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Protein

Regulator of V-ATPase in vacuolar membrane protein 1

Gene

RAV1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the RAVE complex, which is required for stable assembly of the vacuolar ATPase complex V-ATPase under many conditions. Required for transport between the early endosome and the late endosome/prevacuolar compartment (PVC), suggesting that assembly of vacuolar ATPase at the early endosome is required for transport from the early endosome to the PVC.3 Publications

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • early endosome to late endosome transport Source: SGD
  • protein transport Source: UniProtKB-KW
  • regulation of protein complex assembly Source: SGD
  • vacuolar acidification Source: SGD
  • vacuolar proton-transporting V-type ATPase complex assembly Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31670-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of V-ATPase in vacuolar membrane protein 1
Alternative name(s):
Suppression of the onset of impotence protein 3
Gene namesi
Name:RAV1
Synonyms:SOI3
Ordered Locus Names:YJR033C
ORF Names:J1590
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR033C
SGDiS000003794 RAV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511831 – 1357Regulator of V-ATPase in vacuolar membrane protein 1Add BLAST1357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1244PhosphoserineCombined sources1
Modified residuei1248PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP47104
PaxDbiP47104
PRIDEiP47104
TopDownProteomicsiP47104

PTM databases

CarbonylDBiP47104
iPTMnetiP47104

Interactioni

Subunit structurei

Component of the RAVE complex composed of RAV1, RAV2 and CBF3D/SKP1. Within the complex, it interacts directly with RAV2 and CBF3D. Interacts with the V-ATPase V1 subunits VMA1, VMA2 and VMA8.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33786, 255 interactors
ComplexPortaliCPX-1627 RAVE complex
DIPiDIP-916N
IntActiP47104, 6 interactors
MINTiP47104
STRINGi4932.YJR033C

Structurei

3D structure databases

ProteinModelPortaliP47104
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati98 – 134WD 1Add BLAST37
Repeati142 – 182WD 2Add BLAST41
Repeati190 – 239WD 3Add BLAST50
Repeati384 – 423WD 4Add BLAST40
Repeati431 – 470WD 5Add BLAST40
Repeati595 – 636WD 6Add BLAST42
Repeati638 – 679WD 7Add BLAST42
Repeati898 – 939WD 8Add BLAST42

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000000096
HOGENOMiHOG000093808
InParanoidiP47104
OMAiLRYDYTN
OrthoDBiEOG092C0AAM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR022033 Rav1p_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12234 Rav1p_C, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 4 hits

Sequencei

Sequence statusi: Complete.

P47104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNFLPGRP NATPQTACQA TWQNHTIFAY CSGNNLIILT NKFTRLQTIY
60 70 80 90 100
TQSDCTAVDI NSQNGFIALS FHNRVLIYKP IHQIMQNPKW TQCCQLFHDD
110 120 130 140 150
TPVNCLRWSS DNELAIGSDF LSFWKIKDNF GVYQPILQWN QKQPKPVYNV
160 170 180 190 200
IISQDSQLIV SIGKYDCNAK LWKRVSIVGE QAIFNLTMLP HPKPITAMRW
210 220 230 240 250
KKEPDQVSKN NTASHALYTL CEDKVLRIWS CFEMEKNHTV QIWGEVPLSP
260 270 280 290 300
TQKFCVIIDN WIIRQTLSVK DSEIFDISDS DIVILGSMTG EMEVLALNNL
310 320 330 340 350
SQDPPKPMTK KTISHKKVKK ATMLNDTRYL YLPEIQPYDN VKGKLSFLVH
360 370 380 390 400
DLQGVIRHLL IDILQLINNK TEDLSAALEH KFTGHNKSVQ KLVRSSDGEA
410 420 430 440 450
LLTTSRFSEN GVWYPQKLNH GVSLRLQNTI QTESPIKFAV VHELGKQVIC
460 470 480 490 500
LLENGALQAW ECPTNRKEDS EQKQSYLRVE TRLKEEKKIH PIVMLNTPEP
510 520 530 540 550
KHSHERHFTA LIFSDGSIKA FEVSLTRGIF EVKSDSLDID GDDIYKISII
560 570 580 590 600
DPVHQTFVSN RPLISLITKK GLTRTYKAIV NYNDRHVQWI KACEINTGIM
610 620 630 640 650
NCTCIRGSST GKLCIVNSTG KVMSLWDLNR GVLEYEETFH NPIEDIDWTS
660 670 680 690 700
TEYGQSIVSI GFTGYALLYT QLRYDYTNNT PSYLPIEKID ITAHTAHNIG
710 720 730 740 750
DSVWMKNGTF VVASGNQFYI KDKSLDLTDP FTYQSIGSRK ILSNDILHLS
760 770 780 790 800
SVLNGPLPVY HPQFLIQAIY ANKLQLVKEL LLRLFLALRK LDFESQDVSN
810 820 830 840 850
LDSNLGMDPL KYFIAKDRDY PVESFPDPYP CFNKTVSLAL TEQLTKTTLP
860 870 880 890 900
YLTRHQQITL ITVIEAVDEV TKNENIVDYN GVRFLLGVKL FLSHKNIQKS
910 920 930 940 950
ILMRDVSWAL HSDNKEILLS SIDRHITSWN RAREYRIAYW IKEQDLVKKF
960 970 980 990 1000
EDIAKYEFSK DDKRDPSRCA IFYLALKKKQ ILLSLWKMAI GHPEQQKMVR
1010 1020 1030 1040 1050
FISNDFTVPR WRTAALKNAF VLLSKHRYMD AAVFFLLTDS LKDCVNVLCK
1060 1070 1080 1090 1100
QVHDMDLAIG VCRVYEGDNG PVLGELLTAQ MLPETIKEND RWKASFIYWK
1110 1120 1130 1140 1150
LRKQEVAIKA LLTAPIDLEN NSSIVDKEVC VNRSFLVEDP ALLYLYNHLR
1160 1170 1180 1190 1200
NRNLKYFIGS LNVEAKIECT LILRVTDILC RMGCNYLAVS LVKNWKFIER
1210 1220 1230 1240 1250
NSIPVQKLLK SPTKDRAYSA IGAMASEPIS TARMRPSLFD KFGSPSASDI
1260 1270 1280 1290 1300
ESPNPKLPNS LLDDFLQPPP NSTSSNSLAQ SSSSAPRSIL DEFVSPSYSQ
1310 1320 1330 1340 1350
HKENLTPKAP NDSVGETDNS ENRKDKLSKD ILDDLSSQKP QKPKKSAITK

NLLDDFV
Length:1,357
Mass (Da):154,933
Last modified:February 1, 1996 - v1
Checksum:i6B7270B6901274CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49533 Genomic DNA Translation: CAA89560.1
L36344 Genomic DNA Translation: AAA88735.1
X87297 Genomic DNA Translation: CAA60726.1
BK006943 Genomic DNA Translation: DAA08822.1
PIRiS57052
RefSeqiNP_012567.3, NM_001181691.3

Genome annotation databases

EnsemblFungiiYJR033C; YJR033C; YJR033C
GeneIDi853490
KEGGisce:YJR033C

Similar proteinsi

Entry informationi

Entry nameiRAV1_YEAST
AccessioniPrimary (citable) accession number: P47104
Secondary accession number(s): D6VWK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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