DNA polymerase delta subunit 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-directed DNA polymerase activity Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "DNA polymerase delta is highly processive with proliferating cell nuclear antigen and undergoes collision release upon completing DNA."
    Langston L.D., O'Donnell M.
    J. Biol. Chem. 283:29522-29531(2008) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• base-excision repair Source: SGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Eukaryotic DNA polymerases in DNA replication and DNA repair."
    Burgers P.M.
    Chromosoma 107:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• DNA amplification Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "A mechanism of gene amplification driven by small DNA fragments."
    Mukherjee K., Storici F.
    PLoS Genet. 8:e1003119-e1003119(2012) [PubMed] [Europe PMC] [Abstract]
• DNA replication, removal of RNA primer Source: SGDInferred from direct assayⁱ
  • "Reconstituted Okazaki fragment processing indicates two pathways of primer removal."
    Rossi M.L., Bambara R.A.
    J. Biol. Chem. 281:26051-26061(2006) [PubMed] [Europe PMC] [Abstract]
• double-strand break repair via break-induced replication Source: SGDInferred from mutant phenotypeⁱ
  • "Break-induced replication and telomerase-independent telomere maintenance require Pol32."
    Lydeard J.R., Jain S., Yamaguchi M., Haber J.E.
    Nature 448:820-823(2007) [PubMed] [Europe PMC] [Abstract]
• lagging strand elongation Source: SGDTraceable author statementⁱ
  • "Eukaryotic DNA polymerases in DNA replication and DNA repair."
    Burgers P.M.
    Chromosoma 107:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• leading strand elongation Source: SGDTraceable author statementⁱ
  • "Eukaryotic DNA polymerases in DNA replication and DNA repair."
    Burgers P.M.
    Chromosoma 107:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• nucleic acid phosphodiester bond hydrolysis Source: GOC
• nucleotide-excision repair Source: SGDTraceable author statementⁱ
  • "Eukaryotic DNA polymerases in DNA replication and DNA repair."
    Burgers P.M.
    Chromosoma 107:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• postreplication repair Source: SGDTraceable author statementⁱ
  • "Eukaryotic DNA polymerases in DNA replication and DNA repair."
    Burgers P.M.
    Chromosoma 107:218-227(1998) [PubMed] [Europe PMC] [Abstract]
• RNA-dependent DNA biosynthetic process Source: SGDInferred from direct assayⁱ
  • "RNA-templated DNA repair."
    Storici F., Bebenek K., Kunkel T.A., Gordenin D.A., Resnick M.A.
    Nature 447:338-341(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Phylogenomic databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDQKASYFIN EKLFTEVKPV LFTDLIHHLK IGPSMAKKLM FDYYKQTTNA 
        60         70         80         90        100
KYNCVVICCY KDQTIKIIHD LSNIPQQDSI IDCFIYAFNP MDSFIPYYDI 
       110        120        130        140        150
IDQKDCLTIK NSYELKVSES SKIIERTKTL EEKSKPLVRP TARSKTTPEE 
       160        170        180        190        200
TTGRKSKSKD MGLRSTALLA KMKKDRDDKE TSRQNELRKR KEENLQKINK 
       210        220        230        240        250
QNPEREAQMK ELNNLFVEDD LDTEEVNGGS KPNSPKETDS NDKDKNNDDL 
       260        270        280        290        300
EDLLETTAED SLMDVPKIQQ TKPSETEHSK EPKSEEEPSS FIDEDGYIVT 
       310        320        330        340        350
KRPATSTPPR KPSPVVKRAL SSSKKQETPS SNKRLKKQGT LESFFKRKAK 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. Yeast chromosome X
   Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
3. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD