAD12499.1
PIRiF64207
RefSeqiWP_009885925.1, NZ_AAGX01000011.1

3D structure databases

SMRiP47315
ModBaseiSearch...

Protein-protein interaction databases

STRINGi243273.MG_069

Proteomic databases

PRIDEiP47315

Genome annotation databases

EnsemblBacteriaiAAC71287; AAC71287; MG_069
KEGGimge:MG_069

Phylogenomic databases

eggNOGiENOG4105CI1 Bacteria
COG1263 LUCA
COG1264 LUCA
COG2190 LUCA
HOGENOMiCLU_012312_1_1_14
KOiK20118
OMAiAWAFNRF
OrthoDBi2035550at2

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-81-MONOMER

Family and domain databases

CDDicd00212 PTS_IIB_glc, 1 hit
Gene3Di2.70.70.10, 1 hit
3.30.1360.60, 1 hit
InterProiView protein in InterPro
IPR011055 Dup_hybrid_motif
IPR036878 Glu_permease_IIB
IPR018113 PTrfase_EIIB_Cys
IPR001127 PTS_EIIA_1_perm
IPR003352 PTS_EIIC
IPR013013 PTS_EIIC_1
IPR001996 PTS_IIB_1
PfamiView protein in Pfam
PF00358 PTS_EIIA_1, 1 hit
PF00367 PTS_EIIB, 1 hit
PF02378 PTS_EIIC, 2 hits
SUPFAMiSSF51261 SSF51261, 1 hit
SSF55604 SSF55604, 1 hit
TIGRFAMsiTIGR00826 EIIB_glc, 1 hit
TIGR00830 PTBA, 1 hit
PROSITEiView protein in PROSITE
PS51093 PTS_EIIA_TYPE_1, 1 hit
PS00371 PTS_EIIA_TYPE_1_HIS, 1 hit
PS51098 PTS_EIIB_TYPE_1, 1 hit
PS51103 PTS_EIIC_TYPE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTG3C_MYCGE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47315
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 17, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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