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Entry version 153 (10 Feb 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Vacuolar protein sorting-associated protein 70

Gene

VPS70

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in vacuolar protein sorting.1 Publication

Miscellaneous

Present with 112 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi445Zinc 2By similarity1
Metal bindingi456Zinc 1By similarity1
Metal bindingi456Zinc 2By similarity1
Metal bindingi522Zinc 2By similarity1
Metal bindingi607Zinc 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-8963693, Aspartate and asparagine metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 70 (EC:3.4.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS70
Ordered Locus Names:YJR126C
ORF Names:J2050
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003887, VPS70

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YJR126C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei90 – 110HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001741381 – 811Vacuolar protein sorting-associated protein 70Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi568N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi670N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P47161

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P47161

PRoteomics IDEntifications database

More...
PRIDEi
P47161

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33882, 65 interactors

Database of interacting proteins

More...
DIPi
DIP-4989N

Protein interaction database and analysis system

More...
IntActi
P47161, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4932.YJR126C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P47161, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M28 family. M28B subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2195, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01010000222351

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005688_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P47161

Identification of Orthologs from Complete Genome Data

More...
OMAi
QGSTEWV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.930.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007484, Peptidase_M28
IPR039373, Peptidase_M28B
IPR007365, TFR-like_dimer_dom
IPR036757, TFR-like_dimer_dom_sf
IPR034308, VPS70

The PANTHER Classification System

More...
PANTHERi
PTHR10404, PTHR10404, 1 hit
PTHR10404:SF46, PTHR10404:SF46, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04389, Peptidase_M28, 1 hit
PF04253, TFR_dimer, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47672, SSF47672, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47161-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRMIQRERKR EKEEGQLKER TVVNMADPDD NEAEATGLQQ YSGETTRDDN
60 70 80 90 100
EESMNDSFTL TSRNRGRSNT ISSIVSGYEI MKEHMDKEKF MYLILASLLL
110 120 130 140 150
YMGFVAAFAP RTSLSRDFRR FHSSRLTNAE VYRIYLNSLQ QENRAKEHVY
160 170 180 190 200
KYAGYMSNGA SDSSTFKYTL DEFLDMGYKP KVEKYYPWIG EPVDTNVAPL
210 220 230 240 250
ENGKVVYEAS MIEDRVKGDP ASHARKRQKG FHQYSKNGSV TARYVFCNYG
260 270 280 290 300
SISDYKLLLK KNIDIEDKIH IVRSGKILPG LKVKNAELYG ASSVIIYTDP
310 320 330 340 350
FDDGKVTEEN GFLHYPYGPA RNPSYIRRDS VNYFSDTPGD PTTPGYPSKD
360 370 380 390 400
SDTEHMSPVG RVPRIPSVPM SARDVQPILE RLNGRGFQIG PGSNIKDFGS
410 420 430 440 450
FTGPSSSIDK VHLHNELTYN IKEMSSVEVS IPGIFTEGEI IIGAHRDSLA
460 470 480 490 500
SSSAGDANSG SAILLEIARG MSKLLKHGWK PLRPIKLISW DGERSGLLGS
510 520 530 540 550
TDYAEAHAAI LRRRALVYLN LDNAISGTNF HCKANPLLQD VIYEAAKLTE
560 570 580 590 600
FNGHEDWSLF DHWKYTSNAT ISLLDGLSSY TSFQYHLGVP AAHFQFNAND
610 620 630 640 650
TSGAVYHSNS VFDSPTWLEK FTNSDYKLHN TMAMFVGLTT LMLSENELAR
660 670 680 690 700
FNTHVYLKKI YNWYIAWHSN LSSAFPQDDE VNSLAKRVLD LLKVATQEDS
710 720 730 740 750
IQFDQQNGIL YKECREALPV WAFYKKIKSY IKLQRSNSKS KQIDQLFITH
760 770 780 790 800
RGLKDREWMK YSLLAPSKFE GSVGEVLPGL HEGLADIDRN EVIQWLTILL
810
SQFSNVRYLL Q
Length:811
Mass (Da):92,018
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i932818225880E49B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49626 Genomic DNA Translation: CAA89657.1
BK006943 Genomic DNA Translation: DAA08911.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S57149

NCBI Reference Sequences

More...
RefSeqi
NP_012660.1, NM_001181784.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YJR126C_mRNA; YJR126C; YJR126C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853590

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YJR126C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49626 Genomic DNA Translation: CAA89657.1
BK006943 Genomic DNA Translation: DAA08911.1
PIRiS57149
RefSeqiNP_012660.1, NM_001181784.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi33882, 65 interactors
DIPiDIP-4989N
IntActiP47161, 1 interactor
STRINGi4932.YJR126C

Proteomic databases

MaxQBiP47161
PaxDbiP47161
PRIDEiP47161

Genome annotation databases

EnsemblFungiiYJR126C_mRNA; YJR126C; YJR126C
GeneIDi853590
KEGGisce:YJR126C

Organism-specific databases

SGDiS000003887, VPS70
VEuPathDBiFungiDB:YJR126C

Phylogenomic databases

eggNOGiKOG2195, Eukaryota
GeneTreeiENSGT01010000222351
HOGENOMiCLU_005688_2_0_1
InParanoidiP47161
OMAiQGSTEWV

Enzyme and pathway databases

ReactomeiR-SCE-8963693, Aspartate and asparagine metabolism

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P47161
RNActiP47161, protein

Family and domain databases

Gene3Di1.20.930.40, 1 hit
InterProiView protein in InterPro
IPR007484, Peptidase_M28
IPR039373, Peptidase_M28B
IPR007365, TFR-like_dimer_dom
IPR036757, TFR-like_dimer_dom_sf
IPR034308, VPS70
PANTHERiPTHR10404, PTHR10404, 1 hit
PTHR10404:SF46, PTHR10404:SF46, 1 hit
PfamiView protein in Pfam
PF04389, Peptidase_M28, 1 hit
PF04253, TFR_dimer, 1 hit
SUPFAMiSSF47672, SSF47672, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS70_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47161
Secondary accession number(s): D6VWU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 10, 2021
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
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