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Entry version 137 (18 Sep 2019)
Sequence version 1 (01 Feb 1996)
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Protein

Histone transcription regulator 3

Gene

HIR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

HIR1, HIR2 and HIR3 are repressors of histone gene transcription. They are required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. Also has a role in nucleosome assembly.2 Publications

Miscellaneous

Present with 922 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription corepressor activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-31755-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone transcription regulator 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HIR3
Synonyms:HPC1
Ordered Locus Names:YJR140C
ORF Names:J2161
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YJR140C

Saccharomyces Genome Database

More...
SGDi
S000003901 HIR3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002031241 – 1648Histone transcription regulator 3Add BLAST1648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei302PhosphothreonineCombined sources1
Modified residuei304PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P47171

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P47171

PRoteomics IDEntifications database

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PRIDEi
P47171

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P47171

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33896, 359 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-124 HIR complex

Database of interacting proteins

More...
DIPi
DIP-2631N

Protein interaction database and analysis system

More...
IntActi
P47171, 9 interactors

Molecular INTeraction database

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MINTi
P47171

STRING: functional protein association networks

More...
STRINGi
4932.YJR140C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P47171

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HIR3 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112902

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P47171

Identification of Orthologs from Complete Genome Data

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OMAi
NVWKCDA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033053 Hir3/CABIN1

The PANTHER Classification System

More...
PANTHERi
PTHR15502 PTHR15502, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47171-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMFNALNSN IEGEQYEAEE HSRELQIEQS FNILQDALID LKNKDFEKSD
60 70 80 90 100
SKFQELFQID VVKPDRWGMY RNSSPTLDNL RYLCYRNRGM YYHLYLENNY
110 120 130 140 150
ERLNSQELVN CILKAVENLV ESIQHSDADF AVTDLLARIF KSFNSVKLER
160 170 180 190 200
LISEYEFTKQ ENLSLLLGRH RKFLLNDLTL MMNNYVELTN KLLVPNLSDN
210 220 230 240 250
TIFERYHLEK YKDIKPEPLA FGPILSRISE MKKQDEEIMK KLDVFNVTLN
260 270 280 290 300
EESWDEVAKA LKNLLPSVKT SSLIGRNMDP YNEIEEPIEA VKFELSEAIN
310 320 330 340 350
NTPSLDRESE RQEEEQDNES VRADDKSGNL APSDIQTNEE ARPNKRTDEH
360 370 380 390 400
IDSTKPLQRS SKRFKEREQE NSKELVMDVH KRFFGEFNTL LSYIHILPFC
410 420 430 440 450
DFDTFASKFI IGSSDKQPEK FIPYTDLYEC LKSWSSRYTD IFNQNDYLSS
460 470 480 490 500
GSNENEELFQ LNALLKSNAF DDKESFPRYL NDLDSDHIRS FISEVNAGNL
510 520 530 540 550
HFHQVRLKLL FKLLGTYDEG NGRRLIIDYL WESQLLKIVL WFVFGIESNI
560 570 580 590 600
FALINKNKRQ CKYLALSIYE LLVNHLGNIV EEITNKRIQG HKSADLKSQR
610 620 630 640 650
NKVEKRIRSW HTLLEQIADE KDKELYVHFQ WTHYCFLQYT CDIVDSRLSE
660 670 680 690 700
TLTSLENTIK DSDSSLDIAY PNYRHIPALN LNTVQSQKRK IRIIQNITVE
710 720 730 740 750
DISEDTNSDT HSENHLETLE KVLLHILHPS TNHSNIDEEM VSFIFNSPFL
760 770 780 790 800
LKIRLWGVLF SSYVKKSSIQ DVQRIYFHVL DFMKGALTSP VYKESNPHGR
810 820 830 840 850
HQMLLTVLTA IGYLSSQLTA ILNSNRWESS DFVLEDYMFE KLLQTFFFFY
860 870 880 890 900
TVLFYESSAV NDVSNKSFFK RASKSSGKMK DIMIDLATLI LYYYDLQAKL
910 920 930 940 950
RTPAEQGIET TELIWSLHTL FGHFHFCDAS NGKFLDLAEK LLCQFINNDS
960 970 980 990 1000
FLQLKQILWC RYHYAIASDN FSPDLHDTKA VEMEKIHSLP LGTYLIKLQY
1010 1020 1030 1040 1050
QNKNPYLSSS KTTLKQIMDN IIEKIGDPST LDNHIISRNS FLLNEYLSRP
1060 1070 1080 1090 1100
ITADLLKHTF SGATSLYLTS PNDELQQGMT AGLFYVSSLQ SLGLYKMRKK
1110 1120 1130 1140 1150
SMQARPSELD SIIRMLKNDI IYNTNRFESW ILLGKCYSYI VEDDLIWTSD
1160 1170 1180 1190 1200
KITVPEKKDV IALTQRKAIL CYLMAISIYY SKLDRTIDDK KIILEALDDL
1210 1220 1230 1240 1250
GSMLISGYYN PMNKLCFSWK SSAENTMRLS ETGEVVMEKT KKITTISDFN
1260 1270 1280 1290 1300
IEQSIFLCFN RACSLSGDIK SQDDVFVLNW SSFYNLAKFF FKTDGGNNCK
1310 1320 1330 1340 1350
LVAKYITQGC QIAYESSPAK DPIIEPHYLL VNACYKWVKR GVIGVNEALT
1360 1370 1380 1390 1400
LLSKDNQFFQ EQEEFWVNDE GLAWDYQEKF FFDKIIRLLR HLLSVDKKKW
1410 1420 1430 1440 1450
QHRPRYRIAR ILFDDLGDVN GALEEMDSLI SAKSINKNLV NIWKPDFERP
1460 1470 1480 1490 1500
GKHFIYTYQY LVLYLDLLFA IKDFNTTGLV IKKLRRFGSG TVNVNELLER
1510 1520 1530 1540 1550
AINVYTQSAK IKLQLQDKSY VEQILPTLNY QEFLKISEQL NQVFDQGKYP
1560 1570 1580 1590 1600
EEISSGLKLA FQLKKGHSGI AFDSVCLGIY FEYLYFPLAR QDQSLTDVND
1610 1620 1630 1640
ENNPALPSSG SVTSKSTPDP TSKPSAIKKR VTKKEVFDRV RLLVDKIT
Length:1,648
Mass (Da):191,680
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1F31815797852D4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49640 Genomic DNA Translation: CAA89672.1
Z49641 Genomic DNA Translation: CAA89674.1
BK006943 Genomic DNA Translation: DAA08925.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S57163

NCBI Reference Sequences

More...
RefSeqi
NP_012674.1, NM_001181798.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YJR140C_mRNA; YJR140C; YJR140C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853605

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YJR140C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49640 Genomic DNA Translation: CAA89672.1
Z49641 Genomic DNA Translation: CAA89674.1
BK006943 Genomic DNA Translation: DAA08925.1
PIRiS57163
RefSeqiNP_012674.1, NM_001181798.1

3D structure databases

SMRiP47171
ModBaseiSearch...

Protein-protein interaction databases

BioGridi33896, 359 interactors
ComplexPortaliCPX-124 HIR complex
DIPiDIP-2631N
IntActiP47171, 9 interactors
MINTiP47171
STRINGi4932.YJR140C

PTM databases

iPTMnetiP47171

Proteomic databases

MaxQBiP47171
PaxDbiP47171
PRIDEiP47171

Genome annotation databases

EnsemblFungiiYJR140C_mRNA; YJR140C; YJR140C
GeneIDi853605
KEGGisce:YJR140C

Organism-specific databases

EuPathDBiFungiDB:YJR140C
SGDiS000003901 HIR3

Phylogenomic databases

HOGENOMiHOG000112902
InParanoidiP47171
OMAiNVWKCDA

Enzyme and pathway databases

BioCyciYEAST:G3O-31755-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P47171

Family and domain databases

InterProiView protein in InterPro
IPR033053 Hir3/CABIN1
PANTHERiPTHR15502 PTHR15502, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIR3_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47171
Secondary accession number(s): D6VWV9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 18, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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