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Entry version 152 (17 Jun 2020)
Sequence version 1 (01 Feb 1996)
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Protein

Phosphoinositide 3-phosphatase

Gene

YMR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P). Involved in the control of PI3P-dependent signaling and in the maintenance of endosomal system integrity.2 Publications

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei397Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:MONOMER3O-76

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-1483248 Synthesis of PIPs at the ER membrane
R-SCE-1632852 Macroautophagy
R-SCE-1660499 Synthesis of PIPs at the plasma membrane
R-SCE-1660516 Synthesis of PIPs at the early endosome membrane
R-SCE-1660517 Synthesis of PIPs at the late endosome membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoinositide 3-phosphatase (EC:3.1.3.64)
Alternative name(s):
Yeast myotubularin-related protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YMR1
Ordered Locus Names:YJR110W
ORF Names:J2007
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YJR110W

Saccharomyces Genome Database

More...
SGDi
S000003871 YMR1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000949481 – 688Phosphoinositide 3-phosphataseAdd BLAST688

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P47147

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P47147

PRoteomics IDEntifications database

More...
PRIDEi
P47147

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P47147

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33866, 67 interactors

Database of interacting proteins

More...
DIPi
DIP-5260N

Protein interaction database and analysis system

More...
IntActi
P47147, 15 interactors

Molecular INTeraction database

More...
MINTi
P47147

STRING: functional protein association networks

More...
STRINGi
4932.YJR110W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P47147 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 637Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST483

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000172348

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001839_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P47147

KEGG Orthology (KO)

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KOi
K18083

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRDFTFV

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR10807 PTHR10807, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06602 Myotub-related, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47147-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEYIKIAKVS NVVLHRRGTA TQGTLHLTTH HLIFESPQLS TEFWFPYPLI
60 70 80 90 100
YGVHKNPGST LLSKLTSTNQ IQLEGTDSQN YKLYQGKDLW SFVNIKVIGK
110 120 130 140 150
DYAVFSLDFG GDLHLQARKV YDSILNLTVL SNITQLYAFI YISNNLERKL
160 170 180 190 200
PSPDSWDIYD PIKEFRRQGL DSKDETCPWR LSTVNEHYEF CPTYPSKLFV
210 220 230 240 250
PRSTSDILLK HASKFRSQKR IPVLTYHHKA TDCNILRSSQ PLPGLINQRS
260 270 280 290 300
IQDEKLVWES FNSFCNKDIR RTKHVIVDAR PRTNALAQMA LGGGTENMDN
310 320 330 340 350
YNFFLADNNM GVDKSLKLPT VTRLFLGIDN IHIVSNTAAY MTEVICQGGD
360 370 380 390 400
LNLPLEQNLI RSQKFSNWLK LNTLILKSVD MLLKSIIFNH SNVLVHCSDG
410 420 430 440 450
WDRTSQVVSL LEICLDPFYR TFEGFMILVE KDWCSFGHRF LERSGHLNSD
460 470 480 490 500
IRFHDNTMHS NFNDVDTNGD DLDIGVNTQD DYAEDDEGGE DETNLINLSR
510 520 530 540 550
ISKKFNENFK LNKKSLKFVS PVFQQFLDCV YQLLTQNPDL FEFNERFLRR
560 570 580 590 600
LVYHLYSCQY GTFLSNSEKE KFQQNLPNKT KSVWDYFRSR RKQFINPNFI
610 620 630 640 650
QRKRSGMNEH DQNLEEEEKV EWISPDLKKV QWWWQLYGRK DSEMNDELRH
660 670 680
KRDSVPISVD KKSKEHSNSD GGKGLNLSIF GFDMFNRK
Length:688
Mass (Da):80,152
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA097F4B98B626C01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85Q → H in AAA66903 (PubMed:2689869).Curated1
Sequence conflicti85Q → H in AAA66901 (PubMed:2689869).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49610 Genomic DNA Translation: CAA89640.1
M30466 Genomic DNA Translation: AAA66903.1
K01178 Genomic DNA Translation: AAA66901.1
BK006943 Genomic DNA Translation: DAA08895.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S57131

NCBI Reference Sequences

More...
RefSeqi
NP_012644.1, NM_001181768.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YJR110W_mRNA; YJR110W; YJR110W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853574

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YJR110W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49610 Genomic DNA Translation: CAA89640.1
M30466 Genomic DNA Translation: AAA66903.1
K01178 Genomic DNA Translation: AAA66901.1
BK006943 Genomic DNA Translation: DAA08895.1
PIRiS57131
RefSeqiNP_012644.1, NM_001181768.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi33866, 67 interactors
DIPiDIP-5260N
IntActiP47147, 15 interactors
MINTiP47147
STRINGi4932.YJR110W

PTM databases

iPTMnetiP47147

Proteomic databases

MaxQBiP47147
PaxDbiP47147
PRIDEiP47147

Genome annotation databases

EnsemblFungiiYJR110W_mRNA; YJR110W; YJR110W
GeneIDi853574
KEGGisce:YJR110W

Organism-specific databases

EuPathDBiFungiDB:YJR110W
SGDiS000003871 YMR1

Phylogenomic databases

GeneTreeiENSGT00940000172348
HOGENOMiCLU_001839_5_1_1
InParanoidiP47147
KOiK18083
OMAiCRDFTFV

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-76
ReactomeiR-SCE-1483248 Synthesis of PIPs at the ER membrane
R-SCE-1632852 Macroautophagy
R-SCE-1660499 Synthesis of PIPs at the plasma membrane
R-SCE-1660516 Synthesis of PIPs at the early endosome membrane
R-SCE-1660517 Synthesis of PIPs at the late endosome membrane

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P47147
RNActiP47147 protein

Family and domain databases

InterProiView protein in InterPro
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF06602 Myotub-related, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYMR1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47147
Secondary accession number(s): D6VWS9, Q12388
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 17, 2020
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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