UniProtKB - P47039 (BNA3_YEAST)
Protein
Probable kynurenine--oxoglutarate transaminase BNA3
Gene
BNA3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA).By similarity
Miscellaneous
Present with 1600 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:2.6.1.7
Cofactori
pyridoxal 5'-phosphateCurated
: L-kynurenine degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes kynurenate from L-kynurenine.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Probable kynurenine--oxoglutarate transaminase BNA3 (BNA3), Aromatic amino acid aminotransferase 2 (ARO9)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes kynurenate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.
GO - Molecular functioni
- 2-aminoadipate transaminase activity Source: SGD
- kynurenine-oxoglutarate transaminase activity Source: SGD
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- kynurenic acid biosynthetic process Source: SGD
- L-kynurenine catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Aminotransferase, Transferase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | MetaCyc:YJL060W-MONOMER |
BRENDAi | 2.6.1.7, 984 |
Reactomei | R-SCE-71240, Tryptophan catabolism R-SCE-8964208, Phenylalanine metabolism R-SCE-8964539, Glutamate and glutamine metabolism |
UniPathwayi | UPA00334;UER00726 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable kynurenine--oxoglutarate transaminase BNA3 (EC:2.6.1.7)Alternative name(s): Biosynthesis of nicotinic acid protein 3 Kynurenine aminotransferase |
Gene namesi | Name:BNA3 Ordered Locus Names:YJL060W ORF Names:J1138 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003596, BNA3 |
VEuPathDBi | FungiDB:YJL060W |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Mitochondrion
- Mitochondrion 2 Publications
Mitochondrion
- mitochondrion Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
Cytoplasm, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123930 | 1 – 444 | Probable kynurenine--oxoglutarate transaminase BNA3Add BLAST | 444 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 271 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Proteomic databases
MaxQBi | P47039 |
PaxDbi | P47039 |
PRIDEi | P47039 |
PTM databases
iPTMneti | P47039 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 33694, 91 interactors |
DIPi | DIP-6723N |
IntActi | P47039, 8 interactors |
MINTi | P47039 |
STRINGi | 4932.YJL060W |
Miscellaneous databases
RNActi | P47039, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P47039 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P47039 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated
Phylogenomic databases
eggNOGi | KOG0257, Eukaryota |
GeneTreei | ENSGT00940000171422 |
HOGENOMi | CLU_017584_4_0_1 |
InParanoidi | P47039 |
OMAi | SVAMTGW |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR004838, NHTrfase_class1_PyrdxlP-BS IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00105, AA_TRANSFER_CLASS_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P47039-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQRFIRQFT NLMSTSRPKV VANKYFTSNT AKDVWSLTNE AAAKAANNSK
60 70 80 90 100
NQGRELINLG QGFFSYSPPQ FAIKEAQKAL DIPMVNQYSP TRGRPSLINS
110 120 130 140 150
LIKLYSPIYN TELKAENVTV TTGANEGILS CLMGLLNAGD EVIVFEPFFD
160 170 180 190 200
QYIPNIELCG GKVVYVPINP PKELDQRNTR GEEWTIDFEQ FEKAITSKTK
210 220 230 240 250
AVIINTPHNP IGKVFTREEL TTLGNICVKH NVVIISDEVY EHLYFTDSFT
260 270 280 290 300
RIATLSPEIG QLTLTVGSAG KSFAATGWRI GWVLSLNAEL LSYAAKAHTR
310 320 330 340 350
ICFASPSPLQ EACANSINDA LKIGYFEKMR QEYINKFKIF TSIFDELGLP
360 370 380 390 400
YTAPEGTYFV LVDFSKVKIP EDYPYPEEIL NKGKDFRISH WLINELGVVA
410 420 430 440
IPPTEFYIKE HEKAAENLLR FAVCKDDAYL ENAVERLKLL KDYL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49335 Genomic DNA Translation: CAA89351.1 BK006943 Genomic DNA Translation: DAA08738.1 |
PIRi | S56832 |
RefSeqi | NP_012475.3, NM_001181493.3 |
Genome annotation databases
EnsemblFungii | YJL060W_mRNA; YJL060W; YJL060W |
GeneIDi | 853386 |
KEGGi | sce:YJL060W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49335 Genomic DNA Translation: CAA89351.1 BK006943 Genomic DNA Translation: DAA08738.1 |
PIRi | S56832 |
RefSeqi | NP_012475.3, NM_001181493.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3B46 | X-ray | 2.00 | A/B | 1-444 | [»] | |
SMRi | P47039 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33694, 91 interactors |
DIPi | DIP-6723N |
IntActi | P47039, 8 interactors |
MINTi | P47039 |
STRINGi | 4932.YJL060W |
PTM databases
iPTMneti | P47039 |
Proteomic databases
MaxQBi | P47039 |
PaxDbi | P47039 |
PRIDEi | P47039 |
Genome annotation databases
EnsemblFungii | YJL060W_mRNA; YJL060W; YJL060W |
GeneIDi | 853386 |
KEGGi | sce:YJL060W |
Organism-specific databases
SGDi | S000003596, BNA3 |
VEuPathDBi | FungiDB:YJL060W |
Phylogenomic databases
eggNOGi | KOG0257, Eukaryota |
GeneTreei | ENSGT00940000171422 |
HOGENOMi | CLU_017584_4_0_1 |
InParanoidi | P47039 |
OMAi | SVAMTGW |
Enzyme and pathway databases
UniPathwayi | UPA00334;UER00726 |
BioCyci | MetaCyc:YJL060W-MONOMER |
BRENDAi | 2.6.1.7, 984 |
Reactomei | R-SCE-71240, Tryptophan catabolism R-SCE-8964208, Phenylalanine metabolism R-SCE-8964539, Glutamate and glutamine metabolism |
Miscellaneous databases
EvolutionaryTracei | P47039 |
PROi | PR:P47039 |
RNActi | P47039, protein |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR004838, NHTrfase_class1_PyrdxlP-BS IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00105, AA_TRANSFER_CLASS_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BNA3_YEAST | |
Accessioni | P47039Primary (citable) accession number: P47039 Secondary accession number(s): D6VWC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families