UniProtKB - P47111 (VPS55_YEAST)
Protein
Vacuolar protein sorting-associated protein 55
Gene
VPS55
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in protein transport from endosomes to the vacuole.1 Publication
Miscellaneous
Present with 2340 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- late endosome to vacuole transport via multivesicular body sorting pathway Source: SGD
- negative regulation of protein localization to cell surface Source: GO_Central
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 55 |
Gene namesi | Name:VPS55 Ordered Locus Names:YJR044C ORF Names:J1637 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003805, VPS55 |
VEuPathDBi | FungiDB:YJR044C |
Subcellular locationi
Endosome
- Endosome membrane Curated; Multi-pass membrane protein Curated
Endosome
- endosome Source: GO_Central
- late endosome Source: SGD
- Vps55/Vps68 complex Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 33 – 37 | LumenalSequence analysis | 5 | |
Transmembranei | 38 – 58 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 59 – 76 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 98 – 107 | LumenalSequence analysis | 10 | |
Transmembranei | 108 – 128 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 140 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215201 | 1 – 140 | Vacuolar protein sorting-associated protein 55Add BLAST | 140 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 137 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P47111 |
PRIDEi | P47111 |
PTM databases
iPTMneti | P47111 |
Interactioni
Binary interactionsi
P47111
With | #Exp. | IntAct |
---|---|---|
VPS68 [Q12016] | 3 | EBI-25497,EBI-29309 |
Protein-protein interaction databases
BioGRIDi | 33796, 210 interactors |
ComplexPortali | CPX-1413, VPS55-VPS68 sorting complex |
DIPi | DIP-7667N |
IntActi | P47111, 5 interactors |
MINTi | P47111 |
STRINGi | 4932.YJR044C |
Miscellaneous databases
RNActi | P47111, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the OB-RGRP/VPS55 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2174, Eukaryota |
GeneTreei | ENSGT00390000006503 |
HOGENOMi | CLU_134810_0_0_1 |
InParanoidi | P47111 |
OMAi | GTNACIE |
Family and domain databases
InterProi | View protein in InterPro IPR007262, Vps55/LEPROT |
PANTHERi | PTHR12050, PTHR12050, 1 hit |
Pfami | View protein in Pfam PF04133, Vps55, 1 hit |
i Sequence
Sequence statusi: Complete.
P47111-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMEFKVSPLT KIISLSGFLA LGFLLVILSC ALFHNYYPLF DILIFLLAPI
60 70 80 90 100
PNTIFNAGNK YHTSDFMSDS SNTGQDLAHF LTGMLVTSGI ALPVVFYHCQ
110 120 130 140
LIGHLSCIMC MIGGLIIYSS IVIFKWFFKK DFNEDDSLFG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49544 Genomic DNA Translation: CAA89572.1 L36344 Genomic DNA Translation: AAA88746.1 AY557891 Genomic DNA Translation: AAS56217.1 BK006943 Genomic DNA Translation: DAA08831.1 |
PIRi | S57063 |
RefSeqi | NP_012578.3, NM_001181702.3 |
Genome annotation databases
EnsemblFungii | YJR044C_mRNA; YJR044C; YJR044C |
GeneIDi | 853502 |
KEGGi | sce:YJR044C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49544 Genomic DNA Translation: CAA89572.1 L36344 Genomic DNA Translation: AAA88746.1 AY557891 Genomic DNA Translation: AAS56217.1 BK006943 Genomic DNA Translation: DAA08831.1 |
PIRi | S57063 |
RefSeqi | NP_012578.3, NM_001181702.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33796, 210 interactors |
ComplexPortali | CPX-1413, VPS55-VPS68 sorting complex |
DIPi | DIP-7667N |
IntActi | P47111, 5 interactors |
MINTi | P47111 |
STRINGi | 4932.YJR044C |
PTM databases
iPTMneti | P47111 |
Proteomic databases
PaxDbi | P47111 |
PRIDEi | P47111 |
Genome annotation databases
EnsemblFungii | YJR044C_mRNA; YJR044C; YJR044C |
GeneIDi | 853502 |
KEGGi | sce:YJR044C |
Organism-specific databases
SGDi | S000003805, VPS55 |
VEuPathDBi | FungiDB:YJR044C |
Phylogenomic databases
eggNOGi | KOG2174, Eukaryota |
GeneTreei | ENSGT00390000006503 |
HOGENOMi | CLU_134810_0_0_1 |
InParanoidi | P47111 |
OMAi | GTNACIE |
Miscellaneous databases
PROi | PR:P47111 |
RNActi | P47111, protein |
Family and domain databases
InterProi | View protein in InterPro IPR007262, Vps55/LEPROT |
PANTHERi | PTHR12050, PTHR12050, 1 hit |
Pfami | View protein in Pfam PF04133, Vps55, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS55_YEAST | |
Accessioni | P47111Primary (citable) accession number: P47111 Secondary accession number(s): D6VWL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names - SIMILARITY comments
Index of protein domains and families