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Protein

Galanin receptor type 1

Gene

GALR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.2 Publications

GO - Molecular functioni

  • galanin receptor activity Source: UniProtKB
  • G protein-coupled peptide receptor activity Source: GO_Central
  • neuropeptide binding Source: Ensembl
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 1
Short name:
GAL1-R
Short name:
GALR-1
Gene namesi
Name:GALR1
Synonyms:GALNR, GALNR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000166573.5
HGNCiHGNC:4132 GALR1
MIMi600377 gene
neXtProtiNX_P47211

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 70CytoplasmicSequence analysisAdd BLAST13
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 109ExtracellularSequence analysisAdd BLAST18
Transmembranei110 – 131Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini132 – 151CytoplasmicSequence analysisAdd BLAST20
Transmembranei152 – 172Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini173 – 200ExtracellularSequence analysisAdd BLAST28
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 248CytoplasmicSequence analysisAdd BLAST27
Transmembranei249 – 269Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini270 – 271ExtracellularSequence analysis2
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 349CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2587
OpenTargetsiENSG00000166573
PharmGKBiPA28545

Chemistry databases

ChEMBLiCHEMBL4894
GuidetoPHARMACOLOGYi243

Polymorphism and mutation databases

BioMutaiGALR1
DMDMi311033447

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694631 – 349Galanin receptor type 1Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi108 ↔ 187PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi320S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP47211
PRIDEiP47211
ProteomicsDBi55783

PTM databases

iPTMnetiP47211
PhosphoSitePlusiP47211

Expressioni

Gene expression databases

BgeeiENSG00000166573 Expressed in 65 organ(s), highest expression level in adenohypophysis
CleanExiHS_GALR1
GenevisibleiP47211 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GALP224662EBI-6624741,EBI-6624800

Protein-protein interaction databases

IntActiP47211, 2 interactors
STRINGi9606.ENSP00000299727

Chemistry databases

BindingDBiP47211

Structurei

3D structure databases

ProteinModelPortaliP47211
SMRiP47211
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150908
HOGENOMiHOG000230487
HOVERGENiHBG101447
InParanoidiP47211
KOiK04230
OMAiKQVFKCH
OrthoDBiEOG091G0ZDG
PhylomeDBiP47211
TreeFamiTF315737

Family and domain databases

CDDicd15098 7tmA_Gal1_R, 1 hit
InterProiView protein in InterPro
IPR003906 GAL1_rcpt
IPR000405 Galanin_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01418 GALANIN1R
PR00663 GALANINR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG
60 70 80 90 100
NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT
110 120 130 140 150
WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR
160 170 180 190 200
NALLGVGCIW ALSIAMASPV AYHQGLFHPR ASNQTFCWEQ WPDPRHKKAY
210 220 230 240 250
VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA SKKKTAQTVL
260 270 280 290 300
VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP
310 320 330 340
IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV
Length:349
Mass (Da):38,953
Last modified:November 2, 2010 - v3
Checksum:iA0664227157B3410
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00351415W → C2 PublicationsCorresponds to variant dbSNP:rs1143093Ensembl.1
Natural variantiVAR_014682334S → N7 PublicationsCorresponds to variant dbSNP:rs5376Ensembl.1
Natural variantiVAR_014683342P → L. Corresponds to variant dbSNP:rs5377Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34339 mRNA Translation: AAA50767.1
U53511 mRNA Translation: AAC51936.1
U90660, U90658, U90659 Genomic DNA Translation: AAC95397.1
U23854 mRNA Translation: AAB60356.1
AY541036 mRNA Translation: AAS47032.1
AC100863 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66603.1
BC095530 mRNA Translation: AAH95530.1
CCDSiCCDS12012.1
PIRiI59336
RefSeqiNP_001471.2, NM_001480.3
UniGeneiHs.272191

Genome annotation databases

EnsembliENST00000299727; ENSP00000299727; ENSG00000166573
GeneIDi2587
KEGGihsa:2587
UCSCiuc002lms.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34339 mRNA Translation: AAA50767.1
U53511 mRNA Translation: AAC51936.1
U90660, U90658, U90659 Genomic DNA Translation: AAC95397.1
U23854 mRNA Translation: AAB60356.1
AY541036 mRNA Translation: AAS47032.1
AC100863 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66603.1
BC095530 mRNA Translation: AAH95530.1
CCDSiCCDS12012.1
PIRiI59336
RefSeqiNP_001471.2, NM_001480.3
UniGeneiHs.272191

3D structure databases

ProteinModelPortaliP47211
SMRiP47211
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47211, 2 interactors
STRINGi9606.ENSP00000299727

Chemistry databases

BindingDBiP47211
ChEMBLiCHEMBL4894
GuidetoPHARMACOLOGYi243

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47211
PhosphoSitePlusiP47211

Polymorphism and mutation databases

BioMutaiGALR1
DMDMi311033447

Proteomic databases

PaxDbiP47211
PRIDEiP47211
ProteomicsDBi55783

Protocols and materials databases

DNASUi2587
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299727; ENSP00000299727; ENSG00000166573
GeneIDi2587
KEGGihsa:2587
UCSCiuc002lms.5 human

Organism-specific databases

CTDi2587
DisGeNETi2587
EuPathDBiHostDB:ENSG00000166573.5
GeneCardsiGALR1
H-InvDBiHIX0039721
HGNCiHGNC:4132 GALR1
MIMi600377 gene
neXtProtiNX_P47211
OpenTargetsiENSG00000166573
PharmGKBiPA28545
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150908
HOGENOMiHOG000230487
HOVERGENiHBG101447
InParanoidiP47211
KOiK04230
OMAiKQVFKCH
OrthoDBiEOG091G0ZDG
PhylomeDBiP47211
TreeFamiTF315737

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiGalanin_receptor_1
GenomeRNAii2587
PROiPR:P47211
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166573 Expressed in 65 organ(s), highest expression level in adenohypophysis
CleanExiHS_GALR1
GenevisibleiP47211 HS

Family and domain databases

CDDicd15098 7tmA_Gal1_R, 1 hit
InterProiView protein in InterPro
IPR003906 GAL1_rcpt
IPR000405 Galanin_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01418 GALANIN1R
PR00663 GALANINR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGALR1_HUMAN
AccessioniPrimary (citable) accession number: P47211
Secondary accession number(s): Q4VBL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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