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Protein

GPI mannosyltransferase 1

Gene

GPI14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • fungal-type cell wall organization Source: SGD
  • GPI anchor biosynthetic process Source: SGD
  • mannosylation Source: GOC

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation, GPI-anchor biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31658-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00196

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT50 Glycosyltransferase Family 50

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GPI mannosyltransferase 1 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase I
Short name:
GPI-MT-I
Glycosylphosphatidylinositol-anchor biosynthesis protein 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPI14
Synonyms:PMH1
Ordered Locus Names:YJR013W
ORF Names:J1444, YJR83.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003774 GPI14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4CytoplasmicSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 78LumenalSequence analysisAdd BLAST53
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 110CytoplasmicSequence analysisAdd BLAST11
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132LumenalSequence analysis1
Transmembranei133 – 149HelicalSequence analysisAdd BLAST17
Topological domaini150 – 160CytoplasmicSequence analysisAdd BLAST11
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 193LumenalSequence analysisAdd BLAST12
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 266CytoplasmicSequence analysisAdd BLAST52
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 310LumenalSequence analysisAdd BLAST23
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 334CytoplasmicSequence analysis3
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 361LumenalSequence analysis6
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 403CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002030841 – 403GPI mannosyltransferase 1Add BLAST403

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P47088

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P47088

PRoteomics IDEntifications database

More...
PRIDEi
P47088

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33769, 166 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1270 Glycosylphosphatidylinositol-mannosyltransferase I complex

Protein interaction database and analysis system

More...
IntActi
P47088, 54 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YJR013W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P47088

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIGM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017728

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000186884

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P47088

KEGG Orthology (KO)

More...
KOi
K05284

Identification of Orthologs from Complete Genome Data

More...
OMAi
IQIISHY

Database of Orthologous Groups

More...
OrthoDBi
EOG092C1YEW

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007704 PIG-M

The PANTHER Classification System

More...
PANTHERi
PTHR12886 PTHR12886, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05007 Mannosyl_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47088-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGEEWGLTV LSFLVRVGFF LFGIYQDANF KVRYTDIDYF VFHDAAKYVY
60 70 80 90 100
EGKSPYARDT YRYTPLLSWL LVPNHYFGWF HLGKVIFVIF DLVTGLIIMK
110 120 130 140 150
LLNQAISRKR ALILESIWLL NPMVITISTR GNAESVLCCL IMFTLFFLQK
160 170 180 190 200
SRYTLAGILY GLSIHFKIYP IIYCIPIAIF IYYNKRNQGP RTQLTSLLNI
210 220 230 240 250
GLSTLTTLLG CGWAMYKIYG YEFLDQAYLY HLYRTDHRHN FSVWNMLLYL
260 270 280 290 300
DSANKENGES NLSRYAFVPQ LLLVLVTGCL EWWNPTFDNL LRVLFVQTFA
310 320 330 340 350
FVTYNKVCTS QYFVWYLIFL PFYLSRTHIG WKKGLLMATL WVGTQGIWLS
360 370 380 390 400
QGYYLEFEGK NVFYPGLFIA SVLFFVTNVW LLGQFITDIK IPTQPTVSNK

KNN
Length:403
Mass (Da):47,166
Last modified:July 25, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1017701557FDB0F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA60935 differs from that shown. Reason: Frameshift at position 40.Curated
The sequence CAA89537 differs from that shown. Reason: Frameshift at position 40.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X87611 Genomic DNA Translation: CAA60935.1 Frameshift.
Z49513 Genomic DNA Translation: CAA89537.1 Frameshift.
AY260895 Genomic DNA Translation: AAP21763.1
AY557910 Genomic DNA Translation: AAS56236.1
BK006943 Genomic DNA Translation: DAA08805.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S55201

NCBI Reference Sequences

More...
RefSeqi
NP_012547.2, NM_001181671.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YJR013W_mRNA; YJR013W_mRNA; YJR013W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853470

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YJR013W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87611 Genomic DNA Translation: CAA60935.1 Frameshift.
Z49513 Genomic DNA Translation: CAA89537.1 Frameshift.
AY260895 Genomic DNA Translation: AAP21763.1
AY557910 Genomic DNA Translation: AAS56236.1
BK006943 Genomic DNA Translation: DAA08805.1
PIRiS55201
RefSeqiNP_012547.2, NM_001181671.1

3D structure databases

ProteinModelPortaliP47088
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33769, 166 interactors
ComplexPortaliCPX-1270 Glycosylphosphatidylinositol-mannosyltransferase I complex
IntActiP47088, 54 interactors
STRINGi4932.YJR013W

Protein family/group databases

CAZyiGT50 Glycosyltransferase Family 50

Proteomic databases

MaxQBiP47088
PaxDbiP47088
PRIDEiP47088

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR013W_mRNA; YJR013W_mRNA; YJR013W
GeneIDi853470
KEGGisce:YJR013W

Organism-specific databases

SGDiS000003774 GPI14

Phylogenomic databases

GeneTreeiENSGT00390000017728
HOGENOMiHOG000186884
InParanoidiP47088
KOiK05284
OMAiIQIISHY
OrthoDBiEOG092C1YEW

Enzyme and pathway databases

UniPathwayi
UPA00196

BioCyciYEAST:G3O-31658-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P47088

Family and domain databases

InterProiView protein in InterPro
IPR007704 PIG-M
PANTHERiPTHR12886 PTHR12886, 1 hit
PfamiView protein in Pfam
PF05007 Mannosyl_trans, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPI14_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47088
Secondary accession number(s): D6VWI9, E9P8R4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 25, 2006
Last modified: December 5, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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