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Protein

Paired box protein Pax-7

Gene

Pax7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi215 – 274HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: MGI
  • sequence-specific DNA binding Source: MGI
  • transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding Source: MGI

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • cartilage development Source: MGI
  • chromatin remodeling Source: MGI
  • dorsal/ventral neural tube patterning Source: MGI
  • embryonic skeletal system development Source: MGI
  • muscle tissue morphogenesis Source: MGI
  • neuron fate commitment Source: MGI
  • positive regulation of histone methylation Source: MGI
  • positive regulation of myoblast proliferation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell fate commitment Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of protein binding Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • skeletal muscle satellite cell commitment Source: MGI
  • skeletal muscle tissue development Source: MGI
  • skeletal muscle tissue regeneration Source: MGI
  • spinal cord association neuron differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processMyogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-7
Gene namesi
Name:Pax7
Synonyms:Pax-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97491 Pax7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501951 – 503Paired box protein Pax-7Add BLAST503

Proteomic databases

MaxQBiP47239
PaxDbiP47239
PRIDEiP47239

PTM databases

iPTMnetiP47239
PhosphoSitePlusiP47239

Expressioni

Developmental stagei

Expressed specifically during the development of the nervous and muscular system.1 Publication

Gene expression databases

BgeeiENSMUSG00000028736
CleanExiMM_PAX7
ExpressionAtlasiP47239 baseline and differential
GenevisibleiP47239 MM

Interactioni

Subunit structurei

Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX (By similarity). Interacts with PAXBP1; the interaction links PAX7 to a WDR5-containing histone methyltransferase complex (PubMed:22862948).By similarity1 Publication

Protein-protein interaction databases

BioGridi202034, 1 interactor
CORUMiP47239
STRINGi10090.ENSMUSP00000030508

Structurei

3D structure databases

ProteinModelPortaliP47239
SMRiP47239
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 161PairedPROSITE-ProRule annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 208Sufficient to mediate interaction with PAXBP11 PublicationAdd BLAST182

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi477 – 489OARPROSITE-ProRule annotationAdd BLAST13

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiKOG0849 Eukaryota
ENOG410XS01 LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230939
HOVERGENiHBG009115
InParanoidiP47239
KOiK09381
PhylomeDBiP47239
TreeFamiTF351610

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
IPR001523 Paired_dom
IPR022106 Pax7_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00292 PAX, 1 hit
PF12360 Pax7, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALPGAVPR MMRPGPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP
60 70 80 90 100
LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA
110 120 130 140 150
IGGSKPRQVA TPDVEKKIEE YKRENPGMFS WEIRDRLLKD GHCDRSTVPS
160 170 180 190 200
VSSISRVLRI KFGKKEDDEE GDKKEEDGEK KAKHSIDGIL GDKGNRLDEG
210 220 230 240 250
SDVESEPDLP LKRKQRRSRT TFTAEQLEEL EKAFERTHYP DIYTREELAQ
260 270 280 290 300
RTKLTEARVQ VWFSNRRARW RKQAGANQLA AFNHLLPGGF PPTGMPTLPP
310 320 330 340 350
YQLPDSTYPT TTISQDGGST VHRPQPLPPS TMHQGGLAAA AAAADTSSAY
360 370 380 390 400
GARHSFSSYS DSFMNPGAPS NHMNPVSNGL SPQVMSILSN PSAVPPQPQA
410 420 430 440 450
DFSISPLHGG LDSASSISAS CSQRADSIKP GDSLPTSQSY CPPTYSTTGY
460 470 480 490 500
SVDPVAGYQY SQYGQTAVDY LAKNVSLSTQ RRMKLGEHSA VLGLLPVETG

QAY
Length:503
Mass (Da):54,939
Last modified:September 27, 2004 - v2
Checksum:i8ECC952C5C2FCA27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60V → VV in AAA64491 (PubMed:1982921).Curated1
Sequence conflicti137L → W in AAA64491 (PubMed:1982921).Curated1
Sequence conflicti202D → G in AAA64491 (PubMed:1982921).Curated1
Sequence conflicti259V → F in AAA64491 (PubMed:1982921).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254422 mRNA Translation: AAG16663.3
U20792 mRNA Translation: AAA64491.1
CCDSiCCDS18850.1
PIRiI49265
RefSeqiNP_035169.1, NM_011039.2
UniGeneiMm.218760

Genome annotation databases

EnsembliENSMUST00000030508; ENSMUSP00000030508; ENSMUSG00000028736
GeneIDi18509
KEGGimmu:18509
UCSCiuc008vms.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPAX7_MOUSE
AccessioniPrimary (citable) accession number: P47239
Secondary accession number(s): Q9ES16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2004
Last modified: March 28, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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