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Protein

Guanine nucleotide exchange factor MSS4

Gene

RABIF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi26ZincPROSITE-ProRule annotation1
Metal bindingi94ZincPROSITE-ProRule annotation1
Metal bindingi97ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor MSS4
Alternative name(s):
Rab-interacting factor
Gene namesi
Name:RABIF
Synonyms:MSS4, RASGRF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183155.4
HGNCiHGNC:9797 RABIF
MIMi603417 gene
neXtProtiNX_P47224

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5877
OpenTargetsiENSG00000183155
PharmGKBiPA34158

Polymorphism and mutation databases

BioMutaiRABIF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741741 – 123Guanine nucleotide exchange factor MSS4Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP47224
MaxQBiP47224
PaxDbiP47224
PeptideAtlasiP47224
PRIDEiP47224
ProteomicsDBi55784
TopDownProteomicsiP47224

PTM databases

iPTMnetiP47224
PhosphoSitePlusiP47224

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000183155 Expressed in 216 organ(s), highest expression level in cervix squamous epithelium
CleanExiHS_RABIF
GenevisibleiP47224 HS

Organism-specific databases

HPAiHPA027715
HPA054936

Interactioni

Subunit structurei

Interacts with RAB8A.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111815, 49 interactors
IntActiP47224, 26 interactors
MINTiP47224
STRINGi9606.ENSP00000356231

Structurei

Secondary structure

1123
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP47224
SMRiP47224
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47224

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 123MSS4PROSITE-ProRule annotationAdd BLAST115

Sequence similaritiesi

Belongs to the DSS4/MSS4 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4113 Eukaryota
ENOG4111UFA LUCA
GeneTreeiENSGT00390000016889
HOGENOMiHOG000007903
HOVERGENiHBG006402
InParanoidiP47224
KOiK19952
OMAiGPIGWHD
OrthoDBiEOG091G0XXM
PhylomeDBiP47224
TreeFamiTF314029

Family and domain databases

CDDicd00246 RabGEF, 1 hit
Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR007515 Mss4
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumour
PANTHERiPTHR13276 PTHR13276, 1 hit
PfamiView protein in Pfam
PF04421 Mss4, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS51796 MSS4, 1 hit

Sequencei

Sequence statusi: Complete.

P47224-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPAEQPSEL VSAEGRNRKA VLCQRCGSRV LQPGTALFSR RQLFLPSMRK
60 70 80 90 100
KPALSDGSNP DGDLLQEHWL VEDMFIFENV GFTKDVGNIK FLVCADCEIG
110 120
PIGWHCLDDK NSFYVALERV SHE
Length:123
Mass (Da):13,839
Last modified:November 1, 1997 - v2
Checksum:i78E98395FAE10257
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 6EQ → DE in AAB34955 (PubMed:7619808).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78873 mRNA Translation: AAB34955.1
U74324 mRNA Translation: AAB18264.1
BT007133 mRNA Translation: AAP35797.1
AK311900 mRNA Translation: BAG34841.1
CH471067 Genomic DNA Translation: EAW91443.1
BC018488 mRNA Translation: AAH18488.1
BC037392 mRNA Translation: AAH37392.1
CCDSiCCDS1428.1
PIRiI52427
RefSeqiNP_002862.2, NM_002871.4
UniGeneiHs.90875

Genome annotation databases

EnsembliENST00000367262; ENSP00000356231; ENSG00000183155
GeneIDi5877
KEGGihsa:5877
UCSCiuc001gyl.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78873 mRNA Translation: AAB34955.1
U74324 mRNA Translation: AAB18264.1
BT007133 mRNA Translation: AAP35797.1
AK311900 mRNA Translation: BAG34841.1
CH471067 Genomic DNA Translation: EAW91443.1
BC018488 mRNA Translation: AAH18488.1
BC037392 mRNA Translation: AAH37392.1
CCDSiCCDS1428.1
PIRiI52427
RefSeqiNP_002862.2, NM_002871.4
UniGeneiHs.90875

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FWQNMR-A1-123[»]
2FU5X-ray2.00A/B11-123[»]
ProteinModelPortaliP47224
SMRiP47224
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111815, 49 interactors
IntActiP47224, 26 interactors
MINTiP47224
STRINGi9606.ENSP00000356231

PTM databases

iPTMnetiP47224
PhosphoSitePlusiP47224

Polymorphism and mutation databases

BioMutaiRABIF

Proteomic databases

EPDiP47224
MaxQBiP47224
PaxDbiP47224
PeptideAtlasiP47224
PRIDEiP47224
ProteomicsDBi55784
TopDownProteomicsiP47224

Protocols and materials databases

DNASUi5877
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367262; ENSP00000356231; ENSG00000183155
GeneIDi5877
KEGGihsa:5877
UCSCiuc001gyl.4 human

Organism-specific databases

CTDi5877
DisGeNETi5877
EuPathDBiHostDB:ENSG00000183155.4
GeneCardsiRABIF
HGNCiHGNC:9797 RABIF
HPAiHPA027715
HPA054936
MIMi603417 gene
neXtProtiNX_P47224
OpenTargetsiENSG00000183155
PharmGKBiPA34158
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4113 Eukaryota
ENOG4111UFA LUCA
GeneTreeiENSGT00390000016889
HOGENOMiHOG000007903
HOVERGENiHBG006402
InParanoidiP47224
KOiK19952
OMAiGPIGWHD
OrthoDBiEOG091G0XXM
PhylomeDBiP47224
TreeFamiTF314029

Miscellaneous databases

EvolutionaryTraceiP47224
GeneWikiiRABIF
GenomeRNAii5877
PROiPR:P47224
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183155 Expressed in 216 organ(s), highest expression level in cervix squamous epithelium
CleanExiHS_RABIF
GenevisibleiP47224 HS

Family and domain databases

CDDicd00246 RabGEF, 1 hit
Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR007515 Mss4
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumour
PANTHERiPTHR13276 PTHR13276, 1 hit
PfamiView protein in Pfam
PF04421 Mss4, 1 hit
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS51796 MSS4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMSS4_HUMAN
AccessioniPrimary (citable) accession number: P47224
Secondary accession number(s): B2R4P4, Q92992
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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