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Protein

Cell division cycle protein CDT1

Gene

TAH11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA replication licensing factor, required for pre-replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM2-7 helicase complex to the replication origins.7 Publications

Miscellaneous

Present with 2190 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • DNA replication origin binding Source: SGD

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-31681-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein CDT1
Alternative name(s):
SIC1 indispensable protein 2
Topoisomerase-A hypersensitive protein 11
Gene namesi
Name:TAH11
Synonyms:CDT1, SID2
Ordered Locus Names:YJR046W
ORF Names:J1641
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR046W
SGDiS000003807 TAH11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002030951 – 604Cell division cycle protein CDT1Add BLAST604

Proteomic databases

MaxQBiP47112
PaxDbiP47112
PRIDEiP47112

PTM databases

iPTMnetiP47112

Interactioni

Subunit structurei

Associates with the MCM2-7 complex. Interacts with MCM2, ORC1, ORC2 and ORC6.3 Publications

Protein-protein interaction databases

BioGridi33798, 184 interactors
DIPiDIP-7948N
IntActiP47112, 17 interactors
STRINGi4932.YJR046W

Structurei

Secondary structure

1604
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP47112
SMRiP47112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cdt1 family.Curated

Phylogenomic databases

InParanoidiP47112
KOiK12414
OMAiDEPDCLL
OrthoDBiEOG092C18HE

Family and domain databases

InterProiView protein in InterPro
IPR032054 Cdt1_C
PfamiView protein in Pfam
PF16679 CDT1_C, 1 hit

Sequencei

Sequence statusi: Complete.

P47112-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTANSRRK EVLRVPVIDL NRVSDEEQLL PVVRAILLQH DTFLLKNYAN
60 70 80 90 100
KAVLDALLAG LTTKDLPDTS QGFDANFTGT LPLEDDVWLE QYIFDTDPQL
110 120 130 140 150
RFDRKCRNES LCSIYSRLFK LGLFFAQLCV KSVVSSAELQ DCISTSHYAT
160 170 180 190 200
KLTRYFNDNG STHDGADAGA TVLPTGDDFQ YLFERDYVTF LPTGVLTIFP
210 220 230 240 250
CAKAIRYKPS TMATTDNSWV SIDEPDCLLF HTGTLLARWS QGMHTTSPLQ
260 270 280 290 300
IDPRANIVSL TIWPPLTTPI SSKGEGTIAN HLLEQQIKAF PKVAQQYYPR
310 320 330 340 350
ELSILRLQDA MKFVKELFTV CETVLSLNAL SRSTGVPPEL HVLLPQISSM
360 370 380 390 400
MKRKIVQDDI LKLLTIWSDA YVVELNSRGE LTMNLPKRDN LTTLTNKSRT
410 420 430 440 450
LAFVERAESW YQQVIASKDE IMTDVPAFKI NKRRSSSNSK TVLSSKVQTK
460 470 480 490 500
SSNANALNNS RYLANSKENF MYKEKMPDSQ ANLMDRLRER ERRSAALLSQ
510 520 530 540 550
RQKRYQQFLA MKMTQVFDIL FSLTRGQPYT ETYLSSLIVD SLQDSNNPIG
560 570 580 590 600
TKEASEILAG LQGILPMDIS VHQVDGGLKV YRWNSLDKNR FSKLLQIHKS

KQQD
Length:604
Mass (Da):68,405
Last modified:February 1, 1996 - v1
Checksum:i099992C0E3CCA726
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36344 Genomic DNA Translation: AAA88748.1
Z49546 Genomic DNA Translation: CAA89574.1
BK006943 Genomic DNA Translation: DAA08833.1
PIRiS57065
RefSeqiNP_012580.1, NM_001181704.1

Genome annotation databases

EnsemblFungiiYJR046W; YJR046W; YJR046W
GeneIDi853504
KEGGisce:YJR046W

Similar proteinsi

Entry informationi

Entry nameiCDT1_YEAST
AccessioniPrimary (citable) accession number: P47112
Secondary accession number(s): D6VWL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 18, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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