UniProtKB - P47191 (SYT1_CHICK)
Protein
Synaptotagmin-1
Gene
SYT1
Organism
Gallus gallus (Chicken)
Status
Functioni
Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes.By similarity
Cofactori
Ca2+PROSITE-ProRule annotationNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 174 | Calcium 2; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 175 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 175 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 181 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 233 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 233 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 234 | Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 235 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 235 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 235 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 238 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 239 | Calcium 3; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 241 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 241 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 306 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 306 | Calcium 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 312 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 366 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 366 | Calcium 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 368 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 368 | Calcium 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 374 | Calcium 5PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: GO_Central
- calcium ion binding Source: GO_Central
- clathrin binding Source: GO_Central
- phosphatidylserine binding Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: GO_Central
GO - Biological processi
- calcium-ion regulated exocytosis Source: GO_Central
- calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
- cell differentiation Source: UniProtKB-KW
- cellular response to calcium ion Source: GO_Central
- regulation of calcium ion-dependent exocytosis Source: GO_Central
- regulation of dopamine secretion Source: GO_Central
- synaptic vesicle endocytosis Source: GO_Central
- synaptic vesicle exocytosis Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | Differentiation |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-GGA-210500, Glutamate Neurotransmitter Release Cycle R-GGA-264642, Acetylcholine Neurotransmitter Release Cycle R-GGA-8856825, Cargo recognition for clathrin-mediated endocytosis R-GGA-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-1Alternative name(s): Synaptotagmin I Short name: SytI p65 |
Gene namesi | Name:SYT1 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Other locations
- secretory vesicle membrane By similarity; Single-pass membrane protein Sequence analysis
- synaptic vesicle membrane By similarity; Single-pass membrane protein By similarity
- chromaffin granule membrane By similarity; Single-pass membrane protein By similarity
- Cytoplasm By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- axon Source: GO_Central
- chromaffin granule membrane Source: UniProtKB-SubCell
- dense core granule Source: GO_Central
- exocytic vesicle Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- synaptic vesicle membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 60 | VesicularSequence analysisAdd BLAST | 60 | |
Transmembranei | 61 – 82 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 83 – 424 | CytoplasmicSequence analysisAdd BLAST | 342 |
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoplasmic vesicle, Membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183941 | 1 – 424 | Synaptotagmin-1Add BLAST | 424 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 77 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 78 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 80 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 82 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 85 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P47191 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000010319, Expressed in brain and 7 other tissues |
ExpressionAtlasi | P47191, baseline and differential |
Interactioni
Subunit structurei
Homotetramer.
CuratedGO - Molecular functioni
- clathrin binding Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000042359 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 144 – 263 | C2 1PROSITE-ProRule annotationAdd BLAST | 120 | |
Domaini | 275 – 408 | C2 2PROSITE-ProRule annotationAdd BLAST | 134 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 138 – 384 | Phospholipid bindingCuratedAdd BLAST | 247 |
Domaini
The first C2 domain mediates Ca2+-dependent phospholipid binding.By similarity
The second C2 domain mediates interaction with SV2A and probably with STN2.By similarity
Sequence similaritiesi
Belongs to the synaptotagmin family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000155394 |
HOGENOMi | CLU_023008_0_1_1 |
InParanoidi | P47191 |
OrthoDBi | 925064at2759 |
PhylomeDBi | P47191 |
TreeFami | TF315600 |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR015428, Synaptotagmin1 |
PANTHERi | PTHR10024:SF239, PTHR10024:SF239, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P47191-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSESHHEAL AAPPATTVAA ALPSNVTEPA APGGGGGKED AFSNLKKKFM
60 70 80 90 100
NELNKIPLPP WALIAIAIVA VLLILTCCFC LCKKCLFKKK NKKKGKEKGG
110 120 130 140 150
KNAINMKDVK DLGKTMKDQA LKDDDAETGL TDGEEKEEPK EVEKLGKIQY
160 170 180 190 200
SLDYDFQNNQ LLVGIIQAAE LPALDMGGTS DPYVKVFLLP DKKKKYETKV
210 220 230 240 250
HRKTLNPVFN EQFTFKVPYS ELGGKTLVMA VYDFDRFSKH DIIGEYKVAM
260 270 280 290 300
NTVDFGHVTE EWRDLQSAEK EEQEKLGDIC FSLRYVPTAG KLTVVILEAK
310 320 330 340 350
NLKKMDVGGL SDPYVKIHLM QNGKRLKKKK TTIKKNTLNP YYNESFSFEV
360 370 380 390 400
PFEQIQKVQI VVTVLDYDKI GKNDAIGKVF VGYNSTGAEL RHWSDMLANP
410 420
RRPIAQWHTL QPEEEVDAML AVKK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketR4GIX6 | R4GIX6_CHICK | Synaptotagmin-1 | SYT1 | 430 | Annotation score: | ||
A0A3Q2U6N8 | A0A3Q2U6N8_CHICK | Synaptotagmin-1 | SYT1 | 421 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S64957 mRNA Translation: AAB28081.1 |
PIRi | I51210 |
RefSeqi | NP_990502.1, NM_205171.1 XP_015134173.1, XM_015278687.1 XP_015134214.1, XM_015278728.1 XP_015134261.1, XM_015278775.1 XP_015134330.1, XM_015278844.1 |
Genome annotation databases
Ensembli | ENSGALT00000059750; ENSGALP00000056597; ENSGALG00000041094 ENSGALT00000106562; ENSGALP00000074181; ENSGALG00000041094 |
GeneIDi | 396083 |
KEGGi | gga:396083 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S64957 mRNA Translation: AAB28081.1 |
PIRi | I51210 |
RefSeqi | NP_990502.1, NM_205171.1 XP_015134173.1, XM_015278687.1 XP_015134214.1, XM_015278728.1 XP_015134261.1, XM_015278775.1 XP_015134330.1, XM_015278844.1 |
3D structure databases
SMRi | P47191 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000042359 |
Proteomic databases
PaxDbi | P47191 |
Genome annotation databases
Ensembli | ENSGALT00000059750; ENSGALP00000056597; ENSGALG00000041094 ENSGALT00000106562; ENSGALP00000074181; ENSGALG00000041094 |
GeneIDi | 396083 |
KEGGi | gga:396083 |
Organism-specific databases
CTDi | 6857 |
Phylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000155394 |
HOGENOMi | CLU_023008_0_1_1 |
InParanoidi | P47191 |
OrthoDBi | 925064at2759 |
PhylomeDBi | P47191 |
TreeFami | TF315600 |
Enzyme and pathway databases
Reactomei | R-GGA-210500, Glutamate Neurotransmitter Release Cycle R-GGA-264642, Acetylcholine Neurotransmitter Release Cycle R-GGA-8856825, Cargo recognition for clathrin-mediated endocytosis R-GGA-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
PROi | PR:P47191 |
Gene expression databases
Bgeei | ENSGALG00000010319, Expressed in brain and 7 other tissues |
ExpressionAtlasi | P47191, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR015428, Synaptotagmin1 |
PANTHERi | PTHR10024:SF239, PTHR10024:SF239, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYT1_CHICK | |
Accessioni | P47191Primary (citable) accession number: P47191 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families