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Protein

Myosin tail region-interacting protein MTI1

Gene

BBC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of actin cytoskeleton.1 Publication

GO - Molecular functioni

  • myosin I binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: SGD
  • cytoskeleton organization Source: UniProtKB
  • negative regulation of Arp2/3 complex-mediated actin nucleation Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31492-MONOMER

Protein family/group databases

MoonDBiP47068 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin tail region-interacting protein MTI1
Alternative name(s):
Protein BBC1
Gene namesi
Name:BBC1
Synonyms:MTI1
Ordered Locus Names:YJL020C
ORF Names:J1286, J1305, YJL021C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

SGDiS000003557 BBC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648391 – 1157Myosin tail region-interacting protein MTI1Add BLAST1157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei636PhosphothreonineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei850PhosphothreonineCombined sources1
Modified residuei889PhosphoserineCombined sources1
Modified residuei894PhosphothreonineCombined sources1
Modified residuei895PhosphothreonineCombined sources1
Cross-linki1012Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP47068
PaxDbiP47068
PRIDEiP47068

PTM databases

iPTMnetiP47068

Interactioni

Subunit structurei

Binds to the SH3 domains of the type I myosins MYO3 and MYO5.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33738, 190 interactors
DIPiDIP-6279N
IntActiP47068, 79 interactors
MINTiP47068
STRINGi4932.YJL020C

Structurei

Secondary structure

11157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP47068
SMRiP47068
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47068

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 69SH3PROSITE-ProRule annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili234 – 301Sequence analysisAdd BLAST68
Coiled coili356 – 430Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 412Glu-richAdd BLAST135
Compositional biasi674 – 830Pro-richAdd BLAST157

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

InParanoidiP47068
KOiK20521
OMAiHIVERRN
OrthoDBiEOG092C0BBJ

Family and domain databases

CDDicd11887 SH3_Bbc1, 1 hit
InterProiView protein in InterPro
IPR035552 Mti1_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

P47068-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEPEVPFKV VAQFPYKSDY EDDLNFEKDQ EIIVTSVEDA EWYFGEYQDS
60 70 80 90 100
NGDVIEGIFP KSFVAVQGSE VGKEAESSPN TGSTEQRTIQ PEVEQKDLPE
110 120 130 140 150
PISPETKKET LSGPVPVPAA TVPVPAATVP VPAATAVSAQ VQHDSSSGNG
160 170 180 190 200
ERKVPMDSPK LKARLSMFNQ DITEQVPLPK STHLDLENIP VKKTIVADAP
210 220 230 240 250
KYYVPPGIPT NDTSNLERKK SLKENEKKIV PEPINRAQVE SGRIETENDQ
260 270 280 290 300
LKKDLPQMSL KERIALLQEQ QRLQAAREEE LLRKKAKLEQ EHERSAVNKN
310 320 330 340 350
EPYTETEEAE ENEKTEPKPE FTPETEHNEE PQMELLAHKE ITKTSREADE
360 370 380 390 400
GTNDIEKEQF LDEYTKENQK VEESQADEAR GENVAEESEI GYGHEDREGD
410 420 430 440 450
NDEEKEEEDS EENRRAALRE RMAKLSGASR FGAPVGFNPF GMASGVGNKP
460 470 480 490 500
SEEPKKKQHK EKEEEEPEQL QELPRAIPVM PFVDPSSNPF FRKSNLSEKN
510 520 530 540 550
QPTETKTLDP HATTEHEQKQ EHGTHAYHNL AAVDNAHPEY SDHDSDEDTD
560 570 580 590 600
DHEFEDANDG LRKHSMVEQA FQIGNNESEN VNSGEKIYPQ EPPISHRTAE
610 620 630 640 650
VSHDIENSSQ NTTGNVLPVS SPQTRVARNG SINSLTKSIS GENRRKSINE
660 670 680 690 700
YHDTVSTNSS ALTETAQDIS MAAPAAPVLS KVSHPEDKVP PHPVPSAPSA
710 720 730 740 750
PPVPSAPSVP SAPPVPPAPP ALSAPSVPPV PPVPPVSSAP PALSAPSIPP
760 770 780 790 800
VPPTPPAPPA PPAPLALPKH NEVEEHVKSS APLPPVSEEY HPMPNTAPPL
810 820 830 840 850
PRAPPVPPAT FEFDSEPTAT HSHTAPSPPP HQNVTASTPS MMSTQQRVPT
860 870 880 890 900
SVLSGAEKES RTLPPHVPSL TNRPVDSFHE SDTTPKVASI RRSTTHDVGE
910 920 930 940 950
ISNNVKIEFN AQERWWINKS APPAISNLKL NFLMEIDDHF ISKRLHQKWV
960 970 980 990 1000
VRDFYFLFEN YSQLRFSLTF NSTSPEKTVT TLQERFPSPV ETQSARILDE
1010 1020 1030 1040 1050
YAQRFNAKVV EKSHSLINSH IGAKNFVSQI VSEFKDEVIQ PIGARTFGAT
1060 1070 1080 1090 1100
ILSYKPEEGI EQLMKSLQKI KPGDILVIRK AKFEAHKKIG KNEIINVGMD
1110 1120 1130 1140 1150
SAAPYSSVVT DYDFTKNKFR VIENHEGKII QNSYKLSHMK SGKLKVFRIV

ARGYVGW
Length:1,157
Mass (Da):128,297
Last modified:January 17, 2003 - v2
Checksum:i88A5899B89CCE8ED
GO

Sequence cautioni

The sequence CAA89311 differs from that shown. Reason: Frameshift at positions 729 and 732.Curated
The sequence CAA89312 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49295 Genomic DNA Translation: CAA89311.1 Frameshift.
Z49296 Genomic DNA Translation: CAA89312.1 Different initiation.
AF373805 Genomic DNA Translation: AAL57239.1
BK006943 Genomic DNA Translation: DAA08776.1
PIRiS56791
S56792
RefSeqiNP_012514.2, NM_001181454.1

Genome annotation databases

EnsemblFungiiYJL020C; YJL020C; YJL020C
GeneIDi853433
KEGGisce:YJL020C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49295 Genomic DNA Translation: CAA89311.1 Frameshift.
Z49296 Genomic DNA Translation: CAA89312.1 Different initiation.
AF373805 Genomic DNA Translation: AAL57239.1
BK006943 Genomic DNA Translation: DAA08776.1
PIRiS56791
S56792
RefSeqiNP_012514.2, NM_001181454.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TG0X-ray0.97A1-68[»]
1WDXX-ray2.50A/B/C/D1-68[»]
1ZUKX-ray1.90A/B1-68[»]
2DYFNMR-B796-802[»]
ProteinModelPortaliP47068
SMRiP47068
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33738, 190 interactors
DIPiDIP-6279N
IntActiP47068, 79 interactors
MINTiP47068
STRINGi4932.YJL020C

Protein family/group databases

MoonDBiP47068 Predicted

PTM databases

iPTMnetiP47068

Proteomic databases

MaxQBiP47068
PaxDbiP47068
PRIDEiP47068

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL020C; YJL020C; YJL020C
GeneIDi853433
KEGGisce:YJL020C

Organism-specific databases

SGDiS000003557 BBC1

Phylogenomic databases

InParanoidiP47068
KOiK20521
OMAiHIVERRN
OrthoDBiEOG092C0BBJ

Enzyme and pathway databases

BioCyciYEAST:G3O-31492-MONOMER

Miscellaneous databases

EvolutionaryTraceiP47068
PROiPR:P47068

Family and domain databases

CDDicd11887 SH3_Bbc1, 1 hit
InterProiView protein in InterPro
IPR035552 Mti1_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBBC1_YEAST
AccessioniPrimary (citable) accession number: P47068
Secondary accession number(s): D6VWG0, P47067, Q8X1F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 17, 2003
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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Main funding by: National Institutes of Health

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