UniProtKB - P47112 (CDT1_YEAST)
Protein
Cell division cycle protein CDT1
Gene
TAH11
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
DNA replication licensing factor, required for pre-replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM2-7 helicase complex to the replication origins.7 Publications
Miscellaneous
Present with 2190 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- DNA replication origin binding Source: SGD
GO - Biological processi
- cell division Source: UniProtKB-KW
- double-strand break repair via break-induced replication Source: SGD
- pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD
- regulation of DNA-dependent DNA replication initiation Source: SGD
Keywordsi
| Molecular function | DNA-binding |
| Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
| BioCyci | YEAST:G3O-31681-MONOMER |
Names & Taxonomyi
| Protein namesi | Recommended name: Cell division cycle protein CDT1Alternative name(s): SIC1 indispensable protein 2 Topoisomerase-A hypersensitive protein 11 |
| Gene namesi | Name:TAH11 Synonyms:CDT1, SID2 Ordered Locus Names:YJR046W ORF Names:J1641 |
| Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic identifieri | 559292 [NCBI] |
| Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | FungiDB:YJR046W |
| SGDi | S000003807 TAH11 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000203095 | 1 – 604 | Cell division cycle protein CDT1Add BLAST | 604 |
Proteomic databases
| MaxQBi | P47112 |
| PaxDbi | P47112 |
| PRIDEi | P47112 |
PTM databases
| iPTMneti | P47112 |
Interactioni
Subunit structurei
Associates with the MCM2-7 complex. Interacts with MCM2, ORC1, ORC2 and ORC6.3 Publications
Protein-protein interaction databases
| BioGridi | 33798, 184 interactors |
| DIPi | DIP-7948N |
| IntActi | P47112, 17 interactors |
| STRINGi | 4932.YJR046W |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| ProteinModelPortali | P47112 |
| SMRi | P47112 |
| ModBasei | Search... |
| MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the Cdt1 family.Curated
Phylogenomic databases
| InParanoidi | P47112 |
| KOi | K12414 |
| OMAi | DEPDCLL |
| OrthoDBi | EOG092C18HE |
Family and domain databases
| InterProi | View protein in InterPro IPR032054 Cdt1_C |
| Pfami | View protein in Pfam PF16679 CDT1_C, 1 hit |
Sequencei
Sequence statusi: Complete.
P47112-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGTANSRRK EVLRVPVIDL NRVSDEEQLL PVVRAILLQH DTFLLKNYAN
60 70 80 90 100
KAVLDALLAG LTTKDLPDTS QGFDANFTGT LPLEDDVWLE QYIFDTDPQL
110 120 130 140 150
RFDRKCRNES LCSIYSRLFK LGLFFAQLCV KSVVSSAELQ DCISTSHYAT
160 170 180 190 200
KLTRYFNDNG STHDGADAGA TVLPTGDDFQ YLFERDYVTF LPTGVLTIFP
210 220 230 240 250
CAKAIRYKPS TMATTDNSWV SIDEPDCLLF HTGTLLARWS QGMHTTSPLQ
260 270 280 290 300
IDPRANIVSL TIWPPLTTPI SSKGEGTIAN HLLEQQIKAF PKVAQQYYPR
310 320 330 340 350
ELSILRLQDA MKFVKELFTV CETVLSLNAL SRSTGVPPEL HVLLPQISSM
360 370 380 390 400
MKRKIVQDDI LKLLTIWSDA YVVELNSRGE LTMNLPKRDN LTTLTNKSRT
410 420 430 440 450
LAFVERAESW YQQVIASKDE IMTDVPAFKI NKRRSSSNSK TVLSSKVQTK
460 470 480 490 500
SSNANALNNS RYLANSKENF MYKEKMPDSQ ANLMDRLRER ERRSAALLSQ
510 520 530 540 550
RQKRYQQFLA MKMTQVFDIL FSLTRGQPYT ETYLSSLIVD SLQDSNNPIG
560 570 580 590 600
TKEASEILAG LQGILPMDIS VHQVDGGLKV YRWNSLDKNR FSKLLQIHKS
KQQD
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36344 Genomic DNA Translation: AAA88748.1 Z49546 Genomic DNA Translation: CAA89574.1 BK006943 Genomic DNA Translation: DAA08833.1 |
| PIRi | S57065 |
| RefSeqi | NP_012580.1, NM_001181704.1 |
Genome annotation databases
| EnsemblFungii | YJR046W; YJR046W; YJR046W |
| GeneIDi | 853504 |
| KEGGi | sce:YJR046W |
Similar proteinsi
Entry informationi
| Entry namei | CDT1_YEAST | |
| Accessioni | P47112Primary (citable) accession number: P47112 Secondary accession number(s): D6VWL7 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
| Last sequence update: | February 1, 1996 | |
| Last modified: | July 18, 2018 | |
| This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Fungal Protein Annotation Program | |



